Journal of Microbiology

Full article

Prebiotic potential of proso millet and quinoa: Effects on gut microbiota composition and functional metabolic pathways: Jinwoo Kim, Jiwoon Kim, Yewon Jung, Gyungcheon Kim, Seongok Kim, Hakdong Shin; J. Microbiol. 2025;63(7):e2503002. Published online July 31, 2025; DOI: https://doi.org/10.71150/jm.2503002

1,897 View
67 Download

Abstract PDF Supplementary Material: Prebiotics are indigestible dietary components that improve host health by stimulating the growth and metabolic activity of beneficial intestinal microbes. The whole grains are rich in non-digestible carbohydrates, which may confer prebiotic potential. Among them, millet and quinoa have gained attention as dietary alternatives due to the growing popularity of gluten-free diets. In this study, we examined the effects of proso millet and quinoa on the human gut microbiota using an in vitro fecal incubation model. Both grains altered alpha diversity metrics, including microbial richness, evenness, and phylogenetic diversity. Beta diversity analysis showed that the proso millet and quinoa treatment groups exhibited distinct clustering patterns compared to the control, highlighting their impact on microbial community structure. Taxonomic analysis showed an increase in beneficial genera, including Bifidobacterium, and a decrease in taxa such as Enterobacteriaceae and Flavonifractor. To assess metabolic changes associated with microbial fermentation, short-chain fatty acid (SCFA) intensities were measured. The intensities of acetic acid, propionic acid, and butyric acid were significantly higher in the proso millet- and quinoa-treated groups compared to the control group. Spearman correlation analysis showed that the abundances of Bifidobacterium and Blautia were significantly positively associated with SCFA intensities. Furthermore, predicted functional pathway analysis identified enrichment of carbohydrate-related pathways in proso millet and quinoa treatments. Quinoa supplementation led to a broader enhancement of metabolic pathways, including glycolysis/gluconeogenesis, starch and sucrose metabolism, and pentose phosphate pathways, whereas proso millet enriched galactose metabolism, and starch and sucrose metabolism. These findings suggest that proso millet and quinoa influence gut microbial diversity, composition, and function.

Research Article

Synbiotic combination of fructooligosaccharides and probiotics ameliorates the metabolic dysfunction-associated steatotic liver disease: Sang Yoon Lee, Su-Been Lee, Goo-Hyun Kwon, Seol Hee Song, Jeong Ha Park, Min Ju Kim, Jung A Eom, Kyeong Jin Lee, Sang Jun Yoon, Hyunjoon Park, Sung-Min Won, Jin-Ju Jeong, Ki-Kwang Oh, Young Lim Ham, Gwang Ho Baik, Dong Joon Kim, Satya Priya Sharma, Ki Tae Suk; J. Microbiol. 2025;63(2):e2411002. Published online February 27, 2025; DOI: https://doi.org/10.71150/jm.2411002

1,386 View
78 Download
1 Web of Science
1 Crossref

Synbiotics have become a new-age treatment tool for limiting the progression of metabolic dysfunction-associated steatotic liver disease; however, inclusive comparisons of various synbiotic treatments are still lacking. Here, we have explored and evaluated multiple synbiotic combinations incorporating three distinctive prebiotics, lactitol, lactulose and fructooligosaccharides. Of the synbiotic treatments evaluated, a combination of fructooligosaccharides and probiotics (FOS+Pro) exhibited superior protection against western diet-induced liver degeneration. This synbiotic (FOS+Pro) combination resulted in the lowest body weight gains, liver weights and liver/body weight ratios. The FOS+Pro synbiotic combination substantially alleviated liver histopathological markers and reduced serum AST and cholesterol levels. FOS+Pro ameliorated hepatic inflammation by lowering expression of proinflammatory markers including TNF-α, IL-1β, IL-6, and CCL2. FOS+Pro significantly improved steatosis by restricting the expression of lipid metabolic regulators (ACC1, FAS) and lipid transporters (CD36) in the liver. These findings are critical in suggesting that synbiotic treatments are capable of restraining western diet-induced metabolic dysfunction in the liver. Additionally, this study demonstrated that adding probiotic strains amplified the effectiveness of fructooligosaccharides but not all prebiotics.

Citations

Citations to this article as recorded by

Therapeutic Potential of Probiotics in Metabolic Dysfunction-Associated Steatohepatitis: A Comprehensive Review
Xueying Wang, Zhiying Wei, Qing Xiang, Lijie Tang, Weichun Xie
Microorganisms.2025; 13(8): 1894. CrossRef

Reviews

[MINIREVIEW] Modulation of gut microbiome in nonalcoholic fatty liver disease: pro-, pre-, syn-, and antibiotics: Min Seok Cho , Sang Yeol Kim , Ki Tae Suk , Byung-Yong Kim; J. Microbiol. 2018;56(12):855-867. Published online October 25, 2018; DOI: https://doi.org/10.1007/s12275-018-8346-2

193 View
0 Download
31 Web of Science
30 Crossref

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the most common types of liver diseases worldwide and its incidence continues to increase. NAFLD occurs when the body can no longer effectively store excess energy in the adipose tissue. Despite the increasing prevalence of NAFLD, making lifestyle changes, including increased exercise, is often an elusive goal for patients with NAFLD. The liver directly connects to the gut-gastrointestinal milieu via the portal vein, which are all part of the gut-liver axis. Therefore, the gut-microbiome and microbial products have been actively studied as likely key factors in NAFLD pathophysiology. Hence, dysbiosis of the gut microbiome and therapeutic manipulation of the gut-liver axis are being investigated. Novel therapeutic approaches for modulating gut microbiota through the administration of probiotics, prebiotics, synbiotics, and antibiotics have been proposed with numerous promising initial reports on the effectiveness and clinical applications of these approaches. This review delves into the current evidence on novel therapies that modulate gut microbiota and discusses ongoing clinical trials targeting the gut-liver axis for the management and prevention of NAFLD.

