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Review
MINIREVIEW] Overview: Replication of Porcine Reproductive and Respiratory Syndrome Virus
Sang-Im Yun , Young-Min Lee
J. Microbiol. 2013;51(6):711-723.   Published online December 19, 2013
DOI: https://doi.org/10.1007/s12275-013-3431-z
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AbstractAbstract
Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus that causes significant losses in the pig industry, is one of the most important animal pathogens of global significance. Since the discovery of the virus, significant progress has been made in understanding its epidemiology and transmission, but no adequate control measures are yet available to eliminate infection with this pathogen. The genome replication of PRRSV is required to reproduce, within a few hours of infection, the millions of progeny virions that establish, disseminate, and maintain infection. Replication of the viral RNA genome is a multistep process involving a replication complex that is formed not only from components of viral and cellular origin but also from the viral genomic RNA template; this replication complex is embedded within particular virus-induced membrane vesicles. PRRSV RNA replication is directed by at least 14 replicase proteins that have both common enzymatic activities, including viral RNA polymerase, and also unusual and poorly understood RNAprocessing functions. In this review, we summarize our current understanding of PRRSV replication, which is important for developing a successful strategy for the prevention and control of this pathogen.

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  • Mechanism of PRRSV infection and antiviral role of polyphenols
    Fructueux Modeste Amona, Yipeng Pang, Xingyu Gong, Yanhong Wang, Xingtang Fang, Chunlei Zhang, Xi Chen
    Virulence.2024;[Epub]     CrossRef
  • Unveiling Shared Immune Responses in Porcine Alveolar Macrophages during ASFV and PRRSV Infection Using Single-Cell RNA-seq
    Bo Jiang, Lu Li, Yu Wu, Xiaoying Wang, Ning Gao, Zhichao Xu, Chunhe Guo, Sheng He, Guihong Zhang, Yaosheng Chen, Xiaohong Liu, Zhengcao Li
    Microorganisms.2024; 12(3): 563.     CrossRef
  • A Comprehensive Review on Porcine Reproductive and Respiratory Syndrome Virus with Emphasis on Immunity
    Jorian Fiers, Ann Brigitte Cay, Dominiek Maes, Marylène Tignon
    Vaccines.2024; 12(8): 942.     CrossRef
  • Development of a Real-Time TaqMan RT-PCR Assay for the Detection of NADC34-like Porcine Reproductive and Respiratory Syndrome Virus
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    Veterinary Sciences.2023; 10(4): 279.     CrossRef
  • Research Progress of Porcine Reproductive and Respiratory Syndrome Virus NSP2 Protein
    Benjin Liu, Lingzhi Luo, Ziqi Shi, Houbin Ju, Lingxue Yu, Guoxin Li, Jin Cui
    Viruses.2023; 15(12): 2310.     CrossRef
  • Development of Polycistronic Baculovirus Surface Display Vectors to Simultaneously Express Viral Proteins of Porcine Reproductive and Respiratory Syndrome and Analysis of Their Immunogenicity in Swine
    Chao-Yu Hsu, Yun Jang, Wei-Ru Huang, Chi-Young Wang, Hsiao-Wei Wen, Pei-Chien Tsai, Cheng-Yao Yang, Muhammad Munir, Hung-Jen Liu
    Vaccines.2023; 11(11): 1666.     CrossRef
  • Bergamottin Inhibits PRRSV Replication by Blocking Viral Non-Structural Proteins Expression and Viral RNA Synthesis
    Zhenbang Zhu, Yuqian Xu, Lulu Chen, Meng Zhang, Xiangdong Li
    Viruses.2023; 15(6): 1367.     CrossRef
  • Pathogenicity Studies of NADC34-like Porcine Reproductive and Respiratory Syndrome Virus LNSY-GY and NADC30-like Porcine Reproductive and Respiratory Syndrome Virus GXGG-8011 in Piglets
    Hechao Zhu, Liuqing Wei, Xiangzu Liu, Shudan Liu, Huanchun Chen, Pin Chen, Xiangmin Li, Ping Qian
