- Volume 53(10); October 2015
-
Review
- MINIREVIEW] Regulation and function of the Salmonella MgtC virulence protein
-
Jang-Woo Lee , Eun-Jin Lee
-
J. Microbiol. 2015;53(10):667-672. Published online August 1, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5283-1
-
-
49
View
-
0
Download
-
22
Crossref
-
Abstract
-
Salmonella enterica serovar Typhimurium produces many
virulence proteins to cause diseases. The Salmonella MgtC
protein is one of such virulence proteins specially required
for intracellular proliferation inside macrophages and mouse
virulence. In this review, we will cover how the mgtC gene
is turned on or off and what the signals required for mgtC
expression are. Later in this review, we will discuss a recent
understanding of MgtC function in Salmonella pathogenesis
by identifying its target proteins.
-
Citations
Citations to this article as recorded by

- The peptidoglycan-associated lipoprotein gene mutant elicits robust immunological defense in mice against Salmonella enteritidis
Guixin Zhao, Wenlong Duan, Lu Zhang, Wenchao Sun, Wan Liu, Xiaoyu Zhang, Yanying Zhang, Qiumei Shi, Tonglei Wu
Frontiers in Microbiology.2024;[Epub] CrossRef - Insights into the global genomic features of Salmonella enterica serovar Gallinarum biovars Gallinarum and Pullorum
Isabela C Campos, Felipe Pinheiro Vilela, Mauro de M S Saraiva, Angelo Berchieri Junior, Juliana Pfrimer Falcão
Journal of Applied Microbiology.2024;[Epub] CrossRef - Salmonella Gallinarum mgtC mutant shows a delayed fowl typhoid progression in chicken
Lucas Bocchini Rodrigues Alves, Oliveiro Caetano de Freitas Neto, Mauro de Mesquita Souza Saraiva, Daniel Farias Marinho do Monte, Bruna Nestlehner de Lima, Julia Memrava Cabrera, Fernanda de Oliveira Barbosa, Valdinete Pereira Benevides, Túlio Spina de L
Gene.2024; 892: 147827. CrossRef - CRISPR-Cas system positively regulates virulence of Salmonella enterica serovar Typhimurium
Nandita Sharma, Ankita Das, Abhilash Vijay Nair, Palash Sethi, Vidya Devi Negi, Dipshikha Chakravortty, Sandhya Amol Marathe
Gut Pathogens.2024;[Epub] CrossRef - Contribution of intramacrophage stages to Pseudomonas aeruginosa infection outcome in zebrafish embryos: insights from mgtC and oprF mutants
Hélène Hajjar, Laurence Berry, Yongzheng Wu, Lhousseine Touqui, Annette C. Vergunst, Anne-Béatrice Blanc-Potard
Scientific Reports.2024;[Epub] CrossRef - Impact of Arsenic Stress on the Antioxidant System and Photosystem of Arthrospira platensis
Jiawei Liu, Jie Du, Di Wu, Xiang Ji, Xiujuan Zhao
Biology.2024; 13(12): 1049. CrossRef - Horizontal Gene Transfer and Drug Resistance Involving Mycobacterium tuberculosis
Xuhua Xia
Antibiotics.2023; 12(9): 1367. CrossRef - Virulence genes identification in Salmonella enterica isolates from humans, crocodiles, and poultry farms from two regions in Colombia
Julieth Michel Petano-Duque, Valentina Rueda-García, Iang Schroniltgen Rondón-Barragán
Veterinary World.2023; : 2096. CrossRef - Virulence and Antimicrobial Resistance Gene Profiling of Salmonella Isolated from Swine Meat Samples in Abattoirs and Wet Markets of Metro Manila, Philippines
Rance Derrick N. Pavon, Windell L. Rivera
Microbiology and Biotechnology Letters.2023; 51(4): 390. CrossRef - Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design
Kia C. Ferrell, Matt D. Johansen, James A. Triccas, Claudio Counoupas
Frontiers in Microbiology.2022;[Epub] CrossRef - Characterization of Salmonella spp. Isolates from Swine: Virulence and Antimicrobial Resistance
Hai Nguyen Thi, Thi-Thanh-Thao Pham, Barbara Turchi, Filippo Fratini, Valentina Virginia Ebani, Domenico Cerri, Fabrizio Bertelloni
Animals.2020; 10(12): 2418. CrossRef - The mgtCBR mRNA Leader Secures Growth of Salmonella in Both Host and Non-host Environments
Myungseo Park, Hyunkeun Kim, Daesil Nam, Dae-Hyuk Kweon, Dongwoo Shin
Frontiers in Microbiology.2019;[Epub] CrossRef - Synthetic hydrophobic peptides derived from MgtR weaken Salmonella pathogenicity and work with a different mode of action than endogenously produced peptides
Mariana Rosas Olvera, Preeti Garai, Grégoire Mongin, Eric Vivès, Laila Gannoun-Zaki, Anne-Béatrice Blanc-Potard
Scientific Reports.2019;[Epub] CrossRef - The malS-5′UTR weakens the ability of Salmonella enterica serovar Typhi to survive in macrophages by increasing intracellular ATP levels
Fang Dong, Lin Xia, Renfei Lu, Xin Zhao, Yiquan Zhang, Ying Zhang, Xinxiang Huang
Microbial Pathogenesis.2018; 115: 321. CrossRef - High‐level, constitutive expression of the mgtC gene confers increased thermotolerance on Salmonella enterica serovar Typhimurium
Aaron R. Gall, Annie E. Hegarty, Kirill A. Datsenko, Richard P. Westerman, Phillip SanMiguel, Laszlo N. Csonka
Molecular Microbiology.2018; 109(3): 327. CrossRef - Regulatory RNAs in Virulence and Host-Microbe Interactions
Alexander J. Westermann, Gisela Storz, Kai Papenfort
Microbiology Spectrum.2018;[Epub] CrossRef - Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus
Michael Rahe, Michael Murtaugh
Viruses.2017; 9(6): 148. CrossRef - Regulating Bacterial Virulence with RNA
Juan J. Quereda, Pascale Cossart
Annual Review of Microbiology.2017; 71(1): 263. CrossRef -
A
trans
-acting leader RNA from a
Salmonella
virulence gene
Eunna Choi, Yoontak Han, Yong-Joon Cho, Daesil Nam, Eun-Jin Lee
Proceedings of the National Academy of Sciences.2017; 114(38): 10232. CrossRef - Elongation factor P restricts Salmonella’s growth by controlling translation of a Mg2+ transporter gene during infection
Eunna Choi, Soomin Choi, Daesil Nam, Shinae Park, Yoontak Han, Jung-Shin Lee, Eun-Jin Lee
Scientific Reports.2017;[Epub] CrossRef - Intramacrophage Survival for Extracellular Bacterial Pathogens: MgtC As a Key Adaptive Factor
Claudine Belon, Anne-Béatrice Blanc-Potard
Frontiers in Cellular and Infection Microbiology.2016;[Epub] CrossRef - Behavior variability of Salmonella enterica isolates from meat-related sources
Huhu Wang, Yun Jiang, Xuan Liu, Wenjuan Qian, Xinglian Xu, Guanghong Zhou
LWT.2016; 73: 375. CrossRef
Research Support, Non-U.S. Gov'ts
- Sphingomonas parvus sp. nov. isolated from a ginseng-cultivated soil
-
Jae-Hyung Ahn , Byoung-chan Kim , Soo-Jin Kim , Geun-Hey Lee , Jaekyeong Song , Soon-Wo Kwon , Hang-Yeon Weon
-
J. Microbiol. 2015;53(10):673-677. Published online October 2, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5132-2
-
-
49
View
-
0
Download
-
5
Crossref
-
Abstract
-
Strain GP20-2T was isolated from a soil cultivated with ginseng
in Korea. The 16S rRNA gene sequence of this strain
showed the highest sequence similarity with Sphingomonas
daechungensis CH15-11T (96.7%) and Sphingomonas sediminicola
Dae 20T (96.2%) among the type strains. The strain
GP20-2T was a strictly aerobic, Gram-negative, non-motile,
rod-shaped bacterium that formed very tiny colonies, less than
0.3 mm in diameter after 10 days on R2A agar. The strain
grew at 10–35°C (optimum, 35°C), at a pH of 5.0–8.0 (optimum,
pH 6.0), and in the absence of NaCl. The DNA G+C
content of strain GP20-2T was 67.2 mol%. It contained ubiquinone
Q-10 as the major isoprenoid quinone, and summed
feature 8 (C18:1ω6c and/or C18:1ω7c, 49.8%) and C16:0 (17.0%)
as the major fatty acids. On the basis of evidence from our
polyphasic taxonomic study, we concluded that strain GP20-2T
should be classified as a novel species of the genus Sphingomonas,
for which the name Sphingomonas parvus sp. nov. is
proposed. The type strain is GP20-2T (=KACC 12865T =DSM
100456T).
