Journal of Microbiology

Review

[Minireview] Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy: Bora Shin , Woojun Park; J. Microbiol. 2017;55(11):837-849. Published online October 27, 2017; DOI: https://doi.org/10.1007/s12275-017-7288-4

53 View
0 Download
38 Crossref

The increasing antibiotic resistance of Acinetobacter species in both natural and hospital environments has become a serious problem worldwide in recent decades. Because of both intrinsic and acquired antimicrobial resistance (AMR) against last-resort antibiotics such as carbapenems, novel therapeutics are urgently required to treat Acinetobacter-associated infectious diseases. Among the many pathogenic Acinetobacter species, A. baumannii has been reported to be resistant to all classes of antibiotics and contains many AMR genes, such as blaADC (Acinetobacter-derived cephalosporinase). The AMR of pathogenic Acinetobacter species is the result of several different mechanisms, including active efflux pumps, mutations in antibiotic targets, antibiotic modification, and low antibiotic membrane permeability. To overcome the limitations of existing drugs, combination theraphy that can increase the activity of antibiotics should be considered in the treatment of Acinetobacter infections. Understanding the molecular mechanisms behind Acinetobacter AMR resistance will provide vital information for drug development and therapeutic strategies using combination treatment. Here, we summarize the classic mechanisms of Acinetobacter AMR, along with newly-discovered genetic AMR factors and currently available antimicrobial adjuvants that can enhance drug efficacy in the treatment of A. baumannii infections.