    Viruses.2023; 15(11): 2247.     CrossRef
  • Growth kinetics of an Indian isolate of highly pathogenic porcine reproductive and respiratory syndrome virus in MARC-145 cells
    Subbiah Kombiah, Dhanapal Senthilkumar, Manoj Kumar, Panickan Sivasankar, Vijendra P. Singh, Katherukamem Rajukumar
    VirusDisease.2022; 33(2): 208.     CrossRef
  • Host Cells Actively Resist Porcine Reproductive and Respiratory Syndrome Virus Infection via the IRF8-MicroRNA-10a-SRP14 Regulatory Pathway
    Zifang Zheng, Xiali Fu, Xue Ling, Huanhuan Sun, Yang Li, Zhiqian Ma, Bingjie Wei, Haixue Zheng, Shuqi Xiao, Bryan R.G. Williams
    Journal of Virology.2022;[Epub]     CrossRef
  • Genome-wide CRISPR/Cas9 screen identifies host factors important for porcine reproductive and respiratory syndrome virus replication
    Jinhe Jiang, Yumei Sun, Yunlong Wang, Ahmed Sabek, Aishao Shangguan, Kai Wang, Shuhong Zhao, Guoliang Li, Ao Zhou, Shujun Zhang
    Virus Research.2022; 314: 198738.     CrossRef
  • cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity
    Xiao-Na Liu, Li-Wei Li, Fei Gao, Yi-Feng Jiang, Wan-Zhe Yuan, Guo-Xin Li, Ling-Xue Yu, Yan-Jun Zhou, Guang-Zhi Tong, Kuan Zhao
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Porcine reproductive and respiratory syndrome virus genetic variability a management and diagnostic dilemma
    Jessica Risser, Matthew Ackerman, Robert Evelsizer, Stephen Wu, Byungjoon Kwon, James Mark Hammer
    Virology Journal.2021;[Epub]     CrossRef
  • Activation of Fc gamma receptor IIb up-regulates the production of interferon-alpha and interferon-gamma in porcine alveolar macrophages during PRRSV infection
    Liujun Zhang, Yuhao Xia, Wen Li, Yangyang Sun, Linghao Kong, Pengli Xu, Pingan Xia, Junming Yue
    Developmental & Comparative Immunology.2020; 109: 103696.     CrossRef
  • Screening of PRRSV- and ASFV-encoded proteins involved in the inflammatory response using a porcine iGLuc reporter
    Jie Song, Kang Li, Ting Li, Gaihong Zhao, Shijun Zhou, Huang Li, Jiangnan Li, Changjiang Weng
    Journal of Virological Methods.2020; 285: 113958.     CrossRef
  • Porcine reproductive and respiratory syndrome virus Nsp4 cleaves ZAP to antagonize its antiviral activity
    Yongxiang Zhao, Zhongbao Song, Juan Bai, Xuewei Liu, Hans Nauwynck, Ping Jiang
    Veterinary Microbiology.2020; 250: 108863.     CrossRef
  • Early infection of Streptococcus suis serotype 2 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome MLV-like virus in pigs
    Ying-Feng Sun, Xuan Jiang, Ao Zhang, Ji-Fei Ma, Xiao-Xue Yu, Liu-An Li, Hai Yu
    Research in Veterinary Science.2020; 130: 68.     CrossRef
  • Simultaneous detection of classical PRRSV, highly pathogenic PRRSV and NADC30-like PRRSV by TaqMan probe real-time PCR
    Wenbin Qiu, Kai Meng, Yanyan Liu, Yuyu Zhang, Zhao Wang, Zhi Chen, Jie Yang, Wenbo Sun, Lihui Guo, Sufang Ren, Lei Chen, Guiwen Yang, Fan Zhang, Jianli Shi, Jun Li, Yijun Du, Jiang Yu, Jiaqiang Wu
    Journal of Virological Methods.2020; 282: 113774.     CrossRef
  • Porcine reproductive and respiratory syndrome virus infection promotes C1QBP secretion to enhance inflammatory responses
    Yang Li, Ying Wei, Wanjun Hao, Wenkai Zhao, Yanrong Zhou, Dang Wang, Shaobo Xiao, Liurong Fang
    Veterinary Microbiology.2020; 241: 108563.     CrossRef
  • GSH-ZnS Nanoparticles Exhibit High-Efficiency and Broad-Spectrum Antiviral Activities via Multistep Inhibition Mechanisms
    Yanrong Zhou, Ting Tong, Xiaohan Jiang, Liurong Fang, Yuan Wu, Jiangong Liang, Shaobo Xiao
    ACS Applied Bio Materials.2020; 3(8): 4809.     CrossRef
  • A Field Recombinant Strain Derived from Two Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-1) Modified Live Vaccines Shows Increased Viremia and Transmission in SPF Pigs
