Membrane Proteins as a Regulator for Antibiotic Persistence in Gram‑Negative Bacteria

Jia Xin Yee; Juhyun Kim; Jinki Yeom

doi:10.1007/s12275-023-00024-w

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Membrane Proteins as a Regulator for Antibiotic Persistence in Gram‑Negative Bacteria: Jia Xin Yee ¹, Juhyun Kim ², Jinki Yeom ^1,3,4; Journal of Microbiology 2023;61(3):331-341
DOI: https://doi.org/10.1007/s12275-023-00024-w
Published online: February 17, 2023

¹Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore, ²School of Life Science, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea, ³Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea, ⁴Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea¹Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore, ²School of Life Science, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea, ³Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea, ⁴Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea

Corresponding author: Jinki Yeom , Tel: ,

Received: 3 January 2023 • Revised: 26 January 2023 • Accepted: 27 January 2023

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Abstract

Antibiotic treatment failure threatens our ability to control bacterial infections that can cause chronic diseases. Persister bacteria are a subpopulation of physiological variants that becomes highly tolerant to antibiotics. Membrane proteins play crucial roles in all living organisms to regulate cellular physiology. Although a diverse membrane component involved in persistence can result in antibiotic treatment failure, the regulations of antibiotic persistence by membrane proteins has not been fully understood. In this review, we summarize the recent advances in our understanding with regards to membrane proteins in Gram-negative bacteria as a regulator for antibiotic persistence, highlighting various physiological mechanisms in bacteria.

Keywords: Pseudomonas aeruginosa;Antimicrobial agent;Chalcone;Multidrug resistant bacteria;Oxidative stress

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Membrane Proteins as a Regulator for Antibiotic Persistence in Gram‑Negative Bacteria

J. Microbiol. 2023;61(3):331-341. Published online February 17, 2023

DOI: https://doi.org/10.1007/s12275-023-00024-w

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