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HOME > J. Microbiol > Volume 56(6); 2018 > Article
Journal Article
Colistin resistance in Enterobacter spp. isolates in Korea
Yoon-Kyoung Hong , Ji-Young Lee , Kwan Soo Ko
Journal of Microbiology 2018;56(6):435-440.
DOI: https://doi.org/10.1007/s12275-018-7449-0
Published online: June 1, 2018
Department of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of KoreaDepartment of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea
Corresponding author:  Kwan Soo Ko , Tel: +82-31-299-6223, 
Received: 23 October 2017   • Revised: 14 February 2018   • Accepted: 6 April 2018
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Abstract

We investigated the colistin resistance rate among 356 Enterobacter spp. clinical isolates from eight hospitals in Korea. Antibiotic susceptibility testing was performed by broth microdilution. While 51 of 213 (23.9%) Enterobacter cloacae isolates were colistin-resistant, only six of 143 (4.2%) E. aerogenes isolates showed resistance. We also identified the skip well phenotype in eight E. cloacae and three E. aerogenes isolates. Multilocus sequence typing for E. cloacae and randomly amplified polymorphic DNA analysis and enterobacterial repetitive intergenic consensus PCR for E. aerogenes revealed that clonal spreading of colistin-resistant and skip well Enterobacter spp. isolates had not occurred. In vitro time-kill assays were performed with three colistin-resistant, three skip well, and two colistin-susceptible isolates of E. cloacae and E. aerogenes. Inconsistent results were observed among isolates with skip well phenotypes; while some were eradicated by 2 mg/L colistin, others were not. This suggests that skip well isolates have differentiated into different categories. As the high rates of colistin resistance in E. cloacae detected are of clinical concern, continuous monitoring is warranted. In addition, the clinical implications and mechanisms of the skip well phenotype should be investigated to ensure the appropriate use of colistin against Enterobacter infections.

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    Colistin resistance in Enterobacter spp. isolates in Korea
    J. Microbiol. 2018;56(6):435-440.   Published online June 1, 2018
    DOI: https://doi.org/10.1007/s12275-018-7449-0
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