Review
- Searching for a Reliable Viral Indicator of Faecal Pollution in Aquatic Environments
-
Felana Harilanto Andrianjakarivony , Yvan Bettarel , Christelle Desnues
-
J. Microbiol. 2023;61(6):589-602. Published online June 1, 2023
-
DOI: https://doi.org/10.1007/s12275-023-00052-6
-
-
46
View
-
0
Download
-
1
Web of Science
-
1
Crossref
-
Abstract
- The disposal of sewage in significant quantities poses a health hazard to aquatic ecosystems. These effluents can contain
a wide range of pathogens, making faecal contamination a leading source of waterborne diseases around the world. Yet
monitoring bacteria or viruses in aquatic environments is time consuming and expensive. The standard indicators of faecal
pollution all have limitations, including difficulty in determining the source due to lack of host specificity, poor connection
with the presence of non-bacterial pathogens, or low environmental persistence. Innovative monitoring techniques are sorely
needed to provide more accurate and targeted solutions. Viruses are a promising alternative to faecal indicator bacteria for
monitoring, as they are more persistent in ambient water, more abundant in faeces, and are extremely host-specific. Given
the range of viruses found in diverse contexts, it is not easy to find one “ideal” viral indicator of faecal pollution; however,
several are of interest. In parallel, the ongoing development of molecular techniques coupled with metagenomics and bioinformatics
should enable improved ways to detect faecal contamination using viruses. This review examines the evolution
of faecal contamination monitoring with the following aims (i) to identify the characteristics of the main viral indicators of
faecal contamination, including human enteric viruses, bacteriophages, CRESS and plant viruses, (ii) to assess how these
have been used to monitor water pollution in recent years, (iii) to evaluate the reliability of recent detection methods of such
viruses, and (iv) to tentatively determine which viruses may be most effective as markers of faecal pollution.
-
Citations
Citations to this article as recorded by

- Review of carbon dot–hydrogel composite material as a future water-environmental regulator
Minghao Jiang, Yong Wang, Jichuan Li, Xing Gao
International Journal of Biological Macromolecules.2024; 269: 131850. CrossRef
Journal Article
- Antiviral effects of human placenta hydrolysate (Laennec) against SARS-CoV-2 in vitro and in the ferret model
-
Eun-Ha Kim , Young-il Kim , Seung-Gyu Jang , Minju Im , Kyeongsoo Jeong , Young Ki Choi , Hae-Jung Han
-
J. Microbiol. 2021;59(11):1056-1062. Published online October 6, 2021
-
DOI: https://doi.org/10.1007/s12275-021-1367-2
-
-
42
View
-
0
Download
-
6
Web of Science
-
7
Crossref
-
Abstract
- The COVID-19 pandemic has caused unprecedented health,
social, and economic crises worldwide. However, to date, there
is an only a limited effective treatment for this disease. Human
placenta hydrolysate (hPH) has previously been shown to be
safe and to improve the health condition in patients with hyperferritinemia
and COVID-19. In this study, we aimed to
determine the antiviral effects of hPH against SARS-CoV-2
in vitro and in vivo models and compared with Remdesivir,
an FDA-approved drug for COVID-19 treatment. To assess
whether hPH inhibited SARS-CoV-2 replication, we determined
the CC50, EC50, and selective index (SI) in Vero cells
by infection with a SARS-CoV-2 at an MOI of 0.01. Further,
groups of ferrets infected with 105.8 TCID50/ml of SARS-CoV-2
and treated with hPH at 2, 4, 6 dpi, and compared their clinical
manifestation and virus titers in respiratory tracts with
PBS control-treated group. The mRNA expression of immunerelated
cytokines was determined by qRT-PCR. hPH treatment
attenuated virus replication in a dose-dependent manner in
vitro. In a ferret infection study, treatment with hPH resulted
in minimal bodyweight loss and attenuated virus replication
in the nasal wash, turbinates, and lungs of infected ferrets.
In addition, qRT-PCR results revealed that the hPH treatment
remarkably upregulated the gene expression of type I
(IFN-α and IFN-β) and II (IFN-γ) IFNs in SARS-CoV-2 infected
ferrets. Our data collectively suggest that hPH has antiviral
efficacy against SARS-CoV-2 and might be a promising
therapeutic agent for the treatment of SARS-CoV-2 infection.
-
Citations
Citations to this article as recorded by

- Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic
I Kawikova, K Hakenova, M Lebedeva, L Kleteckova, L Jakob, V Spicka, L Wen, F Spaniel, K Vales
Physiological Research.2024; : S615. CrossRef - Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model
Jung Ok Lee, Youna Jang, A Yeon Park, Jung Min Lee, Kyeongsoo Jeong, So-Hyun Jeon, Hui Jin, Minju Im, Jae-Won Kim, Beom Joon Kim
Journal of Microbiology and Biotechnology.2024; 34(10): 1969. CrossRef - Systematic analysis of the pharmacology of standardized extracts of human placenta
T. E. Bogacheva, I. Yu. Torshin, O. A. Gromova
Pharmacokinetics and Pharmacodynamics.2024; (4): 3. CrossRef - Distinctive Combinations of RBD Mutations Contribute to Antibody Evasion in the Case of the SARS-CoV-2 Beta Variant
Tae-Hun Kim, Sojung Bae, Sunggeun Goo, Jinjong Myoung
Journal of Microbiology and Biotechnology.2023; 33(12): 1587. CrossRef - Current state-of-the-art and potential future therapeutic drugs against COVID-19
Ailong Sha, Yi Liu, Haiyan Hao
Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef - SARS-CoV-2 Aerosol and Intranasal Exposure Models in Ferrets
Elizabeth E. Zumbrun, Samantha E. Zak, Eric D. Lee, Philip A. Bowling, Sara I. Ruiz, Xiankun Zeng, Jeffrey W. Koehler, Korey L. Delp, Russel R. Bakken, Shannon S. Hentschel, Holly A. Bloomfield, Keersten M. Ricks, Tamara L. Clements, April M. Babka, John
Viruses.2023; 15(12): 2341. CrossRef - Human placenta hydrolysates: from V.P. Filatov to the present day: Review
Olga A. Gromova, Ivan Yu. Torshin, Alexander G. Chuchalin, Valeriy А. Maximov
Terapevticheskii arkhiv.2022; 94(3): 434. CrossRef
Reviews
- REVIEW] Recent advances in the understanding of the Aspergillus fumigatus cell wall
-
Mark J. Lee , Donald C. Sheppard
-
J. Microbiol. 2016;54(3):232-242. Published online February 27, 2016
-
DOI: https://doi.org/10.1007/s12275-016-6045-4
-
-
43
View
-
0
Download
-
56
Crossref
-
Abstract
- Over the past several decades, research on the synthesis and
organization of the cell wall polysaccharides of Aspergillus
fumigatus has expanded our knowledge of this important
fungal structure. Besides protecting the fungus from environmental
stresses and maintaining structural integrity of
the organism, the cell wall is also the primary site for interaction
with host tissues during infection. Cell wall polysaccharides
are important ligands for the recognition of fungi
by the innate immune system and they can mediate potent
immunomodulatory effects. The synthesis of cell wall polysaccharides
is a complicated process that requires coordinated
regulation of many biosynthetic and metabolic pathways.
Continuous synthesis and remodeling of the polysaccharides
of the cell wall is essential for the survival of the
fungus during development, reproduction, colonization and
invasion. As these polysaccharides are absent from the human
host, these biosynthetic pathways are attractive targets
for antifungal development. In this review, we present recent
advances in our understanding of Aspergillus fumigatus cell
wall polysaccharides, including the emerging role of cell
wall polysaccharides in the host-pathogen interaction.