Citations

Citations to this article as recorded by

Disruption of bacterial interactions and community assembly in Babesia-infected Haemaphysalis longicornis following antibiotic treatment
Myriam Kratou, Apolline Maitre, Lianet Abuin-Denis, Elianne Piloto-Sardiñas, Ivan Corona-Guerrero, Ana Laura Cano-Argüelles, Alejandra Wu-Chuang, Timothy Bamgbose, Consuelo Almazan, Juan Mosqueda, Dasiel Obregón, Lourdes Mateos-Hernández, Mourad Ben Said,
BMC Microbiology.2024;[Epub] CrossRef
A 19-year longitudinal study to characterize carbapenem-nonsusceptible Acinetobacter isolated from patients with bloodstream infections and the contribution of conjugative plasmids to carbapenem resistance and virulence
Pek Kee Chen, Yi-Tzu Lee, Chia-Ying Liu, Tran Thi Dieu Thuy, Kieu Anh, Jiunn-Jong Wu, Chun-Hsing Liao, Yu-Tsung Huang, Yu-Chen Chen, Cheng-Yen Kao
Journal of Microbiology, Immunology and Infection.2024; 57(2): 288. CrossRef
MOLECULAR ANALYSIS OF THE MCR-1 GENE IN PSEUDOMONAS AERUGINOSA AND ACINETOBACTER BAUMANII STRAINS
Ömer Akgül
Ankara Universitesi Eczacilik Fakultesi Dergisi.2024; 48(3): 21. CrossRef
Effect of Phenylalanine–Arginine Beta-Naphthylamide on the Values of Minimum Inhibitory Concentration of Quinolones and Aminoglycosides in Clinical Isolates of Acinetobacter baumannii
Stefany Plasencia-Rebata, Saul Levy-Blitchtein, Juana del Valle-Mendoza, Wilmer Silva-Caso, Isaac Peña-Tuesta, William Vicente Taboada, Fernando Barreda Bolaños, Miguel Angel Aguilar-Luis
Antibiotics.2023; 12(6): 1071. CrossRef
A comprehensive genomic analysis provides insights on the high environmental adaptability of Acinetobacter strains
Yang Zhao, Hua-Mei Wei, Jia-Li Yuan, Lian Xu, Ji-Quan Sun
Frontiers in Microbiology.2023;[Epub] CrossRef
Acinetobacter baumannii in blood-borne and central nervous system infections in intensive care unit children: molecular and genetic characteristics and clinical significance
Zulfirya Z. Sadeeva, Irina E. Novikova, Natalia M. Alyabyeva, Anna V. Lazareva, Tatiana M. Komyagina, Olga V. Karaseva, Marina G. Vershinina, Andrey P. Fisenko
Russian Journal of Infection and Immunity.2023; 13(2): 289. CrossRef
Herbal Products and Their Active Constituents Used Alone and in Combination with Antibiotics against Multidrug-Resistant Bacteria
Anna Herman, Andrzej P. Herman
Planta Medica.2023; 89(02): 168. CrossRef
A Systematic Review of Culture-Based Methods for Monitoring Antibiotic-Resistant Acinetobacter, Aeromonas, and Pseudomonas as Environmentally Relevant Pathogens in Wastewater and Surface Water
Erin G. Milligan, Jeanette Calarco, Benjamin C. Davis, Ishi M. Keenum, Krista Liguori, Amy Pruden, Valerie J. Harwood
Current Environmental Health Reports.2023; 10(2): 154. CrossRef
Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice
Jaeyeong Park, Eunkyoung Shin, Ji-Hyun Yeom, Younkyung Choi, Minju Joo, Minho Lee, Je Hyeong Kim, Jeehyeon Bae, Kangseok Lee
Journal of Microbiology.2022; 60(1): 128. CrossRef
In vitro study to evaluate the antimicrobial activity of various multifunctional cosmetic ingredients and chlorphenesin on bacterial species at risk in the cosmetic industry
Benjamin Youenou, Amandine Chauviat, Chrisse Ngari, Valérie Poulet, Sylvie Nazaret
Journal of Applied Microbiology.2022; 132(2): 933. CrossRef
Profiles of Microbial Community and Antibiotic Resistome in Wild Tick Species
Nana Wei, Jinmiao Lu, Yi Dong, Shibo Li, Jack A. Gilbert
mSystems.2022;[Epub] CrossRef
Conventional and Real-Time PCR Targeting blaOXA Genes as Reliable Methods for a Rapid Detection of Carbapenem-Resistant Acinetobacter baumannii Clinical Strains
Dagmara Depka, Agnieszka Mikucka, Tomasz Bogiel, Mateusz Rzepka, Patryk Zawadka, Eugenia Gospodarek-Komkowska
Antibiotics.2022; 11(4): 455. CrossRef
In vitro synergistic activity of colistin and teicoplanin combination against multidrug-resistant Acinetobacter spp
Osama Mohamed Samy Mohamed Rady, Laila El-Attar, Amira Amine
The Journal of Antibiotics.2022; 75(3): 181. CrossRef
Biogenic silver nanoparticle (Bio‐AgNP) has an antibacterial effect against carbapenem‐resistant Acinetobacter baumannii with synergism and additivity when combined with polymyxin B
Suzane Olachea Allend, Marcelle Oliveira Garcia, Kamila Furtado da Cunha, Déborah Trota Farias de Albernaz, Mirian Elert da Silva, Rodrigo Yudi Ishikame, Luciano Aparecido Panagio, Gerson Nakazaro, Guilherme Fonseca Reis, Daniela Brayer Pereira, Daiane Dr
Journal of Applied Microbiology.2022; 132(2): 1036. CrossRef
RapidResa Polymyxin Acinetobacter NP® Test for Rapid Detection of Polymyxin Resistance in Acinetobacter baumannii
Maxime Bouvier, Mustafa Sadek, Stefano Pomponio, Fernando D’Emidio, Laurent Poirel, Patrice Nordmann
Antibiotics.2021; 10(5): 558. CrossRef
Rapid detection of carbapenemase-producing Pseudomonas spp. using the NitroSpeed-Carba NP test
Mustafa Sadek, Laurent Poirel, Patrice Nordmann
Diagnostic Microbiology and Infectious Disease.2021; 99(3): 115280. CrossRef
Gain and loss of antibiotic resistant genes in multidrug resistant bacteria: One Health perspective
Misung Kim, Jaeeun Park, Mingyeong Kang, Jihye Yang, Woojun Park
Journal of Microbiology.2021; 59(6): 535. CrossRef
OXA-23 and OXA-40 producing carbapenem-resistant Acinetobacter baumannii in Central Illinois
