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Hepatitis B virus (HBV) codon adapts well to the gene expression profile of liver cancer: an evolutionary explanation for HBV’s oncogenic role
Chunpeng Yu , Jian Li , Qun Li , Shuai Chang , Yufeng Cao , Hui Jiang , Lingling Xie , Gang Fan , Song Wang
J. Microbiol. 2022;60(11):1106-1112.   Published online October 17, 2022
DOI: https://doi.org/10.1007/s12275-022-2371-x
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AbstractAbstract
Due to the evolutionary arms race between hosts and viruses, viruses must adapt to host translation systems to rapidly synthesize viral proteins. Highly expressed genes in hosts have a codon bias related to tRNA abundance, the primary RNA translation rate determinant. We calculated the relative synonymous codon usage (RSCU) of three hepatitis viruses (HAV, HBV, and HCV), SARS-CoV-2, 30 human tissues, and hepatocellular carcinoma (HCC). After comparing RSCU between viruses and human tissues, we calculated the codon adaptation index (CAI) of viral and human genes. HBV and HCV showed the highest correlations with HCC and the normal liver, while SARS-CoV-2 had the strongest association with lungs. In addition, based on HCC RSCU, the CAI of HBV and HCV genes was the highest. HBV and HCV preferentially adapt to the tRNA pool in HCC, facilitating viral RNA translation. After an initial trigger, rapid HBV/HCV translation and replication may change normal liver cells into HCC cells. Our findings reveal a novel perspective on virus-mediated oncogenesis.

Citations

Citations to this article as recorded by  
  • Conserved spatiotemporal expression landscape of dominant tRNA genes in human and mouse
    Evan Y. Wu, Laura Landry
    Biochemical and Biophysical Research Communications.2023; 681: 173.     CrossRef
  • Evolution and diversity of nucleotide and dinucleotide composition in poxviruses
    Cristian Molteni, Diego Forni, Rachele Cagliani, Ignacio G. Bravo, Manuela Sironi
    Journal of General Virology .2023;[Epub]     CrossRef
  • Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming
    Hao Chen, Lan-Lan Li, Yan Du
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
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