Production and Biological Activity of Laidlomycin, Anti-MRSA/VRE Antibiotic from Streptomyces sp. CS684

Jin Cheol Yoo; Jun Ho Kim; Jung Wan Ha; Nae Soo Park; Jae Kyung Sohng; June Woo Lee; Seong Chan Park; Mi Sun Kim; Chi Nam Seong

doi:2499 [pii]

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Production and Biological Activity of Laidlomycin, Anti-MRSA/VRE Antibiotic from Streptomyces sp. CS684: Jin Cheol Yoo ¹, Jun Ho Kim ¹, Jung Wan Ha ¹, Nae Soo Park ¹, Jae Kyung Sohng ², June Woo Lee ³, Seong Chan Park ⁴, Mi Sun Kim ⁴, Chi Nam Seong ⁴; Journal of Microbiology 2007;45(1):6-10
DOI: https://doi.org/2499 [pii]

¹Department of Pharmacy, Chosun University, Gwangju 501-759, Republic of Korea, ²Department of Pharmaceutical Engineering, Sunmoon University, Chungnam 337-708, Republic of Korea, ³Department of Environmental Engineering, College of Applied Science, Catholic University of Pusan, Pusan 607-757, Republic of Korea, ⁴Department of Biology, College of Natural Sciences, Sunchon National University, Jeonnam 540-742, Republic of Korea¹Department of Pharmacy, Chosun University, Gwangju 501-759, Republic of Korea, ²Department of Pharmaceutical Engineering, Sunmoon University, Chungnam 337-708, Republic of Korea, ³Department of Environmental Engineering, College of Applied Science, Catholic University of Pusan, Pusan 607-757, Republic of Korea, ⁴Department of Biology, College of Natural Sciences, Sunchon National University, Jeonnam 540-742, Republic of Korea

Corresponding author: Chi Nam Seong , Tel: 82-8-61-750-3613,

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Abstract

Culture broth of a streptomycete isolate, Streptomyces sp. CS684 showed antibacterial activity on methicilin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE). Among purified substances from the organism, CSU-1, which is active against MRSA and VRE, is a C37H62O12Na (M+, 721.3875), and identified as laidlomycin. The anti-MRSA and anti-VRE activity of CSU-1 was stronger than oxacillin and vancomycin. Phylogenetic analysis showed that strain CS684 is very similar to Streptomyces ardus NRRL 2817T, whereas the ability of Streptomyces sp. CS684 to produce laidlomycin was shown to be unique.

Keywords: Anti-MRSA; Anti-VRE; polyether antibiotic; laidlomycin; Streptomyces sp. CS684

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Production and Biological Activity of Laidlomycin, Anti-MRSA/VRE Antibiotic from Streptomyces sp. CS684

J. Microbiol. 2007;45(1):6-10.

DOI: https://doi.org/2499 [pii]

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