Journal of Microbiology

Full article

Antiviral effects of heme oxygenase-1 against canine coronavirus and canine influenza virus in vitro: Jae-Hyeong Kim, Dong-Hwi Kim, Kyu-Beom Lim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Dong-Hun Lee, Do-Geun Kim, Hun-Young Yoon, In-Soo Choi; J. Microbiol. 2025;63(5):e2501029. Published online May 27, 2025; DOI: https://doi.org/10.71150/jm.2501029

142 View
9 Download

Abstract PDF Supplementary Material: Heme oxygenase-1 (HO-1) has antioxidant, anti-apoptotic, and anti-inflammatory properties. Emerging evidence shows that HO-1 also exhibits antiviral activity against severe acute respiratory syndrome coronavirus 2, human immunodeficiency virus, hepatitis B virus, and Ebola virus. Its antiviral effects are mediated not only by its enzymatic function but also through the modulation of interferon-related pathways, thereby inhibiting viral replication. In this study, we investigated the antiviral effects of HO-1 on canine coronavirus (CCoV) and canine influenza virus (CIV) H3N2 using cell-based assays. To determine whether HO-1 suppresses CCoV and CIV, cells were treated with hemin to induce HO-1 expression. Hemin treatment successfully induced HO-1 expression in A72 and Madin-Darby canine kidney cells, resulting in the suppression of CCoV and CIV replication. The canine HO-1 gene was cloned into an expression vector and transfected into cells to achieve transient overexpression. Recombinant canine HO-1 protein was expressed in Escherichia coli and purified using an expression vector. HO-1 overexpression suppressed CCoV and CIV replication in cells. Following viral infection, treatment with purified HO-1 protein led to a reduction in viral protein levels. Therefore, both HO-1 expression and exogenous protein treatment effectively inhibited CCoV and CIV replication. Elevated HO-1 protein levels consistently reduced viral RNA and protein expression in vitro. These findings suggest that HO-1 could serve as a potential therapeutic agent for managing viral infections in dogs.

Research Article

Korean Red ginseng enhances ZBP1-mediated cell death to suppress viral protein expression in host defense against Influenza A virus: Jueun Oh, Hayeon Kim, Jihye Lee, Suhyun Kim, Seyun Shin, Young-Eui Kim, Sehee Park, SangJoon Lee; J. Microbiol. 2025;63(1):e.2409007. Published online January 24, 2025; DOI: https://doi.org/10.71150/jm.2409007

900 View
80 Download

Abstract PDF Supplementary Material: Korean Red ginseng has emerged as a potent candidate in the fight against various viral infections, demonstrating significant efficacy both in vitro and in vivo, particularly against influenza A viruses. Despite substantial evidence of its antiviral properties, the detailed molecular mechanisms through which it reduces viral lethality remain insufficiently understood. Our investigations have highlighted the superior effectiveness of Korean Red ginseng against influenza viruses, outperforming its effects on numerous other viral strains. We aim to uncover the specific mechanisms by which Korean Red ginseng exerts its antiviral effects, focusing on influenza A viruses. Our prior studies have identified the role of Z-DNA-binding protein 1 (ZBP1), a signaling complex involved in inducing programmed cell death in response to influenza virus infection. Given the critical role of ZBP1 as a sensor for viral nucleic acid, we hypothesize that Korean Red ginseng may modulate the ZBP1-derived cell death pathway. This interaction is anticipated to enhance cell death while concurrently suppressing viral protein expression, offering novel insights into the antiviral mechanism of Korean Red ginseng against influenza A viruses.

Journal Articles

NEDD4 Regulated Pyroptosis Occurred from Co‑infection between Influenza A Virus and Streptococcus pneumoniae: Jiangzhou You , Linlin Zhou , Xudong San , Hailing Li , Mingyuan Li , Baoning Wang; J. Microbiol. 2023;61(8):777-789. Published online October 4, 2023; DOI: https://doi.org/10.1007/s12275-023-00076-y

71 View
0 Download
5 Web of Science
3 Crossref

Abstract

Co-infection of respiratory tract viruses and bacteria often result in excess mortality, especially pneumonia caused by influenza viruses and Streptococcus pneumoniae. However, the synergistic mechanisms remain poorly understood. Therefore, it is necessary to develop a clearer understanding of the molecular basis of the interaction between influenza virus and Streptococcus pneumonia. Here, we developed the BALB/c mouse model and the A549 cell model to investigate inflammation and pyroptotic cell death during co-infection. Co-infection significantly activated the NLRP3 inflammasome and induced pyroptotic cell death, correlated with excess mortality. The E3 ubiquitin ligase NEDD4 interacted with both NLRP3 and GSDMD, the executor of pyroptosis. NEDD4 negatively regulated NLRP3 while positively regulating GSDMD, thereby modulating inflammation and pyroptotic cell death. Our findings suggest that NEDD4 may play a crucial role in regulating the GSDMD-mediated pyroptosis signaling pathway. Targeting NEDD4 represents a promising approach to mitigate excess mortality during influenza pandemics by suppressing synergistic inflammation during co-infection of influenza A virus and Streptococcus pneumoniae.

Citations

Citations to this article as recorded by

Yinqin Qingfei granules alleviate Mycoplasma pneumoniae pneumonia via inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis
Zhe Song, Chengen Han, Guangzhi Luo, Guangyuan Jia, Xiao Wang, Baoqing Zhang
Frontiers in Pharmacology.2024;[Epub] CrossRef
Overexpression of DTX1 inhibits D-GalN/TNF-α-induced pyroptosis and inflammation in hepatocytes by regulating NLRP3 ubiquitination
Mingshui Liu, Jing Gu, Li Chen, Wei Sun, Xiaoping Huang, Jianhe Gan
Toxicology Research.2024;[Epub] CrossRef
NLRP3 Inflammasomes: Dual Function in Infectious Diseases
Yanbo Li, Rui Qiang, Zhengmin Cao, Qingjuan Wu, Jiuchong Wang, Wenliang Lyu
The Journal of Immunology.2024; 213(4): 407. CrossRef

Correlation between fat accumulation and fecal microbiota in crossbred pigs: Xin Li , Mengyu Li , Jinyi Han , Chuang Liu , Xuelei Han , Kejun Wang , Ruimin Qiao , Xiu-Ling Li , Xin-Jian Li; J. Microbiol. 2022;60(11):1077-1085. Published online September 9, 2022; DOI: https://doi.org/10.1007/s12275-022-2218-5

90 View
0 Download
4 Web of Science
3 Crossref

Abstract

Backfat thickness (BF) is an important indicator of fat deposition capacity and lean meat rate in pigs and is very important in porcine genetics and breeding. Intestinal microbiota plays a key role in nutrient digestion and utilization with a profound impact on fat deposition of livestock animals. To investigate the relationship between the pig gut microbiome and BF, 20 low-BF (L-BF) and 20 high-BF (H-BF) pigs were selected as two groups from Yunong Black pigs in the present study. Fecal samples from pigs were analyzed for microbial diversity, composition, and predicted functionality using 16S rRNA gene sequencing. The results showed that there were significant differences in microbial β diversity between the two groups. LEfSe analysis revealed a number of bacterial features being differentially enriched in either L-BF or H-BF pigs. Spearman correlation analysis identified the abundance of Oscillospira, Peptococcus, and Bulleidia were significantly positive correlations with BF (P < 0.05), while Sutterella and Bifidobacterium were significantly negatively correlated with BF (P < 0.05). Importantly, the bacteria significantly positively correlated with BF mainly belong to Clostridium, which can ferment host-indigestible plant polysaccharides into shortchain fatty acid (SCFA) and promote fat synthesis and deposition. Predictive functional analysis indicated that the pathway abundance of cell motility and glycan biosynthesis were significantly widespread in the microbiota of the H-BF group. The results of this study will be useful for the development of microbial biomarkers for predicting and improving porcine BF, as well as for the investigation of targets for dietary strategies.

Citations

Citations to this article as recorded by

Carboxymethyl chitosan-dialdehyde glucan/polydopamine carrier targeted delivery Bacillus subtilis on enhancing oral utilization and intestinal colonization in mice
Lulu Chu, Luyu Xie, Bingzhi Chen, Yuji Jiang, Wenjie Wang
International Journal of Biological Macromolecules.2024; 280: 135574. CrossRef
Impact of Early Weaning on Development of the Swine Gut Microbiome
Benoit St-Pierre, Jorge Yair Perez Palencia, Ryan S. Samuel
Microorganisms.2023; 11(7): 1753. CrossRef
Comparison of Conjunctival Sac Microbiome between Low and High Myopic Eyes
Kang Xiao, Zhengyu Chen, Qin Long
Journal of Microbiology.2023; 61(5): 571. CrossRef

Vibrio vulnificus PlpA facilitates necrotic host cell death induced by the pore forming MARTX toxin: Changyi Cho , Sanghyeon Choi , Myung Hee Kim , Byoung Sik Kim; J. Microbiol. 2022;60(2):224-233. Published online February 1, 2022; DOI: https://doi.org/10.1007/s12275-022-1448-x

76 View
0 Download
10 Web of Science
6 Crossref

Abstract

Opportunistic pathogen Vibrio vulnificus causes severe systemic infection in humans with high mortality. Although multiple exotoxins have been characterized in V. vulnificus, their interactions and potential synergistic roles in pathogen-induced host cell death have not been investigated previously. By employing a series of multiple exotoxin deletion mutants, we investigated whether specific exotoxins of the pathogen functioned together to achieve severe and rapid necrotic cell death. Human epithelial cells treated with V. vulnificus with a plpA deletion background exhibited an unusually prolonged cell blebbing, suggesting the importance of PlpA, a phospholipase A2, in rapid necrotic cell death by this pathogen. Additional deletion of the rtxA gene encoding the multifunctional autoprocessing repeats-in-toxin (MARTX) toxin did not result in necrotic cell blebs. However, if the rtxA gene was engineered to produce an effector-free MARTX toxin, the cell blebbing was observed, indicating that the pore forming activity of the MARTX toxin is sufficient, but the MARTX toxin effector domains are not necessary, for the blebbing. When a recombinant PlpA was treated on the blebbed cells, the blebs were completely disrupted. Consistent with this, MARTX toxin-pendent rapid release of cytosolic lactate dehydrogenase was significantly delayed in the plpA deletion background. Mutations in other exotoxins such as elastase, cytolysin/hemolysin, and/or extracellular metalloprotease did not affect the bleb formation or disruption. Together, these findings indicate that the pore forming MARTX toxin and the phospholipase A2, PlpA, cooperate sequentially to achieve rapid necrotic cell death by inducing cell blebbing and disrupting the blebs, respectively.

