Journal of Microbiology

Volume 59(9); September 2021

Review

[MINIREVIEW]The rapid adaptation of SARS-CoV-2–rise of the variants: transmission and resistance: Sandrine M. Soh , Yeongjun Kim , Chanwoo Kim , Ui Soon Jang , Hye-Ra Lee; J. Microbiol. 2021;59(9):807-818. Published online August 27, 2021; DOI: https://doi.org/10.1007/s12275-021-1348-5

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The causative factor of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating. Interestingly, identified mutations mainly occur in the spike (S) protein which interacts with the ACE2 receptor and is cleaved via serine protease TMPRSS2. Some mutated strains are becoming dominant in various parts of the globe because of increased transmissibility as well as cell entry efficacy. Remarkably, the neutralizing activity of monoclonal antibodies, convalescent sera, and vaccines against the variants has been reported to be significantly reduced. Therefore, the efficacy of various monoclonal antibodies therapy and vaccines against these variants is becoming a great global concern. We herein summarize the current status of SARS-CoV- 2 with gears shifted towards the recent and most common genetic variants in relation to transmission, neutralizing activity, and vaccine efficacy.

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Understanding the Molecular Actions of Spike Glycoprotein in SARS-CoV-2 and Issues of a Novel Therapeutic Strategy for the COVID-19 Vaccine
Yasunari Matsuzaka, Ryu Yashiro
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Complex vaccination strategies prevent the emergence of vaccine resistance
Simon A Rella, Yuliya A Kulikova, Aygul R Minnegalieva, Fyodor A Kondrashov, Ben Ashby, Tim Connallon
Evolution.2024; 78(10): 1722. CrossRef
Distinctive Combinations of RBD Mutations Contribute to Antibody Evasion in the Case of the SARS-CoV-2 Beta Variant
Tae-Hun Kim, Sojung Bae, Sunggeun Goo, Jinjong Myoung
Journal of Microbiology and Biotechnology.2023; 33(12): 1587. CrossRef
Analysis of 3.5 million SARS-CoV-2 sequences reveals unique mutational trends with consistent nucleotide and codon frequencies
Sarah E. Fumagalli, Nigam H. Padhiar, Douglas Meyer, Upendra Katneni, Haim Bar, Michael DiCuccio, Anton A. Komar, Chava Kimchi-Sarfaty
Virology Journal.2023;[Epub] CrossRef
Broad neutralization against SARS-CoV-2 variants induced by ancestral and B.1.351 AS03-Adjuvanted recombinant Plant-Derived Virus-Like particle vaccines
Charlotte Dubé, Sarah Paris-Robidas, Guadalupe Andreani, Cindy Gutzeit, Marc-André D'Aoust, Brian J. Ward, Sonia Trépanier
Vaccine.2022; 40(30): 4017. CrossRef
A tentative tracking of the SARS-Cov2 pandemic in France, based on a corrected SIR model including vaccination effects
Mathilde Varret, François Xavier Martin, François Varret, J.-C.S. Lévy
EPJ Web of Conferences.2022; 263: 01002. CrossRef
Changing Dynamics of SARS-CoV-2: A Global Challenge
Ananya Chugh, Nimisha Khurana, Kangna Verma, Ishita Sehgal, Rajan Rolta, Pranjal Vats, Rajendra Phartyal, Deeksha Salaria, Neha Kaushik, Eun Ha Choi, Mansi Verma, Nagendra Kumar Kaushik
Applied Sciences.2022; 12(11): 5546. CrossRef
The SARS-CoV-2 differential genomic adaptation in response to varying UVindex reveals potential genomic resources for better COVID-19 diagnosis and prevention
Naveed Iqbal, Muhammad Rafiq, Masooma, Sanaullah Tareen, Maqsood Ahmad, Faheem Nawaz, Sumair Khan, Rida Riaz, Ting Yang, Ambrin Fatima, Muhsin Jamal, Shahid Mansoor, Xin Liu, Nazeer Ahmed
Frontiers in Microbiology.2022;[Epub] CrossRef
SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells
Rayhane Nchioua, Annika Schundner, Dorota Kmiec, Caterina Prelli Bozzo, Fabian Zech, Lennart Koepke, Alexander Graf, Stefan Krebs, Helmut Blum, Manfred Frick, Konstantin M. J. Sparrer, Frank Kirchhoff, Tom Gallagher
Journal of Virology.2022;[Epub] CrossRef
Viral Load in COVID-19 Patients: Implications for Prognosis and Vaccine Efficacy in the Context of Emerging SARS-CoV-2 Variants
Severino Jefferson Ribeiro da Silva, Suelen Cristina de Lima, Ronaldo Celerino da Silva, Alain Kohl, Lindomar Pena
Frontiers in Medicine.2022;[Epub] CrossRef
Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants
Lili Li, Meiling Gao, Peng Jiao, Shulong Zu, Yong-qiang Deng, Dingyi Wan, Yang Cao, Jing Duan, Saba R Aliyari, Jie Li, Yueyue Shi, Zihe Rao, Cheng-feng Qin, Yu Guo, Genhong Cheng, Heng Yang
Cell & Bioscience.2022;[Epub] CrossRef
Perspectives and Factors Affecting the Preventive Behavior Pertinent to COVID-19 among School Employees in Chiang Mai, Thailand: A Cross-Sectional Study
Pheerasak Assavanopakun, Tharntip Promkutkao, Suchat Promkutkeo, Wachiranun Sirikul
International Journal of Environmental Research and Public Health.2022; 19(9): 5662. CrossRef
Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial
Karin Hardt, An Vandebosch, Jerald Sadoff, Mathieu Le Gars, Carla Truyers, David Lowson, Ilse Van Dromme, Johan Vingerhoets, Tobias Kamphuis, Gert Scheper, Javier Ruiz-Guiñazú, Saul N Faust, Christoph D Spinner, Hanneke Schuitemaker, Johan Van Hoof, Macay
The Lancet Infectious Diseases.2022; 22(12): 1703. CrossRef
Fundamentals of genomic epidemiology, lessons learned from the coronavirus disease 2019 (COVID-19) pandemic, and new directions
Denis Jacob Machado, Richard Allen White, Janice Kofsky, Daniel A. Janies
Antimicrobial Stewardship & Healthcare Epidemiology.2021;[Epub] CrossRef
Daily Physical Activity and Sleep Measured by Wearable Activity Trackers during the Coronavirus Disease 2019 Pandemic: A Lesson for Preventing Physical Inactivity during Future Pandemics
Hidetaka Hamasaki
Applied Sciences.2021; 11(21): 9956. CrossRef
The adaptation of SARS-CoV-2 to humans
Eduardo Tosta
Memórias do Instituto Oswaldo Cruz.2021;[Epub] CrossRef