Citations

Citations to this article as recorded by

Schisandra chinensis lignans ameliorate hepatic inflammation and steatosis in methionine choline-deficient diet-fed mice by modulating the gut-liver axis
Li-Shan Yan, Jian-Ying Kang, Chun-Yu Gu, Xin-Yu Qiu, Jia-Jia Li, Brian Chi-Yan Cheng, Yi-Wei Wang, Gan Luo, Yi Zhang
Journal of Ethnopharmacology.2025; 348: 119801. CrossRef
ACG Clinical Guideline: Malnutrition and Nutritional Recommendations in Liver Disease
Ashwani K. Singal, Robert J. Wong, Srinivasan Dasarathy, Manal F. Abdelmalek, Brent A. Neuschwander-Tetri, Berkeley N. Limketkai, Jessica Petrey, Craig J. McClain
American Journal of Gastroenterology.2025; 120(5): 950. CrossRef
The crosstalk between gut microbiota and microbiota-derived metabolites in hepatocellular carcinoma
Sang Jun Yoon, Seul Ki Han, Tae Suk Kim, Ki Tae Suk, Dae Hee Choi, Young Don Kim, Moon Young Kim, Gab Jin Cheon, Soon Koo Baik, Dong Joon Kim
Critical Reviews in Microbiology.2025; : 1. CrossRef
Metabolic dysfunction-associated steatotic liver disease (MASLD): emerging insights into gut microbiota interactions and therapeutic perspectives
Wenchu Qian, Ling He, Chenxue Fu, Tiantian Zeng, Hanyu Wang, Haifang Li
Exploration of Digestive Diseases.2025;[Epub] CrossRef
Highland barley β-glucan supplementation attenuated hepatic lipid accumulation in Western diet-induced non-alcoholic fatty liver disease mice by modulating gut microbiota
Huicui Liu, Chenxi Nie, Xinzhong Hu, Juxiu Li
Food & Function.2024; 15(3): 1250. CrossRef
Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite
Atousa Moghadam Fard, Pardis Goodarzi, Mehran Mottahedi, Setareh Garousi, Hamed Zadabhari, Mohammad Kalantari Shahijan, Saeedeh Esmaeili, Mohsen Nabi-Afjadi, Bahman Yousefi
Naunyn-Schmiedeberg's Archives of Pharmacology.2024; 397(8): 5335. CrossRef
Bifidobacterium lactis Probio‐M8 prevents nonalcoholic fatty liver disease in high‐fat diet‐fed rats: The potential role in modulating gut microbiota
Wen Fan, Kairui Tang, Yuanjun Deng, Chuiyang Zheng, Maoxing Pan, Dajin Pi, Zheng Liang, Jianwei Zhen, Qinhe Yang, Yupei Zhang
Food Bioengineering.2024; 3(1): 29. CrossRef
Manipulating the Gut Microbiome to Alleviate Steatotic Liver Disease: Current Progress and Challenges
Ernesto Saenz, Nathally Espinosa Montagut, Baohong Wang, Christoph Stein-Thöringer, Kaicen Wang, Honglei Weng, Matthias Ebert, Kai Markus Schneider, Lanjuan Li, Andreas Teufel
Engineering.2024; 40: 51. CrossRef
The gut-liver axis in fatty liver disease: role played by natural products
Zhu Ming, Xie Ruishi, Xu Linyi, Yang Yonggang, Luo Haoming, Lan Xintian
Frontiers in Pharmacology.2024;[Epub] CrossRef
Dietary fiber intake and mortality among survivors of liver cirrhosis: A prospective cohort study
Zahra Hariri, Azita Hekmatdoost, Fereshteh Pashayee-khamene, Sara Karimi, Salehe Ahmadzadeh, Zahra Yari
Heliyon.2023; 9(6): e16170. CrossRef
The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic Syndrome
Alicia Rodríguez-Pastén, Nury Pérez-Hernández, Javier Añorve-Morga, Rubén Jiménez-Alvarado, Raquel Cariño-Cortés, Teresa Sosa-Lozada, Eduardo Fernández-Martínez
International Journal of Molecular Sciences.2022; 23(13): 7229. CrossRef
Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms linking mood, metabolism and medicines
Anwesha Gangopadhyay, Radwa Ibrahim, Karli Theberge, Meghan May, Karen L. Houseknecht
Frontiers in Neuroscience.2022;[Epub] CrossRef
Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease
Omar Ramos-Lopez
Genes.2022; 13(11): 2142. CrossRef
Construction of two new polyoxometalate complexes and their recyclability in photodegradation of cephalexin and ceftiofur
Qian-Qian Wang, Li-Hui Mao, Da-Xiang Wang, Yan-Mei Ma, Xin-Li Shi, Xi-Hao Tian
Inorganica Chimica Acta.2022; 536: 120902. CrossRef
Gut–Liver Axis in Nonalcoholic Fatty Liver Disease: the Impact of the Metagenome, End Products, and the Epithelial and Vascular Barriers
Antonio Gil-Gómez, Paola Brescia, Maria Rescigno, Manuel Romero-Gómez
Seminars in Liver Disease.2021; 41(02): 191. CrossRef
Promising diagnostic biomarkers of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: From clinical proteomics to microbiome
Carolina Castillo-Castro, Alexandro José Martagón-Rosado, Rocio Ortiz-Lopez, Luis Felipe Garrido-Treviño, Melissa Villegas-Albo, Francisco Javier Bosques-Padilla
World Journal of Hepatology.2021; 13(11): 1494. CrossRef
Increased Prevalence of Liver Fibrosis in People Living With Human Immunodeficiency Virus Without Viral Hepatitis Compared to Population Controls
Ditte Marie Kirkegaard-Klitbo, Flemming Bendtsen, Jens Lundgren, Robert J de Knegt, Klaus Fuglsang Kofoed, Susanne Dam Nielsen, Thomas Benfield
The Journal of Infectious Diseases.2021; 224(3): 443. CrossRef
Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase
Dragana Rajcic, Anja Baumann, Angélica Hernández-Arriaga, Annette Brandt, Anika Nier, Cheng Jun Jin, Victor Sánchez, Finn Jung, Amélia Camarinha-Silva, Ina Bergheim
Redox Biology.2021; 41: 101879. CrossRef
Gut metabolites and inflammation factors in non-alcoholic fatty liver disease: A systematic review and meta-analysis
Xiongfeng Pan, Shi Wu Wen, Atipatsa C. Kaminga, Aizhong Liu
Scientific Reports.2020;[Epub] CrossRef
Therapeutic advances in non-alcoholic fatty liver disease: A microbiota-centered view
Hui-Ting Chen, Hong-Li Huang, Yong-Qiang Li, Hao-Ming Xu, Yong-Jian Zhou
World Journal of Gastroenterology.2020; 26(16): 1901. CrossRef
LactobacillusandPediococcusameliorate progression of non-alcoholic fatty liver disease through modulation of the gut microbiome
Na Young Lee, Sang Jun Yoon, Dae Hee Han, Haripriya Gupta, Gi Soo Youn, Min Jea Shin, Young Lim Ham, Min Jung Kwak, Byung Yong Kim, Jeong Seok Yu, Do Yup Lee, Tae-Sik Park, Si-Hyun Park, Byoung Kook Kim, Hyun Chae Joung, In Suk Choi, Ji Taek Hong, Dong Jo
Gut Microbes.2020; 11(4): 882. CrossRef
Macrophages in the pathophysiology of NAFLD: The role of sex differences
Stefano Ministrini, Fabrizio Montecucco, Amirhossein Sahebkar, Federico Carbone
European Journal of Clinical Investigation.2020;[Epub] CrossRef
IMPACT OF CURRENT DIET AT THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
Sebastião Mauro Bezerra DUARTE, José Tadeu STEFANO, Denise Siqueira VANNI, Flair José CARRILHO, Claudia Pinto Marques Souza de OLIVEIRA
Arquivos de Gastroenterologia.2019; 56(4): 431. CrossRef
Microbiota and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH)
Sebastião M.B. Duarte, Jose Tadeu Stefano, Claudia P. Oliveira
Annals of Hepatology.2019; 18(3): 416. CrossRef
Aged garlic extract ameliorates fatty liver and insulin resistance and improves the gut microbiota profile in a mouse model of insulin resistance
Toshio Maeda, Satomi Miki, Naoaki Morihara, Yoshiyuki Kagawa
Experimental and Therapeutic Medicine.2019;[Epub] CrossRef
Microbiota and nonalcoholic fatty liver disease
Christelle Knudsen, Audrey M. Neyrinck, Nicolas Lanthier, Nathalie M. Delzenne
Current Opinion in Clinical Nutrition & Metabolic Care.2019; 22(5): 393. CrossRef
Gold Nanoparticles Cure Bacterial Infection with Benefit to Intestinal Microflora
Juanjuan Li, Ruitao Cha, Xiaohui Zhao, Hongbo Guo, Huize Luo, Mingzheng Wang, Fengshan Zhou, Xingyu Jiang
ACS Nano.2019; 13(5): 5002. CrossRef
Role of Gut Microbiota in Hepatocarcinogenesis
Haripriya Gupta, Gi Soo Youn, Min Jea Shin, Ki Tae Suk
Microorganisms.2019; 7(5): 121. CrossRef
The Prenatal Microbiome: A New Player for Human Health
Valeria D’Argenio
High-Throughput.2018; 7(4): 38. CrossRef
Intestinal Microbiota Modulation in Obesity-Related Non-alcoholic Fatty Liver Disease
David Porras, Esther Nistal, Susana Martínez-Flórez, Javier González-Gallego, María Victoria García-Mediavilla, Sonia Sánchez-Campos
Frontiers in Physiology.2018;[Epub] CrossRef

