The coronavirus disease 2019 (COVID-19) pandemic has
underscored the lack of approved drugs against acute viral
diseases. Plants are considered inexhaustible sources of drugs
for several diseases and clinical conditions, but plant-derived
compounds have seen little success in the field of antivirals.
Here, we present the case for the use of compounds from vascular
plants, including alkaloids, flavonoids, polyphenols,
and tannins, as antivirals, particularly for the treatment of
COVID-19. We review current evidence for the use of these
phytochemicals against SARS-CoV-2 infection and present
their potential targets in the SARS-CoV-2 replication cycle.
Citations
Citations to this article as recorded by
Role of dietary supplements in the continuous battle against COVID‐19 Rahela Zaman, Vignesh Ravichandran, Chung Keat Tan Phytotherapy Research.2024; 38(2): 1071. CrossRef
The Potential of Anti-coronavirus Plant Secondary Metabolites in COVID-19 Drug Discovery as an Alternative to Repurposed Drugs: A Review Zahra Alipour, Somayeh Zarezadeh, Ali Akbar Ghotbi-Ravandi Planta Medica.2024; 90(03): 172. CrossRef
In Silico Screening of Some Active Phytochemicals to Identify Promising
Inhibitors Against SARS-CoV-2 Targets V. Alagarsamy, V. Raja Solomon, S. Murugesan, P. Shyam Sundar, MD. Muzaffar-Ur-Rehman, A. Chandu, A. Dharshini Aishwarya, B. Narendhar, M.T. Sulthana, V. Ravikumar Current Drug Discovery Technologies.2024;[Epub] CrossRef
Screening Commercial Tea for Rapid Inactivation of Infectious SARS-CoV-2 in Saliva Julianna N. Morris, Malak A. Esseili Food and Environmental Virology.2024; 16(2): 159. CrossRef
Phytochemical-loaded Nanoparticles in COVID-19 Management Suneetha Vuppu, Toshika Mishra, Shatakshi Mishra, Stany B, Anushka Das Natural Resources for Human Health.2023; 4(1): 51. CrossRef
Nutritional deficiencies that may predispose to long COVID John V. Schloss Inflammopharmacology.2023; 31(2): 573. CrossRef
Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review Lucas Fornari Laurindo, Gabriel Magno de Carvalho, Bárbara de Oliveira Zanuso, Maria Eduardo Figueira, Rosa Direito, Ricardo de Alvares Goulart, Daiene Santos Buglio, Sandra Maria Barbalho Pharmaceutics.2023; 15(1): 229. CrossRef
Changes in phytochemical compositions and antioxidant activity of Schisandra sphenathera fruit during ripening Bohan Ma, Xinghua Zhao, Bin Dai, Mengge Zhao, Xingbin Yang, Langjun Cui, Hongjun Shao Industrial Crops and Products.2023; 199: 116773. CrossRef
Role of nutrition in minimizing mental and health-related issues during COVID-19: a systematic literature review Luxita Sharma, Dhananjay Sharma Nutrition & Food Science.2023; 53(4): 659. CrossRef
Current Update of Phytotherapeutic Agents in the Treatment of COVID-19: In-Silico Based Virtual Screening Approach for the Development of Antiviral Drug Veena Ramesh, Seema A. Kulkarni, Palaniyandi Velusamy, Velmurugan Devadasan, Panneer Devaraju, Kandathil Narayanan Rajnish, Thirumurthy Madhavan, Periasamy Anbu, Palaniappan Ramasamy, Rajamanikandan Sundarraj Frontiers in Bioscience-Landmark.2022;[Epub] CrossRef
Promising natural products against SARS‐CoV‐2: Structure, function, and clinical trials Yan Zhao, Shanshan Deng, Yujiao Bai, Jinlin Guo, Guoyin Kai, Xinhe Huang, Xu Jia Phytotherapy Research.2022; 36(10): 3833. CrossRef
Effective food hygiene principles and dietary intakes to reinforce the immune system for prevention of COVID-19: a systematic review Jalaledin Mirzay-Razaz, Majid Hassanghomi, Marjan Ajami, Glareh Koochakpoor, Firoozeh Hosseini-Esfahani, Parvin Mirmiran BMC Nutrition.2022;[Epub] CrossRef
Beneficial effect of polyphenols in COVID‐19 and the ectopic F1FO‐ATP synthase: Is there a link? Isabella Panfoli, Alfonso Esposito Journal of Cellular Biochemistry.2022; 123(8): 1281. CrossRef
In vitro inhibition of SARS-CoV-2 Infection by dry algae powders Daniel Garcia-Ruiz, Erendira Villalobos-Sánchez, David Alam-Escamilla, Darwin Elizondo-Quiroga Scientific Reports.2022;[Epub] CrossRef
Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2 Te-Kai Sun, Wen-Chin Huang, Yu-Wen Sun, Jeng-Shyan Deng, Liang-Hsuan Chien, Ya-Ni Chou, Wen-Ping Jiang, Jaung-Geng Lin, Guan-Jhong Huang International Journal of Molecular Sciences.2022; 23(23): 14766. CrossRef
An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations Shiv Kumar Prajapati, Akanksha Malaiya, Gaurav Mishra, Dolly Jain, Payal Kesharwani, Nishi Mody, Amirhossein Ahmadi, Rishi Paliwal, Ankit Jain Journal of Ethnopharmacology.2022; 296: 115420. CrossRef
Computational screening for investigating the synergistic regulatory potential of drugs and phytochemicals in combination with 2-deoxy-D-glucose against SARS-CoV-2 Anshika Gupta, Shweta Singh Chauhan, Anamika Singh Gaur, Ramakrishnan Parthasarathi Structural Chemistry.2022; 33(6): 2179. CrossRef
BOTANICALS AS PROSPECTIVE AGENTS AGAINST SARS-COV-2 VIRUS V. DUSHENKOV, A. DUSHENKOV AVICENNA BULLETIN.2022; 24(1): 113. CrossRef