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- The Microbiome Matters: Its Impact on Cancer Development and Therapeutic Responses
- In‑Young Chung, Jihyun Kim, Ara Koh
- J. Microbiol. 2024;62(3):137-152. Published online April 8, 2024
- DOI: https://doi.org/10.1007/s12275-024-00110-7
- 75 View
- 4 Download
- 2 Web of Science
- 4 Crossref
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Abstract
- In the evolving landscape of cancer research, the human microbiome emerges as a pivotal determinant reshaping our understanding of tumorigenesis and therapeutic responses. Advanced sequencing technologies have uncovered a vibrant microbial community not confned to the gut but thriving within tumor tissues. Comprising bacteria, viruses, and fungi, this diverse microbiota displays distinct signatures across various cancers, with most research primarily focusing on bacteria. The correlations between specifc microbial taxa within diferent cancer types underscore their pivotal roles in driving tumorigenesis and infuencing therapeutic responses, particularly in chemotherapy and immunotherapy. This review amalgamates recent discoveries, emphasizing the translocation of the oral microbiome to the gut as a potential marker for microbiome dysbiosis across diverse cancer types and delves into potential mechanisms contributing to cancer promotion. Furthermore, it highlights the adverse efects of the microbiome on cancer development while exploring its potential in fortifying strategies for cancer prevention and treatment.
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- COVID-19, Long COVID, and Gastrointestinal Neoplasms: Exploring the Impact of Gut Microbiota and Oncogenic Interactions
do Rêgo Amália Cinthia Meneses, Araújo-Filho Irami
Archives of Cancer Science and Therapy.2024; 8(1): 054. CrossRef - Glycans in the oral bacteria and fungi: Shaping host-microbe interactions and human health
Xiameng Ren, Min Wang, Jiabao Du, Yu Dai, Liuyi Dang, Zheng Li, Jian Shu
International Journal of Biological Macromolecules.2024; 282: 136932. CrossRef - A Review of the Relationship between Tumors of the Biliary System and Intestinal Microorganisms
勇利 李
Advances in Clinical Medicine.2024; 14(07): 833. CrossRef - Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef
- COVID-19, Long COVID, and Gastrointestinal Neoplasms: Exploring the Impact of Gut Microbiota and Oncogenic Interactions
Research Support, Non-U.S. Gov't
- The Photodynamic Effect of Methylene Blue and Toluidine Blue on Candida albicans Is Dependent on Medium Conditions
- Gabriela Guimarães Carvalho , Monalisa Poliana Felipe , Maricilia Silva Costa
- J. Microbiol. 2009;47(5):619-623. Published online October 24, 2009
- DOI: https://doi.org/10.1007/s12275-009-0059-0
- 22 View
- 0 Download
- 48 Scopus
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Abstract
- Due to the increased number of immunocompromised patients, the infections associated with the pathogen of the genus Candida and other fungi have increased dramatically. Photodynamic antimicrobial chemotherapy (PACT) has been presented as a potential antimicrobial therapy, in a process that combines light and a photosensitizing drug, which promotes a phototoxic response by the treated cells. In this work, we studied the effects of the different medium conditions during PACT, using either methylene blue (MB) or toluidine blue (TB) on Candida albicans. The inhibition of the growth produced by PACT was decreased for different pH values (6.0, 7.0, and 8.0) in a buffered medium. The phototoxic effects were observed only in the presence of saline (not buffered medium). PACT was modulated by calcium in a different manner using either MB or TB. Also when using MB both verapamil or sodium azide were able to decrease the phototoxic effects on the C. albicans. These results show that PACT is presented as a new and promising antifungal therapy, however, new studies are necessary to understand the mechanism by which this event occurs.
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