REVIEW] Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease: Taekil Eom , Yong Sung Kim , Chang Hwan Choi , Michael J. Sadowsky , Tatsuya Unno; J. Microbiol. 2018;56(3):189-198. Published online February 28, 2018; DOI: https://doi.org/10.1007/s12275-018-8049-8

241 View
0 Download
89 Crossref

Abstract

Inflammatory bowel disease (IBD) is a result of chronic inflammation caused, in some part, by dysbiosis of intestinal microbiota, mainly commensal bacteria. Gut dysbiosis can be caused by multiple factors, including abnormal immune responses which might be related to genetic susceptibility, infection, western dietary habits, and administration of antibiotics. Consequently, the disease itself is characterized as having multiple causes, etiologies, and severities. Recent studies have identified > 200 IBD risk loci in the host. It has been postulated that gut microbiota interact with these risk loci
result
ing in dysbiosis, and this subsequently leads to the development of IBD. Typical gut microbiota in IBD patients are characterized with decrease in species richness and many of the commensal, and beneficial, fecal bacteria such as Firmicutes and Bacteroidetes and an increase or bloom of Proteobacteria. However, at this time, cause and effect relationships have not been rigorously established. While treatments of IBD usually includes medications such as corticosteroids, 5-aminosalicylates, antibiotics, immunomodulators, and anti- TNF agents, restoration of gut dysbiosis seems to be a safer and more sustainable approach. Bacteriotherapies (now called microbiota therapies) and dietary interventions are effective way to modulate gut microbiota. In this review, we summarize factors involved in IBD and studies attempted to treat IBD with probiotics. We also discuss the potential use of microbiota therapies as one promising approach in treating IBD. As therapies based on the modulation of gut microbiota becomes more common, future studies should include individual gut microbiota differences to develop personalized therapy for IBD.