    Julie Eclercy, Patricia Renson, Arnaud Lebret, Edouard Hirchaud, Valérie Normand, Mathieu Andraud, Frédéric Paboeuf, Yannick Blanchard, Nicolas Rose, Olivier Bourry
    Viruses.2019; 11(3): 296.     CrossRef
  • Involvement of PRRSV NSP3 and NSP5 in the autophagy process
    Wei Zhang, Keren Chen, Yang Guo, Yaosheng Chen, Xiaohong Liu
    Virology Journal.2019;[Epub]     CrossRef
  • Chlorine dioxide inhibits the replication of porcine reproductive and respiratory syndrome virus by blocking viral attachment
    Zhenbang Zhu, Yang Guo, Piao Yu, Xiaoying Wang, Xiaoxiao Zhang, Wenjuan Dong, Xiaohong Liu, Chunhe Guo
    Infection, Genetics and Evolution.2019; 67: 78.     CrossRef
  • Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)
    Sergio Montaner-Tarbes, Hernando A. del Portillo, María Montoya, Lorenzo Fraile
    Frontiers in Veterinary Science.2019;[Epub]     CrossRef
  • DDX5 RNA Helicases: Emerging Roles in Viral Infection
    Wenyu Cheng, Guohua Chen, Huaijie Jia, Xiaobing He, Zhizhong Jing
    International Journal of Molecular Sciences.2018; 19(4): 1122.     CrossRef
  • Spatiotemporal immunofluorescent evaluation of porcine reproductive and respiratory syndrome virus transmission across the maternal-fetal interface
    M Suleman, P Novakovic, C M Malgarin, S E Detmer, J C S Harding, D J MacPhee
    Pathogens and Disease.2018;[Epub]     CrossRef
  • Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection
    Taofeng Du, Yunpeng Shi, Shuqi Xiao, Na Li, Qin Zhao, Angke Zhang, Yuchen Nan, Yang Mu, Yani Sun, Chunyan Wu, Hongtao Zhang, En-Min Zhou
    BMC Veterinary Research.2017;[Epub]     CrossRef
  • Porcine reproductive and respiratory syndrome virus (PRRSV) up-regulates IL-8 expression through TAK-1/JNK/AP-1 pathways
    Yihao Liu, Yinping Du, Honglei Wang, Li Du, Wen-hai Feng
    Virology.2017; 506: 64.     CrossRef
  • Cellular DEAD-box RNA helicase 18 (DDX18) Promotes the PRRSV Replication via Interaction with Virus nsp2 and nsp10
    Huan Jin, Lei Zhou, Xinna Ge, Han Zhang, Ruimin Zhang, Cong Wang, Li Wang, Zhibang Zhang, Hanchun Yang, Xin Guo
    Virus Research.2017; 238: 204.     CrossRef
  • ORF1a of highly pathogenic PRRS attenuated vaccine virus plays a key role in neutralizing antibody induction in piglets and virus neutralization in vitro
    Chaoliang Leng, Wuchao Zhang, Hongliang Zhang, Yunchao Kan, Lunguang Yao, Hongyue Zhai, Mingliang Li, Zhen Li, Chunxiao Liu, Tongqing An, Jinmei Peng, Qian Wang, Yumin Leng, Xuehui Cai, Zhijun Tian, Guangzhi Tong
    Virology Journal.2017;[Epub]     CrossRef
  • Secondary Haemophilus parasuis infection enhances highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection-mediated inflammatory responses
    Jiangnan Li, Shengnan Wang, Changyao Li, Chunlai Wang, Yonggang Liu, Gang Wang, Xijun He, Liang Hu, Yuanyuan Liu, Mengmeng Cui, Caihong Bi, Zengyu Shao, Xiaojie Wang, Tao Xiong, Xuehui Cai, Li Huang, Changjiang Weng
    Veterinary Microbiology.2017; 204: 35.     CrossRef
  • Identification of a linear B-cell epitope on non-structural protein 12 of porcine reproductive and respiratory syndrome virus, using a monoclonal antibody
    Caihong Bi, Zengyu Shao, Yuanfeng Zhang, Liang Hu, Jiangnan Li, Li Huang, Changjiang Weng
    Archives of Virology.2017; 162(8): 2239.     CrossRef
  • Pyrithione inhibits porcine reproductive and respiratory syndrome virus replication through interfering with NF-κB and heparanase
    Chunhe Guo, Zhenbang Zhu, Xiaoying Wang, Yaosheng Chen, Xiaohong Liu
    Veterinary Microbiology.2017; 201: 231.     CrossRef
