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- Stimulation of Tissue Transglutaminase Activity by Clostridium botulinum Neurotoxin Type B
- Yu Seok Moon 1, Gi-Hyeok Yang 2, Sang-Dal Rhee 1, Hyun Ho Jung 2,3
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Journal of Microbiology 2003;41(2):161-164
1 Department of Biological Science, Korea Advanced Institute of Science and Technology, Yusong, Daejeon 305-701, Korea; 2 Microbial Toxin Research Institute, Medy-Tox Inc., Asan, Chungnam 337-150, Kora; 3 Division of Applied Biological Sciences, Sunmoon University, Asan, Chungnam 337-150, Korea (Received February 14, 2003 / Accepted April 11, 2003)1 Department of Biological Science, Korea Advanced Institute of Science and Technology, Yusong, Daejeon 305-701, Korea; 2 Microbial Toxin Research Institute, Medy-Tox Inc., Asan, Chungnam 337-150, Kora; 3 Division of Applied Biological Sciences, Sunmoon University, Asan, Chungnam 337-150, Korea (Received February 14, 2003 / Accepted April 11, 2003)
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Corresponding author:
Hyun Ho Jung , Tel: 82-41-530-2271,
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Abstract
Recombinant light chain of Clostridium botulinum neurotoxin type B stimulated transglutaminase activity in a dose dependent manner. Compared to native toxin, recombinant light chain showed a greater stimulatory effect on transglutaminase activity. Zn-chelating agents, inhibiting the roteolytic activity of the clostridial toxins, did not interfere with this stimulation. These results suggest that the light chain plays a major stimulatory role, which is not due to its metallopeptidase activity, but is possibly due to specific interaction with transglutaminase. More importantly, this report provides a new insight into the intracellular action of C. botulinum neurotoxins.
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