Citations

Citations to this article as recorded by

Benzo[a]Pyrene Induces Pyroptotic Colon Damage and Gut Dysbacteriosis by Activating Aryl Hydrocarbon Receptor
Yingyu Jia, Yao Meng, Zhulin Wang, Hao Li, Jianke Li, Li Yuan
Food Biophysics.2025;[Epub] CrossRef
Patient–donor similarity and donor-derived species contribute to the outcome of fecal microbiota transplantation for ulcerative colitis
Dai Ishikawa, Hikaru Watanabe, Kei Nomura, Xiaochen Zhang, Takafumi Maruyama, Rina Odakura, Masao Koma, Tomoyoshi Shibuya, Taro Osada, Shinji Fukuda, Taku Nakahara, Jun Terauchi, Akihito Nagahara, Takuji Yamada
Journal of Crohn's and Colitis.2025;[Epub] CrossRef
Sturgeon cartilage-derived chondroitin sulfate exhibited anti-inflammatory activity against dextran sulfate sodium-induced colitis via modification of gut microbiota
Ruiyun Wu, Zixin Han, Zhenyu Wang, Pinglan Li, Nan Shang
Food Science and Human Wellness.2025; 14(4): 9250227. CrossRef
Intestinal microecology in pediatric surgery-related gastrointestinal diseases: Current insights and future perspectives
Yuqing Wu, Suolin Li, Lin Liu, Xiaoyi Zhang, Jiaxun Lv, Qinqin Li, Yingchao Li
Journal of Pediatric Surgery Open.2024; 6: 100134. CrossRef
Gut Microbiome as a Target of Intervention in Inflammatory Bowel Disease Pathogenesis and Therapy
Helal F. Hetta, Yasmin N. Ramadan, Ahmad A. Alharbi, Shomokh Alsharef, Tala T. Alkindy, Alanoud Alkhamali, Abdullah S. Albalawi, Hussein El Amin
Immuno.2024; 4(4): 400. CrossRef
Intestinal and hepatic benefits of BBR-EVO on DSS-induced experimental colitis in mice
Wenjia Wang, Yiheng Han, Wen Yin, Qiaozhi Wang, Yi Wu, Maobo Du
Frontiers in Microbiology.2024;[Epub] CrossRef
Exploring the Connections: Autophagy, Gut Microbiota, and Inflammatory Bowel Disease Pathogenesis
Arunkumar Subramanian, Afrarahamed J, Tamilanban T, Vinoth Kumarasamy, M Yasmin Begum, Mahendran Sekar, Vetriselvan Subramaniyan, Ling Shing Wong, Adel Al Fatease
Journal of Inflammation Research.2024; Volume 17: 10453. CrossRef
Network Analysis of Gut Microbial Communities Reveals Key Reason for Quercetin Protects against Colitis
Yanan Lv, Jing Peng, Xiaoyu Ma, Zeyi Liang, Ghasem Hosseini Salekdeh, Qunhua Ke, Wenxiang Shen, Zuoting Yan, Hongsheng Li, Shengyi Wang, Xuezhi Ding
Microorganisms.2024; 12(10): 1973. CrossRef
Analysis of the Preventive Effect of Lonicera caerulea Pomace and Its Isolated Components on Colitis in Mice Based on Gut Microbiota and Serum Metabolomics
Zinuo Zhou, Xinwen Huang, Baixi Zhang
Antioxidants.2024; 13(12): 1478. CrossRef
Stachyose Exerts Anticolitis Efficacy by Re-balancing Treg/Th17 and Activating the Butyrate-Derived PPARγ Signaling Pathway
Ningning He, Kaiwei Chen, Shengnan Yu, Luwen Cui, Son Hai Vu, Samil Jung, Myeong-sok Lee, Shangyong Li
Journal of Agricultural and Food Chemistry.2024; 72(21): 12171. CrossRef
Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as Food
Emanuelle Natalee Santos, Karina Teixeira Magalhães-Guedes, Fernando Elias de Melo Borges, Danton Diego Ferreira, Daniele Ferreira da Silva, Pietro Carlos Gonçalves Conceição, Ana Katerine de Carvalho Lima, Lucas Guimarães Cardoso, Marcelo Andrés Umsza-Gu
Foods.2024; 13(24): 4097. CrossRef
Raffinose Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Targeting the Inflammatory TLR4–MyD88–NF-κB Signaling Pathway
Peng Zhang, Yuyang Xue, Zhengyu Cao, Yaya Guo, Xiaotong Pang, Cheng Chen, Wenju Zhang
Foods.2024; 13(12): 1849. CrossRef
Fecal Microbiota Transplantation: Indications, Methods, and Challenges
Jee Young Lee, Yehwon Kim, Jiyoun Kim, Jiyeun Kate Kim
Journal of Microbiology.2024; 62(12): 1057. CrossRef
Ethyl acetate extract of Terminalia chebula alleviates DSS-induced ulcerative colitis in C57BL/6 mice
Wan-Rong Dong, Yao-Yao Li, Tian-Tian Liu, Gao Zhou, Yu-Xin Chen
Frontiers in Pharmacology.2023;[Epub] CrossRef
A Novel Polysaccharide Separated from Panax Notoginseng Residue Ameliorates Restraint Stress‐ and Lipopolysaccharide‐induced Enteritis in Mice
Bi Luo, Fan Yang, Peng Chen, Hao‐Yu Zuo, Yun‐Fei Liang, Ming‐Hua Xian, Nan Tang, Guo‐En Wang
Chemistry & Biodiversity.2023;[Epub] CrossRef
Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation
Rongrong Wu, Rui Xiong, Yan Li, Junru Chen, Ru Yan
Journal of Autoimmunity.2023; 141: 103062. CrossRef
Current advances in the anti-inflammatory effects and mechanisms of natural polysaccharides
Dan Yuan, Chao Li, Qiang Huang, Xiong Fu, Hao Dong
