MSK
Search
- Page Path
- HOME > Search
Review
- Advancements in dengue vaccines: A historical overview and pro-spects for following next-generation candidates
- Kai Yan, Lingjing Mao, Jiaming Lan, Zhongdang Xiao
- J. Microbiol. 2025;63(2):e2410018. Published online February 27, 2025
- DOI: https://doi.org/10.71150/jm.2410018
- 282 View
- 21 Download
-
Abstract
PDF - Dengue, caused by four serotypes of dengue viruses (DENV-1 to DENV-4), is the most prevalent and widely mosquito-borne viral disease affecting humans. Dengue virus (DENV) infection has been reported in over 100 countries, and approximately half of the world's population is now at risk. The paucity of universally licensed DENV vaccines highlights the urgent need to address this public health concern. Action and atten-tion to antibody-dependent enhancement increase the difficulty of vaccine development. With the worsen-ing dengue fever epidemic, Dengvaxia® (CYD-TDV) and Qdenga® (TAK-003) have been approved for use in specific populations in affected areas. However, these vaccines do not provide a balanced immune response to all four DENV serotypes and the vaccination cannot cover all populations. There is still a need to develop a safe, broad-spectrum, and effective vaccine to address the increasing number of dengue cases worldwide. This review provides an overview of the existing DENV vaccines, as well as potential candidates for future studies on DENV vaccine development, and discusses the challenges and possible solutions in the field.
Journal Article
- Anti-inflammatory and anti-oxidative effect of Korean propolis on Helicobacter pylori-induced gastric damage in vitro
- Moon-Young Song , Da-Young Lee , Eun-Hee Kim
- J. Microbiol. 2020;58(10):878-885. Published online September 2, 2020
- DOI: https://doi.org/10.1007/s12275-020-0277-z
- 46 View
- 0 Download
- 28 Web of Science
- 27 Crossref
-
Abstract
- Helicobacter pylori, present in the stomach lining, is a Gramnegative bacterium that causes various gastrointestinal diseases, including gastritis and peptic ulcers. Propolis is a natural resinous substance collected from a variety of plants, and contains several natural bioactive substances. The aim of this study was to investigate the anti-inflammatory and antioxidative effects of Korean propolis on H. pylori-induced damage in the human adenocarcinoma gastric cell line. The propolis used in this study was obtained from the Korea Beekeeping Association in South Korea. The expression of pro-inflammatory interleukins (ILs), such as IL-8, IL-12, IL-1β, tumor necrosis factor alpha, cyclooxygenase-2, and inducible nitric oxide synthase, which was increased after H. pylori infection, significantly decreased in a dose-dependent manner upon pretreatment with Korean propolis, because of the suppression of mitogen-activated protein kinases and nuclear factor κB pathway. The anti-oxidative activity of propolis was assessed using the 2,2-diphenyl-1-picrylhydrazyl hydrate free radical assay. Korean propolis showed significant anti-oxidative effects via reactive oxygen species scavenging. In addition, pretreatment with Korean propolis upregulated the expression of anti-oxidant enzymes through Nrf2 signaling activation. These findings indicate that the use of Korean propolis, which has anti-inflammatory and anti-oxidative effects, can be promising for the prevention of H. pylori-induced gastric damage.