Janak Koirala, Isha Tyagi, Lohitha Guntupalli, Sameena Koirala, Udita Chapagain, Christopher Quarshie, Sami Akram, Vidya Sundareshan, Sajan Koirala, Jerry Lawhorn, Yohei Doi, Michael Olson
Diagnostic Microbiology and Infectious Disease.2020; 97(1): 114999. CrossRef
Rapid Polymyxin/Pseudomonas NP test for rapid detection of polymyxin susceptibility/resistance in Pseudomonas aeruginosa
Mustafa Sadek, Camille Tinguely, Laurent Poirel, Patrice Nordmann
European Journal of Clinical Microbiology & Infectious Diseases.2020; 39(9): 1657. CrossRef
Stress responses linked to antimicrobial resistance in Acinetobacter species
Bora Shin, Chulwoo Park, Woojun Park
Applied Microbiology and Biotechnology.2020; 104(4): 1423. CrossRef
Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace
Maria Soledad Ramirez, Robert A. Bonomo, Marcelo E. Tolmasky
Biomolecules.2020; 10(5): 720. CrossRef
Pharmacokinetics, Safety, and Tolerability of Intravenous Durlobactam and Sulbactam in Subjects with Renal Impairment and Healthy Matched Control Subjects
John O’Donnell, Richard A. Preston, Grigor Mamikonyan, Emily Stone, Robin Isaacs
Antimicrobial Agents and Chemotherapy.2019;[Epub] CrossRef
Efficient Delivery of Antisense Oligonucleotides by an Amphipathic Cell-Penetrating Peptide in Acinetobacter baumannii
Zhou Chen, Dan Nie, Yue Hu, Mingkai Li, Zheng Hou, Xinggang Mao, Xiaoxing Luo, Xiaoyan Xue
Current Drug Delivery.2019; 16(8): 728. CrossRef
Restoring the activity of the antibiotic aztreonam using the polyphenol epigallocatechin gallate (EGCG) against multidrug-resistant clinical isolates of Pseudomonas aeruginosa
Jonathan W. Betts, Michael Hornsey, Paul G. Higgins, Kai Lucassen, Julia Wille, Francisco J. Salguero, Harald Seifert, Roberto M. La Ragione
Journal of Medical Microbiology .2019; 68(10): 1552. CrossRef
Antibiotic-resistant clones in Gram-negative pathogens: presence of global clones in Korea
Kwan Soo Ko
Journal of Microbiology.2019; 57(3): 195. CrossRef
Alternative fate of glyoxylate during acetate and hexadecane metabolism in Acinetobacter oleivorans DR1
Chulwoo Park, Bora Shin, Woojun Park
Scientific Reports.2019;[Epub] CrossRef
Nationwide surveillance of antimicrobial resistance among clinically important Gram-negative bacteria, with an emphasis on carbapenems and colistin: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) in 2018
Yu-Lin Lee, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Yen-Hsu Chen, Shu-Hsing Cheng, Wen-Chien Ko, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Yu-
International Journal of Antimicrobial Agents.2019; 54(3): 318. CrossRef
The use of polymyxins to treat carbapenem resistant infections in neonates and children
Reenu Thomas, Sithembiso Velaphi, Sally Ellis, A. Sarah Walker, Joseph F. Standing, Paul Heath, Mike Sharland, Daniele Dona’
Expert Opinion on Pharmacotherapy.2019; 20(4): 415. CrossRef
Plasmid-mediated mcr-1 gene in Acinetobacter baumannii and Pseudomonas aeruginosa: first report from Pakistan
Fareeha Hameed, Muhammad Asif Khan, Hafsah Muhammad, Tahir Sarwar, Hazrat Bilal, Tayyab Ur Rehman
Revista da Sociedade Brasileira de Medicina Tropical.2019;[Epub] CrossRef
Identification of factors needed by a clinical isolate of Acinetobacter baumannii to resist antibacterial compounds
Celena M. Gwin, Natalia Prakash, Nathan W. Rigel
BIOS.2019; 90(3): 149. CrossRef
A Resazurin Reduction-Based Assay for Rapid Detection of Polymyxin Resistance in Acinetobacter baumannii and Pseudomonas aeruginosa
Mathilde Lescat, Laurent Poirel, Camille Tinguely, Patrice Nordmann, Nathan A. Ledeboer
Journal of Clinical Microbiology.2019;[Epub] CrossRef
Expansion of antibacterial spectrum of xanthorrhizol against Gram-negatives in combination with PMBN and food-grade antimicrobials
Man Su Kim, Ha-Rim Kim, Haebom Kim, Soo-Keun Choi, Chang-Hwan Kim, Jae-Kwan Hwang, Seung-Hwan Park
Journal of Microbiology.2019; 57(5): 405. CrossRef
Carbapenem-resistant Acinetobacter baumannii in patients with burn injury: A systematic review and meta-analysis
William Gustavo Lima, Geisa Cristina Silva Alves, Cristina Sanches, Simone Odília Antunes Fernandes, Magna Cristina de Paiva
Burns.2019; 45(7): 1495. CrossRef
Performances of the Rapid Polymyxin Acinetobacter and Pseudomonas Tests for Colistin Susceptibility Testing
Mathilde Lescat, Laurent Poirel, Aurélie Jayol, Patrice Nordmann
Microbial Drug Resistance.2019; 25(4): 520. CrossRef
In vitro activities of ceftazidime/avibactam alone or in combination with antibiotics against multidrug-resistant Acinetobacter baumannii isolates
Emel Mataracı Kara, Mesut Yılmaz, Berna Özbek Çelik
Journal of Global Antimicrobial Resistance.2019; 17: 137. CrossRef
Zoonotic Diseases and Phytochemical Medicines for Microbial Infections in Veterinary Science: Current State and Future Perspective
Bora Shin, Woojun Park
Frontiers in Veterinary Science.2018;[Epub] CrossRef
A formidable foe: carbapenem-resistant Acinetobacter baumannii and emerging nonantibiotic therapies
Richard R. Watkins
Expert Review of Anti-infective Therapy.2018; 16(8): 591. CrossRef
Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam following Intravenous Administration of ETX2514SUL to Healthy Adult Subjects
Keith A. Rodvold, Mark H. Gotfried, Robin D. Isaacs, John P. O'Donnell, Emily Stone
Antimicrobial Agents and Chemotherapy.2018;[Epub] CrossRef

