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- The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse
- Mei Ling Xu , Hyoung Jin Kim , Ga Ram Wi , Hong-Jin Kim
- J. Microbiol. 2015;53(9):661-666. Published online August 27, 2015
- DOI: https://doi.org/10.1007/s12275-015-5353-4
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- 20 Crossref
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Abstract
- Human respiratory syncytial virus (hRSV) is the most common cause of respiratory tract infection among young children because of immature T cell immunity of them against hRSV. CD8 T cells play a pivotal role in clearing hRSV and preventing subsequent infection. We examined the effects of dietary bovine colostrum on virus infection and CD8 T cell responses following hRSV infection in the mouse model. Mice received bovine colostrum for 14 days prior to hRSV challenge, and lung indexes (severity of symptom) and lung virus titers were analyzed. In addition, the activation of CD8 T cells in the bronchoalveolar lavage fluids (BALFs) of mice receiving bovine colostrum were compared with those in the BALFs of mice receiving phosphate-buffered saline (PBS) or ribavirin, post virus challenge. The severity of infection and lung virus titers were reduced in the mice receiving bovine colostrum, compared to those receiving PBS. Moreover CD8 T cell responses were selectively enhanced in the former. Our results suggest that dietary bovine colostrum exerts the effects to inhibit hRSV and ameliorate the symptom by hRSV infection, and enhances the CD8 T cell response during the hRSV infection.
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Citations
Citations to this article as recorded by
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- Bovine Colostrum: Unveiling its Potent Health Benefits and Emerging Trends in Optimizing Well-being
Journal Article
- The Effect of Dietary Intake of the Acidic Protein Fraction of Bovine Colostrum on Influenza A (H1N1) Virus Infection
- Mei Ling Xu , Hyoung Jin Kim , Don Yong Chang , Hong-Jin Kim
- J. Microbiol. 2013;51(3):389-393. Published online April 26, 2013
- DOI: https://doi.org/10.1007/s12275-013-2683-y
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- 6 Scopus
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Abstract
- Acidic protein levels in the milk decrease markedly as lactation progresses, suggesting that it is an important part of the colostrum. However, little attention has been paid to their biological function. In this study, we isolated the acidic protein fraction of bovine colostrum (AFC, isoelectric point <5) by anion-exchange chromatography, and investigated the effect of its dietary intake on influenza A (H1N1) virus infection. 100% of mice infected with 1 LD50 of the virus survived when administered AFC for 14 days prior to infection, compared with 33% survival when administered phosphate buffered saline (PBS). Moreover, consumption of AFC reduced the weight loss associated with infection. We propose that dietary intake of AFC has a prophylactic effect on influenza A virus infection.
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