Journal Articles

A study of P release from Fe-P and Ca-P via the organic acids secreted by Aspergillus niger: Da Tian , Liyan Wang , Jun Hu , Liangliang Zhang , Ningning Zhou , Jingjing Xia , Meiyue Xu , Kianpoor Kalkhajeh Yusef , Shimei Wang , Zhen Li , Hongjian Gao; J. Microbiol. 2021;59(9):819-826. Published online August 12, 2021; DOI: https://doi.org/10.1007/s12275-021-1178-5

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Abstract

Phosphate solubilizing fungi (PSF) have been widely applied to dissolve insoluble phosphates (IPs). However, the PSF usually demonstrates a different phosphate solubilizing capacity for various IPs. This study explored the mechanisms of Aspergillus niger for the dissolution of ferric phosphate (FePO4, Fe-P), and tricalcium phosphate (Ca3[PO4]2, Ca-P) regarding the tricarboxylic acid (TCA) cycle. Aspergillus niger has higher phosphorus (P) content released from Ca-P, reached the maximum value of 861 mg/L after seven days of incubation, compared with the 169 mg/L from Fe-P. Oxalic acid promoted the release of P from Ca-P through the formation of calcium oxalate. The presence of Fe-P can stimulate A. niger to secrete large amounts of citric acid, confirmed by the enhancement of citrate synthase (CS) activity. However, citric acid only promotes 0.5% of P released from Fe-P. Meanwhile, although oxalic acid still dominates the release of P from Fe-P, its abundance was significantly declined. In contrast, oxalic acid also shows a higher P release ratio in Ca-P than citric acid, i.e., 36% vs. 22%. This study points to the future usage of A. niger to dissolve IPs in soil required to enhance oxalic acid secretion.