-
Citations
Citations to this article as recorded by
- Propolis as an autophagy modulator in relation to its roles in redox balance and inflammation regulation
R. Lesmana, S. Tandean, A. Christoper, A.A. Suwantika, N. Wathoni, R. Abdulah, J. Fearnley, V. Bankova, F. Zulhendri
Biomedicine & Pharmacotherapy.2024; 175: 116745. CrossRef - Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks
Carla Scorza, Valeria Goncalves, Josef Finsterer, Fúlvio Scorza, Fernando Fonseca
Cells.2024; 13(5): 390. CrossRef - Development of a chitosan/propolis-based polymeric system: Characterization, biocompatibility, and modulation of transcription factor expression
Raquel Velázquez-Rodríguez, Amaury Pozos-Guillén, Martha Gabriela Chuc-Gamboa, Juan Valerio Cauich-Rodríguez, Héctor Flores-Reyes, Francisco Javier Tejeda-Nava, Fernando Javier Aguilar-Perez, Diana Maria Escobar Garcia
Journal of Bioactive and Compatible Polymers.2024; 39(5): 329. CrossRef - Therapeutic potential of propolis in alleviating inflammatory response and promoting wound healing in skin burn
Christian Oktavianus Manginstar, Trina Ekawati Tallei, Nurdjannah Jane Niode, Christina Leta Salaki, Sofia Safitri Hessel
Phytotherapy Research.2024; 38(2): 856. CrossRef - A review for non-antibiotic treatment of Helicobacter pylori: new insight
Neda Shadvar, Sousan Akrami, Seyyed-Mohammad-Amin Mousavi Sagharchi, Rafee Habib Askandar, Alireza Merati, Masoomeh Aghayari, Nikki Kaviani, Hamed Afkhami, Mojtaba Kashfi
Frontiers in Microbiology.2024;[Epub] CrossRef - Wound Healing, Anti-Inflammatory and Anti-Oxidant Activities, and Chemical Composition of Korean Propolis from Different Sources
Aman Dekebo, Chalshisa Geba, Daniel Bisrat, Jin Boo Jeong, Chuleui Jung
International Journal of Molecular Sciences.2024; 25(21): 11352. CrossRef - Effects of oxidative stress regulation in inflammation-associated gastric cancer progression treated using traditional Chinese medicines: A review
Bo Chen, Xinqian Dong, Jinlong Zhang, Wei Wang, Yujiao Song, Xitong Sun, Kangning Zhao, Zhen Sun
Medicine.2023; 102(46): e36157. CrossRef - Emodin Attenuates Inflammasome Activation Induced by Helicobacter pylori Infection through Inhibition of VacA Translocation
Thach Phan Van, Anh Duy Do
Microbiology and Biotechnology Letters.2023; 51(4): 507. CrossRef - Correlation between Chemical Profile of Georgian Propolis Extracts and Their Activity against Helicobacter pylori
Jarosław Widelski, Piotr Okińczyc, Katarzyna Suśniak, Anna Malm, Anna Bozhadze, Malkhaz Jokhadze, Izabela Korona-Głowniak
Molecules.2023; 28(3): 1374. CrossRef - Therapeutic effect of propolis nanoparticles on wound healing
Juan Yang, Yingjuan He, Sha Nan, Juan Li, Anjuan Pi, Lele Yan, Jinshan Xu, Yuhui Hao
Journal of Drug Delivery Science and Technology.2023; 82: 104284. CrossRef - Recent Update on the Anti-Inflammatory Activities of Propolis
Felix Zulhendri, Ronny Lesmana, Steven Tandean, Andreas Christoper, Kavita Chandrasekaran, Ilham Irsyam, Auliya A. Suwantika, Rizky Abdulah, Nasrul Wathoni
Molecules.2022; 27(23): 8473. CrossRef - Construction of a Cuprotosis-Related Gene-Based Model to Improve the Prognostic Evaluation of Patients with Gastric Cancer
Chunyan Han, Kai Zhang, XinKai Mo, Fu Wang
Journal of Immunology Research.2022; 2022: 1. CrossRef - Honey Bee Products: Preclinical and Clinical Studies of Their Anti-inflammatory and Immunomodulatory Properties
Hesham R. El-Seedi, Nehal Eid, Aida A. Abd El-Wahed, Mostafa E. Rateb, Hanan S. Afifi, Ahmed F. Algethami, Chao Zhao, Yahya Al Naggar, Sultan M. Alsharif, Haroon Elrasheid Tahir, Baojun Xu, Kai Wang, Shaden A. M. Khalifa
Frontiers in Nutrition.2022;[Epub] CrossRef - Plant-Based Polyphenols: Anti-Helicobacter pylori Effect and Improvement of Gut Microbiota