Critical Reviews in Food Science and Nutrition.2023; 63(22): 5890. CrossRef
Poria cocos oligosaccharides ameliorate dextran sodium sulfate-induced colitis mice by regulating gut microbiota dysbiosis
Ke Lan, Huabing Yang, Junping Zheng, Haiming Hu, Tianxiang Zhu, Xiaojuan Zou, Baifei Hu, Hongtao Liu
Food & Function.2023; 14(2): 857. CrossRef
Chiral coating-mediated interactions of bacteria with diverse biointerfaces
Hejin Jiang, Rui Liu, Ying Liu, Huilong Luo, Zhenping Cao, Jinyao Liu
Science China Chemistry.2023; 66(12): 3594. CrossRef
Recent Advances in the Nanoshells Approach for Encapsulation of Single Probiotics
Cheng Chen, Ziyu Zhu
Drug Design, Development and Therapy.2023; Volume 17: 2763. CrossRef
Interplay of broccoli/broccoli sprout bioactives with gut microbiota in reducing inflammation in inflammatory bowel diseases
Johanna Holman, Molly Hurd, Peter L. Moses, Gary M. Mawe, Tao Zhang, Suzanne L. Ishaq, Yanyan Li
The Journal of Nutritional Biochemistry.2023; 113: 109238. CrossRef
Lonicera caerulea Pomace Alleviates DSS-Induced Colitis via Intestinal Barrier Improvement and Gut Microbiota Modulation
Baixi Zhang, Xinwen Huang, Lijuan Niu, Xuemei Chen, Bo Hu, Xiaoshu Tang
Foods.2023; 12(18): 3329. CrossRef
The Combined Use of SCD Probiotics and Tauroursodeoksikolik Asit (TUDCA) is More Effective in Controlling Anxiety-Like Behavior in Aged Rats
Taha CEYLANİ, Hikmet Taner TEKER
Bitlis Eren Üniversitesi Fen Bilimleri Dergisi.2023; 12(1): 242. CrossRef
The Possible Role of Probiotic Supplementation in Inflammation: A Narrative Review
Alessandro Colletti, Marzia Pellizzato, Arrigo Francesco Cicero
Microorganisms.2023; 11(9): 2160. CrossRef
A polysaccharide from Allium tenuissimum L. flowers relieves ulcerative colitis by regulating the inflammatory signaling pathway and gut microbiota
Yan Zhang, Siyu Yu, Jia Liu, Ying Liu, Jie Luo, Yong Liu
Food & Function.2023; 14(14): 6582. CrossRef
Molecular mechanisms of Huanglian jiedu decoction on ulcerative colitis based on network pharmacology and molecular docking
Jing Yang, Chaotao Tang, Ruiri Jin, Bixia Liu, Peng Wang, Youxiang Chen, Chunyan Zeng
Scientific Reports.2022;[Epub] CrossRef
Effects of β-glucan, probiotics, and synbiotics on obesity-associated colitis and hepatic manifestations in C57BL/6J mice
Vuong Vu, Karthika Muthuramalingam, Vineet Singh, Changlim Hyun, Young Mee Kim, Tatsuya Unno, Moonjae Cho
European Journal of Nutrition.2022; 61(2): 793. CrossRef
Human umbilical cord-derived mesenchymal stem cells ameliorate experimental colitis by normalizing the gut microbiota
Fan Yang, Beibei Ni, Qiuli Liu, Fangping He, Li Li, Xuemei Zhong, Xiaofan Zheng, Jianxi Lu, Xiaoyan Chen, Huizhu Lin, Ruixuan Xu, Yizhan He, Qi Zhang, Xiaoguang Zou, Wenjie Chen
Stem Cell Research & Therapy.2022;[Epub] CrossRef
The Protective Effect of Sulforaphane on Dextran Sulfate Sodium-Induced Colitis Depends on Gut Microbial and Nrf2-Related Mechanism
Canxia He, Mingfei Gao, Xiaohong Zhang, Peng Lei, Haitao Yang, Yanping Qing, Lina Zhang
Frontiers in Nutrition.2022;[Epub] CrossRef
The Attenuation of Chronic Ulcerative Colitis by (R)‐salbutamol in Repeated DSS‐Induced Mice
Liangjun Deng, Haihua Guo, Shanping Wang, Xiaoming Liu, Yue Lin, Rui Zhang, Wen Tan, Ivan Srejovic
Oxidative Medicine and Cellular Longevity.2022;[Epub] CrossRef
CROHN’S DISEASE: A REVIEW ON EPIDEMIOLOGY, DIAGNOSIS AND THERAPEUTIC MANAGEMENT
Mohammad Mukim, Mohit Chaturvedi, Rakesh Patel, Supriya Roy, Pratishtha Sharma, Varunesh Chaturvedi, Saloni Goyal, Mohsina F. Patewkar
Indian Drugs.2022; 59(09): 16. CrossRef
Poly‐γ‐Glutamic Acid Microgel‐Encapsulated Probiotics with Gastric Acid Resistance and Smart Inflammatory Factor Targeted Delivery Performance to Ameliorate Colitis
Rui Wang, Kun Guo, Weijie zhang, Yineng He, Kai Yang, Qian Chen, Liang Yang, Zhengao Di, Jiangkai Qiu, Peng Lei, Yian Gu, Zhengshan Luo, Xiaoqi Xu, Zongqi Xu, Xiaohai Feng, Sha Li, Ziyi Yu, Hong Xu
Advanced Functional Materials.2022;[Epub] CrossRef
Probiotic human alcohol dehydrogenase-4 expressing bacteria protects from diet-induced obesity and metabolic impairment: a new concept of disease prevention
Rajnish Prakash Singh, Max Kolton, Mayan Boker, Noy Bar David, Stefan Green, Aharon Helman, Oren Tirosh, Zvi Hayouka
Exploration of Digestive Diseases.2022; : 118. CrossRef
(RS)-bambuterol and its enantiomers: Potential improvement of (R)-bambuterol in mice with colitis
