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Research Support, Non-U.S. Gov't
- NOTE] Regulatory Characteristics of the Vibrio vulnificus rtxHCA Operon Encoding a MARTX Toxin
- Jinseo Park , Seung Min Kim , Hee Gon Jeong , Sang Ho Choi
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Journal of Microbiology 2012;50(5):878-881
DOI: https://doi.org/10.1007/s12275-012-2479-5
Published online: September 21, 2012
National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Center for Food Safety and Toxicology, Seoul National University, Seoul 151-921, Republic of KoreaNational Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Center for Food Safety and Toxicology, Seoul National University, Seoul 151-921, Republic of Korea
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Corresponding author:
Sang Ho Choi , Tel: +82-2-880-4857,
Received: 31 August 2012 • Accepted: 6 September 2012
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Abstract
Vibrio vulnificus MARTX encoded by rtxA, an open reading frame of the rtxHCA operon, is essential for virulence in vitro and in mice. In this study, a primer extension analysis revealed that transcription of the rtxHCA operon begins at a single site, and is under the direction of a single promoter, PrtxHCA. PrtxHCA activity appeared at the beginning of growth and reached a maximum in mid-exponential phase. PrtxHCA activity was induced by exposure to INT-407 cells, and the membrane fraction of INT-407 cells was the most effective for the induction.
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