-
Citations
Citations to this article as recorded by

- Fungal β-1, 3-glucanosyltransferases: A comprehensive review on classification, catalytic mechanism and functional role
Ting-Ting Wen, Zhuo-Yu Qian, Lei Sun, Feng-Jie Cui, Xin-Yi Zan, Li-Juan Meng, Wen-Jing Sun
International Journal of Biological Macromolecules.2025; 289: 138651. CrossRef - The yeast–human coevolution: Fungal transition from passengers, colonizers, and invaders
Stefano Nenciarini, Sonia Renzi, Monica di Paola, Niccolò Meriggi, Duccio Cavalieri
WIREs Mechanisms of Disease.2024;[Epub] CrossRef - The postbiotic potential of Aspergillus oryzae – a narrative review
Yvonne Seidler, Gerald Rimbach, Kai Lüersen, Gabriel Vinderola, Ignacio R. Ipharraguerre
Frontiers in Microbiology.2024;[Epub] CrossRef - Roles of α-1,3-glucosyltransferase in growth and polysaccharides biosynthesis of Ganoderma lucidum
Haixiu Chen, Liting Zhao, Cuiping You, Jingyun Liu, Lei Chen, Zhenghua Gu, Guiyang Shi, Junxun Li, Zhongyang Ding
International Journal of Biological Macromolecules.2024; 276: 134031. CrossRef -
The basic leucine zipper transcription factor MeaB is critical for biofilm formation, cell wall integrity, and virulence in
Aspergillus fumigatus
Yuan Chen, Fei Gao, Xiaojin Chen, Siyuan Tao, Peiying Chen, Wei Lin, Aaron P. Mitchell
mSphere.2024;[Epub] CrossRef - Antifungal mechanism of p-anisaldehyde against Aspergillus flavus based on transcriptome analysis
Yanli Xin, Wei Zhang, Yang Lei, Shan Wei, Shuaibing Zhang, Na Li, Yuansen Hu, Yangyong Lv
LWT.2024; 195: 115844. CrossRef - Aspergillus Cell Surface Structural Analysis and Its Applications to Industrial and Medical Use
Ken Miyazawa, Takashi Umeyama, Akira Yoshimi, Keietsu Abe, Yoshitsugu Miyazaki
Medical Mycology Journal.2024; 65(3): 75. CrossRef - Structural adaptation of fungal cell wall in hypersaline environment
Liyanage D. Fernando, Yordanis Pérez-Llano, Malitha C. Dickwella Widanage, Anand Jacob, Liliana Martínez-Ávila, Andrew S. Lipton, Nina Gunde-Cimerman, Jean-Paul Latgé, Ramón Alberto Batista-García, Tuo Wang
Nature Communications.2023;[Epub] CrossRef - The Lipid Raft-Associated Protein Stomatin Is Required for Accumulation of Dectin-1 in the Phagosomal Membrane and for Full Activity of Macrophages against Aspergillus fumigatus
Marie Goldmann, Franziska Schmidt, Zoltán Cseresnyés, Thomas Orasch, Susanne Jahreis, Susann Hartung, Marc Thilo Figge, Marie von Lilienfeld-Toal, Thorsten Heinekamp, Axel A. Brakhage, Aaron P. Mitchell
mSphere.2023;[Epub] CrossRef - Antifungal effect of triclosan on Aspergillus fumigatus: quorum quenching role as a single agent and synergy with liposomal amphotericin-B
Roya Tamimi, Godfrey Kyazze, Tajalli Keshavarz
World Journal of Microbiology and Biotechnology.2022;[Epub] CrossRef - Quantitative Monitoring of Mycelial Growth of Aspergillus fumigatus in Liquid Culture by Optical Density
Ken Miyazawa, Takashi Umeyama, Yasutaka Hoshino, Keietsu Abe, Yoshitsugu Miyazaki, Slavena Vylkova, Xiaoxiao He, Takuji Oka
Microbiology Spectrum.2022;[Epub] CrossRef - Pharmacokinetic profile of sarcin and thionin from Aspergillus giganteus and in vitro validation against human fungal pathogen
Ramya Ravindhiran, Ramya Krishnamurthy, Karthiga Sivarajan, Jothi Nayaki Sekar, Kumarappan Chidambaram, Ali M Alqahtani, Kavitha Dhandapani
Bioscience Reports.2022;[Epub] CrossRef - Solid-state NMR analysis of unlabeled fungal cell walls from Aspergillus and Candida species
Liyanage D. Fernando, Malitha C. Dickwella Widanage, S. Chandra Shekar, Frederic Mentink-Vigier, Ping Wang, Sungsool Wi, Tuo Wang
Journal of Structural Biology: X.2022; 6: 100070. CrossRef - Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms
Sayema Rahman, Norman van Rhijn, Panagiotis Papastamoulis, Darren D. Thomson, Zorana Carter, Rachael Fortune-Grant, Magnus Rattray, Michael John Bromley, Elaine Bignell
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef - A 13C three-dimensional DQ-SQ-SQ correlation experiment for high-resolution analysis of complex carbohydrates using solid-state NMR
S. Chandra Shekar, Wancheng Zhao, Liyanage D. Fernando, Ivan Hung, Tuo Wang
Journal of Magnetic Resonance.2022; 336: 107148. CrossRef - MicroRNA regulation and host interaction in response to Aspergillus exposure
MANSI SHRIVASTAVA, DIKSHA PANDEY, POONAM SHARMA, RAMBIR SINGH
BIOCELL.2022; 46(2): 339. CrossRef - SfgA Renders Aspergillus flavus More Stable to the External Environment
Xiao-Yu Yuan, Jie-Ying Li, Qing-Qing Zhi, Sheng-Da Chi, Su Qu, Yan-Feng Luo, Zhu-Mei He
Journal of Fungi.2022; 8(6): 638. CrossRef - Online Biomass Monitoring Enables Characterization of the Growth Pattern of Aspergillus fumigatus in Liquid Shake Conditions
Ingo Bauer, Beate Abt, Annie Yap, Bernd Leuchtle, Hubertus Haas
Journal of Fungi.2022; 8(10): 1013. CrossRef - The putative polysaccharide synthase AfCps1 regulates Aspergillus fumigatus morphogenesis and conidia immune response in mouse bone marrow-derived macrophages
Sha Wang, Anjie Yuan, Liping Zeng, Sikai Hou, Meng Wang, Lei Li, Zhendong Cai, Guowei Zhong
Journal of Microbiology.2021; 59(1): 64. CrossRef - Unraveling the sugar code: the role of microbial extracellular glycans in plant–microbe interactions
Alan Wanke, Milena Malisic, Stephan Wawra, Alga Zuccaro, Andreas Weber
Journal of Experimental Botany.2021; 72(1): 15. CrossRef - Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence
Brandon S. Ross, Lotus A. Lofgren, Alix Ashare, Jason E. Stajich, Robert A. Cramer, J. Andrew Alspaugh
mBio.2021;[Epub] CrossRef - Fungal α-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in the Insect Model Host Galleria mellonella
Sylwia Stączek, Agnieszka Zdybicka-Barabas, Iwona Wojda, Adrian Wiater, Paweł Mak, Piotr Suder, Krzysztof Skrzypiec, Małgorzata Cytryńska
Molecules.2021; 26(16): 5097. CrossRef - Genetic and structural validation of phosphomannomutase as a cell wall target in Aspergillus fumigatus
Yuanwei Zhang, Wenxia Fang, Olawale G. Raimi, Deborah E. A. Lockhart, Andrew T. Ferenbach, Ling Lu, Daan M. F. van Aalten
Molecular Microbiology.2021; 116(1): 245. CrossRef - The Influence of Anomeric Configuration and Aglycone Structure on the Outcome of Acid‐Promoted Ring Contraction in 2,3‐Di‐O‐Silylated S‐Galactopyranosides
Polina I. Abronina, Alexander I. Zinin, Nelly N. Malysheva, Maxim Y. Karpenko, Natalya G. Kolotyrkina, Leonid O. Kononov
ChemistrySelect.2021; 6(24): 6223. CrossRef - Effect of Carbohydrate Substrate from Starch-Containing Raw Materials on the Composition of Glucans in the Micromycete Aspergillus niger VKPM F-171 Biomass
N.Yu. Sharova, B.S. Manzhieva, A.A. Printseva, T.V. Vybornova, A.S. Miroshnik, I.V. Kruchina-Bogdanov, I.A. Orekhova
Biotekhnologiya.2020; 36(5): 41. CrossRef - Cell wall polysaccharides from pathogenic fungi for diagnosis of fungal infectious disease
Dandy Ahamefula Osibe, Shuhan Lei, Bin Wang, Cheng Jin, Wenxia Fang
Mycoses.2020; 63(7): 644. CrossRef - What Are the Functions of Chitin Deacetylases in Aspergillus fumigatus?