  • Influence of the amino acid residues at 70 in M protein of porcine reproductive and respiratory syndrome virus on viral neutralization susceptibility to the serum antibody
    Baochao Fan, Xing Liu, Juan Bai, Tingjie Zhang, Qiaoya Zhang, Ping Jiang
    Virology Journal.2016;[Epub]     CrossRef
  • The Attenuation Phenotype of a Ribavirin-Resistant Porcine Reproductive and Respiratory Syndrome Virus Is Maintained during Sequential Passages in Pigs
    Amina Khatun, Nadeem Shabir, Byoung-Joo Seo, Bum-Seok Kim, Kyoung-Jin Yoon, Won-Il Kim, S. Perlman
    Journal of Virology.2016; 90(9): 4454.     CrossRef
  • Matrine displayed antiviral activity in porcine alveolar macrophages co-infected by porcine reproductive and respiratory syndrome virus and porcine circovirus type 2
    Na Sun, Panpan Sun, Haipeng Lv, Yaogui Sun, Jianhua Guo, Zhirui Wang, Tiantian Luo, Shaoyu Wang, Hongquan Li
    Scientific Reports.2016;[Epub]     CrossRef
  • Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus Replication
    Jianyu Fang, Haiyan Wang, Juan Bai, Qiaoya Zhang, Yufeng Li, Fei Liu, Ping Jiang, Kui Li
    PLOS ONE.2016; 11(5): e0156513.     CrossRef
  • Preliminary Study on Prevalence, Risk Factor and Genetic Homogeneity of Porcine Reproductive and Respiratory Syndrome Virus in Registered Pig Farms in Heilongjiang, China
    J. Wang, H. Wen, S. Wang, W. Sun, N. Shen, Z. Liu, Y. Liu, Y. Liu, C. Jiang, G. Sun, F. Goutard, X. Cai
    Transboundary and Emerging Diseases.2016; 63(5): e369.     CrossRef
  • PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity
    Matthew A. Kappes, Kay S. Faaberg
    Virology.2015; 479-480: 475.     CrossRef
  • Generation of porcine reproductive and respiratory syndrome virus by in vitro assembly of viral genomic cDNA fragments
    Maman Suhardiman, Jarin Kramyu, Jaraspim Narkpuk, Anan Jongkaewwattana, Nanchaya Wanasen
    Virus Research.2015; 195: 1.     CrossRef
  • Regulation and evasion of antiviral immune responses by porcine reproductive and respiratory syndrome virus
    Chen Huang, Qiong Zhang, Wen-hai Feng
    Virus Research.2015; 202: 101.     CrossRef
  • Lipid rafts both in cellular membrane and viral envelope are critical for PRRSV efficient infection
    Qian Yang, Qiong Zhang, Jun Tang, Wen-hai Feng
    Virology.2015; 484: 170.     CrossRef
  • DRACO inhibits porcine reproductive and respiratory syndrome virus replication in vitro
    Chunhe Guo, Luxi Chen, Delin Mo, Yaosheng Chen, Xiaohong Liu
    Archives of Virology.2015; 160(5): 1239.     CrossRef
  • DDX19A Senses Viral RNA and Mediates NLRP3-Dependent Inflammasome Activation
    Jiangnan Li, Liang Hu, Yuanyuan Liu, Li Huang, Yang Mu, Xuehui Cai, Changjiang Weng
    The Journal of Immunology.2015; 195(12): 5732.     CrossRef
  • Effect of Nonstructural Protein 2 Hypervariable Regions in the Replication of Porcine Reproductive and Respiratory Syndrome Virus in Marc-145 Cells
    Ying Liu, Feng-Xue Wang, Yong-Jun Wen, Zhen-Guang Li, Xing Liu, Na Sun, Yong Yang, Shu-Qin Zhang, Hong-Wei Zhu, Shi-Peng Cheng, Hua Wu
    Intervirology.2015; 58(5): 288.     CrossRef
  • Different clinical, virological, serological and tissue tropism outcomes of two new and one old Belgian type 1 subtype 1 porcine reproductive and respiratory virus (PRRSV) isolates
    Ilias S Frydas, Ivan Trus, Lise K Kvisgaard, Caroline Bonckaert, Vishwanatha RAP Reddy, Yewei Li, Lars E Larsen, Hans J Nauwynck
    Veterinary Research.2015;[Epub]     CrossRef
  • Threonine and tryptophan supplementation enhance porcine respiratory and reproductive syndrome (PRRS) vaccine‐induced immune responses of growing pigs
    Shengyu Xu, Yingfei Zhao, Jie Shen, Yan Lin, Zhengfeng Fang, Lianqiang Che, De Wu
    Animal Science Journal.2015; 86(3): 294.     CrossRef

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