Abstract
With global expansion of the COVID-19 pandemic and the
emergence of new variants, extensive efforts have been made
to develop highly effective antiviral drugs and vaccines against
SARS-CoV-2. The interactions of coronaviruses with host
antiviral interferon pathways ultimately determine successful
viral replication and SARS-CoV-2-induced pathogenesis.
Innate immune receptors play an essential role in host defense
against SARS-CoV-2 via the induction of IFN production
and signaling. Here, we summarize the recent advances
in innate immune sensing mechanisms of SARS-CoV-2 and
various strategies by which SARS-CoV-2 antagonizes antiviral
innate immune signaling pathways, with a particular
focus on mechanisms utilized by multiple SARS-CoV-2 proteins
to evade interferon induction and signaling in host cell.
Understanding the underlying immune evasion mechanisms
of SARS-CoV-2 is essential for the improvement of vaccines
and therapeutic strategies.
Citations
Citations to this article as recorded by
- Overview of the SARS-CoV-2 nucleocapsid protein
Ahmed Eltayeb, Faisal Al-Sarraj, Mona Alharbi, Raed Albiheyri, Ehab Mattar, Isam M. Abu Zeid, Thamer A. Bouback, Atif Bamagoos, Bassam O. Aljohny, Vladimir N. Uversky, Elrashdy M. Redwan
International Journal of Biological Macromolecules.2024; 260: 129523. CrossRef - Does SARS-CoV-2 Induce IgG4 Synthesis to Evade the Immune System?
Alberto Rubio-Casillas, Elrashdy Redwan, Vladimir Uversky
Biomolecules.2023; 13(9): 1338. CrossRef - Appearance of tolerance-induction and non-inflammatory SARS-CoV-2 spike-specific IgG4 antibodies after COVID-19 booster vaccinations
Marjahan Akhtar, Md. Rashedul Islam, Fatema Khaton, Umma Hany Soltana, Syeda Anoushka Jafrin, Sadia Isfat Ara Rahman, Imam Tauheed, Tasnuva Ahmed, Ishtiakul Islam Khan, Afroza Akter, Zahid Hasan Khan, Md. Taufiqul Islam, Farhana Khanam, Prasanta Kumar Bis
Frontiers in Immunology.2023;[Epub] CrossRef - Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier
Aileen Faist, Sebastian Schloer, Angeles Mecate-Zambrano, Josua Janowski, André Schreiber, Yvonne Boergeling, Beate C.G. Conrad, Sriram Kumar, Leonie Toebben, Klaus Schughart, Morris Baumgardt, Mirjana Kessler, Katja Hoenzke, Andreas Hocke, Marcel Trautma
Antiviral Research.2023; 209: 105475. CrossRef - Serum neutralization of SARS‐CoV‐2 Omicron BA.2, BA.2.75, BA.2.76, BA.5, BF.7, BQ.1.1 and XBB.1.5 in individuals receiving Evusheld
Qianqian Zhao, Xin Wang, Ze Zhang, Xuefei Liu, Ping Wang, Jin Cao, Qiming Liang, Jieming Qu, Min Zhou
Journal of Medical Virology.2023;[Epub] CrossRef - IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein
Vladimir Uversky, Elrashdy Redwan, William Makis, Alberto Rubio-Casillas
Vaccines.2023; 11(5): 991. CrossRef - Warmer ambient air temperatures reduce nasal turbinate and brain infection, but increase lung inflammation in the K18-hACE2 mouse model of COVID-19
Troy Dumenil, Thuy T. Le, Daniel J. Rawle, Kexin Yan, Bing Tang, Wilson Nguyen, Cameron Bishop, Andreas Suhrbier
Science of The Total Environment.2023; 859: 160163. CrossRef - Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β
John D. O’Neil, Oliwia O. Bolimowska, Sally A. Clayton, Tina Tang, Kalbinder K. Daley, Samuel Lara-Reyna, Jordan Warner, Claire S. Martin, Rahul Y. Mahida, Rowan S. Hardy, J. Simon C. Arthur, Andrew R. Clark
Frontiers in Immunology.2023;[Epub] CrossRef - Selenoprotein S Interacts with the Replication and Transcription Complex of SARS-CoV-2 by Binding nsp7
Farid Ghelichkhani, Fabio A. Gonzalez, Mariia A. Kapitonova, Sharon Rozovsky
Journal of Molecular Biology.2023; 435(8): 168008. CrossRef - Pathogenesis and Mechanisms of SARS-CoV-2 Infection in the Intestine, Liver, and Pancreas
Zaid Khreefa, Mallory T. Barbier, Ali Riza Koksal, Gordon Love, Luis Del Valle
Cells.2023; 12(2): 262. CrossRef - Selenoprotein S: A versatile disordered protein
Farid Ghelichkhani, Fabio A. Gonzalez, Mariia A. Kapitonova, Stephanie Schaefer-Ramadan, Jun Liu, Rujin Cheng, Sharon Rozovsky
Archives of Biochemistry and Biophysics.2022; 731: 109427. CrossRef - Nanomaterials to combat SARS-CoV-2: Strategies to prevent, diagnose and treat COVID-19
Agustín Valenzuela-Fernández, Romina Cabrera-Rodriguez, Laura Ciuffreda, Silvia Perez-Yanes, Judith Estevez-Herrera, Rafaela González-Montelongo, Julia Alcoba-Florez, Rodrigo Trujillo-González, Diego García-Martínez de Artola, Helena Gil-Campesino, Oscar
Frontiers in Bioengineering and Biotechnology.2022;[Epub] CrossRef - Two years of COVID-19 pandemic: where are we now?
Jinjong Myoung
Journal of Microbiology.2022; 60(3): 235. CrossRef - Warmer Ambient Air Temperatures Reduce Nasal Turbinate and Brain Infection, But Increase Lung Inflammation in the K18-hACE2 Mouse Model of COVID-19
Troy Dumenil, Thuy T. Le, Daniel Rawle, Kexin Yan, Bing Tang, Wilson Nguyen, Cameron Bishop, Andreas Suhrbier
SSRN Electronic Journal.2022;[Epub] CrossRef - SARS-CoV-2: A Master of Immune Evasion
Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky
Biomedicines.2022; 10(6): 1339. CrossRef - Interferon α-2b spray shortened viral shedding time of SARS-CoV-2 Omicron variant: An open prospective cohort study
Nan Xu, Jinjin Pan, Li Sun, Cuimei Zhou, Siran Huang, Mingwei Chen, Junfei Zhang, Tiantian Zhu, Jiabin Li, Hong Zhang, Yufeng Gao
Frontiers in Immunology.2022;[Epub] CrossRef
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