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[Minireview]The rationale and potential for using Lactobacillus in the management of periodontitis
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[Minireview]The rationale and potential for using Lactobacillus in the management of periodontitis
Jiaqi Wang 1, Yingman Liu 1, Weiru Wang 1, Jiaojiao Ma 1, Manman Zhang 2, Xiaoying Lu 2, Jie Liu 3, Yurong Kou 1,2
Journal of Microbiology 2022;60(4):355-363
DOI: https://doi.org/10.1007/s12275-022-1514-4
Published online: March 28, 2022
1Department of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110122, P. R. China, 2Department of Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110122, P. R. China, 3Science Experiment Center, China Medical University, Shenyang 110122, P. R. China1Department of Periodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110122, P. R. China, 2Department of Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110122, P. R. China, 3Science Experiment Center, China Medical University, Shenyang 110122, P. R. China
Corresponding author:  Yurong Kou , Tel: +86-24-31927706, 
Received: 5 October 2021   • Revised: 7 February 2022   • Accepted: 25 February 2022
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Periodontitis refers to a wide range of the inflammatory conditions of supporting dental structures. For some patients with periodontitis, antibacterial agents are needed as an adjuvant to mechanical debridement treatments and oral hygiene maintenance. However, the widespread use of broad-spectrum antibiotics for the prophylaxis and treatment of periodontal infections
results
in the emergence of resistant pathogens. Therefore, probiotics have become markedly interesting to researchers as a potentially safe alternative to periodontal treatment and maintenance. Probiotics have been used in medicine for decades and extensively applied to the treatment of inflammatory diseases through the modulation of microbial synergy and other mechanisms. A growing amount of evidence has shown that using Lactobacillus strains for oral cavity maintenance could improve periodontal health. In this study, we reviewed studies showing proof of the inhibitory effects of Lactobacillus species on periodontal inflammation. We also explored the rationale and potential for using Lactobacillus species in the management of periodontitis.

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    [Minireview]The rationale and potential for using Lactobacillus in the management of periodontitis
    J. Microbiol. 2022;60(4):355-363.   Published online March 28, 2022
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