-
Citations
Citations to this article as recorded by

-
Sphingomonas segetis sp. nov., isolated from spinach farming field soil
Jae-Chan Lee, Kyung-Sook Whang
International Journal of Systematic and Evolutionary Microbiology
.2020; 70(6): 3905. CrossRef - Sphingomonas ginkgonis sp. nov., isolated from phyllosphere of Ginkgo biloba
Inseong Cha, Heeyoung Kang, Haneul Kim, Kiseong Joh
International Journal of Systematic and Evolutionary Microbiology.2019; 69(10): 3224. CrossRef - An Effect of Salt Concentration and Inoculum Size on Poly(Vinyl Alcohol) Utilization by Two Sphingomonas Strains
Markéta Měrková, Markéta Julinová, Josef Houser, Jan Růžička
Journal of Polymers and the Environment.2018; 26(6): 2227. CrossRef - Sphingomonas limnosediminicola sp. nov. and Sphingomonas palustris sp. nov., isolated from freshwater environments
Ji Hee Lee, Dae In Kim, Han Na Choe, Soon Dong Lee, Chi Nam Seong
International Journal of Systematic and Evolutionary Microbiology.2017; 67(8): 2834. CrossRef - Sphingomonas lutea sp. nov., isolated from freshwater of an artificial reservoir
Ji Hee Lee, Dae In Kim, Joo Won Kang, Chi Nam Seong
International Journal of Systematic and Evolutionary Microbiology.2016; 66(12): 5493. CrossRef
- Illumina-based analysis of bacterial diversity related to halophytes Salicornia europaea and Sueada aralocaspica
-
Ying-wu Shi , Kai Lou , Chun Li , Lei Wang , Zhen-yong Zhao , Shuai Zhao , Chang-yan Tian
-
J. Microbiol. 2015;53(10):678-685. Published online October 2, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5080-x
-
-
49
View
-
0
Download
-
34
Crossref
-
Abstract
-
We used Illumina-based 16S rRNA V3 amplicon pyrosequencing
to investigate the community structure of soil bacteria
from the rhizosphere surrounding Salicornia europaea, and
endophytic bacteria living in Salicornia europaea plants and
Sueada aralocaspica seeds growing at the Fukang Desert
Ecosystem Observation and Experimental Station (FDEOES)
in Xinjiang Province, China, using an Illumina genome analyzer.
A total of 89.23 M effective sequences of the 16S rRNA
gene V3 region were obtained from the two halophyte species.
These sequences revealed a number of operational taxonomic
units (OTUs) in the halophytes. There were between
22–2,206 OTUs in the halophyte plant sample, at the 3%
cutoff level, and a sequencing depth of 30,000 sequences.
We identified 25 different phyla, 39 classes and 141 genera
from the resulting 134,435 sequences. The most dominant
phylum in all the samples was Proteobacteria (41.61%–99.26%;
average, 43.30%). The other large phyla were Firmicutes (0%–
7.19%; average, 1.15%), Bacteroidetes (0%–1.64%; average,
0.44%) and Actinobacteria (0%–0.46%; average, 0.24%). This
result
suggested that the diversity of bacteria is abundant in
the rhizosphere soil, while the diversity of bacteria was poor
within Salicornia europaea plant samples. To the extent of
our knowledge, this study is the first to characterize and
compare the endophytic bacteria found within different halophytic
plant species roots using PCR-based Illumina pyrosequencing
method
.
-
Citations
Citations to this article as recorded by

- Plant Growth‐Promoting Bacteria Associated With Some Salt‐Tolerant Plants
Fatemeh Beitsayahi, Naeimeh Enayatizamir, Leila Nejadsadeghi, Fatemeh Nasernakhaei
Journal of Basic Microbiology.2024;[Epub] CrossRef - Insight into endophytic microbial diversity in two halophytes and plant beneficial attributes of Bacillus swezeyi
Lei Gao, Jin-Biao Ma, Yin Huang, Murad Muhammad, Hai-Ting Lian, Vyacheslav Shurigin, Dilfuza Egamberdieva, Wen-Jun Li, Li Li
Frontiers in Microbiology.2024;[Epub] CrossRef - Soil bacterial diversity and community structure of Suaeda glauca vegetation in the Hetao Irrigation District, Inner Mongolia, China
Ruixiao Dong, Xinbo Wang, Yuyi Li, Hongyuan Zhang, Xiaobin Li, Jiashen Song, Fangdi Chang, Wenhao Feng, Huancheng Pang, Jing Wang
Frontiers in Microbiology.2024;[Epub] CrossRef - Biostimulation of Salicornia europaea L. crops with plant growth-promoting bacteria in laboratory and field conditions: effects on growth and metabolite profile
Maria J Ferreira, I Natalia Sierra-Garcia, Javier Cremades, Carla António, Ana M Rodrigues, Diana C G A Pinto, Helena Silva, Ângela Cunha
Journal of Applied Microbiology.2023;[Epub] CrossRef - Sustainable agricultural management of saline soils in arid and semi-arid Mediterranean regions through halophytes, microbial and soil-based technologies
Salvadora Navarro-Torre, Pedro Garcia-Caparrós, Amaia Nogales, Maria Manuela Abreu, Erika Santos, Ana Lúcia Cortinhas, Ana Delaunay Caperta
Environmental and Experimental Botany.2023; 212: 105397. CrossRef - Domestication shapes the endophytic microbiome and metabolome ofSalicornia europaea
Maria J Ferreira, I Natalia Sierra-Garcia, António Louvado, Newton C M Gomes, Sandro Figueiredo, Carla Patinha, Diana C G A Pinto, Javier Cremades, Helena Silva, Ângela Cunha
Journal of Applied Microbiology.2023;[Epub] CrossRef - Biotechnological Potential of Galophytes and Their Microbiomes for Agriculture in Russia and Kazakhstan
V. K. Chebotar, E. P. Chizhevskaya, O. V. Khonina, R. D. Kostitsin, A. A. Kurmanbayev, B. Mukhambetov, V. N. Pishchik, M. E. Baganova, N. G. Lapenko
Russian Journal of Plant Physiology.2023;[Epub] CrossRef - Alleviation of Salt Stress via Habitat-Adapted Symbiosis
Nour El Houda Rabhi, Hafsa Cherif-Silini, Allaoua Silini, Faizah N. Alenezi, Ali Chenari Bouket, Tomasz Oszako, Lassaȃd Belbahri
Forests.2022; 13(4): 586. CrossRef - Bacterial Community Structure and Potential Microbial Coexistence Mechanism Associated with Three Halophytes Adapting to the Extremely Hypersaline Environment
Lei Gao, Yin Huang, Yonghong Liu, Osama Abdalla Abdelshafy Mohamed, Xiaorong Fan, Lei Wang, Li Li, Jinbiao Ma
Microorganisms.2022; 10(6): 1124. CrossRef - A comparative study of bacterial diversity based on effects of three different shade shed types in the rhizosphere of Panax quiquefolium L.
