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Review
T cell responses to SARS-CoV-2 in humans and animals
Sameer-ul-Salam Mattoo , Jinjong Myoung
J. Microbiol. 2022;60(3):276-289.   Published online February 14, 2022
DOI: https://doi.org/10.1007/s12275-022-1624-z
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AbstractAbstract
SARS-CoV-2, the causative agent of COVID-19, first emerged in 2019. Antibody responses against SARS-CoV-2 have been given a lot of attention. However, the armamentarium of humoral and T cells may have differing roles in different viral infections. Though the exact role of T cells in COVID-19 remains to be elucidated, prior experience with human coronavirus has revealed an essential role of T cells in the outcomes of viral infections. Moreover, an increasing body of evidence suggests that T cells might be effective against SARS-CoV-2. This review summarizes the role of T cells in mouse CoV, human pathogenic respiratory CoV in general and SARSCoV- 2 in specific.

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