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MINIREVIEW]Phytochemicals for the treatment of COVID-19
Erica Españo , Jiyeon Kim , Kiho Lee , Jeong-Ki Kim
J. Microbiol. 2021;59(11):959-977.   Published online November 1, 2021
DOI: https://doi.org/10.1007/s12275-021-1467-z
  • 47 View
  • 0 Download
  • 17 Web of Science
  • 18 Crossref
AbstractAbstract
The coronavirus disease 2019 (COVID-19) pandemic has underscored the lack of approved drugs against acute viral diseases. Plants are considered inexhaustible sources of drugs for several diseases and clinical conditions, but plant-derived compounds have seen little success in the field of antivirals. Here, we present the case for the use of compounds from vascular plants, including alkaloids, flavonoids, polyphenols, and tannins, as antivirals, particularly for the treatment of COVID-19. We review current evidence for the use of these phytochemicals against SARS-CoV-2 infection and present their potential targets in the SARS-CoV-2 replication cycle.

Citations

Citations to this article as recorded by  
  • Role of dietary supplements in the continuous battle against COVID‐19
    Rahela Zaman, Vignesh Ravichandran, Chung Keat Tan
    Phytotherapy Research.2024; 38(2): 1071.     CrossRef
  • The Potential of Anti-coronavirus Plant Secondary Metabolites in COVID-19 Drug Discovery as an Alternative to Repurposed Drugs: A Review
    Zahra Alipour, Somayeh Zarezadeh, Ali Akbar Ghotbi-Ravandi
    Planta Medica.2024; 90(03): 172.     CrossRef
  • In Silico Screening of Some Active Phytochemicals to Identify Promising Inhibitors Against SARS-CoV-2 Targets
    V. Alagarsamy, V. Raja Solomon, S. Murugesan, P. Shyam Sundar, MD. Muzaffar-Ur-Rehman, A. Chandu, A. Dharshini Aishwarya, B. Narendhar, M.T. Sulthana, V. Ravikumar
    Current Drug Discovery Technologies.2024;[Epub]     CrossRef
  • Screening Commercial Tea for Rapid Inactivation of Infectious SARS-CoV-2 in Saliva
    Julianna N. Morris, Malak A. Esseili
    Food and Environmental Virology.2024; 16(2): 159.     CrossRef
  • Phytochemical-loaded Nanoparticles in COVID-19 Management
    Suneetha Vuppu, Toshika Mishra, Shatakshi Mishra, Stany B, Anushka Das
    Natural Resources for Human Health.2023; 4(1): 51.     CrossRef
  • Nutritional deficiencies that may predispose to long COVID
    John V. Schloss
    Inflammopharmacology.2023; 31(2): 573.     CrossRef
  • Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review
    Lucas Fornari Laurindo, Gabriel Magno de Carvalho, Bárbara de Oliveira Zanuso, Maria Eduardo Figueira, Rosa Direito, Ricardo de Alvares Goulart, Daiene Santos Buglio, Sandra Maria Barbalho
    Pharmaceutics.2023; 15(1): 229.     CrossRef
  • Changes in phytochemical compositions and antioxidant activity of Schisandra sphenathera fruit during ripening
    Bohan Ma, Xinghua Zhao, Bin Dai, Mengge Zhao, Xingbin Yang, Langjun Cui, Hongjun Shao
    Industrial Crops and Products.2023; 199: 116773.     CrossRef
  • Role of nutrition in minimizing mental and health-related issues during COVID-19: a systematic literature review
    Luxita Sharma, Dhananjay Sharma
    Nutrition & Food Science.2023; 53(4): 659.     CrossRef
  • Current Update of Phytotherapeutic Agents in the Treatment of COVID-19: In-Silico Based Virtual Screening Approach for the Development of Antiviral Drug
    Veena Ramesh, Seema A. Kulkarni, Palaniyandi Velusamy, Velmurugan Devadasan, Panneer Devaraju, Kandathil Narayanan Rajnish, Thirumurthy Madhavan, Periasamy Anbu, Palaniappan Ramasamy, Rajamanikandan Sundarraj