Citations

Citations to this article as recorded by

Genome-wide phenotypic profiling of transcription factors and identification of novel targets to control the virulence of Vibrio vulnificus
Dayoung Sung, Garam Choi, Minji Ahn, Hokyung Byun, Tae Young Kim, Hojun Lee, Zee-Won Lee, Ji Yong Park, Young Hyun Jung, Ho Jae Han, Sang Ho Choi
Nucleic Acids Research.2024;[Epub] CrossRef
Vibrio-infecting bacteriophages and their potential to control biofilm
Ana Cevallos-Urena, Jeong Yeon Kim, Byoung Sik Kim
Food Science and Biotechnology.2023; 32(12): 1719. CrossRef
Pathogenic Mechanism of Vibrio Vulnificus Infection
Kun Lu, Yang Li, Rui Chen, Hua Yang, Yong Wang, Wei Xiong, Fang Xu, Qijun Yuan, Haihui Liang, Xian Xiao, Renqiang Huang, Zhipeng Chen, Chunou Tian, Songqing Wang
Future Microbiology.2023; 18(6): 373. CrossRef
Functional conservation of specialized ribosomes bearing genome-encoded variant rRNAs in Vibrio species
Younkyung Choi, Eunkyoung Shin, Minho Lee, Ji-Hyun Yeom, Kangseok Lee, Bashir Sajo Mienda
PLOS ONE.2023; 18(12): e0289072. CrossRef
Complex regulatory networks of virulence factors in Vibrio vulnificus
Garam Choi, Sang Ho Choi
Trends in Microbiology.2022; 30(12): 1205. CrossRef
MARTX toxin of Vibrio vulnificus induces RBC phosphatidylserine exposure that can contribute to thrombosis
Han Young Chung, Yiying Bian, Kyung-Min Lim, Byoung Sik Kim, Sang Ho Choi
Nature Communications.2022;[Epub] CrossRef

NF-κB/ROS and ERK pathways regulate NLRP3 inflammasome activation in Listeria monocytogenes infected BV2 microglia cells: Lin Yuan , Yurong Zhu , Shuang Huang , Lin Lin , Xugan Jiang , Shengxia Chen; J. Microbiol. 2021;59(8):771-781. Published online June 1, 2021; DOI: https://doi.org/10.1007/s12275-021-0692-9

68 View
0 Download
14 Web of Science
13 Crossref

Abstract

Listeria monocytogenes is a food-borne pathogen responsible for neurolisteriosis, which is potentially lethal in immunocompromised individuals. Microglia are the main target cells for L. monocytogenes in central nervous system (CNS). However, the precise mechanisms by which they trigger neuroinflammatory processes remain unknown. The BV2 microglial cell line and a murine model of L. monocytogenes infection were used for experiments in this study. Listeria monocytogenes induced pyroptosis and nucleotide binding and oligomerization, leucine-rich repeat, pyrin domain-containing 3 (NLRP3) inflammasome activation in BV2. Pharmacological inhibition of the NLRP3 inflammasome attenuated L. monocytogenes- induced pyroptosis. Moreover, inhibition of nuclear factor kappa-B (NF-κB) and extracellular regulated protein kinases (ERK) pathways induced a decrease in caspase1 activation and mature IL-1β-17 secretion. Our collective findings support critical involvement of the NLRP3 inflammasome in L. monocytogenes-induced neuroinflammation and, to an extent, ROS production. In addition, ERK and NF-κB signaling play an important role in activation of the NLRP3 inflammasome, both in vitro and in vivo.

Citations

Citations to this article as recorded by

Deletion of Nox from Listeria monocytogenes Strain EGDe Enhances Bacterial Virulence and Reduces the Production of Reactive Oxygen Species and Inflammatory Factors In Vivo
Dezhi Li, Wenwen Ma, Guowei Chen, Zhiqiang Huang, Qing Liu
Foodborne Pathogens and Disease.2025; 22(3): 177. CrossRef
MAPK pathways regulated apoptosis and pyroptosis in respiratory epithelial cells of a primitive vertebrate model during bacterial infection
Zixi Song, Mingxu Jiang, Mengya Wang, Jiahong Zou, Zhenwei Chen, Feifei Zheng, Qingchao Wang
International Journal of Biological Macromolecules.2025; 286: 138587. CrossRef
NLRP12 c.1382dup promotes the development of Crohn’s disease through the ERK/NLRP3/ IL-1β pathway
Yang Huang, Lincheng Xu, Qingqing Yang, Xueyi Xiao, Zhenyu Ye, Rongqing Li, Yanyan Guan, Xudong Wu
Gene.2024; 931: 148855. CrossRef
The critical role of NLRP3 inflammasome activation in Streptococcus suis-induced blood-brain barrier disruption
Xinrui Cao, Kaixiang Jia, Qian Liu, Hang Yin, Xiaoying Yu, Xiaoxiang Hu, Chao Ye, Lianci Peng, Rendong Fang
Veterinary Microbiology.2024; 295: 110161. CrossRef
From cytokines to chemokines: Understanding inflammatory signaling in bacterial meningitis
Ahsan Ibrahim, Nida Saleem, Faiza Naseer, Sagheer Ahmed, Nayla Munawar, Rukhsana Nawaz
Molecular Immunology.2024; 173: 117. CrossRef
Reactive oxygen species trigger inflammasome activation after intracellular microbial interaction
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natália Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patrícia Paiva Corsetti, Leonardo Augusto de Almeida
Life Sciences.2023; 331: 122076. CrossRef
NLRP3 Inflammasome’s Activation in Acute and Chronic Brain Diseases—An Update on Pathogenetic Mechanisms and Therapeutic Perspectives with Respect to Other Inflammasomes
Anna Chiarini, Li Gui, Chiara Viviani, Ubaldo Armato, Ilaria Dal Prà
Biomedicines.2023; 11(4): 999. CrossRef
Pseudomonas aeruginosa-Derived DnaJ Induces the Expression of IL−1β by Engaging the Interplay of p38 and ERK Signaling Pathways in Macrophages
Dae-Kyum Kim, Jin-Won Huh, Hyeonseung Yu, Yeji Lee, Yongxin Jin, Un-Hwan Ha
International Journal of Molecular Sciences.2023; 24(21): 15957. CrossRef
Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation
A. Marijke Keestra-Gounder, Prescilla Emy Nagao
Frontiers in Immunology.2023;[Epub] CrossRef
Sodium butyrate attenuate hyperglycemia-induced inflammatory response and renal injury in diabetic mice
Man Yan, Yan-Yan Zhang, Yue Xi, Long-Kun Ding, Chang Sun, Li-Juan Qu, Xin Qian, Jing-Wen Xu, Wen Sun, Liang Wu
Acta Pharmaceutica.2023; 73(1): 121. CrossRef
TRAF6-TAK1-IKKβ pathway mediates TLR2 agonists activating “one-step” NLRP3 inflammasome in human monocytes
Mengdan Chen, Shi Yu, Yuhui Gao, Jiaxun Li, Xun Wang, Bin Wei, Guangxun Meng
Cytokine.2023; 169: 156302. CrossRef
Chrysophanol-8-O-glucoside protects mice against acute liver injury by inhibiting autophagy in hepatic stellate cells and inflammatory response in liver-resident macrophages
Tao Wang, Zhuo Lu, Xin-Hui Qu, Zi-Ying Xiong, Ya-Ting Wu, Yong Luo, Zi-Yu Zhang, Xiao-Jian Han, Cai-Feng Xie
Frontiers in Pharmacology.2022;[Epub] CrossRef
Microglia Pyroptosis: A Candidate Target for Neurological Diseases Treatment
Xian Wu, Teng Wan, Xiaoyu Gao, Mingyuan Fu, Yunfeng Duan, Xiangru Shen, Weiming Guo
Frontiers in Neuroscience.2022;[Epub] CrossRef

Review

Recent advances in the development of β-lactamase inhibitors: Shivakumar S. Jalde , Hyun Kyung Choi; J. Microbiol. 2020;58(8):633-647. Published online July 27, 2020; DOI: https://doi.org/10.1007/s12275-020-0285-z

69 View
1 Download
23 Web of Science
22 Crossref

Abstract

β-Lactam antibiotics are the most commonly prescribed antibiotics worldwide; however, antimicrobial resistance (AMR) is a global challenge. The β-lactam resistance in Gram-negative bacteria is due to the production of β-lactamases, including extended-spectrum β-lactamases, metallo-β-lactamases, and carbapenem-hydrolyzing class D β-lactamases. To restore the efficacy of BLAs, the most successful strategy is to use them in combination with β-lactamase inhibitors (BLI). Here we review the medically relevant β-lactamase families and penicillins, diazabicyclooctanes, boronic acids, and novel chemical scaffold-based BLIs, in particular approved and under clinical development.