Xianchang Wang, Xu Guo, Lijuan Hou, Jiaohong Zhang, Jing Hu, Feng Zhang, Jilei Mao, Zhifen Wang, Congjing Zhang, Jinlong Han, Yanwei Zhu, Chao Liu, Jinyue Sun, Chenggang Shan
PeerJ.2022; 10: e12807. CrossRef - Deciphering the role of endophytic microbiome in postharvest diseases management of fruits: Opportunity areas in commercial up-scale production
Madhuree Kumari, Kamal A. Qureshi, Mariusz Jaremko, James White, Sandeep Kumar Singh, Vijay Kumar Sharma, Kshitij Kumar Singh, Gustavo Santoyo, Gerardo Puopolo, Ajay Kumar
Frontiers in Plant Science.2022;[Epub] CrossRef - Profiles of Bacillus spp. Isolated from the Rhizosphere of Suaeda glauca and Their Potential to Promote Plant Growth and Suppress Fungal Phytopathogens
Ping Lu, Ke Jiang, Ya-Qiao Hao, Wan-Ying Chu, Yu-Dong Xu, Jia-Yao Yang, Jia-Le Chen, Guo-Hong Zeng, Zhou-Hang Gu, Hong-Xin Zhao
Journal of Microbiology and Biotechnology.2021; 31(9): 1231. CrossRef - The Root Microbiome of Salicornia ramosissima as a Seedbank for Plant-Growth Promoting Halotolerant Bacteria
Maria J. Ferreira, Angela Cunha, Sandro Figueiredo, Pedro Faustino, Carla Patinha, Helena Silva, Isabel N. Sierra-Garcia
Applied Sciences.2021; 11(5): 2233. CrossRef - Alkalinity gradients in grasslands alter soil bacterial community composition and function
Junliang Xiang, Jian Jin, Quan Liu, Yulan Huang, Wensi Wu, Ruixi Tang, Yuan Chen, Kuide Yin
Soil Science Society of America Journal.2021; 85(2): 286. CrossRef - Bacterial community demonstrates stronger network connectivity than fungal community in desert-grassland salt marsh
Yaqing Pan, Peng Kang, Jinpeng Hu, Naiping Song
Science of The Total Environment.2021; 798: 149118. CrossRef - Rhizosphere bacteria community and functions under typical natural halophyte communities in North China salinized areas
Fating Yin, Fenghua Zhang, Haoran Wang, Jian Liu
PLOS ONE.2021; 16(11): e0259515. CrossRef - Mediterranean seasonality and the halophyte Arthrocnemum macrostachyum determine the bacterial community in salt marsh soils in Southwest Spain
Miguel Camacho-Sanchez, José M. Barcia-Piedras, Susana Redondo-Gómez, Maria Camacho
Applied Soil Ecology.2020; 151: 103532. CrossRef - Dynamic changes in bacterial communities in the recirculating nutrient solution of cucumber plug seedlings cultivated in an ebb-and-flow subirrigation system
Chun-Juan Dong, Qian Li, Ling-Ling Wang, Qing-Mao Shang, Kandasamy Ulaganathan
PLOS ONE.2020; 15(4): e0232446. CrossRef - Mining the roots of various species of the halophyte Suaeda for halotolerant nitrogen-fixing endophytic bacteria with the potential for promoting plant growth
Frashad Alishahi, Hossein Ali Alikhani, Nayer Azam Khoshkholgh-Sima, Hassan Etesami
International Microbiology.2020; 23(3): 415. CrossRef - Morphophysiological Features of Some Cultivable Bacteria from Saline Soils of the Aral Sea Region
Sh. A. Begmatov, O. V. Selitskaya, L. V. Vasileva, Yu. Yu. Berestovskaja, N. A. Manucharova, N. V. Drenova
Eurasian Soil Science.2020; 53(1): 90. CrossRef - Comparative Analysis of Bacterial Diversity and Community Structure in the Rhizosphere and Root Endosphere of Two Halophytes, Salicornia europaea and Glaux maritima, Collected from Two Brackish Lakes in Japan
Kosuke Yamamoto, Minenosuke Matsutani, Yuh Shiwa, Taichiro Ishige, Hikaru Sakamoto, Hiromasa Saitoh, Seiya Tsushima
Microbes and Environments.2020; 35(3): n/a. CrossRef - A Microbiome Study Reveals Seasonal Variation in Endophytic Bacteria Among different Mulberry Cultivars
Ting Ou, Wei-fang Xu, Fei Wang, Gary Strobel, Ze-yang Zhou, Zhong-huai Xiang, Jia Liu, Jie Xie
Computational and Structural Biotechnology Journal.2019; 17: 1091. CrossRef - Sustainability of Urban Soil Management: Analysis of Soil Physicochemical Properties and Bacterial Community Structure under Different Green Space Types
Junda Zhang, Suyan Li, Xiangyang Sun, Jing Tong, Zhen Fu, Jing Li
Sustainability.2019; 11(5): 1395. CrossRef - Transcriptome profiling and environmental linkage to salinity across Salicornia europaea vegetation
Bliss Ursula Furtado, Istvan Nagy, Torben Asp, Jarosław Tyburski, Monika Skorupa, Marcin Gołębiewski, Piotr Hulisz, Katarzyna Hrynkiewicz
BMC Plant Biology.2019;[Epub] CrossRef - Bacterial and Fungal Endophytic Microbiomes ofSalicornia europaea
Bliss Ursula Furtado, Marcin Gołębiewski, Monika Skorupa, Piotr Hulisz, Katarzyna Hrynkiewicz, Emma R. Master
Applied and Environmental Microbiology.2019;[Epub] CrossRef - Coastal halophytes alter properties and microbial community structure of the saline soils in the Yellow River Delta, China
Changliang Jing, Zongchang Xu, Ping Zou, Qi Tang, Yiqiang Li, Xiangwei You, Chengsheng Zhang
Applied Soil Ecology.2019; 134: 1. CrossRef - Improved germination efficiency of Salicornia ramosissima seeds inoculated with Bacillus aryabhattai SP1016‐20
Carolina Figueira, Maria J. Ferreira, Helena Silva, Angela Cunha
Annals of Applied Biology.2019; 174(3): 319. CrossRef - Salicornia europaea L. as an underutilized saline-tolerant plant inhabited by endophytic diazotrophs
Katarzyna Hrynkiewicz, Sascha Patz, Silke Ruppel
Journal of Advanced Research.2019; 19: 49. CrossRef - Bacterial Diversity Associated With the Rhizosphere and Endosphere of Two Halophytes: Glaux maritima and Salicornia europaea
Kosuke Yamamoto, Yuh Shiwa, Taichiro Ishige, Hikaru Sakamoto, Keisuke Tanaka, Masataka Uchino, Naoto Tanaka, Suguru Oguri, Hiromasa Saitoh, Seiya Tsushima
Frontiers in Microbiology.2018;[Epub] CrossRef - Diversity of Bacterial Microbiota of Coastal Halophyte Limonium sinense and Amelioration of Salinity Stress Damage by Symbiotic Plant Growth-Promoting Actinobacterium Glutamicibacter halophytocola KLBMP 5180
Sheng Qin, Wei-Wei Feng, Yue-Ji Zhang, Tian-Tian Wang, You-Wei Xiong, Ke Xing, Isaac Cann
Applied and Environmental Microbiology.2018;[Epub] CrossRef - Bacterial microbiome of root-associated endophytes of Salicornia europaea in correspondence to different levels of salinity
Sonia Szymańska, Luigimaria Borruso, Lorenzo Brusetti, Piotr Hulisz, Bliss Furtado, Katarzyna Hrynkiewicz
Environmental Science and Pollution Research.2018; 25(25): 25420. CrossRef - The Grapevine and Wine Microbiome: Insights from High-Throughput Amplicon Sequencing
Horatio H. Morgan, Maret du Toit, Mathabatha E. Setati
Frontiers in Microbiology.2017;[Epub] CrossRef - Effect of halotolerant endophytic bacteria isolated fromSalicornia europaeaL. on the growth of fodder beet (Beta vulgarisL.) under salt stress
Agnieszka Piernik, Katarzyna Hrynkiewicz, Anna Wojciechowska, Sonia Szymańska, Marta Izabela Lis, Adele Muscolo
Archives of Agronomy and Soil Science.2017; 63(10): 1404. CrossRef - Illumina-Based Analysis of Endophytic and Rhizosphere Bacterial Diversity of the Coastal Halophyte Messerschmidia sibirica
Xue-Ying Tian, Cheng-Sheng Zhang
Frontiers in Microbiology.2017;[Epub] CrossRef
- Performance of PCR-reverse blot hybridization assay for detection of rifampicin-resistant Mycobacterium leprae
-
Hye-young Wang , Hyunjung Kim , Yeun Kim , Hyeeun Bang , Jong-Pill Kim , Joo Hwan Hwang , Sang-Nae Cho , Tae Ue Kim , Hyeyoung Lee
-
J. Microbiol. 2015;53(10):686-693. Published online October 2, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5057-9
-
-
50
View
-
0
Download
-
1
Crossref
-
Abstract
-
Drug resistance in Mycobacterium leprae is a significant problem
in countries where leprosy is endemic. A sensitive, specific,
and high-throughput reverse blot hybridization assay
(REBA) for the detection of genotypic resistance to rifampicin
(RIF) was designed and evaluated. It has been shown that
resistance to RIF in M. leprae involves mutations in the rpoB
gene encoding the β-subunit of the RNA polymerase. The
PCR-REBA simultaneously detects both 6 wild-type regions
and 5 different mutations (507AGC, 513GTG, 516TAT,
531ATG, and 531TTC) including the most prevalent mutations
at positions 507 and 531. Thirty-one clinical isolates
provided by Korea Institute of Hansen’s Disease were analyzed
by PCR-REBA with RIF resistance of rpoB gene. As a
result
, missense mutations at codons 507 AGC and 531ATG
with 2-nucleotide substitutions were found in one sample,
and a missense mutation at codon 516 TAT and ΔWT6 (deletion
of 530-534) was found in another sample. These cases
were confirmed by DNA sequence analysis. This rapid, simple,
and highly sensitive assay provides a practical alternative
to sequencing for genotypic evaluation of RIF resistance
in M. leprae.