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Mechanism of A. oleivorans S4 treating soluble phosphorus deficiency and hydrocarbon contamination simultaneously
Panpan Wang, Chaoqi Chen, Kejun Liao, Yue Tao, Yaojia Fu, Lanzhou Chen
Science of The Total Environment.2024; 949: 175215. CrossRef
Heavy Metal Remediation Using Phosphate-Solubilizing Fungi: From Bioprocess to Application
Da Tian, Shuo Zhang, Dechao Wang, Liangliang Zhang, Haoming Chen, Xinxin Ye
Agronomy.2024; 14(11): 2638. CrossRef
Lead remediation by geological fluorapatite combined with Penicillium Oxalicum and Red yeast
Qiang Guan, Xiaohui Cheng, Yue He, Yifan Yan, Lei Zhang, Zhan Wang, Liangliang Zhang, Da Tian
Microbial Cell Factories.2024;[Epub] CrossRef
Application of phosphogypsum and phosphate-solubilizing fungi to Pb remediation: From simulation to in vivo incubation
Lingzi Meng, Kejin Ding, Yige Qiu, Yunhui Chen, Hongxun Huo, Dan Yu, Da Tian, Zhen Li
Science of The Total Environment.2024; 933: 173171. CrossRef
Improvement of fungal extraction of phosphorus from sewage sludge ash by Aspergillus niger using sludge filtrate as nutrient substrate
Long Su, Lingyu Hu, Qinghong Sui, Chengcheng Ding, Di Fang, Lixiang Zhou
Waste Management.2023; 157: 25. CrossRef
The Regulation of Phosphorus Release by Penicillium chrysogenum in Different Phosphate via the TCA Cycle and Mycelial Morphology
Liyan Wang, Da Tian, Xiaoru Zhang, Mingxue Han, Xiaohui Cheng, Xinxin Ye, Chaochun Zhang, Hongjian Gao, Zhen Li
Journal of Microbiology.2023; 61(8): 765. CrossRef
Nematophagous Fungi: A Review of Their Phosphorus Solubilization Potential
Marcos Vera-Morales, Segundo E. López Medina, Jaime Naranjo-Morán, Adela Quevedo, María F. Ratti
Microorganisms.2023; 11(1): 137. CrossRef
Bioleaching rare earth elements from coal fly ash by Aspergillus niger
Juanjuan Ma, Shuyan Li, Jinxi Wang, Shuting Jiang, Balaji Panchal, Yuzhuang Sun
Fuel.2023; 354: 129387. CrossRef
The Production of Oxalate by Aspergillus niger under Different Lead Concentrations
Yijun Huang, Liangliang Zhang, Shijia Yuan, Wenpei Liu, Chaochun Zhang, Da Tian, Xinxin Ye
Agronomy.2023; 13(4): 1182. CrossRef
Characterization and genome analysis of Acinetobacter oleivorans S4 as an efficient hydrocarbon-degrading and plant-growth-promoting rhizobacterium
Panpan Wang, Haiying Wei, Tan Ke, Yaojia Fu, Yuyang Zeng, Chaoqi Chen, Lanzhou Chen
Chemosphere.2023; 331: 138732. CrossRef
Electron microscopic imaging and NanoSIMS investigation on physiological responses of Aspergillus niger under Pb(II) and Cd(II) stress
Shang Pan, Zhaoyan Li, Jiayi Wang, Xuefei Li, Lingzi Meng, Yunhui Chen, Mu Su, Zhen Li
Frontiers in Bioengineering and Biotechnology.2023;[Epub] CrossRef
Lead remediation is promoted by phosphate-solubilizing fungi and apatite via the enhanced production of organic acid
Da Tian, Xiaoru Zhang, Liyan Wang, Mingxue Han, Chaochun Zhang, Xinxin Ye
Frontiers in Bioengineering and Biotechnology.2023;[Epub] CrossRef
Screening of calcium- and iron-targeted phosphorus solubilizing fungi for agriculture production
Xin Zhang, Aravindan Rajendran, Sarah Grimm, Xiao Sun, Hongjian Lin, Ruo He, Bo Hu
Rhizosphere.2023; 26: 100689. CrossRef
Evaluating the survival of Aspergillus niger in a highly polluted red soil with addition of Phosphogypsum and bioorganic fertilizer
Lingzi Meng, Shang Pan, Limin Zhou, Choochad Santasup, Mu Su, Da Tian, Zhen Li
Environmental Science and Pollution Research.2022; 29(50): 76446. CrossRef
Phosphorus-Solubilizing Capacity of Mortierella Species Isolated from Rhizosphere Soil of a Poplar Plantation
Yue Sang, Long Jin, Rui Zhu, Xing-Ye Yu, Shuang Hu, Bao-Teng Wang, Hong-Hua Ruan, Feng-Jie Jin, Hyung-Gwan Lee
Microorganisms.2022; 10(12): 2361. CrossRef
Remediation of Lead-Contaminated Water by Red Yeast and Different Types of Phosphate
Da Tian, Xiaohui Cheng, Liyan Wang, Jun Hu, Ningning Zhou, Jingjing Xia, Meiyue Xu, Liangliang Zhang, Hongjian Gao, Xinxin Ye, Chaochun Zhang
Frontiers in Bioengineering and Biotechnology.2022;[Epub] CrossRef
Decomposition of Maize Straw between Two Phosphate Solubilizing Fungi: Aspergillus Niger and Penicillium Chrysogenum
Liyan Wang, Jun Hu, Hao Guan, Da Tian, Hongjian Gao, C. Yang, H. Chen, P. Duan, F. Jiao, C. Wen
E3S Web of Conferences.2022; 350: 01028. CrossRef
The Utilization of Phosphogypsum as a Sustainable Phosphate-Based Fertilizer by Aspergillus niger
Da Tian, Jingjing Xia, Ningning Zhou, Meiyue Xu, Xiang Li, Liangliang Zhang, Shuhua Du, Hongjian Gao
Agronomy.2022; 12(3): 646. CrossRef
Remediation of Lead Contamination by Aspergillus niger and Phosphate Rocks under Different Nitrogen Sources
Yi Feng, Liangliang Zhang, Xiang Li, Liyan Wang, Kianpoor Kalkhajeh Yusef, Hongjian Gao, Da Tian
Agronomy.2022; 12(7): 1639. CrossRef
Aspergillus nigerEnhances Organic and Inorganic Phosphorus Release from Wheat Straw by Secretion of Degrading Enzymes and Oxalic Acid
Liyan Wang, Hao Guan, Jun Hu, Yi Feng, Xiang Li, Kianpoor Kalkhajeh Yusef, Hongjian Gao, Da Tian
Journal of Agricultural and Food Chemistry.2022; 70(35): 10738. CrossRef
A Study of Phosphate Solubilizing Capacity by Penicillium Aurantiogriseum under Different Carbon and Nitrogen Resources
Jun Hu, Liyan Wang, Liangliang Zhang, Hongjian Gao, Da Tian, C. Yang, H. Chen, P. Duan, F. Jiao, C. Wen
E3S Web of Conferences.2022; 350: 03002. CrossRef
Phosphorus biogeochemistry regulated by carbonates in soil
Yuanyuan Geng, Shang Pan, Lin Zhang, Jingjing Qiu, Kun He, Hongjian Gao, Zhen Li, Da Tian
Environmental Research.2022; 214: 113894. CrossRef