Citations

Citations to this article as recorded by

Functional and structural analyses of IMP-27 metallo-β-lactamase: evolution of IMP-type enzymes to overcome Zn(II) deprivation
Yoshiki Kato, Toshio Yamaguchi, Haruka Nakagawa-Kamura, Yoshikazu Ishii, Akiko Shimizu-Ibuka, Pablo Power
Microbiology Spectrum.2024;[Epub] CrossRef
Current Strategy for Targeting Metallo-β-Lactamase with Metal-Ion-Binding Inhibitors
Jessica L. Ortega-Balleza, Lenci K. Vázquez-Jiménez, Eyra Ortiz-Pérez, Guadalupe Avalos-Navarro, Alma D. Paz-González, Edgar E. Lara-Ramírez, Gildardo Rivera
Molecules.2024; 29(16): 3944. CrossRef
Understanding the Functional Dynamics of the TokK Enzyme in Carbapenem Biosynthesis via MD Simulations and QM/MM Calculations
Shakir Ali Siddiqui, Kshatresh Dutta Dubey
Inorganic Chemistry.2024; 63(40): 18963. CrossRef
Recent advances in functionalized macrocyclic polyamines for medicine applications
Hao Chang, Renzhong Qiao, Chao Li
Chinese Chemical Letters.2024; : 110675. CrossRef
Exploring the dynamics of gut microbiota, antibiotic resistance, and chemotherapy impact in acute leukemia patients: A comprehensive metagenomic analysis
Ying Luo, Taha Majid Mahmood Sheikh, Xin Li, YuMeng Yuan, Fen Yao, Meimei Wang, Xiaoling Guo, Jilong Wu, Muhammad Shafiq, Qingdong Xie, Xiaoyang Jiao
Virulence.2024;[Epub] CrossRef
Decrypting biocontrol functions and application modes by genomes data of three Trichoderma Strains/Species
Shida Ji, Bin Liu, Jing Han, Ning Kong, Yongfeng Yang, Yucheng Wang, Zhihua Liu
Fungal Genetics and Biology.2024; 172: 103889. CrossRef
Revisiting the Checkerboard to Inform Development of β-Lactam/β-Lactamase Inhibitor Combinations
Darren J. Bentley
Antibiotics.2024; 13(4): 337. CrossRef
Role of β-Lactamase Inhibitors as Potentiators in Antimicrobial Chemotherapy Targeting Gram-Negative Bacteria
Song Zhang, Xinyu Liao, Tian Ding, Juhee Ahn
Antibiotics.2024; 13(3): 260. CrossRef
The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases
Clyde A. Smith, Nichole K. Stewart, Marta Toth, Pojun Quan, John D. Buynak, Sergei B. Vakulenko
ACS Infectious Diseases.2023; 9(5): 1123. CrossRef
Phenotypes, genotypes and breakpoints: an assessment of β-lactam/β-lactamase inhibitor combinations against OXA-48
Tomefa E Asempa, Abigail K Kois, Christian M Gill, David P Nicolau
Journal of Antimicrobial Chemotherapy.2023; 78(3): 636. CrossRef
Characteristics of Extended-Spectrum β-Lactamase-Producing Escherichia coli Derived from Food and Humans in Northern Xinjiang, China
Yushuang Wu, Shudi Huang, Donglai Zhang, Hua Ji, Yongqing Ni, Xueling Zhang, Juan Dong, Baokun Li
Foodborne Pathogens and Disease.2023; 20(7): 270. CrossRef
Sequential C−H Methylation Catalyzed by the B12‐Dependent SAM Enzyme TokK: Comprehensive Theoretical Study of Selectivities
Wen‐Hao Deng, Rong‐Zhen Liao
Chemistry – A European Journal.2023;[Epub] CrossRef
CMOS Spectrophotometric Microsystem for Malaria Detection
Gabriel M. Ferreira, Vitória Baptista, Vítor Silva, Maria I. Veiga, Graça Minas, Susana O. Catarino
IEEE Transactions on Biomedical Engineering.2023; 70(8): 2318. CrossRef
Synthesis and β-Lactamase Inhibition Activity of Imidates of Diazabicyclooctane
Lijuan Zhai, Jian Sun, Jingwen Ji, Lili He, Yuanyu Gao, Jinbo Ji, Yuanbai Liu, Yangxiu Mu, Xueqin Ma, Dong Tang, Haikang Yang, Zafar Iqbal, Zhixiang Yang
Russian Journal of Bioorganic Chemistry.2022; 48(5): 1059. CrossRef
Recent Developments to Cope the Antibacterial Resistance via β-Lactamase Inhibition
Zafar Iqbal, Jian Sun, Haikang Yang, Jingwen Ji, Lili He, Lijuan Zhai, Jinbo Ji, Pengjuan Zhou, Dong Tang, Yangxiu Mu, Lin Wang, Zhixiang Yang
Molecules.2022; 27(12): 3832. CrossRef
Retracted and replaced: Phenotypes, genotypes and breakpoints: an assessment of β-lactam/ β-lactamase inhibitor combinations against OXA-48
Tomefa E Asempa, Abigail K Kois, Christian M Gill, David P Nicolau
Journal of Antimicrobial Chemotherapy.2022; 77(10): 2622. CrossRef
Carbapenemase producing Klebsiella pneumoniae: implication on future therapeutic strategies
Ilias Karaiskos, Irene Galani, Vassiliki Papoutsaki, Lamprini Galani, Helen Giamarellou
Expert Review of Anti-infective Therapy.2022; 20(1): 53. CrossRef
Antimicrobial Activity of Dihydroisocoumarin Isolated from Wadi Lajab Sediment-Derived Fungus Penicillium chrysogenum: In Vitro and In Silico Study
Raha Orfali, Shagufta Perveen, Mohamed Fahad AlAjmI, Safina Ghaffar, Md Tabish Rehman, Abdullah R. AlanzI, Saja Bane Gamea, Mona Essa Khwayri
Molecules.2022; 27(11): 3630. CrossRef
The Odd Couple(s): An Overview of Beta-Lactam Antibiotics Bearing More Than One Pharmacophoric Group
Margherita De Rosa, Anna Verdino, Annunziata Soriente, Anna Marabotti
International Journal of Molecular Sciences.2021; 22(2): 617. CrossRef
Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams
Søren Brøgger Christensen
Molecules.2021; 26(19): 6057. CrossRef
In Crystallo Time-Resolved Interaction of the Clostridioides difficile CDD-1 enzyme with Avibactam Provides New Insights into the Catalytic Mechanism of Class D β-lactamases
Nichole K. Stewart, Marta Toth, Anastasiya Stasyuk, Sergei B. Vakulenko, Clyde A. Smith
ACS Infectious Diseases.2021; 7(6): 1765. CrossRef
Inhibition of the Clostridioides difficile Class D β-Lactamase CDD-1 by Avibactam
Nichole K. Stewart, Marta Toth, Anastasiya Stasyuk, Mijoon Lee, Clyde A. Smith, Sergei B. Vakulenko
ACS Infectious Diseases.2021; 7(5): 1164. CrossRef

Journal Articles

Efficacy of A/H1N1/2009 split inactivated influenza A vaccine (GC1115) in mice and ferrets: Hae Jung Han , Min-Suk Song , Su-Jin Park , Han Yeul Byun , Norbert John C. Robles , Suk-Hoon Ha , Young Ki Choi; J. Microbiol. 2019;57(2):163-169. Published online January 31, 2019; DOI: https://doi.org/10.1007/s12275-019-8504-1

70 View
0 Download
4 Web of Science
4 Crossref

Abstract

To evaluate the efficacy of a non-adjuvant A/H1N1/2009 influenza A vaccine (GC1115), we demonstrated the immunogenicity and protective efficacy of GC1115 in mouse and ferret models. The immunogenicity of GC1115 was confirmed after intramuscular administration of 1.875, 3.75, 7.5, and 15 μg hemagglutinin antigen (HA) in mice and 7.5, 15, and 30 μg HA in ferrets at 3-week intervals. A single immunization with GC1115 at HA doses > 7.5 μg induced detectable seroconversion in most mice, and all mice given a second dose exhibited high antibody responses in a dose-dependent manner. The mice in the mock (PBS) and 1.875 μg HA immunized groups succumbed by 13 days following A/California/ 04/09 infection, while all mice in groups given more than 3.75 μg HA were protected from lethal challenge with the A/California/04/09 virus. In ferrets, although immunization with even a single dose of 15 or 30 μg of HA induced detectable HI antibodies, all ferrets given two doses of vaccine seroconverted and exhibited HI titers greater than 80 units. Following challenge with A/California/04/09, the mock (PBS) immunized ferrets showed influenza-like clinical symptoms, such as increased numbers of coughs, elevated body temperature, and body weight loss, for 7 days, while GC1115- immunized ferrets showed attenuated clinical symptoms only for short time period (3–4 days). Further, GC1115-immunized ferrets displayed significantly lower viral titers in the upper respiratory tract (nasal cavity) than the mock vaccinated group in a dose-dependent manner. Taken together, this study demonstrates the immunogenicity and protective efficacy of GC1115 as a non-adjuvanted vaccine.

Citations

Citations to this article as recorded by

Dose sparing enabled by immunization with influenza vaccine using orally dissolving film
Keon-Woong Yoon, Ki Back Chu, Gi-Deok Eom, Jie Mao, Su In Heo, Fu-Shi Quan
International Journal of Pharmaceutics.2024; 667: 124945. CrossRef
Ferrets as a model for tuberculosis transmission
Tuhina Gupta, Naveen Somanna, Thomas Rowe, Monica LaGatta, Shelly Helms, Simon Odera Owino, Tomislav Jelesijevic, Stephen Harvey, Wayne Jacobs, Thomas Voss, Kaori Sakamoto, Cheryl Day, Christopher Whalen, Russell Karls, Biao He, S. Mark Tompkins, Abhijeet
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
AddaVax Formulated with PolyI:C as a Potential Adjuvant of MDCK-based Influenza Vaccine Enhances Local, Cellular, and Antibody Protective Immune Response in Mice
Xuanxuan Nian, Jiayou Zhang, Tao Deng, Jing Liu, Zheng Gong, Chuanshuo Lv, Luyao Yao, Junying Li, Shihe Huang, Xiaoming Yang
AAPS PharmSciTech.2021;[Epub] CrossRef
The Intersection of Age and Influenza Severity: Utility of Ferrets for Dissecting the Age-Dependent Immune Responses and Relevance to Age-Specific Vaccine Development
Melissa Rioux, Magen E. Francis, Cynthia L. Swan, Anni Ge, Andrea Kroeker, Alyson A. Kelvin
Viruses.2021; 13(4): 678. CrossRef

Antiviral activity of Poncirus trifoliata seed extract against oseltamivirresistant influenza virus: Yoonki Heo , Yeondong Cho , Kwon sung Ju , Hansam Cho , Ki Hoon Park , Hanul Choi , Jong Kwang Yoon , Chiung Moon , Young Bong Kim; J. Microbiol. 2018;56(8):586-592. Published online July 25, 2018; DOI: https://doi.org/10.1007/s12275-018-8222-0

70 View
0 Download
15 Crossref

Abstract

The emergence of oseltamivir-resistant variants of influenza virus has highlighted the necessity for the development of more effective novel antiviral drugs. To date, numerous researchers have focused on developing antiviral drugs using natural resources, such as traditional herbal medicines. Poncirus trifoliata is widely used in oriental medicine as a remedy for gastritis, dysentery, inflammation and digestive ulcers. In this study, we investigated the potential antiviral effect of the Poncirus trifoliata orange seed extract against influenza virus. An ethanol extract of Poncirus trifoliata seeds (PTex) inhibited the activity of influenza viruses, in particular, oseltamivir- resistant strains, in Madin-Darby canine kidney cells. In contrast to oseltamivir, PTex exerted a significant inhibitory effect on the cellular penetration pathway of the virus rather than HA receptor binding. The potent antiviral effect and novel working mechanism of PTex support its further development as an effective natural antiviral drug with a wide spectrum of activity against influenza and oseltamivir-resistant viruses.

