Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants

Junsoo Park; Rackhyun Park; Minsu Jang; Yea-In Park; Yeonjeong Park

doi:10.1007/s12275-022-1499-z

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Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants: Junsoo Park , Rackhyun Park , Minsu Jang , Yea-In Park , Yeonjeong Park; Journal of Microbiology 2022;60(3):347-354.
DOI: https://doi.org/10.1007/s12275-022-1499-z
Published online: January 28, 2022

Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of KoreaDivision of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea

Corresponding author: Junsoo Park , Tel: +82-33-760-2560,

Received: 27 September 2021 • Revised: 9 November 2021 • Accepted: 9 November 2021

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Abstract

Coronavirus disease (COVID-19) can cause critical conditions that require efficient therapeutics. Several medicines are derived from plants, and researchers are seeking natural compounds to ameliorate the symptoms of COVID-19. Viral enzymes are popular targets of antiviral medicines; the genome of coronaviruses encodes several enzymes, including RNAdependent RNA polymerase and viral proteases. Various screening systems have been developed to identify potential inhibitors. In this review, we describe the natural compounds that have been shown to exert inhibitory effects on coronavirus enzymes. Although computer-aided molecular structural studies have predicted several antiviral compound candidates, the current review focuses on experimentally proven natural compounds.

Keywords: ROS;cellular senescence;hCMV;p16INK4a;piceatannol

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Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants

J. Microbiol. 2022;60(3):347-354. Published online January 28, 2022

DOI: https://doi.org/10.1007/s12275-022-1499-z

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