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- Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling
- Praveen Rai , Drista Sharma , Rani Soni , Nazia Khatoon , Bhaskar Sharma , Tarun Kumar Bhatt
- J. Microbiol. 2017;55(4):231-236. Published online March 1, 2017
- DOI: https://doi.org/10.1007/s12275-017-6525-1
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- 6 Crossref
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Abstract
- Malaria has been present since ancient time and remains a major global health problem in developing countries. Plas-modium falciparum belongs to the phylum Apicomplexan, largely contain disease-causing parasites and characterized by the presence of apicoplast. It is a very essential organelle of P. falciparum responsible for the synthesis of key mole-cules required for the growth of the parasite. Indispensable nature of apicoplast makes it a potential drug target. Calcium signaling is important in the establishment of malaria para-site inside the host. It has been involved in invasion and egress of merozoites during the asexual life cycle of the parasite. Calcium signaling also regulates apicoplast metabolism. There-fore, in this review, we will focus on the role of apicoplast in malaria biology and its metabolic regulation through Ca++ signaling.
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Citations
Citations to this article as recorded by
- The genetically encoded calcium indicator GCaMP3 reveals spontaneous calcium oscillations at asexual stages of the human malaria parasite Plasmodium falciparum
Benedito M. dos Santos, Mateus F. Pecenin, Lucas Borges-Pereira, Eric Springer, Jude M. Przyborski, David C. Martins-Jr, Ronaldo F. Hashimoto, Célia R.S. Garcia
Molecular and Biochemical Parasitology.2024; 260: 111650. CrossRef - The interaction between free Ca2+ in host cells and invasion of E. tenella
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SSRN Electronic Journal .2022;[Epub] CrossRef - The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites
Yash Gupta, Steven Goicoechea, Catherine M. Pearce, Raman Mathur, Jesus G. Romero, Samuel K. Kwofie, Matthew C. Weyenberg, Bharathi Daravath, Neha Sharma, Poonam, Hoseah M. Akala, Stefan M. Kanzok, Ravi Durvasula, Brijesh Rathi, Prakasha Kempaiah
Medicinal Research Reviews.2022; 42(1): 56. CrossRef - Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review
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Asia Pacific Journal of Molecular Biology and Biotechnology.2019; : 38. CrossRef
- The genetically encoded calcium indicator GCaMP3 reveals spontaneous calcium oscillations at asexual stages of the human malaria parasite Plasmodium falciparum
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