Abstract
Statin response shows great interindividual variations. Recently,
emerging studies have shown that gut microbiota is
linked to therapeutic responses to drugs, including statins.
However, the association between the gut bacteria composition
and statin response is still unclear. In this study, gut
microbiota of 202 hyperlipidemic patients with statin sensitive
(SS) response and statin resistant (SR) response in
East China were investigated by high throughput sequencing
to compare the gut bacteria composition and biodiversity
in distinct statin response patients. Higher biodiversity was
detected in Group SS than Group SR. Specifically, group SS
showed significantly increased proportion of genera Lactobacillus
(P = 0.001), Eubacterium (P = 0.004), Faecalibacterium
(P = 0.005), and Bifidobacterium (P = 0.002) and decreased
proportion of genus Clostridium (P = 0.001) compared
to Group SR. The results indicated that higher gut biodiversity
was associated with statin sensitive response. The
increased genera Lactobacillus, Eubacterium, Faecalibacterium,
Bifidobacterium, and decreased genus Clostridium in
patient gut microbiota may predict patient's statin response,
and hence may guide statin dosage adjustments.
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