The comparison of microbial communities in thyroid tissues from thyroid carcinoma patients

Chen-Jian Liu; Si-Qian Chen; Si-Yao Zhang; Jia-Lun Wang; Xiao-Dan Tang; Kun-Xian Yang; Xiao-Ran Li

doi:10.1007/s12275-021-1271-9

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The comparison of microbial communities in thyroid tissues from thyroid carcinoma patients: Chen-Jian Liu ^1†, Si-Qian Chen ^1†, Si-Yao Zhang ¹, Jia-Lun Wang ¹, Xiao-Dan Tang ^2,3, Kun-Xian Yang ^4,5, Xiao-Ran Li ¹; Journal of Microbiology 2021;59(11):988-1001
DOI: https://doi.org/10.1007/s12275-021-1271-9
Published online: October 6, 2021

¹Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, P. R. China, ²Gastroenterology Department, the First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, P. R. China, ³Gastroenterology Department, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, P. R. China, ⁴Oncology Department, the First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, P. R. China, ⁵Oncology Department, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, P. R. China¹Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, P. R. China, ²Gastroenterology Department, the First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, P. R. China, ³Gastroenterology Department, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, P. R. China, ⁴Oncology Department, the First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan, P. R. China, ⁵Oncology Department, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, P. R. China

Corresponding author: Kun-Xian Yang , Tel: +86-871-65920759,
Xiao-Ran Li , Tel: +86-871-65920759,

Received: 20 May 2021 • Revised: 17 August 2021 • Accepted: 20 August 2021

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Abstract

Thyroid carcinoma is a common endocrine organ cancer associated with abnormal hormone secretion, leading to the disorder of metabolism. The intestinal microbiota is vital to maintain digestive and immunologic homeostasis. The relevant information of the microbial community in the gut and thyroid, including composition, structure, and relationship, is unclear in thyroid carcinoma patients. A total of 93 samples from 25 patients were included in this study. The results showed that microbial communities existed in thyroid tissue; gut and thyroid had high abundance of facultative anaerobes from the Proteobacteria phyla. The microbial metabolism from the thyroid and gut may be affected by the thyroid carcinoma cells. The cooccurrence network showed that the margins of different thyroid tissues were unique areas with more competition; the stabilization of microcommunities from tissue and stool may be maintained by several clusters of species that may execute different vital metabolism processes dominantly that are attributed to the microenvironment of cancer.

Keywords: Interferon;ORF39;STING;VZV

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The comparison of microbial communities in thyroid tissues from thyroid carcinoma patients

J. Microbiol. 2021;59(11):988-1001. Published online October 6, 2021

DOI: https://doi.org/10.1007/s12275-021-1271-9

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