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Research Support, Non-U.S. Gov't
- NOTE] IL-10 Suppresses Bactericidal Response of Macrophages against Salmonella Typhimurium
- Kyoung-Sun Lee 1, Eui-Suk Jeong 1, Seung-Ho Heo 1,2, Jin-Hee Seo 1, Dong-Gu Jeong 1, Yang-Kyu Choi 1
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Journal of Microbiology 2011;49(6):1050-1053
DOI: https://doi.org/10.1007/s12275-011-1043-z
Published online: December 28, 2011
1Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea, 2Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea1Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea, 2Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
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Corresponding author:
Yang-Kyu Choi , Tel: +82-2-2049-,
Received: 26 January 2011 • Accepted: 20 June 2011
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Abstract
We report, herein, an attempt to determine whether an IL-10-induced immunological state affects the response of macrophages against Salmonella Typhimurium (ST). Pretreatment with mrIL-10 induced the intracellular invasion of ST into macrophages in a dose-dependent manner. It also activated AKT phosphorylation, cyclin D1, Bcl-XL, and COX-2 upon ST infection, which may correlate with Salmonella’s survival within the macrophages. However, I-κB phosphorylation was shown to be inhibited, along with the expression of TNF-α and MIP-2α mRNA. Therefore, IL-10 not only suppresses the bactericidal response of macrophages against ST, but also ultimately causes infected macrophages to function as hosts for ST replication.
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