-
Citations
Citations to this article as recorded by

- Prediction of Y haplogroup by polymerase chain reaction-reverse blot hybridization assay
Sehee Oh, Jungho Kim, Sunyoung Park, Seoyong Kim, Kyungmyung Lee, Yang-Han Lee, Si-Keun Lim, Hyeyoung Lee
Genes & Genomics.2019; 41(3): 297. CrossRef
- Antifungal activity of violacein purified from a novel strain of Chromobacterium sp. NIIST (MTCC 5522)
-
Anju Sasidharan , Nishanth Kumar Sasidharan , Dileepkumar Bhaskaran Nair Saraswathy Amma , Radhakrishnan Kokkuvayil Vasu , Anupama Vijaya Nataraja , Krishnakumar Bhaskaran
-
J. Microbiol. 2015;53(10):694-701. Published online October 2, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5173-6
-
-
57
View
-
0
Download
-
44
Crossref
-
Abstract
-
A novel strain of Chromobacterium sp. NIIST (MTCC 5522)
producing high level of purple blue bioactive compound violacein
was isolated from clay mine acidic sediment. During
24 h aerobic incubation in modified Luria Bertani medium,
around 0.6 g crude violacein was produced per gram of dry
weight biomass. An inexpensive method for preparing crystalline,
pure violacein from crude pigment was developed (12.8
mg violacein/L) and the pure compound was characterized
by different spectrometric methods. The violacein prepared
was found effective against a number of plant and human
pathogenic fungi and yeast species such as Cryptococcus gastricus,
Trichophyton rubrum, Fusarium oxysporum, Rhizoctonia
solani, Aspergillus flavus, Penicillium expansum, and
Candida albicans. The best activity was recorded against Trichophyton
rubrum (2 μg/ml), a human pathogen responsible
for causing athlete’s foot infection. This is the first report of
antifungal activity of purified violacein against pathogenic
fungi and yeast.
-
Citations
Citations to this article as recorded by

- Mechanistic Insight of Pharmacological Aspects of Violacein: Recent Trends and Advancements
Abhishek Chauhan, Darin Mansor Mathkor, Hemant Joshi, Ritu Chauhan, Ujjawal Sharma, Vikas Sharma, Manoj Kumar, Reena V. Saini, Adesh K. Saini, Hardeep Singh Tuli, Damandeep Kaur, Shafiul Haque
Journal of Biochemical and Molecular Toxicology.2025;[Epub] CrossRef - Extracellular vesicles of Janthinobacterium lividum as violacein carriers in melanoma cell treatment
Patrycja Kowalska, Jolanta Mierzejewska, Paulina Skrzeszewska, Aleksandra Witkowska, Katarzyna Oksejuk, Ewa Sitkiewicz, Mariusz Krawczyk, Magdalena Świadek, Agata Głuchowska, Klaudia Marlicka, Anna Sobiepanek, Małgorzata Milner-Krawczyk
Applied Microbiology and Biotechnology.2024;[Epub] CrossRef - Chromobacterium indicum sp. nov., a Pigment-Producing Bacterium Isolated from Soil
Nandini Verma, Stanzin Choksket, Riya Singla, Anil Kumar Pinnaka, Suresh Korpole
Current Microbiology.2024;[Epub] CrossRef - AHL-Based Quorum Sensing Regulates the Biosynthesis of a Variety of Bioactive Molecules in Bacteria
Mélanie Gonzales, Pauline Jacquet, Floriane Gaucher, Éric Chabrière, Laure Plener, David Daudé
Journal of Natural Products.2024; 87(4): 1268. CrossRef - Gaining molecular insights towards inhibition of foodborne fungi Aspergillus fumigatus by a food colourant violacein via computational approach
R. Sindhu, Smitha S. Bhat, Jiraporn Sangta, Chandan Dharmashekar, Bhargav Shreevatsa, Chandan Shivamallu, Devananda Devegowda, Shiva Prasad Kollur, Sheikh F. Ahmad, Sabry M. Attia, Sarana Rose Sommano, Shashanka K. Prasad
Scientific Reports.2024;[Epub] CrossRef - New Target Gene Screening Using Shortened and Random sgRNA Libraries in Microbial CRISPR Interference
Song Hee Jeong, Hyun Ju Kim, Sang Jun Lee
ACS Synthetic Biology.2023; 12(3): 800. CrossRef - Natural Pigments Production and Their Application in Food, Health and Other Industries
Eleonora Di Salvo, Giovanna Lo Vecchio, Rita De Pasquale, Laura De Maria, Roberta Tardugno, Rossella Vadalà, Nicola Cicero
Nutrients.2023; 15(8): 1923. CrossRef - Antifungal Compounds from Microbial Symbionts Associated with Aquatic Animals and Cellular Targets: A Review
Madeleine Nina Love Ngo-Mback, Elisabeth Zeuko’o Menkem, Heather G. Marco
Pathogens.2023; 12(4): 617. CrossRef - An extensive review of marine pigments: sources, biotechnological applications, and sustainability
Luis Alfonso Muñoz-Miranda, Maricarmen Iñiguez-Moreno
Aquatic Sciences.2023;[Epub] CrossRef - A Simple Characterisation of Violacein Compound Derived from Chromobacterium sp. strain Dyh27s2016 and its Antimicrobial Activity Against Pseudomonas aeruginosa
Pratheep Sandrasaigaran, Mohamed Jafran Abul Baseer
Malaysian Journal of Science and Advanced Technology.2023; : 1. CrossRef - Priming Chromobacterium violaceum as a Gold Bioleacher in E-wastes: Advantages and Challenges
Thiviaraj Palanysamy, Rattika Sukalingam, Pratheep Sandrasaigaran
Malaysian Journal of Science and Advanced Technology.2023; : 222. CrossRef - Purification of Natural Pigments Violacein and Deoxyviolacein Produced by Fermentation Using Yarrowia lipolytica
Georgio Nemer, Nicolas Louka, Paul Rabiller Blandin, Richard G. Maroun, Eugène Vorobiev, Tristan Rossignol, Jean-Marc Nicaud, Erwann Guénin, Mohamed Koubaa
Molecules.2023; 28(11): 4292. CrossRef - Genome sequencing and multifaceted taxonomic analysis of novel strains of violacein-producing bacteria and non-violacein-producing close relatives
Marina Estella De León, Harriet S. Wilson, Guillaume Jospin, Jonathan A. Eisen
Microbial Genomics
.2023;[Epub] CrossRef - Fermentation in Minimal Media and Fungal Elicitation Enhance Violacein and Deoxyviolacein Production in Two Janthinobacterium Strains
Andri Frediansyah, Yosephine Sri Wulan Manuhara, Alfinda Novi Kristanti, Arif Luqman, Anjar Tri Wibowo
Fermentation.2022; 8(12): 714. CrossRef - Improvement in Violacein Production by Utilizing Formic Acid to Induce Quorum Sensing in Chromobacterium violaceum
Kuan-Chen Cheng, Hsiang-Chun Hsiao, Yu-Chen Hou, Chang-Wei Hsieh, Hsien-Yi Hsu, Hung-Yueh Chen, Shin-Ping Lin
Antioxidants.2022; 11(5): 849. CrossRef - Violacein from an Antarctic Iodobacter sp. 7MAnt and its function as immunomodulator of the defence mechanism of innate immunity in fish cells
Beatriz Valenzuela, Almendra Benavides, Daniela Gutierrez, Lotsé Blamey, María Teresa Monsalves, Brenda Modak, Jenny M. Blamey
Journal of Fish Diseases.2022; 45(3): 485. CrossRef - Fermentation Quality and Microbial Community of Corn Stover or Rice Straw Silage Mixed with Soybean Curd Residue
Xiaolin Wang, Jiamei Song, Zihan Liu, Guangning Zhang, Yonggen Zhang
Animals.2022; 12(7): 919. CrossRef - Development of Methylorubrum extorquens AM1 as a promising platform strain for enhanced violacein production from co-utilization of methanol and acetate
Hoa Thi Quynh Le, Dung Hoang Anh Mai, Jeong-Geol Na, Eun Yeol Lee
Metabolic Engineering.2022; 72: 150. CrossRef - Prey identity affects fitness of a generalist consumer in a brown food web
Lily Khadempour, Leslie Rivas Quijano, Casey P. terHorst
Ecology and Evolution.2022;[Epub] CrossRef - Violacein and its antifungal activity: comments and potentialities
N. Durán, G.R. Castro, R.W.D. Portela, W.J. Fávaro, M. Durán, L. Tasic, G. Nakazato
Letters in Applied Microbiology.2022; 75(4): 796. CrossRef - Applications of Natural Violet Pigments from Halophilic Chromobacterium violaceum PDF23 for Textile Dyeing with Antimicrobial and Antioxidant Potentials
Antonyraj Matharasi Perianaika Anahas, Subramanian Kumaran, Mahmoud Kandeel, Gangatharan Muralitharan, Jenifer Silviya, Geja Lakshmi Adhimoolam, Mani Panagal, Sampath Renuka Pugazhvendan, Gopal Suresh, A. Wilson Aruni, Senthil Rethinam, Nainangu Prasannab
Journal of Nanomaterials.2022;[Epub] CrossRef - Evaluation of the anti‑proliferative activity of violacein, a natural pigment of bacterial origin, in urinary bladder cancer cell lines