Probiotic supplements alleviate gestational diabetes mellitus by restoring the diversity of gut microbiota: a study based on 16S rRNA sequencing: Qing-Xiang Zheng , Xiu-Min Jiang , Hai-Wei Wang , Li Ge , Yu-Ting Lai , Xin-Yong Jiang , Fan Chen , Ping-Ping Huang; J. Microbiol. 2021;59(9):827-839. Published online August 12, 2021; DOI: https://doi.org/10.1007/s12275-021-1094-8

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Abstract

Probiotics effectively prevent and improve metabolic diseases such as diabetes by regulating the intestinal microenvironment and gut microbiota. However, the effects of probiotics in gestational diabetes mellitus are not clear. Here, we showed that probiotic supplements significantly improved fasting blood glucose in a gestational diabetes mellitus rat model. To further understand the mechanisms of probiotics in gestational diabetes mellitus, the gut microbiota were analyzed via 16S rRNA sequencing. We found that compared with the normal pregnant group, the gestational diabetes mellitus rats had decreased diversity of gut microbiota. Moreover, probiotic supplementation restored the diversity of the gut microbiota in gestational diabetes mellitus rats, and the gut microbiota structure tended to be similar to that of normal pregnant rats. In particular, compared with gestational diabetes mellitus rats, the abundance of Firmicutes and Actinobacteria was higher after probiotic supplementation. Furthermore, activating carbohydrate metabolism and membrane transport pathways may be involved in the potential mechanisms by which probiotic supplements alleviate gestational diabetes mellitus. Overall, our results suggested that probiotic supplementation might be a novel approach to restore the gut microbiota of gestational diabetes mellitus rats and provided an experimental evidence for the use of probiotic supplements to treat gestational diabetes melitus.

