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- Hepatitis B virus (HBV) codon adapts well to the gene expression profile of liver cancer: an evolutionary explanation for HBV’s oncogenic role
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Chunpeng Yu , Jian Li , Qun Li , Shuai Chang , Yufeng Cao , Hui Jiang , Lingling Xie , Gang Fan , Song Wang
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J. Microbiol. 2022;60(11):1106-1112. Published online October 17, 2022
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DOI: https://doi.org/10.1007/s12275-022-2371-x
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Abstract
- Due to the evolutionary arms race between hosts and viruses,
viruses must adapt to host translation systems to rapidly synthesize
viral proteins. Highly expressed genes in hosts have a
codon bias related to tRNA abundance, the primary RNA translation
rate determinant. We calculated the relative synonymous
codon usage (RSCU) of three hepatitis viruses (HAV,
HBV, and HCV), SARS-CoV-2, 30 human tissues, and hepatocellular
carcinoma (HCC). After comparing RSCU between
viruses and human tissues, we calculated the codon adaptation
index (CAI) of viral and human genes. HBV and HCV
showed the highest correlations with HCC and the normal
liver, while SARS-CoV-2 had the strongest association with
lungs. In addition, based on HCC RSCU, the CAI of HBV and
HCV genes was the highest. HBV and HCV preferentially adapt
to the tRNA pool in HCC, facilitating viral RNA translation.
After an initial trigger, rapid HBV/HCV translation and replication
may change normal liver cells into HCC cells. Our
findings reveal a novel perspective on virus-mediated oncogenesis.
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