Bruna Neron, Maria Zingaropoli, Giulia Radocchia, Maria Ciardi, Luciana Mosca, Fabrizio Pantanella, Serena Schippa
Oncology Letters.2022;[Epub] CrossRef - Isolation and Properties of the Bacterial Strain Janthinobacterium sp. SLB01
Lubov Chernogor, Kseniya Bakhvalova, Alina Belikova, Sergei Belikov
Microorganisms.2022; 10(5): 1071. CrossRef - Bacterial pigments: A colorful palette reservoir for biotechnological applications
Viviana Teresa Orlandi, Eleonora Martegani, Cristina Giaroni, Andreina Baj, Fabrizio Bolognese
Biotechnology and Applied Biochemistry.2022; 69(3): 981. CrossRef - Lignocellulosic substrates as starting materials for the production of bioactive biopigments
Tiago Daniel Madureira de Medeiros, Laurent Dufossé, Juliano Lemos Bicas
Food Chemistry: X.2022; 13: 100223. CrossRef - Biotechnological Activities and Applications of Bacterial Pigments Violacein and Prodigiosin
Seong Yeol Choi, Sungbin Lim, Kyoung-hye Yoon, Jin I. Lee, Robert J. Mitchell
Journal of Biological Engineering.2021;[Epub] CrossRef - Multi-target drug with potential applications: violacein in the spotlight
Nelson Durán, Gerson Nakazato, Marcela Durán, Ignasio R. Berti, Guillermo R. Castro, Danijela Stanisic, Marcelo Brocchi, Wagner J. Fávaro, Carmen V. Ferreira-Halder, Giselle Z. Justo, Ljubica Tasic
World Journal of Microbiology and Biotechnology.2021;[Epub] CrossRef - Chemical signals driving bacterial–fungal interactions
Saima Khalid, Nancy P. Keller
Environmental Microbiology.2021; 23(3): 1334. CrossRef - Disrupting quorum sensing alters social interactions in Chromobacterium violaceum
Sonia Mion, Nathan Carriot, Julien Lopez, Laure Plener, Annick Ortalo-Magné, Eric Chabrière, Gérald Culioli, David Daudé
npj Biofilms and Microbiomes.2021;[Epub] CrossRef - Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production
Aqsa Ahmed, Abdullah Ahmad, Renhan Li, Waleed AL-Ansi, Momal Fatima, Bilal Sajid Mushtaq, Samra Basharat, Ye Li, Zhonghu Bai
Journal of Microbiology and Biotechnology.2021; 31(11): 1465. CrossRef - Microbial synthesis of violacein pigment and its potential applications
HyunA Park, SeoA Park, Yung-Hun Yang, Kwon-Young Choi
Critical Reviews in Biotechnology.2021; 41(6): 879. CrossRef - Exploitation of Versatile Naturally Derived Blue Colorant Pigment 3-[2-hydroxy-5-(5-hydroxy-1H-indol-3-yl)-1H-pyrrol-3-yl] indol-one
Ishani, Isita, T. Vijayakumar
IOP Conference Series: Materials Science and Engineering.2021; 1219(1): 012020. CrossRef - Characterization and low-cost preservation of Chromobacterium violaceum strain TRFM-24 isolated from Tripura state, India
Sushil K. Sharma, Rakhi Dhyani, Ees Ahmad, Pankaj K. Maurya, Madhu Yadav, Ramesh Chandra Yadav, Vinod Kumar Yadav, Pawan K. Sharma, Mahaveer P. Sharma, Aketi Ramesh, Anil K. Saxena
Journal of Genetic Engineering and Biotechnology.2021; 19(1): 146. CrossRef - Production and antiproliferative effect of violacein, a purple pigment produced by an Antarctic bacterial isolate
Diego Alem, Juan José Marizcurrena, Verónica Saravia, Danilo Davyt, Wilner Martinez-Lopez, Susana Castro-Sowinski
World Journal of Microbiology and Biotechnology.2020;[Epub] CrossRef - An Overview on Industrial and Medical Applications of Bio-Pigments Synthesized by Marine Bacteria
Ali Nawaz, Rida Chaudhary, Zinnia Shah, Laurent Dufossé, Mireille Fouillaud, Hamid Mukhtar, Ikram ul Haq
Microorganisms.2020; 9(1): 11. CrossRef - Isolation and characterization of violacein from an Antarctic Iodobacter: a non-pathogenic psychrotolerant microorganism
Joaquin Atalah, Lotsé Blamey, Sebastian Muñoz-Ibacache, Felipe Gutierrez, Marcela Urzua, Maria Victoria Encinas, Maritza Páez, Junsong Sun, Jenny M. Blamey
Extremophiles.2020; 24(1): 43. CrossRef - Interplay between two quorum sensing‐regulated pathways, violacein biosynthesis and VacJ/Yrb, dictates outer membrane vesicle biogenesis in Chromobacterium violaceum
Juliana H. Batista, Fernanda C. Leal, Taise T. H. Fukuda, Juliana Alcoforado Diniz, Fausto Almeida, Mônica T. Pupo, José F. da Silva Neto
Environmental Microbiology.2020; 22(6): 2432. CrossRef - Violacein Targets the Cytoplasmic Membrane of Bacteria
Ana C. G. Cauz, Gustavo P. B. Carretero, Greice K. V. Saraiva, Peter Park, Laura Mortara, Iolanda M. Cuccovia, Marcelo Brocchi, Frederico J. Gueiros-Filho
ACS Infectious Diseases.2019; 5(4): 539. CrossRef - Optoregulated Drug Release from an Engineered Living Material: Self‐Replenishing Drug Depots for Long‐Term, Light‐Regulated Delivery
Shrikrishnan Sankaran, Judith Becker, Christoph Wittmann, Aránzazu del Campo
Small.2019;[Epub] CrossRef - Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons
Elizabeth Bilsland, Tatyana A. Tavella, Renata Krogh, Jamie E. Stokes, Annabelle Roberts, James Ajioka, David R. Spring, Adriano D. Andricopulo, Fabio T. M. Costa, Stephen G. Oliver
BMC Biotechnology.2018;[Epub] CrossRef - Stimulation of Violacein Biosynthesis in Chromobacterium violaceum Biofilms in the Presence of Dimethyl Sulfoxide
S. V. Mart’yanov, A. V. Letarov, P. A. Ivanov, V. K. Plakunov
Microbiology.2018; 87(3): 437. CrossRef - Investigating the potential use of an Antarctic variant of Janthinobacterium lividum for tackling antimicrobial resistance in a One Health approach
Andreea Baricz, Adela Teban, Cecilia Maria Chiriac, Edina Szekeres, Anca Farkas, Maria Nica, Amalia Dascălu, Corina Oprișan, Paris Lavin, Cristian Coman
Scientific Reports.2018;[Epub] CrossRef - Interaction of violacein in models for cellular membranes: Regulation of the interaction by the lipid composition at the air-water interface
Karine Damaceno de Souza, Katia Regina Perez, Nelson Durán, Giselle Zenker Justo, Luciano Caseli
Colloids and Surfaces B: Biointerfaces.2017; 160: 247. CrossRef - Fungal and Bacterial Pigments: Secondary Metabolites with Wide Applications
Manik Prabhu Narsing Rao, Min Xiao, Wen-Jun Li
Frontiers in Microbiology.2017;[Epub] CrossRef
- Relationships between the use of Embden Meyerhof pathway (EMP) or Phosphoketolase pathway (PKP) and lactate production capabilities of diverse Lactobacillus reuteri strains
-
Grégoire Burgé , Claire Saulou-Bérion , Marwen Moussa , Florent Allais , Violaine Athes , Henry-Eric Spinnler
-
J. Microbiol. 2015;53(10):702-710. Published online October 2, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5056-x
-
-
51
View
-
0
Download
-
23
Crossref
-
Abstract
-
The aims of this study is to compare the growth and glucose
metabolism of three Lactobacillus reuteri strains (i.e.
DSM 20016, DSM 17938, and ATCC 53608) which are lactic
acid bacteria of interest used for diverse applications such
as probiotics implying the production of biomass, or for the
production of valuable chemicals (3-hydroxypropionaldehyde,
3-hydroxypropionic acid, 1,3-propanediol). However, the
physiological diversity inside the species, even for basic metabolisms,
like its capacity of acidification or glucose metabolism,
has not been studied yet. In the present work, the
growth and metabolism of three strains representative of
the species diversity have been studied in batch mode. The
strains were compared through characterization of growth
kinetics and evaluation of acidification kinetics, substrate consumption
and product formation. The results showed significant
differences between the three strains which may be
explained, at least in part, by variations in the distribution
of carbon source between two glycolytic pathways during the
bacterial growth: the phosphoketolase or heterolactic pathway
(PKP) and the Embden-Meyerhof pathway (EMP). It was
also shown that, in the context of obtaining a large amount
of biomass, DSM 20016 and DSM 17938 strains were the
most effective in terms of growth kinetics. The DSM 17938
strain, which shows the more significant metabolic shift from
EMP to PKP when the pH decreases, is more effective for
lactate production.