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Dietary Polyphenols Support Akkermansia muciniphila Growth via Mediation of the Gastrointestinal Redox Environment
Charlene B. Van Buiten, Valerie A. Seitz, Jessica L. Metcalf, Ilya Raskin
Antioxidants.2024; 13(3): 304. CrossRef
The Intervention of Probiotics on Type 2 Diabetes Mellitus in Animal Models
Qianyu Qu, Penggang He, Yuqi Zhang, Shujuan Yang, Peibin Zeng
Molecular Nutrition & Food Research.2024;[Epub] CrossRef
Lactobacillus gasseri BNR17 and Limosilactobacillus fermentum ABF21069 Ameliorate High Sucrose-Induced Obesity and Fatty Liver via Exopolysaccharide Production and β-oxidation
Yu Mi Jo, Yoon Ji Son, Seul-Ah Kim, Gyu Min Lee, Chang Won Ahn, Han-Oh Park, Ji-Hyun Yun
Journal of Microbiology.2024; 62(10): 907. CrossRef
Probiotic therapy as a promising strategy for gestational diabetes mellitus management
Deborah Emanuelle de Albuquerque Lemos, José Luiz de Brito Alves, Evandro Leite de Souza
Expert Opinion on Biological Therapy.2024; 24(11): 1207. CrossRef
Influence of Symbiotic Fermentation Broth on Regulating Metabolism with Gut Microbiota and Metabolite Profiles Is Estimated Using a Third-Generation Sequencing Platform
Chih-Yin Wu, Chun-Kai Huang, Wei-Sheng Hong, Yin-Hsiu Liu, Ming-Chi Shih, Jung-Chun Lin
Metabolites.2023; 13(9): 999. CrossRef
Neuroprotective Effect of Ponicidin Alleviating the Diabetic Cognitive Impairment: Regulation of Gut Microbiota
Xiaojuan Zhang, Feng Guo, Dujuan Cao, Yinan Yan, Ning Zhang, Kaili Zhang, Xinyi Li, Prashant Kumar, Xiaojuan Zhang
Applied Biochemistry and Biotechnology.2023; 195(2): 735. CrossRef
Antidiabetogenic mechanisms of probiotic action in food matrices: A review
Vanessa Moraes Ramalho Castro, Rosa Helena Luchese
PharmaNutrition.2022; 21: 100302. CrossRef
Prepregnancy body mass index and gestational weight gain are associated with maternal and infant adverse outcomes in Chinese women with gestational diabetes
Qing-Xiang Zheng, Hai-Wei Wang, Xiu-Min Jiang, Yan Lin, Gui-Hua Liu, Mian Pan, Li Ge, Xiao-Qian Chen, Jing-Ling Wu, Xiao-Yun Zhang, Yu-Qing Pan, Hong-Gu He
Scientific Reports.2022;[Epub] CrossRef
Probiotic Intervention in the Treatment of Diabetes Mellitus: A Review
Navya Sreepathi, M.K. Jayanthi, S. Jagadeep Chandra, Shrisha Naik Bajpe, Ramith Ramu
Journal of Pure and Applied Microbiology.2022; 16(3): 1519. CrossRef
Ameliorative Effects of Bifidobacterium animalis subsp. lactis J-12 on Hyperglycemia in Pregnancy and Pregnancy Outcomes in a High-Fat-Diet/Streptozotocin-Induced Rat Model
Jianjun Yang, Yumeng Ma, Tong Li, Yuanxiang Pang, Hongxing Zhang, Yuanhong Xie, Hui Liu, Yanfang Sun, Jianhua Ren, Junhua Jin
Nutrients.2022; 15(1): 170. CrossRef
Probiotic Mechanisms Affecting Glucose Homeostasis: A Scoping Review
Maša Pintarič, Tomaž Langerholc
Life.2022; 12(8): 1187. CrossRef
The Roles of Probiotics in the Gut Microbiota Composition and Metabolic Outcomes in Asymptomatic Post-Gestational Diabetes Women: A Randomized Controlled Trial
Zubaidah Hasain, Raja Affendi Raja Ali, Hajar Fauzan Ahmad, Ummul Fahri Abdul Rauf, Seok Fang Oon, Norfilza Mohd Mokhtar
Nutrients.2022; 14(18): 3878. CrossRef
Changes in the Gut Metabolic Profile of Gestational Diabetes Mellitus Rats Following Probiotic Supplementation
Qing-Xiang Zheng, Hai-Wei Wang, Xiu-Min Jiang, Li Ge, Yu-Ting Lai, Xin-Yong Jiang, Ping-Ping Huang, Fan Chen, Xiao-Qian Chen
Frontiers in Microbiology.2022;[Epub] CrossRef
Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health
Tao Feng, Yan Liu
Computational and Structural Biotechnology Journal.2022; 20: 1541. CrossRef
Several Shaping Characteristics of OneCurve Continuously Rotating System versus Three Different Kinematic Systems: ProTaper Universal, Twisted File Adaptive and WaveOne Gold
Ali Türkyılmaz, Volkan Arıkan
Meandros Medical and Dental Journal.2022; 23(1): 67. CrossRef