Citations

Citations to this article as recorded by

A Comprehensive Study on Natural Products and their Bioactive Constituents to Cure Respiratory Diseases
Avadh Biharee, Lokesh Chaudhari, Sudha Bhartiya, Shivam Kumar Kori, Anu Chaudhary, Dheeraj Dubey, Arpita Yadav
The Natural Products Journal.2024;[Epub] CrossRef
Seed extracts as an effective strategy in the control of plant pathogens: Scalable industry bioactive compounds for sustainable agriculture
Tamara Sánchez-Gómez, Óscar Santamaría, Jorge Martín-García, Jorge Poveda
Biocatalysis and Agricultural Biotechnology.2024; 60: 103332. CrossRef
Insights into identifying resistance genes for cold and disease stresses through chromosome-level reference genome analyses of Poncirus polyandra
Shanshan Zhang, Jian Chen, Chuanguang Zhang, Siqi Zhang, Xiaolei Zhang, Lanjing Gao, Wenzhong Yang
Genomics.2023; 115(3): 110617. CrossRef
Poncirus trifoliata (L.) Raf. Seed Extract Induces Cell Cycle Arrest and Apoptosis in the Androgen Receptor Positive LNCaP Prostate Cancer Cells
Francesca Giordano, Stefano Comità, Giulia Venneri, Vittoria Rago, Giuseppina Daniela Naimo, Francesca De Amicis, Anna De Bartolo, Rosa Tundis, Loredana Mauro, Maria Luisa Panno
International Journal of Molecular Sciences.2023; 24(22): 16351. CrossRef
Structural Bioinformatics Used to Predict the Protein Targets of Remdesivir and Flavones in SARS-CoV-2 Infection
Avram Speranta, Laura Manoliu, Catalina Sogor, Maria Mernea, Corina Duda Seiman, Daniel Duda Seiman, Carmen Chifiriuc
Medicinal Chemistry.2022; 18(3): 382. CrossRef
Bioactive Chemical Constituents and Pharmacological Activities of Ponciri Fructus
Gopal Lamichhane, Jitendra Pandey, Hari Prasad Devkota
Molecules.2022; 28(1): 255. CrossRef
Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates
Eyana Thomas, Laura E. Stewart, Brien A. Darley, Ashley M. Pham, Isabella Esteban, Siva S. Panda
Molecules.2021; 26(20): 6197. CrossRef
COVID-19 Prophylaxis Efforts Based on Natural Antiviral Plant Extracts and Their Compounds
Oksana Sytar, Marian Brestic, Shokoofeh Hajihashemi, Milan Skalicky, Jan Kubeš, Laura Lamilla-Tamayo, Ulkar Ibrahimova, Sayyara Ibadullayeva, Marco Landi
Molecules.2021; 26(3): 727. CrossRef
KIF11 inhibition decreases cytopathogenesis and replication of influenza A virus
Dong-In Kim, Ji-Hun Kang, Eui-Ho Kim, Young-Jin Seo
Molecular & Cellular Toxicology.2021; 17(2): 201. CrossRef
Chios mastic gum inhibits influenza A virus replication and viral pathogenicity
Dong-In Kim, Yong-Bin Cho, Younghyun Lim, So-Hee Hong, Bumsuk Hahm, Sang-Myeong Lee, Se Chan Kang, Young-Jin Seo
Journal of General Virology .2021;[Epub] CrossRef
Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection
Fang-Ju Cheng, Thanh-Kieu Huynh, Chia-Shin Yang, Dai-Wei Hu, Yi-Cheng Shen, Chih-Yen Tu, Yang-Chang Wu, Chih-Hsin Tang, Wei-Chien Huang, Yeh Chen, Chien-Yi Ho
Nutrients.2021; 13(8): 2800. CrossRef
Selective and ATP‐competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus
Yong‐Bin Cho, Sungguan Hong, Kyung‐Won Kang, Ji‐Hun Kang, Sang‐Myeong Lee, Young‐Jin Seo
Journal of Cellular and Molecular Medicine.2020; 24(10): 5463. CrossRef
Natural products against acute respiratory infections: Strategies and lessons learned
Julia Langeder, Ulrike Grienke, Ya Chen, Johannes Kirchmair, Michaela Schmidtke, Judith M. Rollinger
Journal of Ethnopharmacology.2020; 248: 112298. CrossRef
Retracted: Phytotherapeutic options for the treatment of COVID‐19: A concise viewpoint
Misbahud Din, Fawad Ali, Abdul Waris, Fatima Zia, Muhammad Ali
Phytotherapy Research.2020; 34(10): 2431. CrossRef
Chung Hun Wha Dam Tang attenuates atherosclerosis in apolipoprotein E-deficient mice via the NF-κB pathway
Yeonsoo Joe, Md Jamal Uddin, Jeongmin Park, Jinhyun Ryu, Gyeong Jae Cho, Jeong Woo Park, Hye-Seon Choi, Min Ho Cha, Stefan W. Ryter, Hun Taeg Chung
Biomedicine & Pharmacotherapy.2019; 120: 109524. CrossRef

Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice: Sehee Park , Jin Il Kim , Joon-Yong Bae , Kirim Yoo , Hyunung Kim , In-Ho Kim , Man-Seong Park , Ilseob Lee; J. Microbiol. 2018;56(2):145-149. Published online February 2, 2018; DOI: https://doi.org/10.1007/s12275-018-7411-1

69 View
0 Download
31 Crossref

Abstract

The potential use of dietary measures to treat influenza can be an important alternative for those who lack access to influenza vaccines or antiviral drugs. Lactobacillus plantarum (Lp) is one of many lactic acid bacteria that grow in ‘kimchi’, an essential part of Korean meal, and several strains of Lp reportedly show protective effects against influenza. Using heat-killed Lp (nF1) isolated from kimchi, which is known for its immunomodulatory effects, we investigated whether regular oral intake of nF1 could influence the outcome of influenza virus infection in a mouse model. In a lethal challenge with influenza A (H1N1 and H3N2 subtypes) and influenza B (Yamagata lineage) viruses, daily oral administration of nF1 delayed the mean number of days to death of the infected mice and resulted in increased survival rates compared with those of the non-treated mice. Consistent with these observations, nF1 treatment also significantly reduced viral replication in the lungs of the infected mice. Taken together, our results might suggest the remedial potential of heatkilled Lactobacillus probiotics against influenza.