Isabelle Mouyna, Sarah Dellière, Anne Beauvais, Fabrice Gravelat, Brendan Snarr, Mélanie Lehoux, Caitlin Zacharias, Yan Sun, Steven de Jesus Carrion, Eric Pearlman, Donald C. Sheppard, Jean-Paul Latgé
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef - The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species
Rocio Garcia-Rubio, Haroldo C. de Oliveira, Johanna Rivera, Nuria Trevijano-Contador
Frontiers in Microbiology.2020;[Epub] CrossRef - Usefulness of serum galactomannan in initiating and modifying antifungal therapy in children with cancer and persistent high‐risk febrile neutropenia
Matías Delgado‐Araneda, Romina Valenzuela, Verónica de la Maza, Marcela Rabello, Ana M. Álvarez, Verónica Contardo, Marcela Zubieta, Valentina Gutierrez, Ximena Claverie, Juan P. Torres, Carmen Salgado, Juan Tordecilla, Mónica Varas, Carmen L. Avilés, Mar
Mycoses.2020; 63(8): 802. CrossRef - The mechanisms of hyphal pellet formation mediated by polysaccharides, α-1,3-glucan and galactosaminogalactan, in Aspergillus species
Ken Miyazawa, Akira Yoshimi, Keietsu Abe
Fungal Biology and Biotechnology.2020;[Epub] CrossRef - Dimethylformamide Inhibits Fungal Growth and Aflatoxin B1 Biosynthesis in Aspergillus flavus by Down-Regulating Glucose Metabolism and Amino Acid Biosynthesis
Lin Pan, Peng Chang, Jing Jin, Qingli Yang, Fuguo Xing
Toxins.2020; 12(11): 683. CrossRef - Overview of the Interplay Between Cell Wall Integrity Signaling Pathways and Membrane Lipid Biosynthesis in Fungi: Perspectives forAspergillus fumigatus
João Henrique T.M. Fabri, Marina C. Rocha, Iran Malavazi
Current Protein & Peptide Science.2020; 21(3): 265. CrossRef - The Myosin Motor Domain-Containing Chitin Synthases Are Involved in Cell Wall Integrity and Sensitivity to Antifungal Proteins in Penicillium digitatum
Mónica Gandía, Sandra Garrigues, Begoña Bolós, Paloma Manzanares, Jose F. Marcos
Frontiers in Microbiology.2019;[Epub] CrossRef - Cell surface display of proteins on filamentous fungi
Jesús Urbar-Ulloa, Paul Montaño-Silva, Ana Sofía Ramírez-Pelayo, Elisa Fernández-Castillo, Lorena Amaya-Delgado, Benjamín Rodríguez-Garay, Jorge Verdín
Applied Microbiology and Biotechnology.2019; 103(17): 6949. CrossRef - Transcriptomic Insights into Benzenamine Effects on the Development, Aflatoxin Biosynthesis, and Virulence of Aspergillus flavus
Mingguan Yang, Laifeng Lu, Shuhua Li, Jing Zhang, Zhenjing Li, Shufen Wu, Qingbin Guo, Huanhuan Liu, Changlu Wang
Toxins.2019; 11(2): 70. CrossRef - Both Galactosaminogalactan and α-1,3-Glucan Contribute to Aggregation of Aspergillus oryzae Hyphae in Liquid Culture
Ken Miyazawa, Akira Yoshimi, Motoaki Sano, Fuka Tabata, Asumi Sugahara, Shin Kasahara, Ami Koizumi, Shigekazu Yano, Tasuku Nakajima, Keietsu Abe
Frontiers in Microbiology.2019;[Epub] CrossRef - Aspergillus fumigatus Mnn9 is responsible for mannan synthesis and required for covalent linkage of mannoprotein to the cell wall
Ting Du, Haomiao Ouyang, Josef Voglmeir, Iain B.H. Wilson, Cheng Jin
Fungal Genetics and Biology.2019; 128: 20. CrossRef - Aspergillus fumigatus phosphoethanolamine transferase gene gpi7 is required for proper transportation of the cell wall GPI-anchored proteins and polarized growth
Haomiao Ouyang, Ting Du, Hui Zhou, Iain B. H. Wilson, Jinghua Yang, Jean-Paul Latgé, Cheng Jin
Scientific Reports.2019;[Epub] CrossRef - Klebsiella pneumoniae prevents spore germination and hyphal development of Aspergillus species
M. F. Nogueira, L. Pereira, S. Jenull, K. Kuchler, T. Lion
Scientific Reports.2019;[Epub] CrossRef - Overexpression of Aspergillus nidulans α-1,3-glucan synthase increases cellular adhesion and causes cell wall defects
Xiaoxiao He, Shengnan Li, Susan G W Kaminskyj
Medical Mycology.2018; 56(5): 645. CrossRef - The Aspergillus fumigatus Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice
Jason R. Nesbitt, Elizabeth Y. Steves, Cole R. Schonhofer, Alissa Cait, Sukhbir S. Manku, Juliana H. F. Yeung, Andrew J. Bennet, Kelly M. McNagny, Jonathan C. Choy, Michael R. Hughes, Margo M. Moore
Frontiers in Microbiology.2018;[Epub] CrossRef -
Protein Kinase A and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in
Aspergillus fumigatus
Leandro José de Assis, Adriana Manfiolli, Eliciane Mattos, João H. T. Marilhano Fabri, Iran Malavazi, Ilse D. Jacobsen, Matthias Brock, Robert A. Cramer, Arsa Thammahong, Daisuke Hagiwara, Laure Nicolas Annick Ries, Gustavo Henrique Goldman, Reinhard Fisc
mBio.2018;[Epub] CrossRef - A Ring Contraction of 2,3-Di-O-Silylated Thiopyranosides To Give Thiofuranosides under Mildly Acidic Conditions
Polina I. Abronina, Nelly N. Malysheva, Veronika V. Litvinenko, Alexander I. Zinin, Natalya G. Kolotyrkina, Leonid O. Kononov
Organic Letters.2018; 20(19): 6051. CrossRef - Aspergillus-specific antibodies – Targets and applications
Max Schubert, Holger Spiegel, Stefan Schillberg, Greta Nölke
Biotechnology Advances.2018; 36(4): 1167. CrossRef - Molecular Mass and Localization of α-1,3-Glucan in Cell Wall Control the Degree of Hyphal Aggregation in Liquid Culture of Aspergillus nidulans
Ken Miyazawa, Akira Yoshimi, Shin Kasahara, Asumi Sugahara, Ami Koizumi, Shigekazu Yano, Satoshi Kimura, Tadahisa Iwata, Motoaki Sano, Keietsu Abe
Frontiers in Microbiology.2018;[Epub] CrossRef - Aspergillusin chronic lung disease: Modeling what goes on in the airways
Takahiro Takazono, Donald C. Sheppard
Medical Mycology.2017; 55(1): 39. CrossRef - Sporothrix schenckii sensu stricto and Sporothrix brasiliensis Are Differentially Recognized by Human Peripheral Blood Mononuclear Cells
José A. Martínez-Álvarez, Luis A. Pérez-García, Erika Mellado-Mojica, Mercedes G. López, Iván Martínez-Duncker, Leila M. Lópes-Bezerra, Héctor M. Mora-Montes
Frontiers in Microbiology.2017;[Epub] CrossRef - Immune responses to invasive aspergillosis: new understanding and therapeutic opportunities
Tobias M. Hohl
Current Opinion in Infectious Diseases.2017; 30(4): 364. CrossRef - Host Soluble Mediators: Defying the Immunological Inertness of Aspergillus fumigatus Conidia
Sarah Sze Wah Wong, Vishukumar Aimanianda
Journal of Fungi.2017; 4(1): 3. CrossRef - Immune Recognition of Fungal Polysaccharides
Brendan Snarr, Salman Qureshi, Donald Sheppard
Journal of Fungi.2017; 3(3): 47. CrossRef - The Role of the Fungal Cell Wall in the Infection of Plants
Ivey Geoghegan, Gero Steinberg, Sarah Gurr
Trends in Microbiology.2017; 25(12): 957. CrossRef - Immunity against fungi
Michail S. Lionakis, Iliyan D. Iliev, Tobias M. Hohl
JCI Insight.2017;[Epub] CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - Proteomic analysis of Aspergillus fumigatus – clinical implications
Nicola M. Moloney, Rebecca A. Owens, Sean Doyle
Expert Review of Proteomics.2016; 13(7): 635. CrossRef - How to invade a susceptible host: cellular aspects of aspergillosis
Sven Krappmann
Current Opinion in Microbiology.2016; 34: 136. CrossRef - The Use of Pyranoside-into-Furanoside Rearrangement and Controlled O(5) → O(6) Benzoyl Migration as the Basis of a Synthetic Strategy To Assemble (1→5)- and (1→6)-Linked Galactofuranosyl Chains
Dmitry A. Argunov, Vadim B. Krylov, Nikolay E. Nifantiev
Organic Letters.2016; 18(21): 5504. CrossRef
- REVIEW] Developmental regulators in Aspergillus fumigatus
-
Hee-Soo Park , Jae-Hyuk Yu
-
J. Microbiol. 2016;54(3):223-231. Published online February 27, 2016
-
DOI: https://doi.org/10.1007/s12275-016-5619-5
-
-
45
View
-
0
Download
-
51
Crossref
-
Abstract
- The filamentous fungus Aspergillus fumigatus is the most prevalent
airborne fungal pathogen causing severe and usually
fatal invasive aspergillosis in immunocompromised patients.
