MSK
Search
- Page Path
- HOME > Search
Journal Article
- Superantigen SpeA attenuates the biofilm forming capacity of Streptococcus pyogenes
- Anshu Babbar , Israel Barrantes , Dietmar H. Pieper , Andreas Itzek
- J. Microbiol. 2019;57(7):626-636. Published online June 27, 2019
- DOI: https://doi.org/10.1007/s12275-019-8648-z
- 51 View
- 0 Download
- 8 Web of Science
- 9 Crossref
-
Abstract
- Beta haemolytic Group A streptococcus (GAS) or Streptococcus pyogenes are strict human pathogens responsible for mild to severe fatal invasive infections. Even with enormous number of reports exploring the role of S. pyogenes exotoxins in its pathogenesis, inadequate knowledge on the biofilm process and the potential role of exotoxins in bacterial dissemination from matured biofilms has been a hindrance in development of effective and targeted treatments. Therefore, the present study was aimed in investigating the uncharted role of these exotoxins in biofilm process. Through our study the putative role of ciaRH in the SpeA dependent ablation of biofilm formation could be speculated and thus helping in bacterial dissemination. The seed-dispersal effect of SpeA was time and concentration dependent and seen to be consistent within various streptococcal species. Transcriptome analysis of SpeA treated S. pyogenes biofilms revealed the involvement of many transcriptional regulators (ciaRH) and response genes (luxS, shr, shp, SPy_0572), hinting towards specific mechanisms underlying the dispersal effect by SpeA. This finding opens up a discussion towards understanding a new mechanism involved in the pathogenesis of Streptococcus pyogenes and might help in understanding the bacterial infections in a better way.
-
Citations
Citations to this article as recorded by
- Pathomolecular epidemiology, antimicrobial resistance, and virulence genes of Streptococcus dysgalactiae subsp. equisimilis isolates from slaughtered pigs in India
Sagar M Patel, Monalisa Sahoo, Jigarji Chaturji Thakor, Dinesh Murali, Pradeep Kumar, Rajendra Singh, Karam Pal Singh, G Saikumar, Chandrakanta Jana, Shailesh Kumar Patel, Akash B Mote, Ravichandran Karthikeyan, Rajesh Kumar Vandre, Jitendra Kumar Biswal,
Journal of Applied Microbiology.2024;[Epub] CrossRef - The involvement of CiaR and the CiaR-regulated serine protease HtrA in thermal adaptation of Streptococcus pneumoniae
Ozcan Gazioglu, Medhanie Habtom, Peter W. Andrew, Hasan Yesilkaya
Microbiology .2023;[Epub] CrossRef - An Inventory of CiaR-Dependent Small Regulatory RNAs in Streptococci
Nancy Jabbour, Marie-Frédérique Lartigue
Frontiers in Microbiology.2021;[Epub] CrossRef - Microbial biofilms and some aspects of anti-inflammatory drug use
T. M. Rumynska, A. R. Hural, Y. T. Konechnyi, R. B. Vynnytska, A. V. Lozynskyi, Y. T. Salyha, O. P. Korniychuk, R.B. Lesyk
Biopolymers and Cell.2021; 37(4): 247. CrossRef -
A current review of pathogenicity determinants of
Streptococcus
sp.
P.S. Lannes‐Costa, J.S.S. Oliveira, G. Silva Santos, P.E. Nagao
Journal of Applied Microbiology.2021; 131(4): 1600. CrossRef - Genital Tract GAS Infection ISIDOG Guidelines
Gilbert Donders, Peter Greenhouse, Francesca Donders, Ulrike Engel, Jorma Paavonen, Werner Mendling
Journal of Clinical Medicine.2021; 10(9): 2043. CrossRef - The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal Species
Li-Yuan He, Yao-Jin Le, Zhong Guo, Sha Li, Xiao-Yan Yang
Frontiers in Microbiology.2021;[Epub] CrossRef - Deciphering Streptococcal Biofilms
Puja Yadav, Shalini Verma, Richard Bauer, Monika Kumari, Meenakshi Dua, Atul Kumar Johri, Vikas Yadav, Barbara Spellerberg
Microorganisms.2020; 8(11): 1835. CrossRef - Dissecting Streptococcus pyogenes interaction with human
Munazza Ijaz, Fuad Ameen, Yaseen Abd Alfoteih, Saba Shamim, Wafa A. Alshehri, Ghulam Murtaza
Archives of Microbiology.2020; 202(8): 2023. CrossRef
- Pathomolecular epidemiology, antimicrobial resistance, and virulence genes of Streptococcus dysgalactiae subsp. equisimilis isolates from slaughtered pigs in India
First
Prev
TOP