Citations

Citations to this article as recorded by

Rising Threats of Viral Infections: Exploring Probiotics as Antiviral Agents
Haneef Mohammad Bhat, Ruqeya Nazir, Zahid Amin Kashoo
Indian Journal of Microbiology.2024;[Epub] CrossRef
Oral Administration of Limosilactobacillus reuteri KBL346 Ameliorates Influenza Virus A/PR8 Infection in Mouse
Doseon Choi, Sung Jae Jang, Sueun Choi, SungJun Park, Woon-Ki Kim, Giljae Lee, Cheonghoon Lee, GwangPyo Ko
Probiotics and Antimicrobial Proteins.2024;[Epub] CrossRef
Effect of Heat-Treated Lactiplantibacillus plantarum nF1 on the Immune System Including Natural Killer Cell Activity: A Randomized, Placebo-Controlled, Double-Blind Study
Geun-Hye Hong, So-Young Lee, In Ah Kim, Jangmi Suk, Chaemin Baeg, Ji Yeon Kim, Sehee Lee, Kyeong Jin Kim, Ki Tae Kim, Min Gee Kim, Kun-Young Park
Nutrients.2024; 16(9): 1339. CrossRef
Orange Peel Lactiplantibacillus plantarum: Development of A Mucoadhesive Nasal Spray with Antimicrobial and Anti-inflammatory Activity
Elisa Corazza, Asia Pizzi, Carola Parolin, Barbara Giordani, Angela Abruzzo, Federica Bigucci, Teresa Cerchiara, Barbara Luppi, Beatrice Vitali
Pharmaceutics.2024; 16(11): 1470. CrossRef
Beyond probiotics, uses of their next‐generation for poultry and humans: A review
Ahmad Salahi, Wafaa A. Abd El‐Ghany
Journal of Animal Physiology and Animal Nutrition.2024; 108(5): 1336. CrossRef
Does kimchi deserve the status of a probiotic food?
Jeongmin Cha, Yeon Bee Kim, Seong-Eun Park, Se Hee Lee, Seong Woon Roh, Hong-Seok Son, Tae Woong Whon
Critical Reviews in Food Science and Nutrition.2024; 64(19): 6512. CrossRef
Lactiplantibacillus plantarum attenuates Coxsackievirus B3-induced pancreatitis through the BAX/BCL2/CASP3 signaling pathway
Xiaomin Yu, Yejia Zhang, Ke Pei, Junjun Tan, Huizhen Tian, Tian Xu, Fadi Liu, Nanqin Peng, Yilin Huang, Xinying Huang, Xinlei Huang, Jianfeng Wu, Qiong Liu, Lingbing Zeng, Wei Hua, Xiaotian Huang
Food & Function.2023; 14(9): 4129. CrossRef
Postbiotics: An overview of concepts, inactivation technologies, health effects, and driver trends
Tatiana Colombo Pimentel, Adriano Gomes Cruz, Eliene Pereira, Whyara Karoline Almeida da Costa, Ramon da Silva Rocha, Geany Targino de Souza Pedrosa, Caíque dos Santos Rocha, Jade Morais Alves, Verônica Ortiz Alvarenga, Anderson S. Sant’Ana, Marciane Magn
Trends in Food Science & Technology.2023; 138: 199. CrossRef
Elucidation of the Tissue Distribution and Host Immunostimulatory Activity of Exogenously Administered Probiotic-Derived Extracellular Vesicles for Immunoadjuvant
Masaki Morishita, Masakatsu Kida, Tomomi Motomura, Rihito Tsukamoto, Mizuho Atari, Kazuya Higashiwaki, Kisa Masuda, Hidemasa Katsumi, Akira Yamamoto
Molecular Pharmaceutics.2023; 20(12): 6104. CrossRef
A Review of the Health Benefits of Kimchi Functional Compounds and Metabolites
Hyun Ju Kim, Min Sung Kwon, Hyelyeon Hwang, Ha-Sun Choi, WooJe Lee, Sang-Pil Choi, Haeun Jo, Sung Wook Hong
Microbiology and Biotechnology Letters.2023; 51(4): 353. CrossRef
Effect of Probiotics on Host-Microbial Crosstalk: A Review on Strategies to Combat Diversified Strain of Coronavirus
Susrita Sahoo, Swati Mohapatra, Swayam prava Dalai, Namrata Misra, Mrutyunjay Suar
Encyclopedia.2022; 2(2): 1138. CrossRef
The Beneficial Role of Probiotic Lactobacillus in Respiratory Diseases
Tingfeng Du, Aihua Lei, Naiyu Zhang, Cuiming Zhu
Frontiers in Immunology.2022;[Epub] CrossRef
Antiobesity Effect of Dead Lactobacillus plantarum nF1 on High-Fat Diet-Induced C57BL/6 Mice
Xuemei Lee, Geun-Hye Hong, So-Young Lee, Hyun Chul Noh, Kun-Young Park
Journal of the Korean Society of Food Science and Nutrition.2022; 51(11): 1119. CrossRef
Prophylactic effects of probiotics on respiratory viruses including COVID-19: a review
Na-Kyoung Lee, Hyun-Dong Paik
Food Science and Biotechnology.2021; 30(6): 773. CrossRef
Health benefits and technological effects of Lacticaseibacillus casei-01: An overview of the scientific literature
Tatiana Colombo Pimentel, Larissa Ramalho Brandão, Matthaws Pereira de Oliveira, Whyara Karoline Almeida da Costa, Marciane Magnani
Trends in Food Science & Technology.2021; 114: 722. CrossRef
Modulation of gut microbiota protects against viral respiratory tract infections: a systematic review of animal and clinical studies
Hai Yun Shi, Xi Zhu, Wei Lin Li, Joyce W. Y. Mak, Sunny H. Wong, Sheng Tao Zhu, Shui Long Guo, Francis K. L. Chan, Shu Tian Zhang, Siew C. Ng
European Journal of Nutrition.2021; 60(8): 4151. CrossRef
Obtaining paraprobiotics from Lactobacilus acidophilus, Lacticaseibacillus casei and Bifidobacterium animalis using six inactivation methods: Impacts on the cultivability, integrity, physiology, and morphology
Caroline N. Almada, Carine N. Almada-Érix, Mariane S. Bonatto, Fernando Pradella, Philipe dos Santos, Yuri K.D. Abud, Alessandro S. Farias, Julian Martínez, Celso B. Sant'Anna Filho, Pablo C. Lollo, Whyara K.A. Costa, Marciane Magnani, Anderson S. Sant'An
Journal of Functional Foods.2021; 87: 104826. CrossRef
The Antiviral Potential of Probiotics—A Review on Scientific Outcomes
Periyanaina Kesika, Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Chaiyavat Chaiyasut
Applied Sciences.2021; 11(18): 8687. CrossRef
Lactiplantibacillus plantarum as a Potential Adjuvant and Delivery System for the Development of SARS-CoV-2 Oral Vaccines
Julio Villena, Chang Li, Maria Guadalupe Vizoso-Pinto, Jacinto Sacur, Linzhu Ren, Haruki Kitazawa
Microorganisms.2021; 9(4): 683. CrossRef
Probiotics: A potential immunomodulator in COVID-19 infection management
Kuljit Singh, Alka Rao
Nutrition Research.2021; 87: 1. CrossRef
Lactobacillus plantarum induces innate cytokine responses that potentially provide a protective benefit against COVID‑19: A single‑arm, double‑blind, prospective trial combined with an in vitro cytokine response assay
Yasunari Kageyama, Yasuhiro Nishizaki, Koichi Aida, Katsuyuki Yayama, Tomoka Ebisui, Tetsu Akiyama, Tsutomu Nakamura
Experimental and Therapeutic Medicine.2021;[Epub] CrossRef
Korean traditional foods as antiviral and respiratory disease prevention and treatments: A detailed review
Gitishree Das, J. Basilio Heredia, Maria de Lourdes Pereira, Ericsson Coy-Barrera, Sonia Marlene Rodrigues Oliveira, Erick Paul Gutiérrez-Grijalva, Luis Angel Cabanillas-Bojórquez, Han-Seung Shin, Jayanta Kumar Patra
Trends in Food Science & Technology.2021; 116: 415. CrossRef
Swine Influenza Virus Infection Decreases the Protective Immune Responses of Subunit Vaccine Against Porcine Circovirus Type 2
Yuhang Sun, Jinlong Zhang, Zixuan Liu, Ying Zhang, Kehe Huang
Frontiers in Microbiology.2021;[Epub] CrossRef
Low pathogenic avian influenza virus infection retards colon microbiota diversification in two different chicken lines
Klaudia Chrzastek, Joy Leng, Mohammad Khalid Zakaria, Dagmara Bialy, Roberto La Ragione, Holly Shelton
Animal Microbiome.2021;[Epub] CrossRef
Paraprobiotics obtained by six different inactivation processes: impacts on the biochemical parameters and intestinal microbiota of Wistar male rats
Caroline N. Almada, Carine N. Almada-Érix, Aline R. Roquetto, Valfredo A. Santos-Junior, Lucélia Cabral, Melline F. Noronha, Any Elisa S. S. Gonçalves, Philipe dos Santos, Andrey dos Santos, Julian Martinez, Pablo C. Lollo, Whyara K. A. Costa, Marciane Ma
International Journal of Food Sciences and Nutrition.2021; 72(8): 1057. CrossRef
Effect of inactivated Bifidobacterium longum intake on obese diabetes model mice (TSOD)
Mahmoud Ben Othman, Kazuichi Sakamoto
Food Research International.2020; 129: 108792. CrossRef
The immunomodulatory effects of probiotics on respiratory viral infections: A hint for COVID-19 treatment?
Mehran Mahooti, Seyed Mohammad Miri, Elahe Abdolalipour, Amir Ghaemi
Microbial Pathogenesis.2020; 148: 104452. CrossRef
Short Communication: Oral Administration of Heat-killed Lactobacillus brevis KB290 in Combination with Retinoic Acid Provides Protection against Influenza Virus Infection in Mice
Shohei Satomi, Sofia Khanum, Poppy Miller, Shigenori Suzuki, Hiroyuki Suganuma, Axel Heiser, Sandeep K Gupta
Nutrients.2020; 12(10): 2925. CrossRef
The effects of heat-killed Lactobacillus plantarum L-137 supplementation on growth performance, intestinal morphology, and immune-related gene expression in broiler chickens
T. Incharoen, R. Charoensook, S. Onoda, W. Tatrakoon, S. Numthuam, T. Pechkong
Animal Feed Science and Technology.2019; 257: 114272. CrossRef
Heat-killed probiotic regulates the body’s regulatory immunity to attenuate subsequent experimental autoimmune arthritis
Hai Jia, Shipu Ren, Xia Wang
Immunology Letters.2019; 216: 89. CrossRef
Isolation of immune-regulatory Tetragenococcus halophilus from miso
Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi, Keiko Abe
PLOS ONE.2018; 13(12): e0208821. CrossRef

Comparison of anti-influenza virus activity and pharmacokinetics of oseltamivir free base and oseltamivir phosphate: Jin Soo Shin , Keun Bon Ku , Yejin Jang , Yi-Seul Yoon , Daeho Shin , Oh Seung Kwon , Yun Young Go , Seong Soon Kim , Myoung Ae Bae , Meehyein Kim; J. Microbiol. 2017;55(12):979-983. Published online December 7, 2017; DOI: https://doi.org/10.1007/s12275-017-7371-x

88 View
0 Download
10 Crossref

Abstract

Influenza viruses are major human respiratory pathogens that cause high morbidity and mortality worldwide. Currently, prophylactic vaccines and therapeutic antiviral agents are used to prevent and control influenza virus infection. Oseltamivir free base (OSV-FB), a modified generic antiviral drug of Tamiflu (oseltamivir phosphate, OSV-P), was launched in the Republic of Korea last year. Here, we examine the bioequivalence of these two compounds by assessing their antiviral efficacy in infected cells and in a mouse model. It was observed that both antivirals showed comparable efficacy against 11 different influenza A and B viruses in vitro. Moreover, in mice infected with influenza A virus (mouse-adapted A/Puerto Rico/8/34), they showed a dose-dependent therapeutic activity and alleviated infection-mediated reductions in body weight, leading to significantly better survival. There was histopathological disappearance of virus-induced inflammatory cell infiltration of the lung after oral treatment with either antiviral agent (at 10 mg/kg). Pharmacokinetic analysis also exhibited similar plasma concentrations of the active drug, oseltamivir carboxylate, metabolised from both OSVB and OSV-P. This is the first report showing bioequivalence of OSV-FB to its phosphate salt form in the mouse system. The free base drug has some beneficial points including simple drug formulation process and reduced risk of undesirable cation-phosphate precipitation within solution. The long term stability of OSV-FB requires further monitoring when it is provided as a national stock in readiness for an influenza pandemic.

Citations

Citations to this article as recorded by

Interaction mechanism of oseltamivir phosphate with bovine serum albumin: multispectroscopic and molecular docking study
Jing Yu, Jian-Ming Liu, Hui-Yi Chen, Wei-Ming Xiong
BMC Chemistry.2024;[Epub] CrossRef
A Lysosome-Targeting hNEU1 Inhibitor Treats Myocardial Infarction: A Potential Therapeutic Breakthrough
Wen Zhou, Wanxiang Yang, Ping Jiang, Shaohua Gou
Journal of Medicinal Chemistry.2024; 67(18): 16899. CrossRef
The possible techniques that used to improve the bioavailablity, pharmacological activity, solubility and permeability of anti-viral drugs: Insight for COVID-19 antiviral drugs
Ghassan Mudher Hashim , Ghaidaa S. Hameed , Dalya Basil Hanna
Al Mustansiriyah Journal of Pharmaceutical Sciences.2023; 23(3): 231. CrossRef
Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic Characteristics
Ran Chen, Tingting Wang, Jie Song, Daojun Pu, Dan He, Jianjun Li, Jie Yang, Kailing Li, Cailing Zhong, Jingqing Zhang
International Journal of Nanomedicine.2021; Volume 16: 4959. CrossRef
Multistage Extraction of Star Anise and Black Pepper Derivatives for Antibacterial, Antioxidant, and Anticancer Activity
Helin Li, Xiaoyu Wu, Xin Li, Xiaobing Cao, Yanjun Li, Huaru Cao, Yongzhi Men
Frontiers in Chemistry.2021;[Epub] CrossRef
Development of Sustained Release Oseltamivir Phosphate Dry Powder Inhaler: In-Vitro Characterization and In-Vivo Toxicological Studies
Harshal Sahastrabudhe, Prathmesh Kenjale, Varsha Pokharkar
Current Drug Delivery.2020; 17(8): 703. CrossRef
In Vitro and In Vivo Antiviral Activity of Nylidrin by Targeting the Hemagglutinin 2-Mediated Membrane Fusion of Influenza A Virus
Yejin Jang, Jin Soo Shin, Joo-Youn Lee, Heegwon Shin, Sang Jick Kim, Meehyein Kim
Viruses.2020; 12(5): 581. CrossRef
A new naphthoquinone analogue and antiviral constituents from the root of Rhinacanthus nasutus
Tran Minh Ngoc, Nguyen Thi Thanh Phuong, Nguyen Minh Khoi, SeonJu Park, Hee Jae Kwak, Nguyen Xuan Nhiem, Bui Thi Thu Trang, Bui Huu Tai, Jae-Hyoung Song, Hyun-Jeong Ko, Seung Hyun Kim
Natural Product Research.2019; 33(3): 360. CrossRef
Salinomycin Inhibits Influenza Virus Infection by Disrupting Endosomal Acidification and Viral Matrix Protein 2 Function
Yejin Jang, Jin Soo Shin, Yi-Seul Yoon, Yun Young Go, Hye Won Lee, Oh Seung Kwon, Sehee Park, Man-Seong Park, Meehyein Kim, Jae U. Jung
Journal of Virology.2018;[Epub] CrossRef
The Cranberry Extract Oximacro® Exerts in vitro Virucidal Activity Against Influenza Virus by Interfering With Hemagglutinin
Anna Luganini, Maria E. Terlizzi, Gianluca Catucci, Gianfranco Gilardi, Massimo E. Maffei, Giorgio Gribaudo
Frontiers in Microbiology.2018;[Epub] CrossRef