This fungus produces a large number of small hydrophobic
asexual spores called conidia as the primary means of reproduction,
cell survival, propagation, and infectivity. The initiation,
progression, and completion of asexual development
(conidiation) is controlled by various regulators that govern
expression of thousands of genes associated with formation
of the asexual developmental structure conidiophore, and
biogenesis of conidia. In this review, we summarize key regulators
that directly or indirectly govern conidiation in this
important pathogenic fungus. Better understanding these
developmental regulators may provide insights into the improvement
in controlling both beneficial and detrimental
aspects of various Aspergillus species.
-
Citations
Citations to this article as recorded by

-
Pleiotropic functions of SscA on the asexual spore of the human pathogenic fungus
Aspergillus fumigatus
Ye-Eun Son, Jiwoo Han, Kyung-Tae Lee, Hee-Soo Park
Mycology.2024; 15(2): 238. CrossRef - Regulation of Conidiation and Aflatoxin B1 Biosynthesis by a Blue Light Sensor LreA in Aspergillus flavus
Kunzhi Jia, Yipu Jia, Qianhua Zeng, Zhaoqi Yan, Shihua Wang
Journal of Fungi.2024; 10(9): 650. CrossRef - Comprehensive Insights into the Remarkable Function and Regulatory Mechanism of FluG during Asexual Development in Beauveria bassiana
Fang Li, Juefeng Zhang, Haiying Zhong, Kaili Yu, Jianming Chen
International Journal of Molecular Sciences.2024; 25(11): 6261. CrossRef - Genome-wide patterns of noncoding and protein-coding sequence variation in the major fungal pathogen Aspergillus fumigatus
Alec Brown, Jacob L Steenwyk, Antonis Rokas, J Comeron
G3: Genes, Genomes, Genetics.2024;[Epub] CrossRef - Cellular communication and fusion regulate cell fusion, trap morphogenesis, conidiation, and secondary metabolism in Arthrobotrys oligospora
Wenjie Wang, Yankun Liu, Shipeng Duan, Na Bai, Meichen Zhu, Jinkui Yang
Microbiological Research.2024; 278: 127516. CrossRef - The Cryptochrome CryA Regulates Lipid Droplet Accumulation, Conidiation, and Trap Formation via Responses to Light in Arthrobotrys oligospora
Yanmei Shen, Xuewei Yang, Meichen Zhu, Shipeng Duan, Qianqian Liu, Jinkui Yang
Journal of Fungi.2024; 10(9): 626. CrossRef - The CfKOB1 gene related to cell apoptosis is required for pathogenicity and involved in mycovirus-induced hypovirulence in Colletotrichum fructicola
Jun Zi Zhu, Ping Li, Zhuo Zhang, Xiao Gang Li, Jie Zhong
International Journal of Biological Macromolecules.2024; 271: 132437. CrossRef - Functional and Quality Assessment of a Spore Harvester for Entomopathogenic Fungi for Biopesticide Production
Fidel Diego-Nava, Carlos Granados-Echegoyen, Jaime Ruíz-Vega, Teodulfo Aquino-Bolaños, Rafael Pérez-Pacheco, Alejo Díaz-Ramos, Nancy Alonso-Hernández, Fabián Arroyo-Balán, Mónica Beatriz López-Hernández
AgriEngineering.2023; 5(2): 801. CrossRef - Verticillium dahliae Asp1 regulates the transition from vegetative growth to asexual reproduction by modulating microtubule dynamic organization
Juan Tian, Mengli Pu, Bin Chen, Guangda Wang, Chunli Li, Xiaxia Zhang, Yanjun Yu, Zhi Wang, Zhaosheng Kong
Environmental Microbiology.2023; 25(3): 738. CrossRef - Antifungal Activity of Plant Secondary Metabolites on Candida albicans: An Updated Review
Andleeb Khan, Sivakumar Sivagurunathan Moni, M. Ali, Syam Mohan, Huma Jan, Saiema Rasool, Mohammad A Kamal, Saeed Alshahrani, Maryam Halawi, Hassan A Alhazmi
Current Molecular Pharmacology.2023; 16(1): 15. CrossRef - Chitin Biosynthesis in Aspergillus Species
Veronica S. Brauer, André M. Pessoni, Mateus S. Freitas, Marinaldo P. Cavalcanti-Neto, Laure N. A. Ries, Fausto Almeida
Journal of Fungi.2023; 9(1): 89. CrossRef - Transcription factor CreA is involved in the inverse regulation of biofilm formation and asexual development through distinct pathways in Aspergillus fumigatus
Shuai Liu, Xiaoyan Lu, Mengyao Dai, Shizhu Zhang
Molecular Microbiology.2023; 120(6): 830. CrossRef - A new butenolide with antifungal activity from solid co-cultivation of Irpex lacteus and Nigrospora oryzae
Ya-Mei Wu, Xue-Qiong Yang, Jing-Xin Chen, Ting Wang, Tai-Ran Li, Fan-Rong Liao, Run-Tong Liu, Ya-Bin Yang, Zhong-Tao Ding
Natural Product Research.2023; 37(13): 2243. CrossRef - A Network of Sporogenesis-Responsive Genes Regulates the Growth, Asexual Sporogenesis, Pathogenesis and Fusaric Acid Production of Fusarium oxysporum f. sp. cubense
Songmao Lu, Huobing Deng, Yaqi Lin, Meimei Huang, Haixia You, Yan Zhang, Weijian Zhuang, Guodong Lu, Yingzi Yun
Journal of Fungi.2023; 10(1): 1. CrossRef - Light regulates the degradation of the regulatory protein VE-1 in the fungus Neurospora crassa
María del Mar Gil-Sánchez, Sara Cea-Sánchez, Eva M. Luque, David Cánovas, Luis M. Corrochano
BMC Biology.2022;[Epub] CrossRef - The C-22 sterol desaturase Erg5 is responsible for ergosterol biosynthesis and conidiation in Aspergillus fumigatus
Nanbiao Long, Guowei Zhong
Journal of Microbiology.2022; 60(6): 620. CrossRef - Comparative Transcriptomic Analyses Reveal the Regulatory Mechanism of Nutrient Limitation-Induced Sporulation of Antrodia cinnamomea in Submerged Fermentation
Huaxiang Li, Dan Ji, Zhishan Luo, Yilin Ren, Zhenming Lu, Zhenquan Yang, Zhenghong Xu
Foods.2022; 11(17): 2715. CrossRef - Azole‐resistant Aspergillus fumigatus as an emerging worldwide pathogen
Sofia Marisel Rivelli Zea, Takahito Toyotome
Microbiology and Immunology.2022; 66(3): 135. CrossRef - Transcriptional Regulation by the Velvet Protein VE-1 during Asexual Development in the Fungus Neurospora crassa
Sara Cea-Sánchez, María Corrochano-Luque, Gabriel Gutiérrez, N. Louise Glass, David Cánovas, Luis M. Corrochano, Reinhard Fischer
mBio.2022;[Epub] CrossRef - The secondary metabolite regulator, BbSmr1, is a central regulator of conidiation via the BrlA‐AbaA‐WetA pathway in Beauveria bassiana
Jin‐Feng Chen, Yu Liu, Gui‐Rong Tang, Dan Jin, Xi Chen, Yan Pei, Yan‐Hua Fan
Environmental Microbiology.2021; 23(2): 810. CrossRef - BbWor1, a Regulator of Morphological Transition, Is Involved in Conidium-Hypha Switching, Blastospore Propagation, and Virulence in Beauveria bassiana
Lei Qiu, Tong-Sheng Zhang, Ji-Zheng Song, Jing Zhang, Ze Li, Juan-Juan Wang, Christina A. Cuomo
Microbiology Spectrum.2021;[Epub] CrossRef - The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans
Yanxia Zhao, Mi-Kyung Lee, Jieyin Lim, Heungyun Moon, Hee-Soo Park, Weifa Zheng, Jae-Hyuk Yu
Journal of Microbiology.2021; 59(8): 746. CrossRef - Novel Biological Functions of the NsdC Transcription Factor in Aspergillus fumigatus
Patrícia Alves de Castro, Clara Valero, Jéssica Chiaratto, Ana Cristina Colabardini, Lakhansing Pardeshi, Lilian Pereira Silva, Fausto Almeida, Marina Campos Rocha, Roberto Nascimento Silva, Iran Malavazi, Wenyue Du, Paul S. Dyer, Matthias Brock, Flávio V
mBio.2021;[Epub] CrossRef -
The Heterotrimeric Transcription Factor CCAAT-Binding Complex and Ca
2+
-CrzA Signaling Reversely Regulate the Transition between Fungal Hyphal Growth and Asexual Reproduction
