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Journal Article
- Burkholderia cepacia Complex Infection in a Cohort of Italian Patients with Cystic Fibrosis
- Antonietta Lambiase 1, Valeria Raia 2, Stefania Stefani 3, Angela Sepe 2, Pasqualina Ferri 2, Paolo Buonpensiero 2, Fabio Rossano 1, Mariassunta Del Pezzo 1
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Journal of Microbiology 2007;45(3):275-279
DOI: https://doi.org/2530 [pii]
1Department of Biology and Pathology Cellular and Molecular “Luigi Califano”, 2Department of Pediatrics, Regional Cystic Fibrosis Center, University of Naples “Federico II”, Pansini Street 5-80131, Italy, 3Department of Microbiological and Gynecological Sciences, University of Catania, Italy1Department of Biology and Pathology Cellular and Molecular “Luigi Califano”, 2Department of Pediatrics, Regional Cystic Fibrosis Center, University of Naples “Federico II”, Pansini Street 5-80131, Italy, 3Department of Microbiological and Gynecological Sciences, University of Catania, Italy
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Corresponding author:
Antonietta Lambiase , Tel: 39-81-746-2530,
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Abstract
The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01).
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