-
Citations
Citations to this article as recorded by

- Exploitation of microbial activities at low pH to enhance planetary health
Merve Atasoy, Avelino Álvarez Ordóñez, Adam Cenian, Aleksandra Djukić-Vuković, Peter A Lund, Fatih Ozogul, Janja Trček, Carmit Ziv, Daniela De Biase
FEMS Microbiology Reviews.2024;[Epub] CrossRef -
Estimating the contribution of the porcine fecal core microbiota to metabolite production via mathematical modeling and
in vitro
fermentation
Salvatore Galgano, Helen Kettle, Andrew Free, Jos G. M. Houdijk, Vanni Bucci
mSystems.2024;[Epub] CrossRef - Solid‐state fermentation: Bioconversions and impacts on bioactive and nutritional compounds in oats
Stella Green, Graham T. Eyres, Dominic Agyei, Biniam Kebede
Comprehensive Reviews in Food Science and Food Safety.2024;[Epub] CrossRef - Characterization of nuvita biosearch center (NBC) isolated lactic acid bacteria strains from human origin and determination of growth kinetic profiles of selected cultures under bioreactor
Akif Emre Kavak, İnci Zent, Ezgi Metin Sağır, Gülistan Öncü, Feride İrem Şimşek
Annals of Microbiology.2024;[Epub] CrossRef - Assessment of autochthonous lactic acid bacteria as starter culture for improving traditional Chinese Dongbei Suancai fermentation
Yujuan Zhao, Zijian Zhao, Yansong Gao, Ge Yang, Xiaoxiao Liu, Ruochen Huang, Wei Liang, Shengyu Li
LWT.2023; 178: 114615. CrossRef - Mannitol Production by Heterofermentative Lactic Acid Bacteria: a Review
Juan Gilberto Martínez-Miranda, Isaac Chairez, Enrique Durán-Páramo
Applied Biochemistry and Biotechnology.2022; 194(6): 2762. CrossRef - Production of high-value added exopolysaccharide by biotherapeutic potential Lactobacillus reuteri strain
Daniel Joe Dailin, Shanmugaprakasham Selvamani, Khaw Michelle, Yanti Maslina Mohd Jusoh, Lai Fatt Chuah, Awais Bokhari, Hesham Ali El Enshasy, Muhammad Mubashir, Pau Loke Show
Biochemical Engineering Journal.2022; 188: 108691. CrossRef - High-resolution structure of phosphoketolase from Bifidobacterium longum determined by cryo-EM single-particle analysis
Kunio Nakata, Naoyuki Miyazaki, Hiroki Yamaguchi, Mika Hirose, Tatsuki Kashiwagi, Nidamarthi H.V. Kutumbarao, Osamu Miyashita, Florence Tama, Hiroshi Miyano, Toshimi Mizukoshi, Kenji Iwasaki
Journal of Structural Biology.2022; 214(2): 107842. CrossRef - In Silico Genomic and Metabolic Atlas of Limosilactobacillus reuteri DSM 20016: An Insight into Human Health
Paisleigh Smythe, Georgios Efthimiou
Microorganisms.2022; 10(7): 1341. CrossRef - Changes and machine learning-based prediction in quality characteristics of sliced Korean cabbage (Brassica rapa L. pekinensis) kimchi: Combined effect of nano-foamed structure film packaging and subcooled storage
So Yoon Park, Miran Kang, Suk-Min Yun, Jong-Bang Eun, Bo-Sung Shin, Ho Hyun Chun
LWT.2022; 171: 114122. CrossRef -
Acids produced by lactobacilli inhibit the growth of commensal
Lachnospiraceae
and S24-7 bacteria
Emma J. E. Brownlie, Danica Chaharlangi, Erin Oi-Yan Wong, Deanna Kim, William Wiley Navarre
Gut Microbes.2022;[Epub] CrossRef - Salinity enhances high optically active L-lactate production from co-fermentation of food waste and waste activated sludge: Unveiling the response of microbial community shift and functional profiling
Xiang Li, Safeena Sadiq, Wenjuan Zhang, Yiren Chen, Xianbao Xu, Anees Abbas, Shanping Chen, Ruina Zhang, Gang Xue, Dominika Sobotka, Jacek Makinia
Bioresource Technology.2021; 319: 124124. CrossRef - Pre-fermentation of malt whisky wort using Lactobacillus plantarum and its influence on new-make spirit character
Struan James Reid, Robert Alexander Speers, Nik Willoughby, William Bain Lumsden, Dawn Louise Maskell
Food Chemistry.2020; 320: 126605. CrossRef - Oriented Fermentation of Food Waste towards High-Value Products: A Review
Qiao Wang, Huan Li, Kai Feng, Jianguo Liu
Energies.2020; 13(21): 5638. CrossRef - Effects of combining two lactic acid bacteria as a starter culture on model kimchi fermentation
Jae-Jun Lee, Yun-Jeong Choi, Min Jung Lee, Sung Jin Park, Su Jin Oh, Ye-Rang Yun, Sung Gi Min, Hye-Young Seo, Sung-Hee Park, Mi-Ai Lee
Food Research International.2020; 136: 109591. CrossRef - Impact of the fermentation parameters pH and temperature on stress resilience of Lactobacillus reuteri DSM 17938
Armando Hernández, Christer U. Larsson, Radoslaw Sawicki, Ed W. J. van Niel, Stefan Roos, Sebastian Håkansson
AMB Express.2019;[Epub] CrossRef - A metabolic reconstruction of Lactobacillus reuteri JCM 1112 and analysis of its potential as a cell factory
Thordis Kristjansdottir, Elleke F. Bosma, Filipe Branco dos Santos, Emre Özdemir, Markus J. Herrgård, Lucas França, Bruno Ferreira, Alex T. Nielsen, Steinn Gudmundsson
Microbial Cell Factories.2019;[Epub] CrossRef - Towards sustainability of lactic acid and poly-lactic acid polymers production
A. Djukić-Vuković, D. Mladenović, J. Ivanović, J. Pejin, L. Mojović
Renewable and Sustainable Energy Reviews.2019; 108: 238. CrossRef - Lactobacilli and pediococci as versatile cell factories – Evaluation of strain properties and genetic tools
Elleke F. Bosma, Jochen Forster, Alex Toftgaard Nielsen
Biotechnology Advances.2017; 35(4): 419. CrossRef - Isothermal microcalorimetry for rapid viability assessment of freeze-dried Lactobacillus reuteri
Armando Hernández Garcia, Anke M. Herrmann, Sebastian Håkansson
Process Biochemistry.2017; 55: 49. CrossRef - Conversion of Glycerol to 3-Hydroxypropanoic Acid by Genetically Engineered Bacillus subtilis
Aida Kalantari, Tao Chen, Boyang Ji, Ivan A. Stancik, Vaishnavi Ravikumar, Damjan Franjevic, Claire Saulou-Bérion, Anne Goelzer, Ivan Mijakovic
Frontiers in Microbiology.2017;[Epub] CrossRef - Novel molecular, structural and evolutionary characteristics of the phosphoketolases from bifidobacteria and Coriobacteriales
Radhey S. Gupta, Anish Nanda, Bijendra Khadka, Eugene A. Permyakov
PLOS ONE.2017; 12(2): e0172176. CrossRef - Redox Balance in Lactobacillus reuteri DSM20016: Roles of Iron-Dependent Alcohol Dehydrogenases in Glucose/ Glycerol Metabolism
Lu Chen, Paul David Bromberger, Gavin Nieuwenhuiys, Rajni Hatti-Kaul, Shihui Yang
PLOS ONE.2016; 11(12): e0168107. CrossRef
- Structural basis for the ATP-independent proteolytic activity of LonB proteases and reclassification of their AAA+ modules
-
Young Jun An , Jung-Hyun Na , Myung-Il Kim , Sun-Shin Cha
-
J. Microbiol. 2015;53(10):711-717. Published online October 2, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5417-5
-
-
47
View
-
0
Download
-
3
Crossref
-
Abstract
-
Lon proteases degrade defective or denature proteins as well
as some folded proteins for the control of cellular protein
quality. There are two types of Lon proteases, LonA and
LonB. Each consists of two functional components: a protease
component and an ATPase associated with various
cellular activities (AAA+ module). Here, we report the 2.03
Å-resolution crystal structure of the isolated AAA+ module
(iAAA+ module) of LonB from Thermococcus onnurineus
NA1 (TonLonB). The iAAA+ module, having no bound
nucleotide, adopts a conformation virtually identical to the
ADP-bound conformation of AAA+ modules in the hexameric
structure of TonLonB; this provides insights into the
ATP-independent proteolytic activity observed in a LonB
protease. Structural comparison of AAA+ modules between
LonA and LonB revealed that the AAA+ modules of Lon
proteases are separated into two distinct clades depending
on their structural features. The AAA+ module of LonB belongs
to the ‘H2 & Ins1 insert clade (HINS clade)’ defined
for the first time in this study, while the AAA+ module of
LonA is a member of the HCLR clade.