Yiran Ren, Chi Zhang, Ziqing Chen, Ling Lu, Reinhard Fischer
mBio.2021;[Epub] CrossRef - The fungal‐specific histone acetyltransferase Rtt109 regulates development, DNA damage response, and virulence in Aspergillus fumigatus
Yuanwei Zhang, Jialu Fan, Jing Ye, Ling Lu
Molecular Microbiology.2021; 115(6): 1191. CrossRef - Deep convolutional neural network: a novel approach for the detection of Aspergillus fungi via stereomicroscopy
Haozhong Ma, Jinshan Yang, Xiaolu Chen, Xinyu Jiang, Yimin Su, Shanlei Qiao, Guowei Zhong
Journal of Microbiology.2021; 59(6): 563. CrossRef - The Arf-GAP AoGlo3 regulates conidiation, endocytosis, and pathogenicity in the nematode-trapping fungus Arthrobotrys oligospora
Yuxin Ma, Xuewei Yang, Meihua Xie, Guosheng Zhang, Le Yang, Na Bai, Yining Zhao, Dongni Li, Ke-Qin Zhang, Jinkui Yang
Fungal Genetics and Biology.2020; 138: 103352. CrossRef - The Autophagy-Related Gene Aolatg4 Regulates Hyphal Growth, Sporulation, Autophagosome Formation, and Pathogenicity in Arthrobotrys oligospora
Duanxu Zhou, Meihua Xie, Na Bai, Le Yang, Ke-Qin Zhang, Jinkui Yang
Frontiers in Microbiology.2020;[Epub] CrossRef -
Molecular Mechanisms of Conidial Germination in
Aspergillus
spp
Tim J. H. Baltussen, Jan Zoll, Paul E. Verweij, Willem J. G. Melchers
Microbiology and Molecular Biology Reviews.2020;[Epub] CrossRef - Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway
James I. P. Stewart, Vinicius M. Fava, Joshua D. Kerkaert, Adithya S. Subramanian, Fabrice N. Gravelat, Melanie Lehoux, P. Lynne Howell, Robert A. Cramer, Donald C. Sheppard, James W. Kronstad
mBio.2020;[Epub] CrossRef - Velvet activated McrA plays a key role in cellular and metabolic development in Aspergillus nidulans
Mi-Kyung Lee, Ye-Eun Son, Hee-Soo Park, Ahmad Alshannaq, Kap-Hoon Han, Jae-Hyuk Yu
Scientific Reports.2020;[Epub] CrossRef - The Transcriptional Regulator HbxA Governs Development, Secondary Metabolism, and Virulence in Aspergillus fumigatus
Timothy Satterlee, Binita Nepal, Sophie Lorber, Olivier Puel, Ana M. Calvo, Irina S. Druzhinina
Applied and Environmental Microbiology.2020;[Epub] CrossRef -
The Cell Wall Integrity Pathway Contributes to the Early Stages of
Aspergillus fumigatus
Asexual Development
Marina Campos Rocha, João Henrique Tadini Marilhano Fabri, Isabelle Taira Simões, Rafael Silva-Rocha, Daisuke Hagiwara, Anderson Ferreira da Cunha, Gustavo Henrique Goldman, David Cánovas, Iran Malavazi, Irina S. Druzhinina
Applied and Environmental Microbiology.2020;[Epub] CrossRef -
In vitro and in vivo characterization of two nonsporulating Aspergillus fumigatus clinical isolates from immunocompetent patients
Zheng Zhang, Yuan Jiang, Jun Chen, Peiying Chen, Qingtao Kong, Ling Lu, Hong Sang
Medical Mycology.2020; 58(4): 543. CrossRef - The brlA Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in Penicillium expansum
Chrystian Zetina-Serrano, Ophélie Rocher, Claire Naylies, Yannick Lippi, Isabelle P. Oswald, Sophie Lorber, Olivier Puel
International Journal of Molecular Sciences.2020; 21(18): 6660. CrossRef - Recurrent Loss of abaA, a Master Regulator of Asexual Development in Filamentous Fungi, Correlates with Changes in Genomic and Morphological Traits
Matthew E Mead, Alexander T Borowsky, Bastian Joehnk, Jacob L Steenwyk, Xing-Xing Shen, Anita Sil, Antonis Rokas, Jason E Stajich
Genome Biology and Evolution.2020; 12(7): 1119. CrossRef - The histone acetyltransferase GcnE regulates conidiation and biofilm formation in Aspergillus fumigatus
Chi-Jan Lin, Yi-Hsuan Hou, Ying-Lien Chen
Medical Mycology.2019;[Epub] CrossRef - Aspergillus fumigatus phosphoethanolamine transferase gene gpi7 is required for proper transportation of the cell wall GPI-anchored proteins and polarized growth
Haomiao Ouyang, Ting Du, Hui Zhou, Iain B. H. Wilson, Jinghua Yang, Jean-Paul Latgé, Cheng Jin
Scientific Reports.2019;[Epub] CrossRef - Identification of a Novel Transcription Factor TP05746 Involved in Regulating the Production of Plant-Biomass-Degrading Enzymes in Talaromyces pinophilus
Ting Zhang, Lu-Sheng Liao, Cheng-Xi Li, Gui-Yan Liao, Xiong Lin, Xue-Mei Luo, Shuai Zhao, Jia-Xun Feng
Frontiers in Microbiology.2019;[Epub] CrossRef - The Velvet Proteins VosA and VelB Play Different Roles in Conidiation, Trap Formation, and Pathogenicity in the Nematode-Trapping Fungus Arthrobotrys oligospora
Guosheng Zhang, Yaqing Zheng, Yuxin Ma, Le Yang, Meihua Xie, Duanxu Zhou, Xuemei Niu, Ke-Qin Zhang, Jinkui Yang
Frontiers in Microbiology.2019;[Epub] CrossRef - An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatus
Abigail L. Lind, Fang Yun Lim, Alexandra A. Soukup, Nancy P. Keller, Antonis Rokas, Aaron P. Mitchell
mSphere.2018;[Epub] CrossRef - MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus
Özlem Sarikaya Bayram, Jean Paul Latgé, Özgür Bayram
Current Genetics.2018; 64(1): 141. CrossRef - C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA in Aspergillus fumigatus
Qusai Al Abdallah, Adela Martin-Vicente, Ana Camila Oliveira Souza, Wenbo Ge, Jarrod R. Fortwendel
Frontiers in Microbiology.2018;[Epub] CrossRef - Aspergillus fumigatus -induced early inflammatory response in pulmonary microvascular endothelial cells: Role of p38 MAPK and inhibition by silibinin
Jun Song, Weihua Pan, Yue Sun, Jing Han, Weimin Shi, Wanqing Liao
International Immunopharmacology.2017; 49: 195. CrossRef - Comparative Transcriptomic and Proteomic Analyses Reveal a FluG‐Mediated Signaling Pathway Relating to Asexual Sporulation of Antrodia camphorata
Hua‐Xiang Li, Zhen‐Ming Lu, Qing Zhu, Jin‐Song Gong, Yan Geng, Jin‐Song Shi, Zheng‐Hong Xu, Yan‐He Ma
PROTEOMICS.2017;[Epub] CrossRef - Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef - Aspergillus fumigatus spore proteomics and genetics reveal that VeA represses DefA-mediated DNA damage response
Kwang-Soo Shin, Hee-Soo Park, Young Kim, In-Beom Heo, Young Hwan Kim, Jae-Hyuk Yu
Journal of Proteomics.2016; 148: 26. CrossRef - Utilization of a Conidia-Deficient Mutant to Study Sexual Development in Fusarium graminearum
Hokyoung Son, Jae Yun Lim, Yoonji Lee, Yin-Won Lee, Sung-Hwan Yun
PLOS ONE.2016; 11(5): e0155671. CrossRef - Putative methyltransferase LaeA and transcription factor CreA are necessary for proper asexual development and controlling secondary metabolic gene cluster expression
Xiujun Zhang, Yingying Zhu, Longfei Bao, Liwei Gao, Guangshan Yao, Yanan Li, Zhifeng Yang, Zhonghai Li, Yaohua Zhong, Fuli Li, Heng Yin, Yinbo Qu, Yuqi Qin
Fungal Genetics and Biology.2016; 94: 32. CrossRef - How to invade a susceptible host: cellular aspects of aspergillosis
Sven Krappmann
Current Opinion in Microbiology.2016; 34: 136. CrossRef - Negative regulation and developmental competence in Aspergillus
Mi-Kyung Lee, Nak-Jung Kwon, Im-Soon Lee, Seunho Jung, Sun-Chang Kim, Jae-Hyuk Yu
Scientific Reports.2016;[Epub] CrossRef
Research Support, Non-U.S. Gov't
- EDITORIAL] Human fungal pathogens: Why should we learn?
