Differences in seroprevalence between epicenter and non-epicenter areas of the COVID-19 outbreak in South Korea

Hye Won Jeong; Hyun-Ha Chang; Eun Ji Kim; Yu Kyung Kim; Se-Mi Kim; Eun-Ha Kim; Young-Il Kim; Mark Anthony B. Casel; Seong-Gyu Kim; Rare Rollon; Seung-Gyu Jang; Kwang-Min Yu; Hee-Sung Kim; Hee Sue Park; Su-Jin Park; Yong-Dae Kim; Eung-Gook Kim; Young Ki Choi

doi:10.1007/s12275-021-1095-7

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Differences in seroprevalence between epicenter and non-epicenter areas of the COVID-19 outbreak in South Korea: Hye Won Jeong ^1,2, Hyun-Ha Chang ³, Eun Ji Kim ⁴, Yu Kyung Kim ⁵, Se-Mi Kim ⁴, Eun-Ha Kim ⁴, Young-Il Kim ⁴, Mark Anthony B. Casel ⁴, Seong-Gyu Kim ⁴, Rare Rollon ⁴, Seung-Gyu Jang ⁴, Kwang-Min Yu ⁴, Hee-Sung Kim ², Hee Sue Park ⁶, Su-Jin Park ⁷, Yong-Dae Kim ^8,9, Eung-Gook Kim ⁴, Young Ki Choi ⁴; Journal of Microbiology 2021;59(5):530-533
DOI: https://doi.org/10.1007/s12275-021-1095-7
Published online: April 28, 2021

¹Department of Internal Medicine, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 28644, Republic of Korea, ²Department of Internal Medicine, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea, ³Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea, ⁴College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 28644, Republic of Korea, ⁵Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea, ⁶Department of Laboratory Medicine, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea, ⁷Division of Life Science and Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea, ⁸Department of Preventive Medicine, College of Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Republic of Korea, ⁹Chungbuk Regional Cancer Center, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea¹Department of Internal Medicine, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 28644, Republic of Korea, ²Department of Internal Medicine, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea, ³Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea, ⁴College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 28644, Republic of Korea, ⁵Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea, ⁶Department of Laboratory Medicine, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea, ⁷Division of Life Science and Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea, ⁸Department of Preventive Medicine, College of Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Republic of Korea, ⁹Chungbuk Regional Cancer Center, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea

Received: 16 February 2021 • Revised: 5 April 2021 • Accepted: 5 April 2021

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Abstract

To compare the standardized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence of high epicenter region with non-epicenter region, serological studies were performed with a total of 3,268 sera from Daegu City and 3,981 sera from Chungbuk Province. Indirect immunofluorescence assay (IFA) for SARS-CoV-2 IgG results showed a high seroprevalence rate in the Daegu City (epicenter) compared with a non-epicenter area (Chungbuk Province) (1.27% vs. 0.91%, P = 0.0358). It is noteworthy that the highest seroprevalence in Daegu City was found in elderly patients (70’s) whereas young adult patients (20’s) in Chungbuk Province showed the highest seroprevalence. Neutralizing antibody (NAb) titers were found in three samples from Daegu City (3/3, 268, 0.09%) while none of the samples from Chungbuk Province were NAb positive. These results demonstrated that even following the large outbreak, the seropositive rate of SARS-CoV-2 in the general population remained low in South Korea.

Keywords: South Yellow Sea;high-throughput sequencing;mcrA gene;methanogen community;shallow sediments

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Differences in seroprevalence between epicenter and non-epicenter areas of the COVID-19 outbreak in South Korea

J. Microbiol. 2021;59(5):530-533. Published online April 28, 2021

DOI: https://doi.org/10.1007/s12275-021-1095-7

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