Review

REVIEW] H5 influenza, a global update: Rhodri Harfoot , Richard J. Webby; J. Microbiol. 2017;55(3):196-203. Published online February 28, 2017; DOI: https://doi.org/10.1007/s12275-017-7062-7

70 View
0 Download
50 Crossref

Abstract

H5 influenza viruses have caused much alarm globally due to their high pathogenic potential. As yet we have not seen sustained spread of the virus amongst humans despite a high prevalence of the virus in avian populations. Nevertheless, isolated human cases of infection have demonstrated high mortality and there are substantial efforts being taken to monitor the evolution of the virus and to undertake preparedness activities. Here we review and discuss the evolution of the A/goose/Guangdong/1/96 (H5N1) virus with emphasis on recent events.

Citations

Citations to this article as recorded by

Enhanced neurotropism of bovine H5N1 compared to the Vietnam H5N1 isolate in C57BL/6J mice
Kerry Goldin, Sarah van Tol, Randall C. Johnson, Reshma Koolaparambil Mukesh, Kendal G. Cooper, Shane Gallogly, Jonathan E. Schulz, Jessica Prado-Smith, Craig Martens, Greg Saturday, Kwe Claude Yinda, Vincent J. Munster, Emmie de Wit, Neeltje van Doremale
npj Viruses.2025;[Epub] CrossRef
Detection and characterization of highly pathogenic avian influenza A (H5N1) clade 2.3.4.4b virus circulating in Argentina in 2023
María Carolina Artuso, Vanina Daniela Marchione, Estefanía Benedetti, Paula Bonastre, Ana María Alvarez, Luana Piccini, Angeles Ponde, Evelyn Barrios Benito, Marcos Fabeiro, Karen Waisman, Luciano Coppola, Tomás Poklepovich, Ariana Chamorro, Martín Avaro,
Revista Argentina de Microbiología.2024;[Epub] CrossRef
Simultaneous Differential Detection of H5, H7, H9 and Nine NA Subtypes of Avian Influenza Viruses via a GeXP Assay
Sisi Luo, Zhixun Xie, Meng Li, Dan Li, Minxiu Zhang, Zhihua Ruan, Liji Xie, Sheng Wang, Qing Fan, Yanfang Zhang, Jiaoling Huang, Tingting Zeng
Microorganisms.2024; 12(1): 143. CrossRef
Multivalent next generation influenza virus vaccines protect against seasonal and pre-pandemic viruses
Naoko Uno, Ted M. Ross
Scientific Reports.2024;[Epub] CrossRef
Recent Occurrence, Diversity, and Candidate Vaccine Virus Selection for Pandemic H5N1: Alert Is in the Air
Yordanka Medina-Armenteros, Daniela Cajado-Carvalho, Ricardo das Neves Oliveira, Milena Apetito Akamatsu, Paulo Lee Ho
Vaccines.2024; 12(9): 1044. CrossRef
Pigs are highly susceptible to but do not transmit mink-derived highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b
Taeyong Kwon, Jessie D. Trujillo, Mariano Carossino, Eu Lim Lyoo, Chester D. McDowell, Konner Cool, Franco S. Matias-Ferreyra, Trushar Jeevan, Igor Morozov, Natasha N. Gaudreault, Udeni B.R. Balasuriya, Richard J. Webby, Nikolaus Osterrieder, Juergen A. R
Emerging Microbes & Infections.2024;[Epub] CrossRef
Transmission dynamics of highly pathogenic avian influenza virus at the wildlife-poultry-environmental interface: A case study
Jolene A. Giacinti, Madeline Jarvis-Cross, Hannah Lewis, Jennifer F. Provencher, Yohannes Berhane, Kevin Kuchinski, Claire M. Jardine, Anthony Signore, Sarah C. Mansour, Denby E. Sadler, Brian Stevens, Natalie A. Prystajecky, Sailendra N. Sarma, Davor Ojk
One Health.2024; 19: 100932. CrossRef
On-Site and Visual Detection of the H5 Subtype Avian Influenza Virus Based on RT-RPA and CRISPR/Cas12a
Xu Zhou, Siwen Wang, Yue Ma, Yongping Jiang, Yanbing Li, Jianzhong Shi, Guohua Deng, Guobin Tian, Huihui Kong, Xiurong Wang
Viruses.2024; 16(5): 753. CrossRef
First Case of Highly Pathogenic Avian Influenza H5N1 in Montenegro
Bojan Adzic, Sejla Goletic, Nikola Pejoviс, Andrej Vizi, Nikita Yolshin
Acta Veterinaria.2024; 74(1): 145. CrossRef
Self-Assembling Nanoparticle Hemagglutinin Influenza Vaccines Induce High Antibody Response
Hongying Ren, Bin Zhang, Xinwei Zhang, Tiantian Wang, Xvchen Hou, Xianyong Lan, Chuanying Pan, Jun Wu, Bo Liu
International Journal of Molecular Sciences.2024; 25(13): 7259. CrossRef
Highly pathogenic avian influenza A (H5N1) in marine mammals and seabirds in Peru
Mariana Leguia, Alejandra Garcia-Glaessner, Breno Muñoz-Saavedra, Diana Juarez, Patricia Barrera, Carlos Calvo-Mac, Javier Jara, Walter Silva, Karl Ploog, Lady Amaro, Paulo Colchao-Claux, Christine K. Johnson, Marcela M. Uhart, Martha I. Nelson, Jesus Les
Nature Communications.2023;[Epub] CrossRef
Global review of the H5N8 avian influenza virus subtype
Saba Rafique, Farooq Rashid, Sajda Mushtaq, Akbar Ali, Meng Li, Sisi Luo, Liji Xie, Zhixun Xie
Frontiers in Microbiology.2023;[Epub] CrossRef
Development and Validation of Competitive ELISA for Detection of H5 Hemagglutinin Antibodies
Orie Hochman, Wanhong Xu, Ming Yang, Chengbo Yang, Aruna Ambagala, Anna Rogiewicz, Joseph J. Wang, Yohannes Berhane
Poultry.2023; 2(3): 349. CrossRef
Global dissemination of H5N1 influenza viruses bearing the clade 2.3.4.4b HA gene and biologic analysis of the ones detected in China
Pengfei Cui, Jianzhong Shi, Congcong Wang, Yuancheng Zhang, Xin Xing, Huihui Kong, Cheng Yan, Xianying Zeng, Liling Liu, Guobin Tian, Chengjun Li, Guohua Deng, Hualan Chen
Emerging Microbes & Infections.2022; 11(1): 1693. CrossRef
Improved Subtyping of Avian Influenza Viruses Using an RT-qPCR-Based Low Density Array: ‘Riems Influenza a Typing Array’, Version 2 (RITA-2)
Kareem E. Hassan, Ann Kathrin Ahrens, Ahmed Ali, Magdy F. El-Kady, Hafez M. Hafez, Thomas C. Mettenleiter, Martin Beer, Timm Harder
Viruses.2022; 14(2): 415. CrossRef
Genetic evolution of hemagglutinin and neuraminidase genes of H5N1 highly pathogenic avian influenza viruses in Thailand
Pirom Noisumdaeng, Juthamas Phadungsombat, Sasrinakarn Weerated, Witthawat Wiriyarat, Pilaipan Puthavathana
PeerJ.2022; 10: e14419. CrossRef
H5N1 infection impairs the alveolar epithelial barrier through intercellular junction proteins via Itch-mediated proteasomal degradation
Tao Ruan, Yuling Sun, Jingting Zhang, Jing Sun, Wei Liu, Richard A. Prinz, Daxin Peng, Xiufan Liu, Xiulong Xu
Communications Biology.2022;[Epub] CrossRef
Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China
Pengfei Cui, Xianying Zeng, Xuyong Li, Yanbing Li, Jianzhong Shi, Conghui Zhao, Zhiyuan Qu, Yanwen Wang, Jing Guo, Wenli Gu, Qi Ma, Yuancheng Zhang, Weipeng Lin, Minghui Li, Jingman Tian, Dongxue Wang, Xin Xing, Yanjing Liu, Shuxin Pan, Yaping Zhang, Hong
Science China Life Sciences.2022; 65(4): 795. CrossRef
A broad spectrum HVT-H5 avian influenza vector vaccine which induces a rapid onset of immunity
Sylvia Reemers, Iwan Verstegen, Stephanie Basten, Willem Hubers, Saskia van de Zande
Vaccine.2021; 39(7): 1072. CrossRef
The genetics of highly pathogenic avian influenza viruses of subtype H5 in Germany, 2006–2020
Jacqueline King, Timm Harder, Franz J. Conraths, Martin Beer, Anne Pohlmann
Transboundary and Emerging Diseases.2021; 68(3): 1136. CrossRef
Safety, Immunogenicity, and Protective Efficacy of an H5N1 Chimeric Cold-Adapted Attenuated Virus Vaccine in a Mouse Model
Weiyang Sun, Zhenfei Wang, Yue Sun, Dongxu Li, Menghan Zhu, Menglin Zhao, Yutian Wang, Jiaqi Xu, Yunyi Kong, Yuanguo Li, Na Feng, Tiecheng Wang, Yongkun Zhao, Songtao Yang, Yuwei Gao, Xianzhu Xia
Viruses.2021; 13(12): 2420. CrossRef
Development and biochemical characterization of the monoclonal antibodies for specific detection of the emerging H5N8 and H5Nx avian influenza virus hemagglutinins
Yu-Chen Cheng, Shih-Chung Chang
Applied Microbiology and Biotechnology.2021; 105(1): 235. CrossRef
Different Sensitivity of Japanese Native-Bred Chickens to H5 Subtypes of Highly Pathogenic Avian Influenza Viruses
Aya Matsuu, Taichiro Tanikawa, Yoshikazu Fujimoto, Mihoko Yabuki, Ryota Tsunekuni, Saki Sakuma, Yuko Uchida, Takehiko Saito
Avian Diseases.2021;[Epub] CrossRef
Development of an antigen-ELISA and a colloidal gold–based immunochromatographic strip based on monoclonal antibodies for detection of avian influenza A(H5) viruses
Yixin Xiao, Fan Yang, Fumin Liu, Linfang Cheng, Hangping Yao, Nanping Wu, Haibo Wu
Journal of Veterinary Diagnostic Investigation.2021; 33(5): 969. CrossRef
N-linked glycosylation at site 158 of the HA protein of H5N6 highly pathogenic avian influenza virus is important for viral biological properties and host immune responses
Ruyi Gao, Min Gu, Liwei Shi, Kaituo Liu, Xiuli Li, Xiaoquan Wang, Jiao Hu, Xiaowen Liu, Shunlin Hu, Sujuan Chen, Daxin Peng, Xinan Jiao, Xiufan Liu
Veterinary Research.2021;[Epub] CrossRef
Wild bird trade at live poultry markets potentiates risks of avian influenza virus introduction in Iran
