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- Limiting the pathogenesis of Salmonella Typhimurium with berry phenolic extracts and linoleic acid overproducing Lactobacillus casei
- Zajeba Tabashsum , Mengfei Peng , Cassendra Bernhardt , Puja Patel , Michael Carrion , Shaik O. Rahaman , Debabrata Biswas
- J. Microbiol. 2020;58(6):489-498. Published online April 22, 2020
- DOI: https://doi.org/10.1007/s12275-020-9545-1
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- 6 Web of Science
- 5 Crossref
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Abstract
- The growing threat of emergent multidrug-resistant enteric bacterial pathogens, and their adopted virulence properties are directing to find alternative antimicrobials and/or development of dietaries that can improve host gut health and/or defense. Recently, we found that modified Lactobacillus casei (Lc + CLA) with increased production of conjugated linoleic acid has antimicrobial and other beneficial properties. Further, prebiotic alike products such as berry pomace extracts (BPEs), increase the growth of probiotics and inhibit the growth of certain bacterial pathogens. In this study, we evaluated the antibacterial effect of genetically modified Lc + CLA along with BPEs against major enteric pathogen Salmonella enterica serovar Typhimurium (ST). In mixed culture condition, the growth of ST was significantly reduced in the presence of Lc + CLA and/or BPEs. Bacterial cell-free cultural supernatant (CFCS) collected from wild-type Lc or modified Lc + CLA strains also inhibited the growth and survival of ST, and those inhibitory effects were enhanced in the presence of BPEs. We also found that the interaction of the pathogen with cultured host (HD-11 and INT-407) cells were also altered in the presence of either Lc or Lc + CLA strain or their CFCSs significantly. Furthermore, the relative expression of genes related to ST virulence and physicochemical properties of ST was altered by the effect of CFCSs of either Lc or Lc + CLA. These findings indicate that a diet containing synbiotic, specifically linoleic acid, over-produced Lc + CLA and prebiotic product BPEs, might have the potential to be effective in controlling ST growth and pathogenesis.
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Citations
Citations to this article as recorded by
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Natural anti-adhesive components against pathogenic bacterial adhesion and infection in gastrointestinal tract: case studies of
Helicobacter pylori
,
Salmonella enterica
,
Clostridiu
Xiaoyu Bao, Jianping Wu
Critical Reviews in Food Science and Nutrition.2024; : 1. CrossRef - Combined effect of metabolites produced by a modified Lactobacillus casei and berry phenolic extract on Campylobacter and microbiome in chicken cecum contents
Zajeba Tabashsum, Zabdiel Alvarado‐Martinez, Matthew J. Wall, Arpita Aditya, Debabrata Biswas
Journal of Food Science.2023; 88(6): 2583. CrossRef - Intracellular autolytic whole cell Salmonella vaccine prevents colonization of pathogenic Salmonella Typhimurium in chicken
Mengfei Peng, Jungsoo Joo, Zabdiel Alvarado-Martinez, Zajeba Tabashsum, Arpita Aditya, Debabrata Biswas
Vaccine.2022; 40(47): 6880. CrossRef - Lactobacilli, a Weapon to Counteract Pathogens through the Inhibition of Their Virulence Factors
Andrea Colautti, Elisabetta Orecchia, Giuseppe Comi, Lucilla Iacumin, Laurie E. Comstock
Journal of Bacteriology.2022;[Epub] CrossRef -
Florfenicol Enhances Colonization of a Salmonella enterica Serovar Enteritidis
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Mutant with Major Alterations to the Intestinal Microbiota and Metabolome in Neonatal Chickens
Xueran Mei, Boheng Ma, Xiwen Zhai, Anyun Zhang, Changwei Lei, Lei Zuo, Xin Yang, Changyu Zhou, Hongning Wang, Johanna Björkroth
Applied and Environmental Microbiology.2021;[Epub] CrossRef
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Natural anti-adhesive components against pathogenic bacterial adhesion and infection in gastrointestinal tract: case studies of
Helicobacter pylori
,
Salmonella enterica
,
Clostridiu
Review
- MINIREVIEW] Development of bacteria as diagnostics and therapeutics by genetic engineering
- Daejin Lim , Miryoung Song
- J. Microbiol. 2019;57(8):637-643. Published online May 11, 2019
- DOI: https://doi.org/10.1007/s12275-019-9105-8
- 46 View
- 0 Download
- 15 Web of Science
- 13 Crossref
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Abstract
- Bacteria sense and respond to the environment, communicate, and continuously interact with their surroundings, including host bodies. For more than a century, engineers have been trying to harness the natural ability of bacteria as live biotherapeutics for the treatment of diseases. Recent advances in synthetic biology facilitate the enlargement of the repertoire of genetic parts, tools, and devices that serve as a framework for biotherapy. This review describes bacterial species developed for specific diseases shown in in vitro studies and clinical stages. Here, we focus on drug delivery by programing bacteria and discuss the challenges for safety and improvement.
