MINIREVIEW] Development of bacteria as diagnostics and therapeutics by genetic engineering

Daejin Lim; Miryoung Song

doi:10.1007/s12275-019-9105-8

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MINIREVIEW] Development of bacteria as diagnostics and therapeutics by genetic engineering: Daejin Lim ¹, Miryoung Song ²; Journal of Microbiology 2019;57(8):637-643.
DOI: https://doi.org/10.1007/s12275-019-9105-8
Published online: May 11, 2019

¹Department of Molecular Medicine (BK21plus), Chonnam National University Graduate School, Gwangju 61186, Republic of Korea, ²Department of Bioscience and Biotechnology, Hankuk University of Foreign Studies, Yongin 17035, Republic of Korea¹Department of Molecular Medicine (BK21plus), Chonnam National University Graduate School, Gwangju 61186, Republic of Korea, ²Department of Bioscience and Biotechnology, Hankuk University of Foreign Studies, Yongin 17035, Republic of Korea

Corresponding author: Miryoung Song , Tel: +82-31-330-4714,

Received: 27 February 2019 • Revised: 8 April 2019 • Accepted: 11 April 2019

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Abstract

Bacteria sense and respond to the environment, communicate, and continuously interact with their surroundings, including host bodies. For more than a century, engineers have been trying to harness the natural ability of bacteria as live biotherapeutics for the treatment of diseases. Recent advances in synthetic biology facilitate the enlargement of the repertoire of genetic parts, tools, and devices that serve as a framework for biotherapy. This review describes bacterial species developed for specific diseases shown in in vitro studies and clinical stages. Here, we focus on drug delivery by programing bacteria and discuss the challenges for safety and improvement.

Keywords: live biotherapy;drug delivery;synthetic biology;engineered bacteria

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MINIREVIEW] Development of bacteria as diagnostics and therapeutics by genetic engineering

J. Microbiol. 2019;57(8):637-643. Published online May 11, 2019

DOI: https://doi.org/10.1007/s12275-019-9105-8

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