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- Hepatitis B virus (HBV) codon adapts well to the gene expression profile of liver cancer: an evolutionary explanation for HBV’s oncogenic role
- Chunpeng Yu , Jian Li , Qun Li , Shuai Chang , Yufeng Cao , Hui Jiang , Lingling Xie , Gang Fan , Song Wang
- J. Microbiol. 2022;60(11):1106-1112. Published online October 17, 2022
- DOI: https://doi.org/10.1007/s12275-022-2371-x
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- 10 Web of Science
- 6 Crossref
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Abstract
PDF - Due to the evolutionary arms race between hosts and viruses, viruses must adapt to host translation systems to rapidly synthesize viral proteins. Highly expressed genes in hosts have a codon bias related to tRNA abundance, the primary RNA translation rate determinant. We calculated the relative synonymous codon usage (RSCU) of three hepatitis viruses (HAV, HBV, and HCV), SARS-CoV-2, 30 human tissues, and hepatocellular carcinoma (HCC). After comparing RSCU between viruses and human tissues, we calculated the codon adaptation index (CAI) of viral and human genes. HBV and HCV showed the highest correlations with HCC and the normal liver, while SARS-CoV-2 had the strongest association with lungs. In addition, based on HCC RSCU, the CAI of HBV and HCV genes was the highest. HBV and HCV preferentially adapt to the tRNA pool in HCC, facilitating viral RNA translation. After an initial trigger, rapid HBV/HCV translation and replication may change normal liver cells into HCC cells. Our findings reveal a novel perspective on virus-mediated oncogenesis.
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Citations
Citations to this article as recorded by
- Decoding codon usage in human papillomavirus type 59
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PLOS One.2025; 20(5): e0323708. CrossRef - Predicting viral host codon fitness and path shifting through tree-based learning on codon usage biases and genomic characteristics
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Scientific Reports.2025;[Epub] CrossRef - Conserved spatiotemporal expression landscape of dominant tRNA genes in human and mouse
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Biochemical and Biophysical Research Communications.2023; 681: 173. CrossRef - Evolution and diversity of nucleotide and dinucleotide composition in poxviruses
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Journal of General Virology .2023;[Epub] CrossRef - Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming
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Frontiers in Pharmacology.2023;[Epub] CrossRef
- Decoding codon usage in human papillomavirus type 59
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