Journal of Microbiology

Journal Article

A rule governing the FtsH-mediated proteolysis of the MgtC virulence protein from Salmonella enterica serovar Typhimurium: Jonghyun Baek , Eunna Choi , Eun-Jin Lee; J. Microbiol. 2018;56(8):565-570. Published online July 25, 2018; DOI: https://doi.org/10.1007/s12275-018-8245-6

50 View
0 Download
6 Crossref

A tightly controlled turnover of membrane proteins is required for lipid bilayer stability, cell metabolism, and cell viability. Among the energy-dependent AAA+ proteases in Salmonella, FtsH is the only membrane-bound protease that contributes to the quality control of membrane proteins. FtsH preferentially degrades the C-terminus or N-terminus of misfolded, misassembled, or damaged proteins to maintain physiological functions. We found that FtsH hydrolyzes the Salmonella MgtC virulence protein when we substitute the MgtC 226th Trp, which is well conserved in other intracellular pathogens and normally protects MgtC from the FtsH-mediated proteolysis. Here we investigate a rule determining the FtsHmediated proteolysis of the MgtC protein at Trp226 residue. Substitution of MgtC tryptophan 226th residue to alanine, glycine, or tyrosine leads to MgtC proteolysis in a manner dependent on the FtsH protease whereas substitution to phenylalanine, methionine, isoleucine, leucine, or valine resists MgtC degradation by FtsH. These data indicate that a large and hydrophobic side chain at 226th residue is required for protection from the FtsH-mediated MgtC proteolysis.

Citations

Citations to this article as recorded by

Edwardsiella piscicida requires SecY homeostasis facilitated by FtsH and YccA for stress resistance and virulence
Qingjuan Wu, Aijun Tian, Jiarui Xu, Qingjian Fang, Huiqin Huang, Yonghua Hu
Aquaculture.2024; 582: 740528. CrossRef
For Someone, You Are the Whole World: Host-Specificity of Salmonella enterica
Anastasiya V. Merkushova, Anton E. Shikov, Anton A. Nizhnikov, Kirill S. Antonets
International Journal of Molecular Sciences.2023; 24(18): 13670. CrossRef
Edwardsiella piscicida YccA: A novel virulence factor essential to membrane integrity, mobility, host infection, and host immune response
Mengru Jin, Jiaojiao He, Jun Li, Yonghua Hu, Dongmei Sun, Hanjie Gu
Fish & Shellfish Immunology.2022; 126: 318. CrossRef
FtsH is required for protein secretion homeostasis and full bacterial virulence in Edwardsiella piscicida
Wei Wang, Jiatiao Jiang, Hao Chen, Yuanxing Zhang, Qin Liu
Microbial Pathogenesis.2021; 161: 105194. CrossRef
RNase G controls tpiA mRNA abundance in response to oxygen availability in Escherichia coli
Jaejin Lee, Dong-Ho Lee, Che Ok Jeon, Kangseok Lee
Journal of Microbiology.2019; 57(10): 910. CrossRef
The coordinated action of RNase III and RNase G controls enolase expression in response to oxygen availability in Escherichia coli
Minho Lee, Minju Joo, Minji Sim, Se-Hoon Sim, Hyun-Lee Kim, Jaejin Lee, Minkyung Ryu, Ji-Hyun Yeom, Yoonsoo Hahn, Nam-Chul Ha, Jang-Cheon Cho, Kangseok Lee
Scientific Reports.2019;[Epub] CrossRef

Review

MINIREVIEW] Regulation and function of the Salmonella MgtC virulence protein: Jang-Woo Lee , Eun-Jin Lee; J. Microbiol. 2015;53(10):667-672. Published online August 1, 2015; DOI: https://doi.org/10.1007/s12275-015-5283-1

50 View
0 Download
22 Crossref

Abstract

Salmonella enterica serovar Typhimurium produces many virulence proteins to cause diseases. The Salmonella MgtC protein is one of such virulence proteins specially required for intracellular proliferation inside macrophages and mouse virulence. In this review, we will cover how the mgtC gene is turned on or off and what the signals required for mgtC expression are. Later in this review, we will discuss a recent understanding of MgtC function in Salmonella pathogenesis by identifying its target proteins.