Characterization of staphylococcal endolysin LysSAP33 possessing untypical domain composition: Jun-Hyeok Yu , Do-Won Park , Jeong-A Lim , Jong-Hyun Park; J. Microbiol. 2021;59(9):840-847. Published online August 12, 2021; DOI: https://doi.org/10.1007/s12275-021-1242-1

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Abstract

Endolysin, a peptidoglycan hydrolase derived from bacteriophage, has been suggested as an alternative antimicrobial agent. Many endolysins on staphylococcal phages have been identified and applied extensively against Staphylococcus spp. Among them, LysK-like endolysin, a well-studied staphylococcal endolysin, accounts for most of the identified endolysins. However, relatively little interest has been paid to LysKunlike endolysin and a few of them has been characterized. An endolysin LysSAP33 encoded on bacteriophage SAP33 shared low homology with LysK-like endolysin in sequence by 41% and domain composition (CHAP-unknown CBD). A green fluorescence assay using a fusion protein for Lys- SAP33_CBD indicated that the CBD domain (157-251 aa) was bound to the peptidoglycan of S. aureus. The deletion of LysSAP33_CBD at the C-terminal region resulted in a significant decrease in lytic activity and efficacy. Compared to LysK-like endolysin, LysSAP33 retained its lytic activity in a broader range of temperature, pH, and NaCl concentrations. In addition, it showed a higher activity against biofilms than LysK-like endolysin. This study could be a helpful tool to develop our understanding of staphylococcal endolysins not belonging to LysK-like endolysins and a potential biocontrol agent against biofilms.

Citations

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Phage-Derived Endolysins Against Resistant Staphylococcus spp.: A Review of Features, Antibacterial Activities, and Recent Applications
Mina Golban, Javad Charostad, Hossein Kazemian, Hamid Heidari
Infectious Diseases and Therapy.2024;[Epub] CrossRef
Molecular Machinery of the Triad Holin, Endolysin, and Spanin: Key Players Orchestrating Bacteriophage-Induced Cell Lysis and their Therapeutic Applications
Safia Samir
Protein & Peptide Letters.2024; 31(2): 85. CrossRef
A Novel Truncated CHAP Modular Endolysin, CHAPSAP26-161, That Lyses Staphylococcus aureus, Acinetobacter baumannii, and Clostridioides difficile, and Exhibits Therapeutic Effects in a Mouse Model of A. baumannii Infection
Yoon-Jung Choi, Shukho Kim, Ram Hari Dahal, Jungmin Kim
Journal of Microbiology and Biotechnology.2024; 34(8): 1718. CrossRef
Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria
He Liu, Zhen Hu, Mengyang Li, Yi Yang, Shuguang Lu, Xiancai Rao
Journal of Biomedical Science.2023;[Epub] CrossRef
Endolysin, a Promising Solution against Antimicrobial Resistance
Mujeeb ur Rahman, Weixiao Wang, Qingqing Sun, Junaid Ali Shah, Chao Li, Yanmei Sun, Yuanrui Li, Bailing Zhang, Wei Chen, Shiwei Wang
Antibiotics.2021; 10(11): 1277. CrossRef

Reversible function of RapA with the C-terminus of RapC in Dictyostelium: Dongju Kim , Wonbum Kim , Taeck Joong Jeon; J. Microbiol. 2021;59(9):853-848.; DOI: https://doi.org/10.1007/s12275-021-1400-5