-
Jeong-Yoon Kim
-
J. Microbiol. 2016;54(3):145-148.
-
DOI: https://doi.org/10.1007/s12275-016-0647-8
-
-
46
View
-
0
Download
-
65
Crossref
-
Abstract
- Human fungal pathogens that cause invasive infections are
hidden killers, taking lives of one and a half million people
every year. However, research progress in this field has not
been rapid enough to effectively prevent or treat life-threatening
fungal diseases. To update recent research progress
and promote more active research in the field of human fungal
pathogens, eleven review articles concerning the virulence
mechanisms and host interactions of four major human fungal
pathogens–Candida albicans, Cryptococcus neoformans,
Aspergillus fumigatus, and Histoplasma capsulatum–are
presented in this special issue.
-
Citations
Citations to this article as recorded by

- Humans vs. Fungi: An Overview of Fungal Pathogens against Humans
Kasun M. Thambugala, Dinushani A. Daranagama, Danushka S. Tennakoon, Dona Pamoda W. Jayatunga, Sinang Hongsanan, Ning Xie
Pathogens.2024; 13(5): 426. CrossRef - Active monitoring of antifungal adverse events in hospitalized patients based on Global Trigger Tool method
Xiao Meng, Yaozhou Wu, Zixuan Liu, Yifan Chen, Zhizhou Dou, Li Wei
Frontiers in Pharmacology.2024;[Epub] CrossRef - Interplay of host-immunity in fungal eye infections
Piyush Baindara, Santi M. Mandal
Fungal Biology Reviews.2024; 48: 100357. CrossRef - Cytotoxicity, antifungal and antioxidant properties of Lonchocarpus capassa leaf extracts
Tambudzani C. Machaba, Salome Mahlo, Jacobus Eloff, Winston Nxumalo, Lyndy McGaw
Journal of Medicinal Plants for Economic Development.2024;[Epub] CrossRef - Alternative and Classical Processes for Disinfection of Water Polluted by Fungi: A Systematic Review
Luz Dary Caicedo-Bejarano, Alejandra Morante-Caicedo, Sandra Patricia Castro-Narváez, Efraím A. Serna-Galvis
Water.2024; 16(7): 936. CrossRef - IRF7 Exacerbates Candida albicans Infection by Compromising CD209-Mediated Phagocytosis and Autophagy-Mediated Killing in Macrophages
Furong Qing, Lina Sui, Wenji He, Yayun Chen, Li Xu, Liangmei He, Qiuxiang Xiao, Tianfu Guo, Zhiping Liu
The Journal of Immunology.2024; 212(12): 1932. CrossRef - Verapamil enhances the activity of Caspofungin against Cryptococcus neoformans, coinciding with inhibited Ca2+/CN pathway and damage to cell wall integrity
Xinyuan Peng, Qingtao Kong, Qian Wei, Shilin Guo, Qiying Chen, Min Peng, Binyi An, Xiaoyu Wang, Chen Zhang, Hong Sang
International Journal of Antimicrobial Agents.2024; 64(4): 107303. CrossRef - Chemical profile, antioxidant, antifungal, and cytotoxic activities of propolis from the stingless bee Tetragona clavipes
Ariane Pinheiro Cruz Bergamini, Brendo Victor Siqueira de Almeida Bergamini, Iana Soares Pessoa, Thiago Antônio de Sousa Cutrim, Tamires Cruz dos Santos, Matheus Campos dos Santos, Victor da Rocha Fonseca, Wanderson Romão, Rodrigo Scherer, Denise Coutinho
Brazilian Journal of Microbiology.2024;[Epub] CrossRef -
Cathelicidin boosts the antifungal activity of neutrophils and improves prognosis during
Aspergillus fumigatus
keratitis
Xiaochen Hou, Cui Li, Jingyi Liu, Shanshan Yang, Xudong Peng, Qian Wang, Chengxiu Liu, Xing Liu, Junjie Luan, Guiqiu Zhao, Jing Lin, Mairi C. Noverr
Infection and Immunity.2024;[Epub] CrossRef - Development, Optimization, and In Vitro/In Vivo Evaluation of Azelaic Acid Transethosomal Gel for Antidermatophyte Activity
Ali M. Nasr, Noha M. Badawi, Yasmine H. Tartor, Nader M. Sobhy, Shady A. Swidan
Antibiotics.2023; 12(4): 707. CrossRef - PU.1-CD23 signaling mediates pulmonary innate immunity against Aspergillus fumigatus infection by driving inflammatory response
Min Wang, Ming Zhang, Jiayong Qiu, Chenyang Liu, Yao Lou, Tongsheng Wang, Yingmin Zhang, Yimin Mao
BMC Immunology.2023;[Epub] CrossRef - Matrix-assisted laser desorption/ionisation-time of flight mass spectrometry azole susceptibility assessment in Candida and Aspergillus species
Ana Luisa Perini Leme Giordano, Lais Pontes, Caio Augusto Gualtieri Beraquet, Luzia Lyra, Angelica Zaninelli Schreiber
Memórias do Instituto Oswaldo Cruz.2023;[Epub] CrossRef - A parallel and silent emerging pandemic: Antimicrobial resistance (AMR) amid COVID-19 pandemic
Suriya Rehman
Journal of Infection and Public Health.2023; 16(4): 611. CrossRef - Current Insights in Fungal Importance—A Comprehensive Review
Viorica Maria Corbu, Irina Gheorghe-Barbu, Andreea Ștefania Dumbravă, Corneliu Ovidiu Vrâncianu, Tatiana Eugenia Șesan
Microorganisms.2023; 11(6): 1384. CrossRef - Clinical infections in neurosurgical oncology: An overview
Tomaz Velnar, Nina Kocivnik, Roman Bosnjak
World Journal of Clinical Cases.2023; 11(15): 3418. CrossRef - The effect of herbal medicine in innate immunity to Candida albicans
Meng-Yuan Bao, Ming Li, Qing-Ru Bu, Yue Yang, Hang Song, Chang-Zhong Wang, Tian-Ming Wang, Ning Li
Frontiers in Immunology.2023;[Epub] CrossRef - Betulinic acid and Drummondin E: Potential inhibitors of Unfolded Protein Response Pathway of Candida auris
Nahid Akhtar, Amit Joshi, Vikas Kaushik, Sangeetha Mohan, M. Amin-ul Mannan
Research Journal of Pharmacy and Technology.2023; : 2867. CrossRef - Understanding the Roles of Host Defense Peptides in Immune Modulation: From Antimicrobial Action to Potential as Adjuvants
Ju Kim, Byeol-Hee Cho, Yong-Suk Jang
Journal of Microbiology and Biotechnology.2023; 33(3): 288. CrossRef - Bacillus Metabolites: Compounds, Identification and Anti-Candida albicans Mechanisms
Weichen Wang, Jin Zhao, Zhizi Zhang
Microbiology Research.2022; 13(4): 972. CrossRef - Uncommon case of histoplasmosis with oral manifestation: A case report of diagnosis in a South American patient
Letícia Copatti Dogenski, Eduarda Mafaciolli Pasqualotto, Mateus José Dutra, Gisele Rovani, Micheline Sandini Trentin, João Paulo De Carli
International Journal of Surgery Case Reports.2022; 93: 106920. CrossRef - Oral delivery of butoconazole nitrate nanoparticles for systemic treatment of chronic paracoccidioidomycosis: A future aspect
Tasleem, Nithya Shanthi, Arun Kumar Mahato, Richa Bahuguna
Journal of Drug Delivery Science and Technology.2022; 77: 103808. CrossRef - Time to Conquer Fungal Infectious Diseases: Employing Nanoparticles as Powerful and Versatile Antifungal Nanosystems against a Wide Variety of Fungal Species
Ali Jangjou, Zahra Zareshahrabadi, Milad Abbasi, Amirreza Talaiekhozani, Hesam Kamyab, Shreeshivadasan Chelliapan, Ahmad Vaez, Ali Golchin, Lobat Tayebi, Ehsan Vafa, Ali Mohammad Amani, Hossein Faramarzi
Sustainability.2022; 14(19): 12942. CrossRef - Does the technical methodology influence the quality attributes and the potential of skin permeation of Luliconazole loaded transethosomes?
