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Microbial Conversion of Major Ginsenoside Rb1 to Pharmaceutically Active Minor Ginsenoside Rd
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HOME > J. Microbiol > Volume 43(5); 2005 > Article
Research Support, Non-U.S. Gov't
Microbial Conversion of Major Ginsenoside Rb1 to Pharmaceutically Active Minor Ginsenoside Rd
Myung Kyum Kim 1, Jun Won Lee 1, Ki Young Lee 2, Deok-Chun Yang 1
Journal of Microbiology 2005;43(5):456-462
DOI: https://doi.org/2275 [pii]
1Department of Oriental Medicinal Material & Processing, College of Life science, Kyung Hee University, Yongin, Kyunggi-do 449-701, Republic of Korea, 2Department of Food & Biotechnology, Hoseo University, Asan, Chungnam 336-795, Republic of Korea1Department of Oriental Medicinal Material & Processing, College of Life science, Kyung Hee University, Yongin, Kyunggi-do 449-701, Republic of Korea, 2Department of Food & Biotechnology, Hoseo University, Asan, Chungnam 336-795, Republic of Korea
Corresponding author:  Deok-Chun Yang , Tel: 82-31-201-2688, 
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Abstract

More than seventy strains of aerobic bacteria showing [beta]-glucosidase activity were isolated from a ginseng field, using a newly designed Esculin-R2A agar, and identified by their 16S rRNA gene sequences. Of these microorganisms, twelve strains could convert the major ginsenoside, Rb1, to the pharmaceutically active minor ginsenoside Rd. Three strains, Burkholderia pyrrocinia GP16, Bacillus megaterium GP27 and Sphingomonas echinoides GP50, were phylogenetically studied, and observed to be most potent at converting ginsenoside Rb1 almost completely within 48 h, as shown by TLC and HPLC analyses.

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    Microbial Conversion of Major Ginsenoside Rb1 to Pharmaceutically Active Minor Ginsenoside Rd
    J. Microbiol. 2005;43(5):456-462.
    DOI: https://doi.org/2275 [pii]
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