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Abstract

Rap small GTPases are involved in diverse signaling pathways associated with cell growth, proliferation, and cell migration. There are three Rap proteins in Dictyostelium, RapA, RapB, and RapC. RapA is a key regulator in the control of cell adhesion and migration. Recently RapA and RapC have been reported to have opposite functions in the regulation of cellular processes. In this study, we demonstrate that the C-terminus of RapC, which is not found in RapA, is essential for the opposite functions of RapC and is able to reverse the functions of RapA when fused to the tail of RapA. Cells lacking RapC displayed several defective phenotypes, including spread morphology, strong adhesion, and decreased cell migration compared to wild-type cells. These phenotypes were rescued by full-length RapC, but not by RapC missing the C-terminus. Furthermore, recombinant RapA fused with the C-terminus of RapC completely recovered the phenotypes of rapC null cells, indicating that the functions of RapA were modified to become similar to those of RapC by the C-terminus of RapC with respect to cell morphology, cell adhesion and migration, cytokinesis, and development. These results suggest that the C-terminal residues of RapC are able to suppress and change the functions of other Ras proteins in Ras oncogenic signaling pathways.

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RapB Regulates Cell Adhesion and Migration in Dictyostelium, Similar to RapA
Uri Han, Nara Han, Byeonggyu Park, Taeck Joong Jeon
Journal of Microbiology.2024; 62(8): 627. CrossRef
Adhesion of Dictyostelium Amoebae to Surfaces: A Brief History of Attachments
Lucija Mijanović, Igor Weber
Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef

Journal Articles

Function of Rhs proteins in porcine extraintestinal pathogenic Escherichia coli PCN033: Wenjia Lu , Jia Tan , Hao Lu , Gaoyan Wang , Wenqi Dong , Chenchen Wang , Xiaodan Li , Chen Tan; J. Microbiol. 2021;59(9):854-860. Published online August 12, 2021; DOI: https://doi.org/10.1007/s12275-021-1189-2

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Abstract

Extraintestinal pathogenic Escherichia coli (ExPEC) is an important zoonotic pathogen that places severe burdens on public health and animal husbandry. There are many pathogenic factors in E. coli. The type VI secretion system (T6SS) is a nano-microbial weapon that can assemble quickly and inject toxic effectors into recipient cells when danger is encountered. T6SSs are encoded in the genomes of approximately 25% of sequenced Gram-negative bacteria. When these bacteria come into contact with eukaryotic cells or prokaryotic microbes, the T6SS assembles and secretes associated effectors. In the porcine ExPEC strain PCN033, we identified four classic rearrangement hotspot (Rhs) genes. We determined the functions of the four Rhs proteins through mutant construction and protein expression. Animal infection experiments showed that the Δrhs-1CT, Δrhs-2CT, Δrhs-3CT, and Δrhs-4CT caused a significant decrease in the multiplication ability of PCN033 in vivo. Cell infection experiments showed that the Rhs protein is involved in anti-phagocytosis activities and bacterial adhesion and invasion abilities. The results of this study demonstrated that rhs1, rhs3, and rh4 plays an important role in the interaction between PCN033 and host cell. Rhs2 has contribution to cell and mice infection. This study helps to elucidate the pathogenic mechanism governing PCN033 and may help to establish a foundation for further research seeking to identify potential T6SS effectors.