Liangjun Deng, Shanping Wang, Haihua Guo, Xiaoming Liu, Xinfeng Zou, Rui Zhang, Yue Lin, Wen Tan
International Immunopharmacology.2022; 103: 108501. CrossRef
Chitosan Oligosaccharides Alleviate Colitis by Regulating Intestinal Microbiota and PPARγ/SIRT1-Mediated NF-κB Pathway
Congcong Guo, Yue Zhang, Tao Ling, Chongjie Zhao, Yanru Li, Meng Geng, Sailun Gai, Wei Qi, Xuegang Luo, Liehuan Chen, Tongcun Zhang, Nan Wang
Marine Drugs.2022; 20(2): 96. CrossRef
Environmentality in biomedicine: microbiome research and the perspectival body
Joana Formosinho, Adam Bencard, Louise Whiteley
Studies in History and Philosophy of Science.2022; 91: 148. CrossRef
Glucocorticosteroids and the Risk of NAFLD in Inflammatory Bowel Disease
Sara Jarmakiewicz-Czaja, Aneta Sokal, Piotr Pardak, Rafał Filip, Alessandro Granito
Canadian Journal of Gastroenterology and Hepatology.2022; 2022: 1. CrossRef
Major yolk protein from sea cucumber (Stichopus japonicus) attenuates acute colitis via regulation of microbial dysbiosis and inflammatory responses
Jianhui Feng, Lina Zhang, Xue Tang, Wei Hu, Peng Zhou
Food Research International.2022; 151: 110841. CrossRef
Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota
Qian Han, Li-rong Deng, Min Zou, Hua-zheng Tang, Chang-yin Huang, Fang-jun Chen, Brian Tomlinson, Yan-hong Li
Phytomedicine.2022; 106: 154416. CrossRef
Alginate Oligosaccharides Ameliorate DSS-Induced Colitis through Modulation of AMPK/NF-κB Pathway and Intestinal Microbiota
Yue Zhang, Congcong Guo, Yanru Li, Xianlei Han, Xuegang Luo, Liehuan Chen, Tongcun Zhang, Nan Wang, Weiming Wang
Nutrients.2022; 14(14): 2864. CrossRef
Gut microbiota in antiviral strategy from bats to humans: a missing link in COVID-19
Jia Luo, Shan Liang, Feng Jin
Science China Life Sciences.2021; 64(6): 942. CrossRef
Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy
Xueling Xu, Huifang Wang, Dandan Guo, Xiaofei Man, Jun Liu, Junying Li, Congjuan Luo, Ming Zhang, Li Zhen, Xuemei Liu
Renal Failure.2021; 43(1): 1063. CrossRef
Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD
Adrian Martyniak, Aleksandra Medyńska-Przęczek, Andrzej Wędrychowicz, Szymon Skoczeń, Przemysław J. Tomasik
Biomolecules.2021; 11(12): 1903. CrossRef
Mitochondrial Metabolism in the Intestinal Stem Cell Niche—Sensing and Signaling in Health and Disease
Elisabeth Urbauer, Eva Rath, Dirk Haller
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
GB1a Ameliorates Ulcerative Colitis via Regulation of the NF-κB and Nrf2 Signaling Pathways in an Experimental Model
Yuanyuan Yu, Congmin Zheng, Xu Lu, Changsheng Deng, Qin Xu, Wenfeng Guo, Qingye Wu, Qi Wang, Changhui Liu, Xinan Huang, Jianping Song
Frontiers in Medicine.2021;[Epub] CrossRef
Dietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation
S. Ali Naqvi, Lorian M. Taylor, Remo Panaccione, Subrata Ghosh, Herman W. Barkema, Naomi Hotte, Nusrat Shommu, Sandeep Kaur, Raylene A. Reimer, Karen L. Madsen, Maitreyi Raman
Scientific Reports.2021;[Epub] CrossRef
Ginger Alleviates DSS-Induced Ulcerative Colitis Severity by Improving the Diversity and Function of Gut Microbiota
Shanshan Guo, Wenye Geng, Shan Chen, Li Wang, Xuli Rong, Shuocun Wang, Tingfang Wang, Liyan Xiong, Jinghua Huang, Xiaobin Pang, Yiming Lu
Frontiers in Pharmacology.2021;[Epub] CrossRef
Long-term and continuous administration of Bacillus subtilis during remission effectively maintains the remission of inflammatory bowel disease by protecting intestinal integrity, regulating epithelial proliferation, and reshaping microbial structure and
Yongqiang Liu, Fang Yin, Linsheng Huang, Hongfei Teng, Tongyi Shen, Huanlong Qin
Food & Function.2021; 12(5): 2201. CrossRef
Cereal Vinegar Sediment Alleviates Spontaneous Ulcerative Colitis in Il‐10 Deficient Mice
Yan Geng, Yuanjia Yue, Qijie Guan, Yilin Ren, Lin Guo, Yifei Fan, Zhen‐Ming Lu, Jin‐Song Shi, Zheng‐Hong Xu
Molecular Nutrition & Food Research.2021;[Epub] CrossRef
Impact of 2′-Fucosyllactose on Gut Microbiota Composition in Adults with Chronic Gastrointestinal Conditions: Batch Culture Fermentation Model and Pilot Clinical Trial Findings
Jennifer Joan Ryan, Andrea Monteagudo-Mera, Nikhat Contractor, Glenn R. Gibson
Nutrients.2021; 13(3): 938. CrossRef
Effects of Anti-Inflammatory Treatment and Surgical Intervention on Endothelial Glycocalyx, Peripheral and Coronary Microcirculatory Function and Myocardial Deformation in Inflammatory Bowel Disease Patients: A Two-Arms Two-Stage Clinical Trial
