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Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
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HOME > J. Microbiol > Volume 60(3); 2022 > Article
Review
Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
Na-Eun Kim , Yoon-Jae Song
Journal of Microbiology 2022;60(3):300-307
DOI: https://doi.org/10.1007/s12275-022-1502-8
Published online: January 28, 2022
Department of Life Science, Gachon University, Seongnam 13120, Republic of KoreaDepartment of Life Science, Gachon University, Seongnam 13120, Republic of Korea
Corresponding author:  Yoon-Jae Song ,
Received: 28 September 2021   • Revised: 6 December 2021   • Accepted: 15 December 2021
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Abstract

Type I and III interferons (IFNs) and the nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome play pivotal roles in the pathogenesis of SARS-CoV-2. While optimal IFN and inflammasome responses are essential for limiting SARS-CoV-2 infection, aberrant activation of these innate immune responses is associated with COVID-19 pathogenesis. In this review, we focus our discussion on recent findings on SARS-CoV-2-induced type I and III IFNs and NLRP3 inflammasome responses and the viral proteins regulating these mechanisms.

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    Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
    J. Microbiol. 2022;60(3):300-307.   Published online January 28, 2022
    DOI: https://doi.org/10.1007/s12275-022-1502-8
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