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- A comprehensive review of SARS-CoV-2 genetic mutations and lessons from animal coronavirus recombination in one health perspective
- Woonsung Na , Hyoungjoon Moon , Daesub Song
- J. Microbiol. 2021;59(3):332-340. Published online February 23, 2021
- DOI: https://doi.org/10.1007/s12275-021-0660-4
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- 17 Web of Science
- 18 Crossref
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Abstract
- SARS-CoV-2 was originated from zoonotic coronaviruses and confirmed as a novel beta-coronavirus, which causes serious respiratory illness such as pneumonia and lung failure, COVID-19. In this review, we describe the genetic characteristics of SARS-CoV-2, including types of mutation, and molecular epidemiology, highlighting its key difference from animal coronaviruses. We further summarized the current knowledge on clinical, genetic, and pathological features of several animal coronaviruses and compared them with SARSCoV- 2, as well as recent evidences of interspecies transmission and recombination of animal coronaviruses to provide a better understanding of SARS-CoV-2 infection in One Health perspectives. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail, that may help mitigate the spread and damages caused by the disease.
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Citations
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Yas Al-Hadeethi, Intesar F. El Ramley, Hiba Mohammed, Abeer Z. Barasheed
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Tae-Hun Kim, Sojung Bae, Sunggeun Goo, Jinjong Myoung
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- IN SILICO COMPARATIVE ANALYSIS OF SARS-COV-2 MUTATIONS IN BRAZIL
Journal Article
- Claritromycin Resistance and Helicobacter pylori Genotypes in Italy
- Vincenzo De Francesco , Marcella Margiotta , Cesare Hassan , Nicola Della Valle , Osvaldo Burattini , Roberto D’Angelo , Giuseppe Stoppino , Ugo Cea , Floriana Giorgio , Rosa Monno , Sergio Morini , Carmine Panella , Enzo Ierardi
- J. Microbiol. 2006;44(6):660-664.
- DOI: https://doi.org/2460 [pii]
- 36 View
- 0 Download
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Abstract
- The relationship between H. pylori clarithromycin resistance and genetic pattern distribution has been differently explained from different geographic areas. Therefore, we aimed to assess the clarithromycin resistance rate, to evaluate the bacterial genetic pattern, and to search for a possible association between clarithromycin resistance and cagA or vacA genes. This prospective study enrolled 62 consecutive H. pylori infected patients. The infection was established by histology and rapid urease test. Clarithromycin resistance, cagA and vacA status, including s/m subtypes, were assessed on paraffin-embedded antral biopsy specimens by TaqMan real time polymerase chain reaction (PCR). Primary clarithromycin resistance was detected in 24.1% of cases. The prevalence of cagA was 69.3%, and a single vacA mosaicism was observed in 95.1% cases. In detail, the s1m1 was observed in 23 (38.9%) patients, the s1m2 in 22 (37.2%), and the s2m2 in 14 (23.7%), whereas the s2m1 combination was never found. The prevalence of cagA and the vacA alleles distribution did not significantly differ between susceptible and resistant strains. Primary clarithromycin resistance is high in our area. The s1m1 and s1m2 are the most frequent vacA mosaicisms. There is no a relationship between clarithromycin resistance and bacterial genotypic pattern and/or cagA positivity.
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