Abstract

In the evolving landscape of cancer research, the human microbiome emerges as a pivotal determinant reshaping our understanding of tumorigenesis and therapeutic responses. Advanced sequencing technologies have uncovered a vibrant microbial community not confned to the gut but thriving within tumor tissues. Comprising bacteria, viruses, and fungi, this diverse microbiota displays distinct signatures across various cancers, with most research primarily focusing on bacteria. The correlations between specifc microbial taxa within diferent cancer types underscore their pivotal roles in driving tumorigenesis and infuencing therapeutic responses, particularly in chemotherapy and immunotherapy. This review amalgamates recent discoveries, emphasizing the translocation of the oral microbiome to the gut as a potential marker for microbiome dysbiosis across diverse cancer types and delves into potential mechanisms contributing to cancer promotion. Furthermore, it highlights the adverse efects of the microbiome on cancer development while exploring its potential in fortifying strategies for cancer prevention and treatment.

• Keywords: Microbiome;Cancer;Oral microbiome;Chemotherapy;Immunotherapy