Journal of Microbiology

Research Support, Non-U.S. Gov'ts

Providencia Isolates Carrying blaPER-1 and blaVIM-2 Genes: Biofilm-Forming Capacity and Biofilm Inhibitory Concentrations for Carbapenem Antibiotics: Jungmin Kim , Shukho Kim , Hee Woo Lee , Sung Min Kim , Sung Yong Seol; J. Microbiol. 2011;49(3):512-515. Published online June 30, 2011; DOI: https://doi.org/10.1007/s12275-011-1221-z

Abstract: Multidrug-resistant clinical isolates of Providencia carrying blaPER-1 and blaVIM-2 were evaluated for the abilities to form biofilm and high biofilm forming capacity was demonstrated in them. Minimum biofilm inhibitory concentrations (MBICs), minimum biofilm eradication concentrations (MBECs), and minimum inhibitory concentrations (MICs) for imipenem and meropenem were also determined. In all tested strains, the MBICs were higher than the MICs for both drugs. Interestingly, the MBICs and the MBEC50 for meropenem were lower than those for imipenem in the isolates producing high amounts of biofilm, suggesting that meropenem is superior to imipenem in the growth inhibition and eradication of biofilm forming Providencia strains.

Multidrug-Resistant Providencia Isolates Carrying blaPER-1, blaVIM-2, and armA: Hee-Woo Lee , Hee-Young Kang , Kyeong-Seob Shin , Jungmin Kim; J. Microbiol. 2007;45(3):272-274.; DOI: https://doi.org/2531 [pii]

Abstract: During May to July 2004, three strains of Providencia spp. with multidrug-resistance (MDR) were isolated from urinary specimen of three patients hospitalized with a same hospital room. By PCR analysis, all three strains have been found to carry both VIM-2 type metallo-β-lactamase gene and PER-1 type extendedspectrum β-lactamase gene. One out of three strains carried additional resistance gene, armA, 16S rRNA methylase gene responsible for high level resistance to aminoglycosides. To our knowledge, this is the first report on the identification of Providencia spp. simultaneously carrying blaVIM-2, blaPER-1, and armA genes.

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