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Molecular characterization of the integrative and conjugative elements harbouring multidrug resistance genes in Glaesserella parasuis
Yongliang Che, Renjie Wu, Hongjie Li, Longbai Wang, Xuemin Wu, Qiuyong Chen, Rujing Chen, Lunjiang Zhou
Veterinary Microbiology.2024; 291: 110014. CrossRef
Genome-wide identification of genes critical for in vivo fitness of multi-drug resistant porcine extraintestinal pathogenic Escherichia coli by transposon-directed insertion site sequencing usin
Fan Yin, Yan Hu, Zixuan Bu, Yuying Liu, Hui Zhang, Yawen Hu, Ying Xue, Shaowen Li, Chen Tan, Xiabing Chen, Lu Li, Rui Zhou, Qi Huang
Virulence.2023;[Epub] CrossRef
Dual RNA-Seq of Flavobacterium psychrophilum and Its Outer Membrane Vesicles Distinguishes Genes Associated with Susceptibility to Bacterial Cold-Water Disease in Rainbow Trout (Oncorhynchus mykiss)
Pratima Chapagain, Ali Ali, Mohamed Salem
Pathogens.2023; 12(3): 436. CrossRef
Distribution and diversity of type VI secretion system clusters in Enterobacter bugandensis and Enterobacter cloacae
Amy J. G. Anderson, Becca Morrell, Guillermo Lopez Campos, Miguel A. Valvano
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Salmonella Typhimurium ST313 isolated in Brazil revealed to be more invasive and inflammatory in murine colon compared to ST19 strains: Amanda Aparecida Seribelli , Tamara R. Machado Ribeiro , Patrick da Silva† , Isabela Mancini Martins , Felipe Pinheiro Vilela , Marta I. Cazentini Medeiros , Kamila Chagas Peronni , Wilson Araújo da Silva Junior , Cristiano Gallina Moreira , Juliana Pfrimer Falcão; J. Microbiol. 2021;59(9):861-870. Published online August 12, 2021; DOI: https://doi.org/10.1007/s12275-021-1082-z

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Abstract

Salmonella Typhimurium (ST313) has caused an epidemic of invasive disease in sub-Saharan Africa and has been recently identified in Brazil. As the virulence of this ST is poorly understood, the present study aimed to (i) perform the RNAseq in vitro of S. Typhimurium STm30 (ST313) grown in Luria-Bertani medium at 37°C; (ii) compare it with the RNAseq of the S. Typhimurium SL1344 (ST19) and S. Typhimurium STm11 (ST19) strains under the same growing conditions; and (iii) examine the colonization capacity and expression of virulence genes and cytokines in murine colon. The STm30 (ST313) strain exhibited stronger virulence and was associated with a more inflammatory profile than the strains SL1344 (ST19) and STm11 (ST19), as demonstrated by transcriptome and in vivo assay. The expression levels of the hilA, sopD2, pipB, and ssaS virulence genes, other Salmonella pathogenicity islands SPI-1 and SPI-2 genes or effectors, and genes of the cytokines IL-1β, IFN-γ, TNF-α, IL-6, IL-17, IL-22, and IL-12 were increased during ST313 infection in C57BL/6J mice. In conclusion, S. Typhimurium STm30 (ST313) isolated from human feces in Brazil express higher levels of pathogenesis- related genes at 37°C and has stronger colonization and invasion capacity in murine colon due to its high expression levels of virulence genes, when compared with the S. Typhimurium SL1344 (ST19) and STm11 (ST19) strains. STm30 (ST313) also induces stronger expression of pro-inflammatory cytokines in this organ, suggesting that it causes more extensive tissue damage.

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Screening of small molecules attenuating biofilm formation of Acinetobacter baumannii by inhibition of ompA promoter activity: Seok Hyeon Na , Hyejin Jeon , Man Hwan Oh , Yoo Jeong Kim , Je Chul Lee; J. Microbiol. 2021;59(9):871-878. Published online August 27, 2021; DOI: https://doi.org/10.1007/s12275-021-1394-z

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Abstract

Anti-virulence therapeutic strategies are promising alternatives against drug-resistant pathogens. Outer membrane protein A (OmpA) plays a versatile role in the pathogenesis and antimicrobial resistance of Acinetobacter baumannii. Therefore, OmpA is an innovative target for anti-virulence therapy against A. baumannii. This study aimed to develop a high-throughput screening (HTS) system to discover small molecules inhibiting the ompA promoter activity of A. baumannii and screen chemical compounds using the bacterial growth-based HTS system. The ompA promoter and open reading frame of nptI fusion plasmids that controlled the expression of nptI encoding resistance to kanamycin by the ompA promoter were constructed and then transformed into A. baumannii ATCC 17978. This reporter strain was applied to screen small molecules inhibiting the ompA promoter activity in a chemical library. Of the 7,520 chemical compounds, 15 exhibited ≥ 70% growth inhibition of the report strain cultured in media containing kanamycin. Three compounds inhibited the expression of ompA and OmpA in the outer membrane of A. baumannii ATCC 17978, which subsequently reduced biofilm formation. In conclusion, our reporter strain is useful for large-scale screening of small molecules inhibiting the ompA expression in A. baumannii. Hit compounds identified by the HTS system are promising scaffolds to develop novel therapeutics against A. baumannii.

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