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Review
- T cell responses to SARS-CoV-2 in humans and animals
- Sameer-ul-Salam Mattoo , Jinjong Myoung
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Journal of Microbiology 2022;60(3):276-289
DOI: https://doi.org/10.1007/s12275-022-1624-z
Published online: February 14, 2022
Korea Zoonosis Research Institute, Department of Bioactive Material Science and Genetic Engineering Research Institute, Jeonbuk National University, Jeonju 54531, Republic of KoreaKorea Zoonosis Research Institute, Department of Bioactive Material Science and Genetic Engineering Research Institute, Jeonbuk National University, Jeonju 54531, Republic of Korea
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Corresponding author:
Jinjong Myoung , Tel: +82-63-9004055,
Received: 1 December 2021 • Revised: 28 December 2021 • Accepted: 28 December 2021
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Abstract
SARS-CoV-2, the causative agent of COVID-19, first emerged in 2019. Antibody responses against SARS-CoV-2 have been given a lot of attention. However, the armamentarium of humoral and T cells may have differing roles in different viral infections. Though the exact role of T cells in COVID-19 remains to be elucidated, prior experience with human coronavirus has revealed an essential role of T cells in the outcomes of viral infections. Moreover, an increasing body of evidence suggests that T cells might be effective against SARS-CoV-2. This review summarizes the role of T cells in mouse CoV, human pathogenic respiratory CoV in general and SARSCoV- 2 in specific.
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