Journal of Microbiology

1 "V. vulnificus rtxA"

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Research Support, Non-U.S. Gov't

NOTE] Regulatory Characteristics of the Vibrio vulnificus rtxHCA Operon Encoding a MARTX Toxin: Jinseo Park , Seung Min Kim , Hee Gon Jeong , Sang Ho Choi; J. Microbiol. 2012;50(5):878-881. Published online September 21, 2012; DOI: https://doi.org/10.1007/s12275-012-2479-5

Abstract: Vibrio vulnificus MARTX encoded by rtxA, an open reading frame of the rtxHCA operon, is essential for virulence in vitro and in mice. In this study, a primer extension analysis revealed that transcription of the rtxHCA operon begins at a single site, and is under the direction of a single promoter, PrtxHCA. PrtxHCA activity appeared at the beginning of growth and reached a maximum in mid-exponential phase. PrtxHCA activity was induced by exposure to INT-407 cells, and the membrane fraction of INT-407 cells was the most effective for the induction.

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