María Guerra-Valle, Patricio Orellana-Palma, Guillermo Petzold
Antioxidants.2022; 11(1): 109. CrossRef - DETERMINATION OF ANTI-UREASE ACTIVITY OF PROPOLIS FROM MARMARA REGION OF TURKEY
Zehra Can, Yakup Kara, Sevgi Kolaylı, İbrahim Çakmak
Uludağ Arıcılık Dergisi.2022; 22(1): 25. CrossRef - Nrf2 Downregulation Contributes to Epithelial-to-Mesenchymal Transition in Helicobacter pylori-Infected Cells
Sarah Bacon, Lornella Seeneevassen, Alison Fratacci, Faustine Rose, Camille Tiffon, Elodie Sifré, Maria M. Haykal, Maya M. Moubarak, Astrid Ducournau, Lucie Bruhl, Stéphane Claverol, Caroline Tokarski, Alina-Roxani Gouloumi, Ioannis S. Pateras, Thomas Dau
Cancers.2022; 14(17): 4316. CrossRef - Anti-Inflammatory Effect of Korean Propolis on Helicobacter pylori-Infected Gastric Mucosal Injury Mice Model
Moon-Young Song, Da-Young Lee, Young-Min Han, Eun-Hee Kim
Nutrients.2022; 14(21): 4644. CrossRef - Antifungal Properties of Chemically Defined Propolis from Various Geographical Regions
Marcin Ożarowski, Tomasz M. Karpiński, Rahat Alam, Małgorzata Łochyńska
Microorganisms.2022; 10(2): 364. CrossRef - The Antimicrobial Properties of Poplar and Aspen–Poplar Propolises and Their Active Components against Selected Microorganisms, including Helicobacter pylori
Jarosław Widelski, Piotr Okińczyc, Emil Paluch, Tomasz Mroczek, Jakub Szperlik, Magdalena Żuk, Zbigniew Sroka, Zuriyadda Sakipova, Ioanna Chinou, Krystyna Skalicka-Woźniak, Anna Malm, Izabela Korona-Głowniak
Pathogens.2022; 11(2): 191. CrossRef - Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing
Juan Yang, Anjuan Pi, Lele Yan, Juan Li, Sha Nan, Jing Zhang, Yuhui Hao, Juraj Majtan
Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1. CrossRef - "GREEN SYNTHESIS OF NANO-SILVER/SODIUM ALGINATE/CARBOXYMETHYL XANTHAN GUM HYDROGEL AND EVALUATION OF ITS ANTI-INFLAMMATORY AND ANTI-Helicobacter pylori ACTIVITY "
NOURA Y. ELMEHBAD, NADIA A. MOHAMED, NAHED A. ABD EL-GHANY, MARWA M. ABDEL-AZIZ
Cellulose Chemistry and Technology.2022; 56(9-10): 983. CrossRef - Propolis-Loaded Chitosan Nanoparticles for the Treatment of Bacterial Diarrhea: In Vitro and In Vivo Evaluation
Jie Qiao, Jun Yang, Saman Jalili
Journal of Biomedical Nanotechnology.2022; 18(7): 1826. CrossRef - Steamed Ginger Extract Exerts Anti-inflammatory Effects in Helicobacter pylori-infected Gastric Epithelial Cells through Inhibition of NF-κB
Moon-Young Song, Da-Young Lee, Sang-Yong Park, Seul-A Seo, Jeong-Seung Hwang, Soo-Hyeon Heo, Eun-Hee Kim
Journal of Cancer Prevention.2021; 26(4): 289. CrossRef - Short‐term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri‐implant mucositis: A double‐blind, randomized, clinical trial
José González‐Serrano, Rosa María López‐Pintor, Julia Serrano, Jesús Torres, Gonzalo Hernández, Mariano Sanz
Journal of Periodontal Research.2021; 56(5): 897. CrossRef - Experimental Evidence for Therapeutic Potentials of Propolis
Priyanshu Bhargava, Debajit Mahanta, Ashish Kaul, Yoshiyuki Ishida, Keiji Terao, Renu Wadhwa, Sunil C. Kaul
Nutrients.2021; 13(8): 2528. CrossRef - Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review
Porfirio Alonso Ruiz-Hurtado, Leticia Garduño-Siciliano, Pilar Domínguez-Verano, Daniela Balderas-Cordero, Gustavo Gorgua-Jiménez, Octavio Canales-Álvarez, María Margarita Canales-Martínez, Marco Aurelio Rodríguez-Monroy
Nutrients.2021; 13(9): 3169. CrossRef - Molecular Insights into the Antistress Potentials of Brazilian Green Propolis Extract and Its Constituent Artepillin C
Ashish Kaul, Raviprasad Kuthethur, Yoshiyuki Ishida, Keiji Terao, Renu Wadhwa, Sunil C. Kaul
Molecules.2021; 27(1): 80. CrossRef
- Propolis as an autophagy modulator in relation to its roles in redox balance and inflammation regulation
First
Prev
TOP