-
Citations
Citations to this article as recorded by

- Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases
Alla Gustchina, Mi Li, Anna G. Andrianova, Arsen M. Kudzhaev, George T. Lountos, Bartosz Sekula, Scott Cherry, Joseph E. Tropea, Ivan V. Smirnov, Alexander Wlodawer, Tatyana V. Rotanova
International Journal of Molecular Sciences.2022; 23(19): 11425. CrossRef - Structure and the Mode of Activity of Lon Proteases from Diverse Organisms
Alexander Wlodawer, Bartosz Sekula, Alla Gustchina, Tatyana V. Rotanova
Journal of Molecular Biology.2022; 434(7): 167504. CrossRef - Proteolytic systems of archaea: slicing, dicing, and mincing in the extreme
Nicholas P. Robinson, Julie A. Maupin-Furlow
Emerging Topics in Life Sciences.2018; 2(4): 561. CrossRef
Journal Article
- Regulation of HBV-specific CD8+ T cell-mediated inflammation is diversified in different clinical presentations of HBV infection
-
Colin M. Dinney , Lu-Dong Zhao , Charles D. Conrad , Jay M. Duker , Richard O. Karas , Zhibin Hu , Michele A. Hamilton , Thomas R. Gillis , Thomas M. Parker , Bing Fan , Andrew H. Advani , Fred B. Poordad , Paulette L. Fauceglia , Kathrin M. Kirsch , Peter T. Munk , Marc P. Ladanyi , Bernard A. Bochner , Justin A. Bekelman , Carla M. Grandori , James C. Olson , Ronald D. Lechan , Ghassan M.A. Abou , Mark A. Goodarzi
-
J. Microbiol. 2015;53(10):718-724. Published online October 2, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5314-y
-
-
52
View
-
0
Download
-
22
Crossref
-
Abstract
-
Chronic HBV infection is the leading cause of liver cirrhosis
and hepatic cancer, but the individual responses toward HBV
infection are highly variable, ranging from asymptomatic to
chronic active hepatitis B inflammation. In this study, we
hypothesized that the different individual responses to HBV
infection was associated with differences in HBV-specific
CD8+ T cell-mediated inflammation and cytotoxicity. Blood
samples were collected from subjects with asymptomatic
HBV-infection, subjects undergoing active chronic HBV
flares (active CHB), and subjects with HBV-infected hepatocellular
carcinoma (HBV-HCC). By tetramer staining, we
found that all three groups had similar frequencies of HBVspecific
CD8+ T cells. However, after HBV peptide stimulation,
the HBV-specific CD8+ T cells in asymptomatic subjects
had significantly stronger interferon gamma (IFN-γ),
tumor necrosis factor alpha (TNF-α), and CD107a expression
than those in active CHB and HBV-HCC patients.
Examination of surface marker expression revealed that the
PD-1-Tim-3- double-negative cell population was the main contributor to HBV-specific inflammation. In active CHB
patients and HBV-HCC patients, however, the frequencies
of activated PD-1-Tim-3- cells were significantly reduced.
Moreover, the serum HBV DNA titer was not correlated
with the frequencies of HBV-specific CD8+ T cells but was
inversely correlated with the frequencies of IFN-g-expressing
and CD107a-express cells in response to HBV stimulation.
Together, our data demonstrated that the status of HBVspecific
CD8+ T cell exhaustion was associated with different
clinical outcomes of chronic HBV infection.
-
Citations
Citations to this article as recorded by

- The Adaptive Immune Response in Hepatitis B Virus-Associated Hepatocellular Carcinoma Is Characterized by Dysfunctional and Exhausted HBV-Specific T Cells
Malene Broholm, Anne-Sofie Mathiasen, Ása Didriksen Apol, Nina Weis
Viruses.2024; 16(5): 707. CrossRef - Tumor-associated macrophages and CD8+ T cells: dual players in the pathogenesis of HBV-related HCC
Muhammad Naveed Khan, Binli Mao, Juan Hu, Mengjia Shi, Shunyao Wang, Adeel Ur Rehman, Xiaosong Li
Frontiers in Immunology.2024;[Epub] CrossRef - The CD8+ T cell exhaustion mechanisms in chronic hepatitis B infection and immunotherapeutic strategies: a systematic review
Esmaeil Allahmoradi, Ramtin Mohammadi, Peyman Kheirandish Zarandi, Seyed Moayed Alavian, Mohammad Heiat
Expert Review of Clinical Immunology.2023; 19(6): 671. CrossRef - Increase in Serum Soluble Tim-3 Level Is Related to the Progression of Diseases After Hepatitis Virus Infection
Lingli Chen, Xiaomei Yu, Chunyan Lv, Yaping Dai, Tao Wang, Shaoxiong Zheng, Yuan Qin, Xiumei Zhou, Yigang Wang, Hao Pei, Hongming Fang, Biao Huang
Frontiers in Medicine.2022;[Epub] CrossRef - Programmed death 1 expressing CD8+CXCR5+ follicular T cells constitute effector rather than exhaustive phenotype in patients with chronic hepatitis B
Arshi Khanam, Lydia S. Y. Tang, Shyam Kottilil
Hepatology.2022; 75(3): 690. CrossRef - Insights into the Relationship between Pentraxin-3 and Cancer
Maria Bogdan, Andreea-Daniela Meca, Adina Turcu-Stiolica, Carmen Nicoleta Oancea, Roxana Kostici, Marin Valeriu Surlin, Cristina Florescu
International Journal of Molecular Sciences.2022; 23(23): 15302. CrossRef - Hepatitis B Flare in Hepatitis B e Antigen-Negative Patients: A Complicated Cascade of Innate and Adaptive Immune Responses
Ming-Ling Chang, Yun-Fan Liaw
International Journal of Molecular Sciences.2022; 23(3): 1552. CrossRef - Soluble programmed cell death-1 predicts hepatocellular carcinoma development during nucleoside analogue treatment
Ritsuzo Kozuka, Masaru Enomoto, Minh Phuong Dong, Hoang Hai, Le Thi Thanh Thuy, Naoshi Odagiri, Kanako Yoshida, Kohei Kotani, Hiroyuki Motoyama, Etsushi Kawamura, Atsushi Hagihara, Hideki Fujii, Sawako Uchida-Kobayashi, Akihiro Tamori, Norifumi Kawada
Scientific Reports.2022;[Epub] CrossRef - The Value of Immune System in the Progression of Chronic Hepatitis B
甜甜 武
Advances in Clinical Medicine.2021; 11(11): 5386. CrossRef - Identification of the association between HBcAg-specific T cell and viral control in chronic HBV infection using a cultured ELISPOT assay
Chengcong Chen, Xiaotao Jiang, Xuan Liu, Ling Guo, Weibin Wang, Shuqin Gu, Chunhua Wen, Xuan Yi, Libo Tang, Yongyin Li
Journal of Leukocyte Biology.2021; 109(2): 455. CrossRef - Molecular signature of hepatitis B virus regulation by interferon‐γ in primary human hepatocytes
Takuto Nosaka, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Tomoyuki Nemoto, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto
Hepatology Research.2020; 50(3): 292. CrossRef - Serum pentraxin 3 as a biomarker of hepatocellular carcinoma in chronic hepatitis B virus infection
Huan Deng, Xiude Fan, Xiaoyun Wang, Lu Zeng, Kun Zhang, Xiaoge Zhang, Na Li, Qunying Han, Yi Lv, Zhengwen Liu
Scientific Reports.2020;[Epub] CrossRef - Immune Checkpoints in Viral Infections
Huiming Cai, Ge Liu, Jianfeng Zhong, Kai Zheng, Haitao Xiao, Chenyang Li, Xun Song, Ying Li, Chenshu Xu, Haiqiang Wu, Zhendan He, Qinchang Zhu
Viruses.2020; 12(9): 1051. CrossRef - PRDM1 levels are associated with clinical diseases in chronic HBV infection and survival of patients with HBV-related hepatocellular carcinoma
Na Li, Xiude Fan, Xiaoyun Wang, Huan Deng, Kun Zhang, Xiaoge Zhang, Ye Wang, Qunying Han, Yi Lv, Zhengwen Liu
International Immunopharmacology.2019; 73: 156. CrossRef - Hepatitis B virus-specific effector CD8+ T cells are an important determinant of disease prognosis: A meta-analysis
Juzeng Zheng, Zhanfan Ou, Yilun Xu, Ziqiang Xia, Xianfan Lin, Sisi Jin, Yang Liu, Jinming Wu
Vaccine.2019; 37(18): 2439. CrossRef - PRDM1 rs1010273 polymorphism is associated with overall survival of patients with hepatitis B virus-related hepatocellular carcinoma
Na Li, Xiude Fan, Xiaoyun Wang, Huan Deng, Kun Zhang, Xiaoge Zhang, Qunying Han, Yi Lv, Zhengwen Liu
Immunology Letters.2019; 213: 39. CrossRef - Association of viral hepatitis and bipolar disorder: a nationwide population-based study
Lee-Won Chong, Chih-Chao Hsu, Chang-Yin Lee, Ruey-Hwang Chou, Cheng-Li Lin, Kuang-Hsi Chang, Yi-Chao Hsu
Journal of Translational Medicine.2018;[Epub] CrossRef - Tim-3 expression and its role in hepatocellular carcinoma
Feifei Liu, Yanning Liu, Zhi Chen
Journal of Hematology & Oncology.2018;[Epub] CrossRef - Novel Immunotherapy Strategies for Hepatobiliary Cancers
Thomas T DeLeon, Yumei Zhou, Bolni M Nagalo, Raquel T Yokoda, Daniel H Ahn, Ramesh K Ramanathan, Marcela A Salomao, Bashar A Aqel, Amit Mahipal, Tanios S Bekaii-Saab, Mitesh J Borad
Immunotherapy.2018; 10(12): 1077. CrossRef - Association of LTBR polymorphisms with chronic hepatitis B virus infection and hepatitis B virus-related hepatocellular carcinoma
Qianqian Zhu, Na Li, Fang Li, Jiao Sang, Huan Deng, Qunying Han, Yi Lv, Chunyan Li, Zhengwen Liu
International Immunopharmacology.2017; 49: 126. CrossRef - The development of hepatocarcinoma after long-term antivirus treatment of Chinese patients with chronic hepatitis B virus infection: Incidence, long-term outcomes and predictive factors
Zhi-Qin Li, Chun-Ling Hu, Ping Yu, Xin-Yu Gu, Jia-Jia Zhang, Hua Li, Hong-Yu Zhang, Jun Lv, Yan-Min Liu, Qing-Lei Zeng, Jing-Ya Yan, Zu-Jiang Yu, Yi Zhang
Clinics and Research in Hepatology and Gastroenterology.2017; 41(3): 311. CrossRef - Impaired Subset Progression and Polyfunctionality of T Cells in Mice Exposed to Methamphetamine during Chronic LCMV Infection
Uma Sriram, Beth L. Hill, Jonathan M. Cenna, Larisa Gofman, Nicole C. Fernandes, Bijayesh Haldar, Raghava Potula, Anil Kumar
PLOS ONE.2016; 11(10): e0164966. CrossRef
Research Support, Non-U.S. Gov'ts
- The hrp pathogenicity island of Pseudomonas syringae pv. tomato DC3000 is induced by plant phenolic acids
-
Jun Seung Lee , Hye Ryun Ryu , Ji Young Cha , Hyung Suk Baik
-
J. Microbiol. 2015;53(10):725-731. Published online October 2, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5256-4
-
-
53
View
-
0
Download
-
6
Crossref
-
Abstract
-
Plants produce a wide array of antimicrobial compounds,
such as phenolic compounds, to combat microbial pathogens.