Research Support, Non-U.S. Gov't

Overexpression of Outer Membrane Protein OprT and Increase of Membrane Permeability in phoU Mutant of Toluene-Tolerant Bacterium Pseudomonas putida GM730: Kyunghee Lee , Juna Jung , Kwang Kim , Dongwon Bae , Dongbin Lim; J. Microbiol. 2009;47(5):557-562. Published online October 24, 2009; DOI: https://doi.org/10.1007/s12275-009-0105-y

38 View
0 Download
5 Scopus

Abstract: Eight toluene-sensitive mutants were previously isolated from the toluene-tolerant bacterium Pseudomonas putida GM730. One of these mutants was TOS6, in which Tn5 had been inserted into phoU. Susceptibility to multiple antibiotics, as well as toluene sensitivity, was increased in the phoU mutant of P. putida GM730. We compared the outer membrane proteins from the phoU mutant and wild-type via two-dimensional gel electrophoresis. A 45 kDa protein was dramatically overexpressed as the result of phoU inactivation, and this protein was identified by peptide mass fingerprinting and microsequencing as a conserved hypothetical protein consisting of 414 amino acids. The protein, designated as OprT, harbors a signal sequence and extended β-sheets, both of which are features common to the bacterial porins. The rate of ethidium bromide accumulation in TOS6 was higher than in GM730, which indicates that the TOS6 membranes may be more permeable to ethidium bromide than are the membranes of GM730. We propose that the toluene sensitivity and increased antibiotic susceptibility observed in the phoU mutant may be attributable to increased membrane permeability.

Iron Increases Susceptibilities of Pseudomonas aeruginosa to Ofloxacin by Increasing the Permeability: Sookyoung Kim , Jinsook Kim , Hyeran Nam , Yusun Jung , Yeonhee Lee; J. Microbiol. 2000;38(4):265-269.

39 View
0 Download

Abstract: Iron increased the susceptibilities of clinical isolates of Pseudomonas aeruginosa to quinolones. In the presence of iron, increased susceptibilities to ofloxacin were observed in twenty-six out of thirty isolates and with no change in four isolates. In the case of norfloxacin, iron increased susceptibilities of twelve isolates but did not render any change in eighteen isolates. In the case of ciprofloxacin, iron decreased the MICs (Minimal Inhibitory Concentration) of twenty isolates, increased the MIC of one isolate, and did not change the MICs of nine isolates. To find out how iron increased susceptibility to ofloxacin, bacterial cells were grown in Muller Hinton (MH) media and succinate minimal media (SMM) to induce iron acquisition systems and the intracellular ofloxacin concentrations were assayed in the presence of iron. The addition of iron to the media decreased the MICs of cells whether they were grown in MH or SMM. Siderophores, carbonyl cyanide m-chlorophenylhydrazone (an inhibitor of proton motive force), and ouabain (an inhibitor of ATPase) did not decrease the effect of iron. Results suggested that the increase in the intracellular ofloxacin concentration by iron is accomplished not by decreasing the efflux but by increasing the ofloxacin permeability.

First
Prev
Page of 1
Next
Last

Search