Journal of Microbiology

1 "IL-10"

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Research Support, Non-U.S. Gov't

NOTE] IL-10 Suppresses Bactericidal Response of Macrophages against Salmonella Typhimurium: Kyoung-Sun Lee , Eui-Suk Jeong , Seung-Ho Heo , Jin-Hee Seo , Dong-Gu Jeong , Yang-Kyu Choi; J. Microbiol. 2011;49(6):1050-1053. Published online December 28, 2011; DOI: https://doi.org/10.1007/s12275-011-1043-z

Abstract: We report, herein, an attempt to determine whether an IL-10-induced immunological state affects the response of macrophages against Salmonella Typhimurium (ST). Pretreatment with mrIL-10 induced the intracellular invasion of ST into macrophages in a dose-dependent manner. It also activated AKT phosphorylation, cyclin D1, Bcl-XL, and COX-2 upon ST infection, which may correlate with Salmonella’s survival within the macrophages. However, I-κB phosphorylation was shown to be inhibited, along with the expression of TNF-α and MIP-2α mRNA. Therefore, IL-10 not only suppresses the bactericidal response of macrophages against ST, but also ultimately causes infected macrophages to function as hosts for ST replication.

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