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HOME > J. Microbiol > Volume 60(11); 2022 > Article
Journal Article
Hepatitis B virus (HBV) codon adapts well to the gene expression profile of liver cancer: an evolutionary explanation for HBV’s oncogenic role
Chunpeng Yu 1, Jian Li 1, Qun Li 1, Shuai Chang 1, Yufeng Cao 2, Hui Jiang 2, Lingling Xie 1, Gang Fan 3, Song Wang 1
Journal of Microbiology 2022;60(11):1106-1112.
DOI: https://doi.org/10.1007/s12275-022-2371-x
Published online: October 17, 2022
1Department of Interventional Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266005, P. R. China, 2Department of Oncology, The Affiliated Qingdao Hiser Hospital of Qingdao University, Qingdao, Shandong 266005, P. R. China, 3Department of Interventional Radiology, Jimo District Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong 266005, P. R. China
Corresponding author:  Song Wang , Tel: +86-0532-96166, 
Received: 16 August 2022   • Revised: 15 September 2022   • Accepted: 20 September 2022
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Abstract

Due to the evolutionary arms race between hosts and viruses, viruses must adapt to host translation systems to rapidly synthesize viral proteins. Highly expressed genes in hosts have a codon bias related to tRNA abundance, the primary RNA translation rate determinant. We calculated the relative synonymous codon usage (RSCU) of three hepatitis viruses (HAV, HBV, and HCV), SARS-CoV-2, 30 human tissues, and hepatocellular carcinoma (HCC). After comparing RSCU between viruses and human tissues, we calculated the codon adaptation index (CAI) of viral and human genes. HBV and HCV showed the highest correlations with HCC and the normal liver, while SARS-CoV-2 had the strongest association with lungs. In addition, based on HCC RSCU, the CAI of HBV and HCV genes was the highest. HBV and HCV preferentially adapt to the tRNA pool in HCC, facilitating viral RNA translation. After an initial trigger, rapid HBV/HCV translation and replication may change normal liver cells into HCC cells. Our findings reveal a novel perspective on virus-mediated oncogenesis.

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    Hepatitis B virus (HBV) codon adapts well to the gene expression profile of liver cancer: an evolutionary explanation for HBV’s oncogenic role
    J. Microbiol. 2022;60(11):1106-1112.   Published online October 17, 2022
    DOI: https://doi.org/10.1007/s12275-022-2371-x
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