Journal of Microbiology

1 "Zn-chelating agent"

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Stimulation of Tissue Transglutaminase Activity by Clostridium botulinum Neurotoxin Type B: Yu Seok Moon , Gi-Hyeok Yang , Sang-Dal Rhee , Hyun Ho Jung; J. Microbiol. 2003;41(2):161-164.

Abstract: Recombinant light chain of Clostridium botulinum neurotoxin type B stimulated transglutaminase activity in a dose dependent manner. Compared to native toxin, recombinant light chain showed a greater stimulatory effect on transglutaminase activity. Zn-chelating agents, inhibiting the roteolytic activity of the clostridial toxins, did not interfere with this stimulation. These results suggest that the light chain plays a major stimulatory role, which is not due to its metallopeptidase activity, but is possibly due to specific interaction with transglutaminase. More importantly, this report provides a new insight into the intracellular action of C. botulinum neurotoxins.

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