Mahmoud M. El-Sonbaty, Mohamed A. Akl, Khalid M. El-Say, Alaa A. Kassem
Journal of Drug Delivery Science and Technology.2022; 68: 103096. CrossRef - Guanylated Hyperbranched Polylysines with High In Vitro and In Vivo Antifungal Activity
Xiao Liu, Yilong Yang, Miaomiao Han, Jianwei Guo, Hui Liu, Yadong Liu, Junjie Xu, Shengxiang Ji, Xuesi Chen
Advanced Healthcare Materials.2022;[Epub] CrossRef - The Role of the Glutathione System in Stress Adaptation, Morphogenesis and Virulence of Pathogenic Fungi
Tanaporn Wangsanut, Monsicha Pongpom
International Journal of Molecular Sciences.2022; 23(18): 10645. CrossRef - HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3
Han Wu, Xiaofan Yin, Xibao Zhao, Zherui Wu, Yue Xiao, Qianqian Di, Ping Sun, Haimei Tang, Jiazheng Quan, Weilin Chen
Redox Biology.2022; 56: 102461. CrossRef - Pre-Exposure With Extracellular Vesicles From Aspergillus fumigatus Attenuates Inflammatory Response and Enhances Fungal Clearance in a Murine Model Pulmonary Aspergillosis
Jéssica Amanda Marques Souza, Isabella Luísa da Silva Gurgel, Nathália Luísa Sousa de Oliveira Malacco, Flávia Rayssa Braga Martins, Celso Martins Queiroz-Junior, Mauro Martins Teixeira, Frederico Marianetti Soriani
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef - The emerging role of neutrophil extracellular traps in fungal infection
Chuting Liang, Ni Lian, Min Li
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef - Permanent, Antimicrobial Coating to Rapidly Kill and Prevent Transmission of Bacteria, Fungi, Influenza, and SARS-CoV-2
Sreyan Ghosh, Riya Mukherjee, Vinay S. Mahajan, Julie Boucau, Shiv Pillai, Jayanta Haldar
ACS Applied Materials & Interfaces.2022; 14(37): 42483. CrossRef - Antifungal Activity of the Frog Skin Peptide Temporin G and Its Effect on Candida albicans Virulence Factors
Felicia Diodata D’Auria, Bruno Casciaro, Marta De Angelis, Maria Elena Marcocci, Anna Teresa Palamara, Lucia Nencioni, Maria Luisa Mangoni
International Journal of Molecular Sciences.2022; 23(11): 6345. CrossRef - WITHDRAWN: Fatty acid dioxygenase-cytochrome P450 fusion enzymes of the top 10 fungal pathogens in molecular plant pathology and human-pathogenic fungi
Ernst H. Oliw
Fungal Genetics and Biology.2021; : 103603. CrossRef - MYO1F regulates antifungal immunity by regulating acetylation of microtubules
Wanwei Sun, Xiaojian Ma, Heping Wang, Yanyun Du, Jianwen Chen, Huijun Hu, Ru Gao, Ruirui He, Qianwen Peng, Zhihui Cui, Huazhi Zhang, Junhan Wang, Xinming Jia, Bradley N. Martin, Cun-Jin Zhang, Xiaoxia Li, Chenhui Wang
Proceedings of the National Academy of Sciences.2021;[Epub] CrossRef - Solubility enhancement, formulation development and antifungal activity of luliconazole niosomal gel-based system
Ashish Kumar Garg, Balaji Maddiboyina, Mohammed Hamed Saeed Alqarni, Aftab Alam, Hibah M. Aldawsari, Pinki Rawat, Sima Singh, Prashant Kesharwani
Journal of Biomaterials Science, Polymer Edition.2021; 32(8): 1009. CrossRef - Preclinical safety evaluation of amphotericin A21: A novel antifungal
Ivan Ortega‐Blake, Mario Fernández‐Zertuche, Ignacio Regla, Walfred Sánchez‐Peña, Antonieta Gómez‐Solis, Paola Jaimes‐Chavez, Arturo Galván‐Hernández, Erika Tovar‐Garduño, Lourdes Rodríguez‐Fragoso
Basic & Clinical Pharmacology & Toxicology.2021; 129(1): 72. CrossRef - Antimicrobial Peptides: The Promising Therapeutics for Cutaneous Wound Healing
Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
Macromolecular Bioscience.2021;[Epub] CrossRef - The transcription factor Cas5 suppresses hyphal morphogenesis during yeast-form growth in Candida albicans
Jong-Myeong Kim, Hye Yun Moon, Dong Wook Lee, Hyun Ah Kang, Jeong-Yoon Kim
Journal of Microbiology.2021; 59(10): 911. CrossRef - Antifungal activity of thiosemicarbazones, bis(thiosemicarbazones), and their metal complexes
Kritika Bajaj, Robert M. Buchanan, Craig A. Grapperhaus
Journal of Inorganic Biochemistry.2021; 225: 111620. CrossRef - Fatty acid dioxygenase-cytochrome P450 fusion enzymes of filamentous fungal pathogens
Ernst H. Oliw
Fungal Genetics and Biology.2021; 157: 103623. CrossRef - Membrane-Interacting Antifungal Peptides
Caroline Struyfs, Bruno P. A. Cammue, Karin Thevissen
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef - Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence
Brandon S. Ross, Lotus A. Lofgren, Alix Ashare, Jason E. Stajich, Robert A. Cramer, J. Andrew Alspaugh
mBio.2021;[Epub] CrossRef - Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis
Angel León-Buitimea, Javier A. Garza-Cervantes, Diana Y. Gallegos-Alvarado, Macario Osorio-Concepción, José Ruben Morones-Ramírez
Pathogens.2021; 10(10): 1303. CrossRef - Cathelicidin-inspired antimicrobial peptides as novel antifungal compounds
Martin van Eijk, Stephanie Boerefijn, Lida Cen, Marisela Rosa, Marnix J H Morren, Cornelis K van der Ent, Bart Kraak, Jan Dijksterhuis, Ivan D Valdes, Henk P Haagsman, Hans de Cock
Medical Mycology.2020; 58(8): 1073. CrossRef - Broad-Spectrum Antimicrobial and Antibiofilm Activity of a Natural Clay Mineral from British Columbia, Canada
Shekooh Behroozian, Sarah L. Svensson, Loretta Y. Li, Julian E. Davies, Pascale F. Cossart
mBio.2020;[Epub] CrossRef - Antimicrobial host defence peptides: functions and clinical potential
Neeloffer Mookherjee, Marilyn A. Anderson, Henk P. Haagsman, Donald J. Davidson
Nature Reviews Drug Discovery.2020; 19(5): 311. CrossRef - Alteration of Fermentative Metabolism Enhances Mucor circinelloides Virulence
Sharel P. Díaz-Pérez, J. Alberto Patiño-Medina, Marco I. Valle-Maldonado, Adolfo López-Torres, Irvin E. Jácome-Galarza, Verónica Anaya-Martínez, Verónica Gómez-Ruiz, Jesús Campos-García, Rosa E. Nuñez-Anita, Rafael Ortiz-Alvarado, Martha I. Ramírez-Díaz,
Infection and Immunity.2020;[Epub] CrossRef - Fungal evolution: major ecological adaptations and evolutionary transitions
Miguel A. Naranjo‐Ortiz, Toni Gabaldón
Biological Reviews.2019; 94(4): 1443. CrossRef -