Amir Modirihamedan, Shabnam Aghajantabar, Jacqueline King, Annika Graaf, Anne Pohlmann, Leila Aghaiyan, Zahra Ziafati Kafi, Yeganeh Mahfoozi, Hossein Hosseini, Martin Beer, Arash Ghalyanchilangeroudi, Timm Harder
Infection Ecology & Epidemiology.2021;[Epub] CrossRef
A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies
Adrian Creanga, Rebecca A. Gillespie, Brian E. Fisher, Sarah F. Andrews, Julia Lederhofer, Christina Yap, Liam Hatch, Tyler Stephens, Yaroslav Tsybovsky, Michelle C. Crank, Julie E. Ledgerwood, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Masar
Nature Communications.2021;[Epub] CrossRef
Outbreak Severity of Highly Pathogenic Avian Influenza A(H5N8) Viruses Is Inversely Correlated to Polymerase Complex Activity and Interferon Induction
René M. Vigeveno, Marjolein J. Poen, Edyth Parker, Melle Holwerda, Karen de Haan, Thijs van Montfort, Nicola S. Lewis, Colin A. Russell, Ron A. M. Fouchier, Menno D. de Jong, Dirk Eggink, Stacey Schultz-Cherry
Journal of Virology.2020;[Epub] CrossRef
Certainty of success: three critical parameters in coronavirus vaccine development
David C. Kaslow
npj Vaccines.2020;[Epub] CrossRef
Transmission experiments support clade-level differences in the transmission and pathogenicity of Cambodian influenza A/H5N1 viruses
Paul F. Horwood, Thomas Fabrizio, Srey Viseth Horm, Artem Metlin, Sopheaktra Ros, Songha Tok, Trushar Jeevan, Patrick Seiler, Phalla Y, Sareth Rith, Annika Suttie, Philippe Buchy, Erik A. Karlsson, Richard Webby, Philippe Dussart
Emerging Microbes & Infections.2020; 9(1): 1702. CrossRef
Effects and safety of Tanreqing injection on viral pneumonia: Retraction
Yue Qiu, Xue Pan, Lin Su, Hui Lui, Ya-Dong Li
Medicine.2020; 99(37): e22022. CrossRef
A recombinant avian paramyxovirus serotype 3 expressing the hemagglutinin protein protects chickens against H5N1 highly pathogenic avian influenza virus challenge
Edris Shirvani, Berin P. Varghese, Anandan Paldurai, Siba K. Samal
Scientific Reports.2020;[Epub] CrossRef
Sequential DNA immunization of chickens with bivalent heterologous vaccines induce highly reactive and cross-specific antibodies against influenza hemagglutinin
Anna Stachyra, Anna Góra-Sochacka, Jan P Radomski, Agnieszka Sirko
Poultry Science.2019; 98(1): 199. CrossRef
A review of H5Nx avian influenza viruses
Ivette A. Nuñez, Ted M. Ross
Therapeutic Advances in Vaccines and Immunotherapy.2019;[Epub] CrossRef
Recombinant H5 hemagglutinin adjuvanted with nanoemulsion protects ferrets against pathogenic avian influenza virus challenge
Su He Wang, Douglas Smith, Zhengyi Cao, Jesse Chen, Hugo Acosta, Jessica A. Chichester, Vidadi Yusibov, Stephen J. Streatfield, Ali Fattom, James R. Baker
Vaccine.2019; 37(12): 1591. CrossRef
The safety and immunogenicity of a cell-derived adjuvanted H5N1 vaccine – A phase I randomized clinical trial
Aristine Cheng, Szu-Min Hsieh, Sung-Ching Pan, Yu-Han Li, Erh-Fang Hsieh, Hsiang-Chi Lee, Ting-Wan Lin, Kuan-Lang Lai, Charles Chen, Stanley Shi-Chung Chang, Shan-Chwen Chang
Journal of Microbiology, Immunology and Infection.2019; 52(5): 685. CrossRef
Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus Challenge
Irina Isakova-Sivak, Victoria Matyushenko, Tatiana Kotomina, Irina Kiseleva, Elena Krutikova, Svetlana Donina, Andrey Rekstin, Natalia Larionova, Daria Mezhenskaya, Konstantin Sivak, Arman Muzhikyan, Anastasia Katelnikova, Larisa Rudenko
Vaccines.2019; 7(3): 61. CrossRef
Sensitivity of Commercially Available Influenza Rapid Diagnostic Tests in the 2018–2019 Influenza Season
Yuko Sakai-Tagawa, Seiya Yamayoshi, Yoshihiro Kawaoka
Frontiers in Microbiology.2019;[Epub] CrossRef
Adaptive Evolution of Human-Isolated H5Nx Avian Influenza A Viruses
Fucheng Guo, Yiliang Li, Shu Yu, Lu Liu, Tingting Luo, Zhiqing Pu, Dan Xiang, Xuejuan Shen, David M. Irwin, Ming Liao, Yongyi Shen
Frontiers in Microbiology.2019;[Epub] CrossRef
DDX5 RNA Helicases: Emerging Roles in Viral Infection
Wenyu Cheng, Guohua Chen, Huaijie Jia, Xiaobing He, Zhizhong Jing
International Journal of Molecular Sciences.2018; 19(4): 1122. CrossRef
Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge
Raffael Nachbagauer, David Shore, Hua Yang, Scott K. Johnson, Jon D. Gabbard, S. Mark Tompkins, Jens Wrammert, Patrick C. Wilson, James Stevens, Rafi Ahmed, Florian Krammer, Ali H. Ellebedy, Stacey Schultz-Cherry
Journal of Virology.2018;[Epub] CrossRef
Advances in Influenza Virus Research: A Personal Perspective
Kanta Subbarao
Viruses.2018; 10(12): 724. CrossRef
Challenges of influenza A viruses in humans and animals and current animal vaccines as an effective control measure
Sung J. Yoo, Taeyong Kwon, Young S. Lyoo
Clinical and Experimental Vaccine Research.2018; 7(1): 1. CrossRef
Characterization of H5N1 Influenza Virus Quasispecies with Adaptive Hemagglutinin Mutations from Single-Virus Infections of Human Airway Cells
Yohei Watanabe, Yasuha Arai, Norihito Kawashita, Madiha S. Ibrahim, Emad M. Elgendy, Tomo Daidoji, Junichi Kajikawa, Hiroaki Hiramatsu, Nongluk Sriwilaijaroen, Takao Ono, Tatsuya Takagi, Kazuo Takahashi, Tatsuo Shioda, Kazuhiko Matsumoto, Yasuo Suzuki, Ta
Journal of Virology.2018;[Epub] CrossRef
A 113-amino-acid truncation at the NS1 C-terminus is a determinant for viral replication of H5N6 avian influenza virus in vitro and in vivo
Xiaole Cui, Yanhong Ji, Zhengxiang Wang, Yingying Du, Haoran Guo, Liang Wang, Hualan Chen, Qiyun Zhu
Veterinary Microbiology.2018; 225: 6. CrossRef
Enhanced Human-Type Receptor Binding by Ferret-Transmissible H5N1 with a K193T Mutation
Wenjie Peng, Kim M. Bouwman, Ryan McBride, Oliver C. Grant, Robert J. Woods, Monique H. Verheije, James C. Paulson, Robert P. de Vries, Adolfo García-Sastre
Journal of Virology.2018;[Epub] CrossRef
Reactivity and sensitivity of commercially available influenza rapid diagnostic tests in Japan
Yuko Sakai-Tagawa, Seiya Yamayoshi, Chiharu Kawakami, Mai Q. Le, Yuko Uchida, Takehiko Saito, Chairul A. Nidom, Ira Humaira, Kathy Toohey-Kurth, Abdel-Satar Arafa, Ming-Tsan Liu, Yuelong Shu, Yoshihiro Kawaoka
Scientific Reports.2017;[Epub] CrossRef
Natural Reassortants of Potentially Zoonotic Avian Influenza Viruses H5N1 and H9N2 from Egypt Display Distinct Pathogenic Phenotypes in Experimentally Infected Chickens and Ferrets
Mahmoud M. Naguib, Reiner Ulrich, Elisa Kasbohm, Christine L. P. Eng, Donata Hoffmann, Christian Grund, Martin Beer, Timm C. Harder, Adolfo García-Sastre
Journal of Virology.2017;[Epub] CrossRef
Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016–2017
Nobuhiro Takemae, Ryota Tsunekuni, Kirill Sharshov, Taichiro Tanikawa, Yuko Uchida, Hiroshi Ito, Kosuke Soda, Tatsufumi Usui, Ivan Sobolev, Alexander Shestopalov, Tsuyoshi Yamaguchi, Junki Mine, Toshihiro Ito, Takehiko Saito
Virology.2017; 512: 8. CrossRef
Efficacy of an Adenoviral Vectored Multivalent Centralized Influenza Vaccine
Amy Lingel, Brianna L. Bullard, Eric A. Weaver
Scientific Reports.2017;[Epub] CrossRef

Journal Article

MDA7/IL-24 is an anti-viral factor that inhibits influenza virus replication: Rak-Kyun Seong , Young-Ki Choi , Ok Sarah Shin; J. Microbiol. 2016;54(10):695-700. Published online September 30, 2016; DOI: https://doi.org/10.1007/s12275-016-6383-2

72 View
0 Download
14 Crossref

Abstract

Melanoma differentiation associated gene-7 (mda-7)/interleukin- 24 (IL-24) is a secreted cytokine, which plays an essential role in tumor suppression. Although its role as a multifunctional protein affecting broad types of cancers is well described, functions of IL-24 in host defense against virus infection are yet to be determined. In this study, we explored the anti-viral effect of recombinant IL-24 treatment during influenza infection. Infection of human lung adenocarcinoma cells (A549) with the influenza A virus up-regulated IL-24 mRNA and protein expression in a time-dependent manner. Pre-treatment of A549 cells with recombinant IL-24 protein effectively suppressed viral plaque formation. Furthermore, IL-24 treatment of A549 cells reduced viral non-structural protein 1 (NS1) synthesis, whereas IL-24 knockdown resulted in increased viral replication. Interestingly, IL-24 treatment following influenza A virus infection led to up-regulation of interferon (IFN)-induced antiviral signaling. Taken together, our results suggest that IL-24 exerts a potent suppressive effect on influenza viral replication and can be used in the treatment of influenza infection.