    Frontiers in Bioscience-Landmark.2022;[Epub]     CrossRef
  • Promising natural products against SARS‐CoV‐2: Structure, function, and clinical trials
    Yan Zhao, Shanshan Deng, Yujiao Bai, Jinlin Guo, Guoyin Kai, Xinhe Huang, Xu Jia
    Phytotherapy Research.2022; 36(10): 3833.     CrossRef
  • Effective food hygiene principles and dietary intakes to reinforce the immune system for prevention of COVID-19: a systematic review
    Jalaledin Mirzay-Razaz, Majid Hassanghomi, Marjan Ajami, Glareh Koochakpoor, Firoozeh Hosseini-Esfahani, Parvin Mirmiran
    BMC Nutrition.2022;[Epub]     CrossRef
  • Beneficial effect of polyphenols in COVID‐19 and the ectopic F1FO‐ATP synthase: Is there a link?
    Isabella Panfoli, Alfonso Esposito
    Journal of Cellular Biochemistry.2022; 123(8): 1281.     CrossRef
  • In vitro inhibition of SARS-CoV-2 Infection by dry algae powders
    Daniel Garcia-Ruiz, Erendira Villalobos-Sánchez, David Alam-Escamilla, Darwin Elizondo-Quiroga
    Scientific Reports.2022;[Epub]     CrossRef
  • Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2
    Te-Kai Sun, Wen-Chin Huang, Yu-Wen Sun, Jeng-Shyan Deng, Liang-Hsuan Chien, Ya-Ni Chou, Wen-Ping Jiang, Jaung-Geng Lin, Guan-Jhong Huang
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  • An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations
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    Journal of Ethnopharmacology.2022; 296: 115420.     CrossRef
  • Computational screening for investigating the synergistic regulatory potential of drugs and phytochemicals in combination with 2-deoxy-D-glucose against SARS-CoV-2
    Anshika Gupta, Shweta Singh Chauhan, Anamika Singh Gaur, Ramakrishnan Parthasarathi
    Structural Chemistry.2022; 33(6): 2179.     CrossRef
  • BOTANICALS AS PROSPECTIVE AGENTS AGAINST SARS-COV-2 VIRUS
    V. DUSHENKOV, A. DUSHENKOV
    AVICENNA BULLETIN.2022; 24(1): 113.     CrossRef
Journal Articles
Optimization of bacterial sporulation using economic nutrient for self-healing concrete
Youngung Ryu , Ki-Eun Lee , In-Tae Cha , Woojun Park
J. Microbiol. 2020;58(4):288-296.   Published online February 27, 2020
DOI: https://doi.org/10.1007/s12275-020-9580-y
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  • 0 Download
  • 17 Web of Science
  • 19 Crossref
AbstractAbstract
The use of heat- and alkali-resistant bacteria is essential for the biological repair of damaged concrete. Lysinibacillus boronitolerans YS11 was isolated from the rhizosphere of Miscanthus sacchariflorus. The increased pH in the urea-minus condition during the growth of the YS11 strain promoted calcium carbonate (CaCO3) formation. To identify the optimum medium that promoted the growth of the YS11 strain, a Plackett- Burman design was conducted for the screening process. Consequently, malt powder, rice bran, (NH4)2SO4, and corn syrup were chosen to enhance YS11 growth. The optimization of these four useful factors was carried out using a central composite design. To obtain higher survivability in mortar, the sporulation process is essential, and additional factors such as Mn2+, Fe2+, and Ca2+ were found to contribute to sporulation. A mixture of L. boronitolerans YS11 spore powder, cement, paste, sand, yeast extract, calcium lactate, and water showed a healing effect on a 0.3 mm mortar crack in 7 days. Furthermore, calcium carbonate precipitation was observed over the crack surface. Thus, we confirmed that mortar treated with YS11 spore powder was effective in healing micro-cracks in concrete.

