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- Host–microbial interactions in metabolic diseases: from diet to immunity
- Ju-Hyung Lee , Joo-Hong Park
- J. Microbiol. 2022;60(6):561-575. Published online May 5, 2022
- DOI: https://doi.org/10.1007/s12275-022-2087-y
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- 5 Web of Science
- 4 Crossref
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Abstract
- Growing evidence suggests that the gut microbiome is an important contributor to metabolic diseases. Alterations in microbial communities are associated with changes in lipid metabolism, glucose homeostasis, intestinal barrier functions, and chronic inflammation, all of which can lead to metabolic disorders. Therefore, the gut microbiome may represent a novel therapeutic target for obesity, type 2 diabetes, and nonalcoholic fatty liver disease. This review discusses how gut microbes and their products affect metabolic diseases and outlines potential treatment approaches via manipulation of the gut microbiome. Increasing our understanding of the interactions between the gut microbiome and host metabolism may help restore the healthy symbiotic relationship between them.
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Citations
Citations to this article as recorded by
- Fecal Microbiota Transplantation: Indications, Methods, and Challenges
Jee Young Lee, Yehwon Kim, Jiyoun Kim, Jiyeun Kate Kim
Journal of Microbiology.2024; 62(12): 1057. CrossRef - Galectin-4 increases the ability of M2 macrophages to enhance antiviral CD4+ T-cell responses
In-Gu Lee, Yong-Hyun Joo, Hoyeon Jeon, Raehyuk Jeong, Eui Ho Kim, Hyunwoo Chung, Seong-il Eyun, Jeongkyu Kim, Young-Jin Seo, So-Hee Hong
Journal of Leukocyte Biology.2023; 113(1): 71. CrossRef - Microencapsulation of Bacteriophages for the Delivery to and Modulation of the Human Gut Microbiota through Milk and Cereal Products
Christina Schubert, Sabina Fischer, Kathrin Dorsch, Lutz Teßmer, Jörg Hinrichs, Zeynep Atamer
Applied Sciences.2022; 12(13): 6299. CrossRef - Beta-Glucan Alters Gut Microbiota and Plasma Metabolites in Pre-Weaning Dairy Calves
Zhengzhong Luo, Li Ma, Tao Zhou, Yixin Huang, Liben Zhang, Zhenlong Du, Kang Yong, Xueping Yao, Liuhong Shen, Shumin Yu, Xiaodong Shi, Suizhong Cao
Metabolites.2022; 12(8): 687. CrossRef
- Fecal Microbiota Transplantation: Indications, Methods, and Challenges
Research Support, Non-U.S. Gov't
- Protein-Protein Interactions between Histidine Kinases and Response Regulators of Mycobacterium tuberculosis H37Rv
- Ha-Na Lee , Kwang-Eun Jung , In-Jeong Ko , Hyung Suk Baik , Jeong-Il Oh
- J. Microbiol. 2012;50(2):270-277. Published online April 27, 2012
- DOI: https://doi.org/10.1007/s12275-012-2050-4
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- 0 Download
- 22 Crossref
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Abstract
- Using yeast two-hybrid assay, we investigated protein-protein interactions between all orthologous histidine kinase (HK)/response regulator (RR) pairs of M. tuberculosis H37Rv and identified potential protein-protein interactions between a noncognate HK/RR pair, DosT/NarL. The protein interaction between DosT and NarL was verified by phosphotransfer reaction from DosT to NarL. Furthermore, we found that the DosT and DosS HKs, which share considerable sequence similarities to each other and form a twocomponent system with the DosR RR, have different crossinteraction capabilities with NarL: DosT interacted with NarL, while DosS did not. The dimerization domains of DosT and DosS were shown to be sufficient to confer specificity for DosR, and the different cross-interaction abilities of DosS and DosT with NarL were demonstrated to be attributable to variations in the amino acid sequences of the α2-helices of their dimerization domains.
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Citations
Citations to this article as recorded by- Modulators targeting protein-protein interactions in Mycobacterium tuberculosis
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- Modulators targeting protein-protein interactions in Mycobacterium tuberculosis
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