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Citations
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Xia Lin, Rong Jiao, Haowen Cui, Xuebing Yan, Kun Zhang
Advanced Science.2024;[Epub] CrossRef - Intestinal Delivery of Probiotics: Materials, Strategies, and Applications
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Advanced Materials.2024;[Epub] CrossRef - Research and application of intelligent diagnosis and treatment engineering bacteria
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Frontiers in Bioengineering and Biotechnology.2024;[Epub] CrossRef - Gastrointestinal worms and bacteria: From association to intervention
James Rooney, Cinzia Cantacessi, Javier Sotillo, Alba Cortés
Parasite Immunology.2023;[Epub] CrossRef - Bacterial Therapy of Cancer: A Way to the Dustbin of History or to the Medicine of the Future?
Larisa N. Ikryannikova, Neonila V. Gorokhovets, Darya A. Belykh, Leonid K. Kurbatov, Andrey A. Zamyatnin
International Journal of Molecular Sciences.2023; 24(11): 9726. CrossRef - Derivation and elimination of uremic toxins from kidney-gut axis
Ying Xu, Wen-Di Bi, Yu-Xuan Shi, Xin-Rui Liang, Hai-Yan Wang, Xue-Li Lai, Xiao-Lu Bian, Zhi-Yong Guo
Frontiers in Physiology.2023;[Epub] CrossRef - Decorated bacteria and the application in drug delivery
Feng Wu, Jinyao Liu
Advanced Drug Delivery Reviews.2022; 188: 114443. CrossRef - Bakterie Modyfikowane Genetycznie – Perspektywy Zastosowania w Profilaktyce, Diagnostyce I Terapii
Barbara Macura, Aneta Kiecka, Marian Szczepanik
Postępy Mikrobiologii - Advancements of Microbiology.2022; 61(1): 21. CrossRef - Bacteria and cells as alternative nano-carriers for biomedical applications
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Expert Opinion on Drug Delivery.2022; 19(1): 103. CrossRef -
Tabrizicola piscis sp. nov., isolated from the intestinal tract of a Korean indigenous freshwater fish, Acheilognathus koreensis
Jeong Eun Han, Woorim Kang, June-Young Lee, Hojun Sung, Dong-Wook Hyun, Hyun Sik Kim, Pil Soo Kim, Euon Jung Tak, Yun-Seok Jeong, Jae-Yun Lee, So-Yeon Lee, Ji-Hyun Yun, Mi-Ja Jung, Na-Ri Shin, Tae Woong Whon, Myung-Suk Kang, Ki-Eun Lee, Byoung-Hee Lee, Ji
International Journal of Systematic and Evolutionary Microbiology .2020; 70(4): 2305. CrossRef - Novel Strategies for Efficient Production and Delivery of Live Biotherapeutics and Biotechnological Uses of Lactococcus lactis: The Lactic Acid Bacterium Model
Laísa M. Tavares, Luís C. L. de Jesus, Tales F. da Silva, Fernanda A. L. Barroso, Viviane L. Batista, Nina D. Coelho-Rocha, Vasco Azevedo, Mariana M. Drumond, Pamela Mancha-Agresti
Frontiers in Bioengineering and Biotechnology.2020;[Epub] CrossRef
- Engineered Microorganisms for Advancing Tumor Therapy
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