Acute Lung Injury and Repair Induced by Single Exposure of
Aspergillus Fumigatus
in Immunocompetent Mice
Nathália L S O Malacco, Jéssica A M Souza, Aline C Mendes, Milene A Rachid, Lucas R Kraemer, Matheus S Mattos, Graziele N Lima, Lirlândia P Sousa, Daniele G Souza, Vanessa Pinho, Mauro M Teixeira, Remo C Russo, Frederico M Soriani
Future Microbiology.2019; 14(17): 1511. CrossRef - Aspergillus fumigatus phosphoethanolamine transferase gene gpi7 is required for proper transportation of the cell wall GPI-anchored proteins and polarized growth
Haomiao Ouyang, Ting Du, Hui Zhou, Iain B. H. Wilson, Jinghua Yang, Jean-Paul Latgé, Cheng Jin
Scientific Reports.2019;[Epub] CrossRef - Characterization of fungal biodiversity and communities associated with the reef macroalga Sargassum ilicifolium reveals fungal community differentiation according to geographic locality and algal structure
Benjamin J. Wainwright, Andrew G. Bauman, Geoffrey L. Zahn, Peter A. Todd, Danwei Huang
Marine Biodiversity.2019; 49(6): 2601. CrossRef - Glycobiology of Human Fungal Pathogens: New Avenues for Drug Development
Danielle J. Lee, Holly O’Donnell, Françoise H. Routier, Joe Tiralongo, Thomas Haselhorst
Cells.2019; 8(11): 1348. CrossRef - Fungal dissemination is limited by liver macrophage filtration of the blood
Donglei Sun, Peng Sun, Hongmei Li, Mingshun Zhang, Gongguan Liu, Ashley B. Strickland, Yanli Chen, Yong Fu, Juan Xu, Mohammed Yosri, Yuchen Nan, Hong Zhou, Xiquan Zhang, Meiqing Shi
Nature Communications.2019;[Epub] CrossRef - Intracellular cAMP Measurements in Candida albicans Biofilms
Liuliu Jiang, Shengyan Chen, Kairui Sun, Peng Zhou, Xin Wei
BIO-PROTOCOL.2019;[Epub] CrossRef - Linolenic Acid-Modified MPEG-PEI Micelles for Encapsulation of Amphotericin B
Hongmei Xu, Fangfang Teng, Feilong Zhou, Li Zhu, Yi Wen, Runliang Feng, Zhimei Song
Future Medicinal Chemistry.2019; 11(20): 2647. CrossRef - Design, synthesis, and evaluation of novel 2-substituted 1,4-benzenediol library as antimicrobial agents against clinically relevant pathogens
Daiane Flores Dalla Lana, Bruna Gerardon Batista, Gabriella da Rosa Machado, Mário Lettieri Teixeira, Luís Flávio Souza de Oliveira, Michel Mansur Machado, Saulo Fernandes de Andrade, William Lopes, Marilene Henning Vainstein, Alejandro Peixoto de Abreu L
Saudi Pharmaceutical Journal.2019; 27(8): 1064. CrossRef - Vesicular nanocarrier based treatment of skin fungal infections: Potential and emerging trends in nanoscale pharmacotherapy
Shivani Verma, Puneet Utreja
Asian Journal of Pharmaceutical Sciences.2019; 14(2): 117. CrossRef - Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients
Patricia Postina, Julian Skladny, Tobias Boch, Oliver A. Cornely, Axel Hamprecht, Peter-Michael Rath, Jörg Steinmann, Oliver Bader, Thomas Miethke, Anne Dietz, Natalia Merker, Wolf-Karsten Hofmann, Dieter Buchheidt, Birgit Spiess
Frontiers in Microbiology.2018;[Epub] CrossRef - Cryptic Aspergillus from clinical samples in the USA and description of a new species in section Flavipedes
João P. Z. Siqueira, Nathan Wiederhold, Josepa Gené, Dania García, Margarete T. G. Almeida, Josep Guarro
Mycoses.2018; 61(11): 814. CrossRef - Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
Ewa Bielska, Marta Arch Sisquella, Maha Aldeieg, Charlotte Birch, Eloise J. O’Donoghue, Robin C. May
Nature Communications.2018;[Epub] CrossRef - Fungi-Induced Upper and Lower Respiratory Tract Allergic Diseases: One Entity
Aleksandra Barac, David S. Y. Ong, Ljiljana Jovancevic, Aleksandar Peric, Pavol Surda, Vesna Tomic Spiric, Salvatore Rubino
Frontiers in Microbiology.2018;[Epub] CrossRef - Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity
Dayanira Alsina‐Beauchamp, Alejandra Escós, Pilar Fajardo, Diego González‐Romero, Ester Díaz‐Mora, Ana Risco, Miguel A Martín‐Serrano, Carlos del Fresno, Jorge Dominguez‐Andrés, Noelia Aparicio, Rafal Zur, Natalia Shpiro, Gordon D Brown, Carlos Ardavín, M
EMBO Molecular Medicine.2018;[Epub] CrossRef - The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors
Surabhi Goyal, Juan Camilo Castrillón-Betancur, Esther Klaile, Hortense Slevogt
Frontiers in Immunology.2018;[Epub] CrossRef - JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression
Xueqiang Zhao, Yahui Guo, Changying Jiang, Qing Chang, Shilei Zhang, Tianming Luo, Bin Zhang, Xinming Jia, Mien-Chie Hung, Chen Dong, Xin Lin
Nature Medicine.2017; 23(3): 337. CrossRef - Identification of Fungal Species in Brain Tissue from Alzheimer’s Disease by Next-Generation Sequencing
Ruth Alonso, Diana Pisa, Begoña Aguado, Luis Carrasco
Journal of Alzheimer's Disease.2017; 58(1): 55. CrossRef - Nanoparticles as safe and effective delivery systems of antifungal agents: Achievements and challenges
Ghareb M. Soliman
International Journal of Pharmaceutics.2017; 523(1): 15. CrossRef - Conclusion and future perspectives on antifungal stewardship
Jose María Aguado, Jose Tiago Silva, Emilio Bouza
Journal of Antimicrobial Chemotherapy.2016; 71(suppl 2): ii43. CrossRef
- Chemical midification of Cytosine Deaminase from Aspergillus fumigatus
-
Yu, Tae Shick , Kim, Jung , Kim, Hyun Soo
-
J. Microbiol. 1998;36(1):39-42.
-
-
-
Abstract
- Essential amino acids involved in the catalytic mechanisms of cytosine deaminase from Aspergillus fumigatus IFO 5840 were determined by chemical modification studies. The enzyme was perfectly inhibited by N-bromosuccinimide, chloramines-T, pyridoxal-5’-phosphate, and p-chloromercuribenzoate. It was strongly inhibited by phenylmethyl sulfonyl fluoride, and weakly inhibited by phenylglyoxal. The inactivation of the enzyme activity by p-CMB was reversed by sulfhydryl reagents. Furthermore, activities inhibited by chloramines-T, pyridoxal-5’-phosphate, results, we speculate that tryptophan, methionine, lysine and cysteine residues are located in ornear the active center of the cytosine deaminase, while a serine is indirectly involved I the enzyme activity.