Abstract
SARS-CoV-2, the causative agent of COVID-19, first emerged
in 2019. Antibody responses against SARS-CoV-2 have been
given a lot of attention. However, the armamentarium of humoral
and T cells may have differing roles in different viral
infections. Though the exact role of T cells in COVID-19 remains
to be elucidated, prior experience with human coronavirus
has revealed an essential role of T cells in the outcomes
of viral infections. Moreover, an increasing body of evidence
suggests that T cells might be effective against SARS-CoV-2.
This review summarizes the role of T cells in mouse CoV,
human pathogenic respiratory CoV in general and SARSCoV-
2 in specific.
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