Citations

Citations to this article as recorded by  
  • Self-Healing Concrete Utilizing Ureolysis Mechanism of Microbially Induced Calcite Precipitation (MICP): a Review
    Yea Shiuan Kho, Kwong Soon Wong, Nurul Noraziemah Mohd Pauzi, Meheron Selowara Joo, Tony Hadibarata
    Iranian Journal of Science and Technology, Transactions of Civil Engineering.2024;[Epub]     CrossRef
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    Results in Engineering.2024; 24: 103235.     CrossRef
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    IOP Conference Series: Earth and Environmental Science.2024; 1347(1): 012080.     CrossRef
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    Construction and Building Materials.2023; 384: 131467.     CrossRef
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    Environmental Earth Sciences.2023;[Epub]     CrossRef
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    Communications Biology.2023;[Epub]     CrossRef
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    Olja Šovljanski, Ana Tomić, Siniša Markov
    Microorganisms.2022; 10(7): 1399.     CrossRef
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    Manpreet Bagga, Charlotte Hamley-Bennett, Aleena Alex, Brubeck L Freeman, Ismael Justo-Reinoso, Iulia C Mihai, Susanne Gebhard, Kevin Paine, Anthony D Jefferson, Enrico Masoero, Irina D Ofiţeru
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    S A Susanto, D Hardjito, A Antoni
    IOP Conference Series: Earth and Environmental Science.2021; 907(1): 012006.     CrossRef
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    Minyoung Hong, Indong Jang, Yongjun Son, Chongku Yi, Woojun Park
    AMB Express.2021;[Epub]     CrossRef
  • Raman spectroscopy reveals alteration of spore compositions under different nutritional conditions in Lysinibacillus boronitolerans YS11
    Youngung Ryu, Minyoung Hong, Soo Bin Kim, Tae Kwon Lee, Woojun Park
    Journal of Microbiology.2021; 59(5): 491.     CrossRef
  • Influences of different calcium sources on the early age cracks of self-healing cementitious mortar
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Non-ureolytic calcium carbonate precipitation by Lysinibacillus sp. YS11 isolated from the rhizosphere of Miscanthus sacchariflorus
Yun Suk Lee , Hyun Jung Kim , Woojun Park
J. Microbiol. 2017;55(6):440-447.   Published online May 28, 2017
DOI: https://doi.org/10.1007/s12275-017-7086-z
  • 48 View
  • 0 Download
  • 37 Crossref
AbstractAbstract
Although microbially induced calcium carbonate precipita-tion (MICP) through ureolysis has been widely studied in en-vironmental engineering fields, urea utilization might cause environmental problems as a result of ammonia and nitrate production. In this study, many non-ureolytic calcium car-bonate-precipitating bacteria that induced an alkaline envi-ronment were isolated from the rhizosphere of Miscanthus sacchariflorus near an artificial stream and their ability to pre-cipitate calcium carbonate minerals with the absence of urea was investigated. MICP was observed using a phase-contrast microscope and ion-selective electrode. Only Lysinibacillus sp. YS11 showed MICP in aerobic conditions. Energy disper-sive X-ray spectrometry and X-ray diffraction confirmed the presence of calcium carbonate. Field emission scanning elec-tron microscopy analysis indicated the formation of morpho-logically distinct minerals around cells under these condi-tions. Monitoring of bacterial growth, pH changes, and Ca2+ concentrations under aerobic, hypoxia, and anaerobic con-ditions suggested that strain YS11 could induce alkaline con-ditions up to a pH of 8.9 and utilize 95% of free Ca2+ only under aerobic conditions. Unusual Ca2+ binding and its re-lease from cells were observed under hypoxia conditions. Bio-film and extracellular polymeric substances (EPS) formation were enhanced during MICP. Strain YS11 has resistance at high pH and in high salt concentrations, as well as its spore- forming ability, which supports its potential application for self-healing concrete.

Citations

Citations to this article as recorded by  
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    Yun Suk Lee, Woojun Park
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