Citations

Citations to this article as recorded by

The peptidoglycan-associated lipoprotein gene mutant elicits robust immunological defense in mice against Salmonella enteritidis
Guixin Zhao, Wenlong Duan, Lu Zhang, Wenchao Sun, Wan Liu, Xiaoyu Zhang, Yanying Zhang, Qiumei Shi, Tonglei Wu
Frontiers in Microbiology.2024;[Epub] CrossRef
Insights into the global genomic features of Salmonella enterica serovar Gallinarum biovars Gallinarum and Pullorum
Isabela C Campos, Felipe Pinheiro Vilela, Mauro de M S Saraiva, Angelo Berchieri Junior, Juliana Pfrimer Falcão
Journal of Applied Microbiology.2024;[Epub] CrossRef
Salmonella Gallinarum mgtC mutant shows a delayed fowl typhoid progression in chicken
Lucas Bocchini Rodrigues Alves, Oliveiro Caetano de Freitas Neto, Mauro de Mesquita Souza Saraiva, Daniel Farias Marinho do Monte, Bruna Nestlehner de Lima, Julia Memrava Cabrera, Fernanda de Oliveira Barbosa, Valdinete Pereira Benevides, Túlio Spina de L
Gene.2024; 892: 147827. CrossRef
CRISPR-Cas system positively regulates virulence of Salmonella enterica serovar Typhimurium
Nandita Sharma, Ankita Das, Abhilash Vijay Nair, Palash Sethi, Vidya Devi Negi, Dipshikha Chakravortty, Sandhya Amol Marathe
Gut Pathogens.2024;[Epub] CrossRef
Contribution of intramacrophage stages to Pseudomonas aeruginosa infection outcome in zebrafish embryos: insights from mgtC and oprF mutants
Hélène Hajjar, Laurence Berry, Yongzheng Wu, Lhousseine Touqui, Annette C. Vergunst, Anne-Béatrice Blanc-Potard
Scientific Reports.2024;[Epub] CrossRef
Impact of Arsenic Stress on the Antioxidant System and Photosystem of Arthrospira platensis
Jiawei Liu, Jie Du, Di Wu, Xiang Ji, Xiujuan Zhao
Biology.2024; 13(12): 1049. CrossRef
Horizontal Gene Transfer and Drug Resistance Involving Mycobacterium tuberculosis
Xuhua Xia
Antibiotics.2023; 12(9): 1367. CrossRef
Virulence genes identification in Salmonella enterica isolates from humans, crocodiles, and poultry farms from two regions in Colombia
Julieth Michel Petano-Duque, Valentina Rueda-García, Iang Schroniltgen Rondón-Barragán
Veterinary World.2023; : 2096. CrossRef
Virulence and Antimicrobial Resistance Gene Profiling of Salmonella Isolated from Swine Meat Samples in Abattoirs and Wet Markets of Metro Manila, Philippines
Rance Derrick N. Pavon, Windell L. Rivera
Microbiology and Biotechnology Letters.2023; 51(4): 390. CrossRef
Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design
Kia C. Ferrell, Matt D. Johansen, James A. Triccas, Claudio Counoupas
Frontiers in Microbiology.2022;[Epub] CrossRef
Characterization of Salmonella spp. Isolates from Swine: Virulence and Antimicrobial Resistance
Hai Nguyen Thi, Thi-Thanh-Thao Pham, Barbara Turchi, Filippo Fratini, Valentina Virginia Ebani, Domenico Cerri, Fabrizio Bertelloni
Animals.2020; 10(12): 2418. CrossRef
The mgtCBR mRNA Leader Secures Growth of Salmonella in Both Host and Non-host Environments
Myungseo Park, Hyunkeun Kim, Daesil Nam, Dae-Hyuk Kweon, Dongwoo Shin
Frontiers in Microbiology.2019;[Epub] CrossRef
Synthetic hydrophobic peptides derived from MgtR weaken Salmonella pathogenicity and work with a different mode of action than endogenously produced peptides
Mariana Rosas Olvera, Preeti Garai, Grégoire Mongin, Eric Vivès, Laila Gannoun-Zaki, Anne-Béatrice Blanc-Potard
Scientific Reports.2019;[Epub] CrossRef
The malS-5′UTR weakens the ability of Salmonella enterica serovar Typhi to survive in macrophages by increasing intracellular ATP levels
Fang Dong, Lin Xia, Renfei Lu, Xin Zhao, Yiquan Zhang, Ying Zhang, Xinxiang Huang
Microbial Pathogenesis.2018; 115: 321. CrossRef
High‐level, constitutive expression of the mgtC gene confers increased thermotolerance on Salmonella enterica serovar Typhimurium
Aaron R. Gall, Annie E. Hegarty, Kirill A. Datsenko, Richard P. Westerman, Phillip SanMiguel, Laszlo N. Csonka
Molecular Microbiology.2018; 109(3): 327. CrossRef
Regulatory RNAs in Virulence and Host-Microbe Interactions
Alexander J. Westermann, Gisela Storz, Kai Papenfort
Microbiology Spectrum.2018;[Epub] CrossRef
Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus
Michael Rahe, Michael Murtaugh
Viruses.2017; 9(6): 148. CrossRef
Regulating Bacterial Virulence with RNA
Juan J. Quereda, Pascale Cossart
Annual Review of Microbiology.2017; 71(1): 263. CrossRef
A trans -acting leader RNA from a Salmonella virulence gene
Eunna Choi, Yoontak Han, Yong-Joon Cho, Daesil Nam, Eun-Jin Lee
Proceedings of the National Academy of Sciences.2017; 114(38): 10232. CrossRef
Elongation factor P restricts Salmonella’s growth by controlling translation of a Mg2+ transporter gene during infection
Eunna Choi, Soomin Choi, Daesil Nam, Shinae Park, Yoontak Han, Jung-Shin Lee, Eun-Jin Lee
Scientific Reports.2017;[Epub] CrossRef
Intramacrophage Survival for Extracellular Bacterial Pathogens: MgtC As a Key Adaptive Factor
Claudine Belon, Anne-Béatrice Blanc-Potard
Frontiers in Cellular and Infection Microbiology.2016;[Epub] CrossRef
Behavior variability of Salmonella enterica isolates from meat-related sources
Huhu Wang, Yun Jiang, Xuan Liu, Wenjuan Qian, Xinglian Xu, Guanghong Zhou
LWT.2016; 73: 375. CrossRef

First
Prev
Page of 1
Next
Last

Search