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Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice
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Journal Article
Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice
Jaeyeong Park 1†, Eunkyoung Shin 1†, Ji-Hyun Yeom 1†, Younkyung Choi 1, Minju Joo 1, Minho Lee 2, Je Hyeong Kim 3, Jeehyeon Bae 4, Kangseok Lee 1
Journal of Microbiology 2022;60(1):128-136
DOI: https://doi.org/10.1007/s12275-022-1620-3
Published online: December 29, 2021
1Department of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea, 2Department of Microbiology, College of Medicine, Hallym University, Chuncheon 24252, Republic of Korea, 3Division of Pulmonology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan 15355, Republic of Korea, 4School of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea1Department of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea, 2Department of Microbiology, College of Medicine, Hallym University, Chuncheon 24252, Republic of Korea, 3Division of Pulmonology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan 15355, Republic of Korea, 4School of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea
Corresponding author:  Jeehyeon Bae , Tel: +82-2-820-5241, 
Kangseok Lee , Tel: +82-2-820-5241, 
Received: 30 November 2021   • Revised: 9 December 2021   • Accepted: 13 December 2021
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Abstract

Acinetobacter baumannii causes multidrug resistance, leading to fatal infections in humans. In this study, we showed that Lys AB2 P3-His–a hexahistidine-tagged form of an antimicrobial peptide (AMP) loaded onto DNA aptamer-functionalized gold nanoparticles (AuNP-Apt)–can effectively inhibit A. baumannii infection in mice. When A. baumannii-infected mice were intraperitoneally injected with AuNP-Apt loaded with Lys AB2 P3-His, a marked reduction in A. baumannii colonization was observed in the mouse organs, leading to prominently increased survival time and rate of the mice compared to those of the control mice treated with AuNP-Apt or Lys AB2 P3-His only. This study shows that AMPs loaded onto AuNP-Apt could be an effective therapeutic tool against infections caused by multidrug-resistant pathogenic bacteria in humans.

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    Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice
    J. Microbiol. 2022;60(1):128-136.   Published online December 29, 2021
    DOI: https://doi.org/10.1007/s12275-022-1620-3
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