Citations

Citations to this article as recorded by

CXCR4/CXCL12 blockade therapy; a new horizon in TNBC therapy
Abdulrahman Qais Khaleel, Farag M. A. Altalbawy, Majid S. Jabir, Thikra F.Hasan, Vicky Jain, Vikrant Abbot, Prashant Nakash, M. Ravi Kumar, Yasser Fakri Mustafa, Mohammed Abed Jawad
Medical Oncology.2025;[Epub] CrossRef
Novel insight into MDA-7/IL-24: A potent therapeutic target for autoimmune and inflammatory diseases
Kangni Feng, Jiemei Cen, Xiaoling Zou, Tiantuo Zhang
Clinical Immunology.2024; 266: 110322. CrossRef
Interleukin-24 Limits Tumor-Infiltrating T Helper 17 Cell Response in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma
Minqi Zhang, Haifeng Zhao, Honglei Gao
Viral Immunology.2022; 35(3): 212. CrossRef
Host–virus interaction and viral evasion
Scheilla T. Strumillo, Denis Kartavykh, Fábio F. de Carvalho , Nicolly C. Cruz, Ana C. de Souza Teodoro, Ricardo Sobhie Diaz, Marli F. Curcio
Cell Biology International.2021; 45(6): 1124. CrossRef
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response
Soo Jin Oh, Ok Sarah Shin
Cells.2021; 10(3): 530. CrossRef
Interleukin-24 as a Pulmonary Target Cytokine in Bronchopulmonary Dysplasia
Ruiwei Gao, Zhihua Li, Danyang Ai, Jinshuai Ma, Chao Chen, Xiuxiang Liu
Cell Biochemistry and Biophysics.2021; 79(2): 311. CrossRef
Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer
Chia-Jung Li, Yen-Dun Tony Tzeng, Yi-Han Chiu, Hung-Yu Lin, Ming-Feng Hou, Pei-Yi Chu
Cancers.2021; 13(12): 2978. CrossRef
MDA-7/interleukin 24 (IL-24) in tumor gene therapy: application of tumor penetrating/homing peptides for improvement of the effects
Mohammad Rasoolian, Majid Kheirollahi, Seyed Younes Hosseini
Expert Opinion on Biological Therapy.2019; 19(3): 211. CrossRef
Alternative Experimental Models for Studying Influenza Proteins, Host–Virus Interactions and Anti-Influenza Drugs
Sonja C. J. H. Chua, Hui Qing Tan, David Engelberg, Lina H. K. Lim
Pharmaceuticals.2019; 12(4): 147. CrossRef
HIV‐1 infection modulates IL‐24 expression which contributes to cell apoptosis in vitro
Scheilla Teixeira Strumillo, Marli Ferreira Curcio, Fábio Ferreira de Carvalho, MariaCecília Araripe Sucupira, Ricardo Sobhie Diaz, Hugo Pequeno Monteiro, Luiz Mário Ramos Janini
Cell Biology International.2019; 43(5): 574. CrossRef
Production of Interleukin-20 cytokines limits bacterial clearance and lung inflammation during infection by Streptococcus pneumoniae
Fahima Madouri, Olivia Barada, Gwenola Kervoaze, François Trottein, Muriel Pichavant, Philippe Gosset
EBioMedicine.2018; 37: 417. CrossRef
Inhibitory Effect and Mechanism of Mesenchymal Stem Cells Cultured in 3D System on Hepatoma Cells HepG2
Diandian Zhao, Lingling Hou, Mengwu Pan, Jilei Hua, Ziling Wang, Jinsheng He, Honggang Hu
Applied Biochemistry and Biotechnology.2018; 184(1): 212. CrossRef
Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas
Sangmin Kang, Jinjong Myoung
Journal of Microbiology.2017; 55(5): 319. CrossRef
Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication
Rak-Kyun Seong, Seong-wook Seo, Ji-Ae Kim, Sarah J. Fletcher, Neil V. Morgan, Mukesh Kumar, Young-Ki Choi, Ok Sarah Shin
Immunobiology.2017; 222(11): 979. CrossRef

Review

MINIREVIEW] Advances in novel influenza vaccines: a patent review: Jae-Min Song; J. Microbiol. 2016;54(6):403-412. Published online May 27, 2016; DOI: https://doi.org/10.1007/s12275-016-6176-7

57 View
0 Download
1 Crossref

Abstract

The threat of a major human influenza pandemic such as the avian H5N1 or the 2009 new H1N1 has emphasized the need for effective prevention strategies to combat these pathogens. Although egg based influenza vaccines have been well established for a long time, it remains an ongoing public health need to develop alternative production methods that ensures improved safety, efficacy, and ease of administration compared with conventional influenza vaccines. This article is intended to cover some of the recent advances and related patents on the development of influenza vaccines including live attenuated, cell based, genomic and synthetic peptide vaccines.

Citations

Citations to this article as recorded by

Plant-made virus-like particles bearing influenza hemagglutinin (HA) recapitulate early interactions of native influenza virions with human monocytes/macrophages
Alexander I. Makarkov, Sabrina Chierzi, Stéphane Pillet, Keith K. Murai, Nathalie Landry, Brian J. Ward
Vaccine.2017; 35(35): 4629. CrossRef

Retracted Publication

Interferon-mediated antiviral activities of Angelica tenuissima Nakai and its active components: Prasanna Weeratunga , Md Bashir Uddin , Myun Soo Kim , Byeong-Hoon Lee , Tae-Hwan Kim , Ji-Eun Yoon , Jin Yeul Ma , Hongik Kim , Jong-Soo Lee; J. Microbiol. 2016;54(1):57-70. Published online January 5, 2016; DOI: https://doi.org/10.1007/s12275-016-5555-4

66 View
0 Download
5 Crossref

Abstract

Angelica tenuissima Nakai is a widely used commodity in traditional medicine. Nevertheless, no study has been conducted on the antiviral and immune-modulatory properties of an aqueous extract of Angelica tenuissima Nakai. In the present study, we evaluated the antiviral activities and the mechanism of action of an aqueous extract of Angelica tenuissima Nakai both in vitro and in vivo. In vitro, an effective dose of Angelica tenuissima Nakai markedly inhibited the replication of Influenza A virus (PR8), Vesicular stomatitis virus (VSV), Herpes simplex virus (HSV), Coxsackie virus, and Enterovirus (EV-71) on epithelial (HEK293T/HeLa) and immune (RAW264.7) cells. Such inhibition can be described by the induction of the antiviral state in cells by antiviral, IFNrelated gene induction and secretion of IFNs and pro-inflammatory cytokines. In vivo, Angelica tenuissima Nakai treated BALB/c mice displayed higher survivability and lower lung viral titers when challenged with lethal doses of highly pathogenic influenza A subtypes (H1N1, H5N2, H7N3, and H9N2). We also found that Angelica tenuissima Nakai can induce the secretion of IL-6, IFN-λ, and local IgA in bronchoalveolar lavage fluid (BALF) of Angelica tenuissima Nakai treated mice, which correlating with the observed prophylactic effects. In HPLC analysis, we found the presence of several compounds in the aqueous fraction and among them; we evaluated antiviral properties of ferulic acid. Therefore, an extract of Angelica tenuissima Nakai and its components, including ferulic acid, play roles as immunomodulators and may be potential candidates for novel anti-viral/anti-influenza agents.

Citations

Citations to this article as recorded by

The stimulatory effect of Angelica tenuissima Nakai in osteoblastic/odontoblastic differentiation of human periodontal ligament stem cells
Won-Jong Park, Youn Ho Han
Korean Journal of Dental Materials.2022; 49(4): 187. CrossRef
Fermented Angelicae tenussimae with Aspergillus oryzae Improves Skin Barrier Properties, Moisturizing, and Anti-Inflammatory Responses
Chang-Woo Ha, Eun-Hwa Sohn, Sung-Hyeok Kim, Sohee Jang, Myung-Rye Park, Youn-Kyu Kim, In-Young Bae
International Journal of Molecular Sciences.2022; 23(20): 12072. CrossRef
Extract of Polygala tenuifolia, Angelica tenuissima, and Dimocarpus longan Reduces Behavioral Defect and Enhances Autophagy in Experimental Models of Parkinson’s Disease
Huan Li, Joonki Kim, Huynh Nguyen Khanh Tran, Chang Hwan Lee, Jonghyun Hur, Min Cheol Kim, Hyun Ok Yang
NeuroMolecular Medicine.2021; 23(3): 428. CrossRef
Chemical Constituents of the Root of Angelica tenuissima and their Anti-allergic Inflammatory Activity
Hyun Gyu Choi, In-Gyu Je, Geum Jin Kim, Joo-Won Nam, Sang Hee Shim, Sang-Hyun Kim, Hyukjae Choi
Natural Product Communications.2017;[Epub] CrossRef
Inhibitory effects of bee venom and its components against viruses in vitro and in vivo
Md Bashir Uddin, Byeong-Hoon Lee, Chamilani Nikapitiya, Jae-Hoon Kim, Tae-Hwan Kim, Hyun-Cheol Lee, Choul Goo Kim, Jong-Soo Lee, Chul-Joong Kim
Journal of Microbiology.2016; 54(12): 853. CrossRef

First
Prev
Page of 3
Next
Last

Search