The hrp PAI is one of the major virulence factors in the
plant pathogen, Pseudomonas syringae. A major role of hrp
PAI is to disable the plant defense system during bacterial
invasion. We examined the influence of phenolic compounds
on hrp PAI gene expression at low and high concentrations.
There was approximately 2.5 times more hrpA and hrpZ
mRNA in PtoDC3000 that was grown in minimal media
(MM) supplemented with 10 μM of ortho-coumaric acid than
in PtoDC3000 grown in MM alone. On the other hand, a
significantly lower amount of hrpA mRNA was observed in
bacteria grown in MM supplemented with a high concentration
of phenolic compounds. To determine the regulation
pathway for hrp PAI gene expression, we performed qRTPCR
using gacS, gacA, and hrpS deletion mutants.
-
Citations
Citations to this article as recorded by

- Liebig review: The role of mineral nutrients in the development of Pseudomonas syringae diseases—Lessons learned and implications for disease control in woody plants
Nathalie Soethe, Michelle T. Hulin, Antje Balasus, Gail Preston, Christoph‐Martin Geilfus
Journal of Plant Nutrition and Soil Science.2024; 187(3): 301. CrossRef - Regulation of the Pseudomonas syringae Type III Secretion System by Host Environment Signals
Megan R. O’Malley, Jeffrey C. Anderson
Microorganisms.2021; 9(6): 1227. CrossRef - Quantification of Viable Cells of Pseudomonas syringae pv. tomato in Tomato Seed Using Propidium Monoazide and a Real-Time PCR Assay
A-li Chai, Hai-yan Ben, Wei-tao Guo, Yan-xia Shi, Xue-wen Xie, Lei Li, Bao-ju Li
Plant Disease.2020; 104(8): 2225. CrossRef - Validation of RT-qPCR Approaches to MonitorPseudomonas syringaeGene Expression During Infection and Exposure to Pattern-Triggered Immunity
Amy Smith, Amelia H. Lovelace, Brian H. Kvitko
Molecular Plant-Microbe Interactions®.2018; 31(4): 410. CrossRef - Multidrug Efflux Pumps at the Crossroad between Antibiotic Resistance and Bacterial Virulence
Manuel Alcalde-Rico, Sara Hernando-Amado, Paula Blanco, José L. Martínez
Frontiers in Microbiology.2016;[Epub] CrossRef - Global Analysis of Type Three Secretion System and Quorum Sensing Inhibition of Pseudomonas savastanoi by Polyphenols Extracts from Vegetable Residues
Carola Biancalani, Matteo Cerboneschi, Francesco Tadini-Buoninsegni, Margherita Campo, Arianna Scardigli, Annalisa Romani, Stefania Tegli, Boris Alexander Vinatzer
PLOS ONE.2016; 11(9): e0163357. CrossRef
- Characterization of the rapamycin-inducible EBV LMP1 activation system
-
Sang Yong Kim , Jung-Eun Kim , Jiyeon Won , Yoon-Jae Song
-
J. Microbiol. 2015;53(10):732-738. Published online October 2, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5455-z
-
-
55
View
-
0
Download
-
6
Crossref
-
Abstract
-
Epstein-Barr virus (EBV) latent infection membrane protein
1 (LMP1) is required for EBV-mediated B lymphocyte
transformation into proliferating lymphoblastoid cell lines
(LCL). LMP1 oligomerizes spontaneously in membrane
lipid rafts via its transmembrane domain and constitutively
activates signal transduction pathways, including NF-κB,
p38 Mitogen-Activated Protein Kinase (MAPK), and c-Jun
N-terminal Kinase (JNK). Since LMP1 mimics the tumor necrosis
factor receptor (TNFR), CD40, it may be effectively
utilized to study the effects of constitutive activation of signal
transduction pathways on cellular physiology. On the other
hand, LMP1 presents a disadvantage in terms of determining
the sequential events and factors involved in signaling pathways.
A CD40-LMP1 chimeric molecule has been generated
to overcome this limitation but does not represent the authentic
and physiological nature of LMP1. In the current
study, a ligand-dependent activation system for LMP1 using
rapamycin-inducible dimerization was generated to delineate
the LMP1 signaling pathway.
-
Citations
Citations to this article as recorded by

- Antiviral Activities of Ethyl Pheophorbides a and b Isolated from Aster pseudoglehnii against Influenza Viruses
Subin Park, Ji-Young Kim, Hak Cheol Kwon, Dae Sik Jang, Yoon-Jae Song
Molecules.2022; 28(1): 41. CrossRef - Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses
Chae Hyun Kim, Jung-Eun Kim, Yoon-Jae Song
Molecules.2020; 25(10): 2379. CrossRef - Human Cytomegalovirus IE2 86 kDa Protein Induces STING Degradation and Inhibits cGAMP-Mediated IFN-β Induction
Jung-Eun Kim, Young-Eui Kim, Mark F. Stinski, Jin-Hyun Ahn, Yoon-Jae Song
Frontiers in Microbiology.2017;[Epub] CrossRef - Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas
Sangmin Kang, Jinjong Myoung
Journal of Microbiology.2017; 55(5): 319. CrossRef - Inhibition of human cytomegalovirus immediate-early gene expression and replication by the ethyl acetate (EtOAc) fraction of Elaeocarpus sylvestris in vitro
Sohee Bae, Se Chan Kang, Yoon-Jae Song
BMC Complementary and Alternative Medicine.2017;[Epub] CrossRef - Inhibition of varicella-zoster virus replication by an ethanol extract of Lysimachia mauritiana
Sohee Bae, Yoon-Jae Song
Molecular Medicine Reports.2017; 15(6): 3847. CrossRef
Published Erratum
- Erratum] Identification of the Vibrio vulnificus htpG Gene and Its Influence on Cold Shock Recovery
-
Slae Choi , Kyungku Jang , Seulah Choi , Hee-jee Yun , Dong-Hyun Kang
-
J. Microbiol. 2015;53(10):739-739.
-
DOI: https://doi.org/10.1007/s12275-015-0740-4
-
-
Abstract
-
In the article by Choi et al. published in Journal of Microbiology 2012; 50, 707-711. The 2nd author name of this paper should
be corrected as Kyung Ku Jang. The authors should be
Slae Choi1†, Kyung Ku Jang1†, Seulah Choi2,
Hee-jee Yun2, and Dong-Hyun Kang1*