Charilaos Triantafyllou, Maria Nikolaou, Ignatios Ikonomidis, Giorgos Bamias, Dimitrios Kouretas, Ioanna Andreadou, Maria Tsoumani, John Thymis, Ioannis Papaconstantinou
Diagnostics.2021; 11(6): 993. CrossRef
Bacteria-Based Microdevices for the Oral Delivery of Macromolecules
Zhenping Cao, Sisi Lin, Jinyao Liu
Pharmaceutics.2021; 13(10): 1610. CrossRef
EEG Changes Related to Gut Dysbiosis in Diabetes—Review
Roxana Toderean, Mihai Dimian, Claudiu Cobuz
Applied Sciences.2021; 11(24): 11871. CrossRef
The Combined Beneficial Effects of Postbiotic Butyrate on Active Vitamin D3-Orchestrated Innate Immunity to Salmonella Colitis
Fu-Chen Huang, Shun-Chen Huang
Biomedicines.2021; 9(10): 1296. CrossRef
Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice
Xingwei Xiang, Qihong Jiang, Wan Shao, Jinhong Li, Yufang Zhou, Lin Chen, Shanggui Deng, Bin Zheng, Yufeng Chen
Frontiers in Nutrition.2021;[Epub] CrossRef
Polymerization‐Mediated Multifunctionalization of Living Cells for Enhanced Cell‐Based Therapy
Chao Pan, Juanjuan Li, Weiliang Hou, Sisi Lin, Lu Wang, Yan Pang, Yufeng Wang, Jinyao Liu
Advanced Materials.2021;[Epub] CrossRef
High Red Meat Intake Exacerbates Dextran Sulfate-Induced Colitis by Altering Gut Microbiota in Mice
Dan-ping Li, Min Cui, Fang Tan, Xiao-yan Liu, Ping Yao
Frontiers in Nutrition.2021;[Epub] CrossRef
Dihydroartemisinin ameliorates dextran sulfate sodium induced inflammatory bowel diseases in mice
Zili Lei, Yanhong Yang, Shaomin Liu, Yuting Lei, Lanxiang Yang, Xueying Zhang, Wanwan Liu, Huijuan Wu, Changyuan Yang, Jiao Guo
Bioorganic Chemistry.2020; 100: 103915. CrossRef
Manipulating resident microbiota to enhance regulatory immune function to treat inflammatory bowel diseases
Yoshiyuki Mishima, Ryan Balfour Sartor
Journal of Gastroenterology.2020; 55(1): 4. CrossRef
Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice
Puze Li, Minna Wu, Wancheng Xiong, Jinsong Li, Yunying An, Jie Ren, Yingguang Xie, Hongfei Xue, Dong Yan, Min Li, Genshen Zhong
International Immunopharmacology.2020; 81: 106288. CrossRef
Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?
Haichao Wang, Chen Ye, Yaling Wu, Pengyu Yang, Chunqiu Chen, Zhanju Liu, Xiaolei Wang
Current Drug Targets.2020; 21(14): 1448. CrossRef
Aqueous extract of Bruguiera gymnorrhiza leaves protects against dextran sulfate sodium induced ulcerative colitis in mice via suppressing NF-κB activation and modulating intestinal microbiota
Jin-Fen Chen, Dan-Dan Luo, Yin-Si Lin, Yu-Hong Liu, Jia-Zhen Wu, Xiao-Qing Yi, Yan Wu, Qian Zhang, Chang-Jun Gao, Jian Cai, Zi-Ren Su
Journal of Ethnopharmacology.2020; 251: 112554. CrossRef
The Link between Oral and Gut Microbiota in Inflammatory Bowel Disease and a Synopsis of Potential Salivary Biomarkers
Allison Bartlett, Robert G. Gullickson, Rajan Singh, Seungil Ro, Stanley T. Omaye
Applied Sciences.2020; 10(18): 6421. CrossRef
Yogurt enriched to correct intestinal microflora in dysbiosis
V Yu Kontareva, S N Belik, E V Morgul, I F Gorlov, M I Slozhenkina
IOP Conference Series: Earth and Environmental Science.2020; 548(8): 082051. CrossRef
Predicting Microbe-Disease Association by Learning Graph Representations and Rule-Based Inference on the Heterogeneous Network
Xiujuan Lei, Yueyue Wang
Frontiers in Microbiology.2020;[Epub] CrossRef
Consumption of a baked corn and bean snack reduced chronic colitis inflammation in CD-1 mice via downregulation of IL-1 receptor, TLR, and TNF-α associated pathways
Ivan Luzardo-Ocampo, Rocio Campos-Vega, Elvira Gonzalez de Mejia, Guadalupe Loarca-Piña
Food Research International.2020; 132: 109097. CrossRef
The role of a plant-based diet in the pathogenesis, etiology and management of the inflammatory bowel diseases
Charlene S. J. Grosse, Claus T. Christophersen, Amanda Devine, Ian C. Lawrance
Expert Review of Gastroenterology & Hepatology.2020; 14(3): 137. CrossRef
Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice
Ziwen Yuan, Lihong Yang, Xiaosong Zhang, Peng Ji, Yanming Wei
Biomedicine & Pharmacotherapy.2020; 121: 109638. CrossRef
Anti-inflammatory activity of grapefruit juice in an in vivo model of ulcerative colitis: Comparability studies of unprocessed and bioprocessed juices
Carla Mendes, João Rocha, Rosa Direito, Adelaide Fernandes, Bruno Sepodes, Maria-Eduardo Figueira, Maria H. Ribeiro
Journal of Functional Foods.2019; 63: 103564. CrossRef
Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function
Ziwen Yuan, Lihong Yang, Xiaosong Zhang, Peng Ji, Yongli Hua, Yanming Wei
Frontiers in Pharmacology.2019;[Epub] CrossRef
The role of the gut microbiota in the treatment of inflammatory bowel diseases
Ioanna Aggeletopoulou, Christos Konstantakis, Stelios F. Assimakopoulos, Christos Triantos
Microbial Pathogenesis.2019; 137: 103774. CrossRef
Parenteral Nutrition in Patients with Inflammatory Bowel Disease Systematic Review, Meta-Analysis and Meta-Regression
Jose M. Comeche, Iris Comino, Cesare Altavilla, Jose Tuells, Ana Gutierrez-Hervas, Pablo Caballero
Nutrients.2019; 11(12): 2865. CrossRef
Neue medikamentöse Ansätze bei chronisch-entzündlichen Darmerkrankungen
S. Pröbsting, B. Terjung
coloproctology.2019; 41(1): 5. CrossRef
Crohn’s Disease Remission with a Plant-Based Diet: A Case Report
Kelsea Sandefur, Hana Kahleova, Alan N. Desmond, Eden Elfrink, Neal D. Barnard
Nutrients.2019; 11(6): 1385. CrossRef
Intestinal Sensing by Gut Microbiota: Targeting Gut Peptides
Mihai Covasa, Richard W. Stephens, Roxana Toderean, Claudiu Cobuz
Frontiers in Endocrinology.2019;[Epub] CrossRef
Enteral Nutrition in Patients with Inflammatory Bowel Disease. Systematic Review, Meta-Analysis, and Meta-Regression
Jose M. Comeche, Pablo Caballero, Ana Gutierrez-Hervas, Sofia García-Sanjuan, Iris Comino, Cesare Altavilla, Jose Tuells
Nutrients.2019; 11(11): 2657. CrossRef
Endothelial and Cardiac Dysfunction in Inflammatory Bowel Diseases: Does Treatment Modify the Inflammatory Load on Arterial and Cardiac Structure and Function?
Charilaos Triantafyllou, Maria Nikolaou, Ignatios Ikonomidis, Giorgos Bamias, Ioannis Papaconstantinou
Current Vascular Pharmacology.2019; 18(1): 27. CrossRef
Exosome-Induced Regulation in Inflammatory Bowel Disease
Huiting Zhang, Liang Wang, Changyi Li, Yue Yu, Yanlin Yi, Jingyu Wang, Dapeng Chen
Frontiers in Immunology.2019;[Epub] CrossRef
Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment
Zhenping Cao, Xinyue Wang, Yan Pang, Shanshan Cheng, Jinyao Liu
Nature Communications.2019;[Epub] CrossRef
Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota
Minna Wu, Puze Li, Yunying An, Jie Ren, Dong Yan, Jiazeng Cui, Duan Li, Min Li, Mingyong Wang, Genshen Zhong
Pharmacological Research.2019; 150: 104489. CrossRef
Commensal and Pathogenic Bacteria Indirectly Induce IL-22 but Not IFNγ Production From Human Colonic ILC3s via Multiple Mechanisms
Moriah J. Castleman, Stephanie M. Dillon, Christine M. Purba, Andrew C. Cogswell, Jon J. Kibbie, Martin D. McCarter, Mario L. Santiago, Edward Barker, Cara C. Wilson
Frontiers in Immunology.2019;[Epub] CrossRef
Ursodeoxycholic acid: a promising therapeutic target for inflammatory bowel diseases?
Stephen J. Keely, Clifford J. Steer, Natalia K. Lajczak-McGinley
American Journal of Physiology-Gastrointestinal and Liver Physiology.2019; 317(6): G872. CrossRef
Probiotics: If It Does Not Help It Does Not Do Any Harm. Really?
Aaron Lerner, Yehuda Shoenfeld, Torsten Matthias
Microorganisms.2019; 7(4): 104. CrossRef
Linking the gut and liver: crosstalk between regulatory T cells and mucosa-associated invariant T cells
Muhammad Atif, Suz Warner, Ye H. Oo
Hepatology International.2018; 12(4): 305. CrossRef
Gut microbiomes and their metabolites shape human and animal health
Woojun Park
Journal of Microbiology.2018; 56(3): 151. CrossRef
Multispecies Probiotic Supplementation Favorably Affects Vascular Function and Reduces Arterial Stiffness in Obese Postmenopausal Women—A 12-Week Placebo-Controlled and Randomized Clinical Study
Monika Szulińska, Igor Łoniewski, Katarzyna Skrypnik, Magdalena Sobieska, Katarzyna Korybalska, Joanna Suliburska, Paweł Bogdański
Nutrients.2018; 10(11): 1672. CrossRef
Update on the Gastrointestinal Microbiome in Systemic Sclerosis
Chiara Bellocchi, Elizabeth R. Volkmann
Current Rheumatology Reports.2018;[Epub] CrossRef
Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases
Luana de Mendonça Oliveira, Franciane Mouradian Emidio Teixeira, Maria Notomi Sato
Mediators of Inflammation.2018; 2018: 1. CrossRef
Micronized Cells of the Probiotic Strain Bifidobacterium lactis BS01 Activate Monocyte Polarization
Luca Mogna, Angela Amoruso, Marco Pane, Stefania Nicola, Serena Allesina, Francesca Deidda
Journal of Clinical Gastroenterology.2018; 52(Supplement): S57. CrossRef

First
Prev
Page of 1
Next
Last

Search