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Identification and Characterization of the Vibrio vulnificus rtxA Essential for Cytotoxicity in vitro and Virulence in Mice
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HOME > J. Microbiol > Volume 45(2); 2007 > Article
Research Support, Non-U.S. Gov't
Identification and Characterization of the Vibrio vulnificus rtxA Essential for Cytotoxicity in vitro and Virulence in Mice
Jeong Hyun Lee 1, Myung Won Kim 1, Byoung Sik Kim 1, Seung Min Kim 1, Byung Cheol Lee 2, Tae Sung Kim 2, Sang Ho Choi 1
Journal of Microbiology 2007;45(2):146-152
DOI: https://doi.org/2520 [pii]
1Department of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University, Seoul 151-742, Republic of Korea, 2School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea1Department of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University, Seoul 151-742, Republic of Korea, 2School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea
Corresponding author:  Sang Ho Choi , Tel: 82-2-880-4857, 
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Abstract

A mutant exhibiting decreased cytotoxic activity toward INT-407 intestinal epithelial cells and carrying a mutation in the rtx gene cluster that consists of rtxCA and rtxBDE operons was screened from a library of V. vulnificus mutants. The functions of the rtxA gene, assessed by constructing an isogenic mutant and evaluating its phenotypic changes, demonstrated that RtxA is essential for the virulence of V. vulnificus in mice as well as in tissue cultures.

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    Identification and Characterization of the Vibrio vulnificus rtxA Essential for Cytotoxicity in vitro and Virulence in Mice
    J. Microbiol. 2007;45(2):146-152.
    DOI: https://doi.org/2520 [pii]
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