Synergistic Antibacterial Effect between Silybin and N,N’-Dicyclohexylcarbodiimide in Clinical Pseudomonas aeruginosa Isolates

Hyun Jun Jung; Dong Gun Lee

doi:10.1007/s12275-008-0138-7

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Synergistic Antibacterial Effect between Silybin and N,N’-Dicyclohexylcarbodiimide in Clinical Pseudomonas aeruginosa Isolates: Hyun Jun Jung , Dong Gun Lee; Journal of Microbiology 2008;46(4):462-467.
DOI: https://doi.org/10.1007/s12275-008-0138-7
Published online: August 31, 2008

Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Republic of KoreaDepartment of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Republic of Korea

Corresponding author: Dong Gun Lee , Tel: 82-53-950-5373,

Received: 4 June 2008 • Accepted: 24 June 2008

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Abstract

Silybin is a composition of the silymarin group as a hepatoprotective agent, and it exhibits various biological activities, including an antibacterial activity. In this study, the effects of a combination of silybin with N,N′-dicyclohexylcarbodiimide (DCCD) against clinical isolates of Pseudomonas aeruginosa were investigated. In the results of susceptibility assay, silybin showed more potent antibacterial activity in methicilin-resistant Staphylococcus aureus (MRSA) than in P. aeruginosa, but DCCD significantly increased the antibacterial activity of silybin in P. aeruginosa. The antibacterial activity of silybin was affected by the strong action of multidrug-resistant pumps rather than by a permeable disruption of lipopolysaccharide and silybin showed a remarkable synergistic activity in combination with some antibiotic agents against drug-resistant bacteria. Therefore, silybin has a potential as a combination therapeutic agent for treatment of infectious diseases by multidrug-resistant bacteria.

Keywords: silybin;antibacterial activity;MDR pump;synergistic effect;N′-dicyclohexylcarbodiimide

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Synergistic Antibacterial Effect between Silybin and N,N’-Dicyclohexylcarbodiimide in Clinical Pseudomonas aeruginosa Isolates

J. Microbiol. 2008;46(4):462-467. Published online August 31, 2008

DOI: https://doi.org/10.1007/s12275-008-0138-7

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