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Mutations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of Topoisomerase IV in Clinical Strains of Fluoroquinolone-Resistant Shigella in Anhui, China
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HOME > J. Microbiol > Volume 45(2); 2007 > Article
Research Support, Non-U.S. Gov't
Mutations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of Topoisomerase IV in Clinical Strains of Fluoroquinolone-Resistant Shigella in Anhui, China
Li-Fen Hu , Jia-Bin Li , Ying Ye , Xu Li
Journal of Microbiology 2007;45(2):168-170
DOI: https://doi.org/2517 [pii]
Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Anhui 230022, P. R. ChinaDepartment of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Anhui 230022, P. R. China
Corresponding author:  Xu Li , Tel: 86-551-292-2281, 
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Abstract

In this research 26 Shigella isolates were examined by PCR and direct nucleotide sequencing for genetic alterations in the quinolone-resistance determining regions (QRDRs). We tested for the presence of qnr genes by PCR in 91 strains, but no qnr genes were found. The results did show, however, some novel mutations at codon 83 of gyrA (Ser→Ile) and codon 64 of parC (Ala64→Cys, Ala64→Asp), which were related to fluroquinolone resistance.

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    Mutations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of Topoisomerase IV in Clinical Strains of Fluoroquinolone-Resistant Shigella in Anhui, China
    J. Microbiol. 2007;45(2):168-170.
    DOI: https://doi.org/2517 [pii]
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