A comprehensive review of SARS-CoV-2 genetic mutations and lessons from animal coronavirus recombination in one health perspective

Woonsung Na; Hyoungjoon Moon; Daesub Song

doi:10.1007/s12275-021-0660-4

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A comprehensive review of SARS-CoV-2 genetic mutations and lessons from animal coronavirus recombination in one health perspective: Woonsung Na ¹, Hyoungjoon Moon ², Daesub Song ³; Journal of Microbiology 2021;59(3):332-340
DOI: https://doi.org/10.1007/s12275-021-0660-4
Published online: February 23, 2021

¹College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea, ²College of Healthcare & Biotechnology, Semyung University, Jecheon 27136, Republic of Korea, ³College of Pharmacy, Korea University, Sejong 30019, Republic of Korea¹College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea, ²College of Healthcare & Biotechnology, Semyung University, Jecheon 27136, Republic of Korea, ³College of Pharmacy, Korea University, Sejong 30019, Republic of Korea

Corresponding author: Daesub Song ,

Received: 15 December 2020 • Revised: 8 February 2021 • Accepted: 15 February 2021

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Abstract

SARS-CoV-2 was originated from zoonotic coronaviruses and confirmed as a novel beta-coronavirus, which causes serious respiratory illness such as pneumonia and lung failure, COVID-19. In this review, we describe the genetic characteristics of SARS-CoV-2, including types of mutation, and molecular epidemiology, highlighting its key difference from animal coronaviruses. We further summarized the current knowledge on clinical, genetic, and pathological features of several animal coronaviruses and compared them with SARSCoV- 2, as well as recent evidences of interspecies transmission and recombination of animal coronaviruses to provide a better understanding of SARS-CoV-2 infection in One Health perspectives. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail, that may help mitigate the spread and damages caused by the disease.

Keywords: EPIYA-C motif;Helicobacter pylori;cagA;geographic diversity;polymorphism

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A comprehensive review of SARS-CoV-2 genetic mutations and lessons from animal coronavirus recombination in one health perspective

J. Microbiol. 2021;59(3):332-340. Published online February 23, 2021

DOI: https://doi.org/10.1007/s12275-021-0660-4

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