Abstract
Bacteria sense and respond to the environment, communicate,
and continuously interact with their surroundings, including
host bodies. For more than a century, engineers have been
trying to harness the natural ability of bacteria as live biotherapeutics
for the treatment of diseases. Recent advances in synthetic
biology facilitate the enlargement of the repertoire of
genetic parts, tools, and devices that serve as a framework for
biotherapy. This review describes bacterial species developed
for specific diseases shown in in vitro studies and clinical stages.
Here, we focus on drug delivery by programing bacteria and
discuss the challenges for safety and improvement.
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